GB 206952006 高效氯氟氰菊酯原药
高效氯氟氰菊酯结构式-概述说明以及解释
高效氯氟氰菊酯结构式-概述说明以及解释1.引言1.1 概述随着农药行业的发展，高效氯氟氰菊酯作为一种新型的杀虫剂受到了广泛关注。
它具有较高的杀虫活性和较长的持效期，被广泛应用于农业生产中的害虫防治。
高效氯氟氰菊酯的化学结构独特，通过对害虫的神经细胞进行破坏，达到杀虫的效果。
同时，高效氯氟氰菊酯的制备方法也越来越成熟，使其生产成本逐渐降低，提高了农业生产的效益。
然而，随着高效氯氟氰菊酯的广泛使用，也引发了一些争议。
一方面，高效氯氟氰菊酯对害虫的杀灭效果显著，能有效减少农作物受害面积，提高农产品的质量和产量。
另一方面，高效氯氟氰菊酯也对环境和人体产生一定的影响。
长期以来，高效氯氟氰菊酯在环境中的残留问题备受关注，其超标使用不仅会对农田土壤和水源造成污染，还会对生态系统产生破坏。
此外，高效氯氟氰菊酯在农作物生长过程中的残留也可能对人体健康造成潜在风险。
因此，在广泛应用高效氯氟氰菊酯的同时，我们也需要重视其对环境和人体的影响，并积极探索替代品或绿色防治方式，以达到农业生产的可持续发展目标。
通过加强监管措施，合理使用农药，并注重环境保护与人体健康，我们可以更好地发挥高效氯氟氰菊酯的优势，为农业生产做出贡献。
文章结构是指文章的组织框架，它能够使读者便于阅读和理解文章内容。
本文主要包括以下几个部分：1. 引言：- 1.1 概述：介绍高效氯氟氰菊酯的基本背景和相关概念。
- 1.2 文章结构：说明文章的组织框架和各个部分的内容。
- 1.3 目的：阐明撰写本文的目的和意义。
2. 正文：- 2.1 高效氯氟氰菊酯的化学结构：详细介绍高效氯氟氰菊酯的化学结构、分子式以及分子量等相关信息。
- 2.2 高效氯氟氰菊酯的制备方法：探讨高效氯氟氰菊酯的制备工艺、原料选择、反应条件等方面的内容。
3. 结论：- 3.1 高效氯氟氰菊酯的应用前景：讨论高效氯氟氰菊酯在农业领域的广泛应用，以及未来的研究方向和发展趋势。
- 3.2 对环境和人体的影响：分析高效氯氟氰菊酯在使用和生命周期中可能对环境和人体带来的潜在影响，以及可能的防护措施和风险评估。
高效氯氟氰菊酯
EUROPEAN COMMISSIONDIRECTORATE-GENERAL HEALTH & CONSUMER PROTECTIONDirectorate E - Public, animal and plant healthUnit E1 Legislation relating to crop products and animal nutritionlambda-cyhalothrin7572/VI/97-final25 January 2001Review report for the active substance lambda-cyhalothrin Finalised in the Standing Committee on Plant Health at its meeting on 19 October 2000 in view of the inclusion of lambda-cyhalothrin in Annex I of Directive 91/414/EEC1.Procedure followed for the re-evaluation processThis review report has been established as a result of the re-evaluation of lambda-cyhalothrin, made in the context of the work programme for review of existing active substances provided for in Article 8(2) of Directive 91/414/EEC concerning the placing of plant protection products on the market, with a view to the possible inclusion of this substance in Annex I to the Directive.Commission Regulation (EEC) No 3600/92(1) laying down the detailed rules for the implementation of the first stage of the programme of work referred to in Article 8(2) of Council Directive 91/414/EEC, as last amended by Regulation (EC) No 1972/992, has laid down the detailed rules on the procedure according to which the re-evaluation has to be carried out. lambda-Cyhalothrin is one of the 90 existing active substances covered by this Regulation. In accordance with the provisions of Article 4 of Regulation (EEC) No 3600/92, Zeneca Agrochemicals on 27 July 1993 and Stefes Pflanzenschutz GmbH on9 and 20 July 1993 notified to the Commission of their wish to secure the inclusion of the active substance lambda-cyhalothrin in Annex I to the Directive.In accordance with the provisions of Article 5 of Regulation (EEC) No 3600/92, the Commission, by its Regulation (EEC) No 933/94(3), as last amended by Regulation (EC) No 2230/95(4), designated Sweden as rapporteur Member State to carry out the assessment of lambda-cyhalothrin on the basis of the dossiers submitted by the notifiers. In the same Regulation, the Commission specified furthermore the deadline for the notifiers with regard to the submission to the rapporteur Member States of the dossiers required under Article 6(2) of1 OJ No L 366, 15.12.1992, p.10.2 OJ No L 244, 16.9.1999, p. 41.3 OJ No L 107, 28.04.1994, p.8.4 OJ No L 225, 22.09.1995, p.1.Regulation (EEC) No 3600/92, as well as for other parties with regard to further technical and scientific information; for lambda-cyhalothrin this deadline was 30 April 1995.Only Zeneca Agrochemicals submitted a dossier to the rapporteur Member State which was considered as complete. Stefes Pflanzenschutz GmbH did not submit a dossier.In accordance with the provisions of Article 7(1) of Regulation (EEC) No 3600/92, Sweden submitted on 12 June1996 to the Commission the report of its examination, hereafter referred to as the draft assessment report, including, as required, a recommendation concerning the possible inclusion of lambda-cyhalothrin in Annex I to the Directive. Moreover, in accordance with the same provisions, the Commission and the Member States received also the summary dossier on lambda-cyhalothrin from Zeneca Agrochemicals, on 31 July 1996.In accordance with the provisions of Article 7(3) of Regulation (EEC) No 3600/92, the Commission forwarded for consultation the draft assessment report to all the Member States as well as to Zeneca Agrochemicals being the main data submitter, on 24 June 1996.The Commission organised an intensive consultation of technical experts from a certain number of Member States, to review the draft assessment report and the comments received thereon (peer review), in particular on each of the following disciplines:-identity and physical /chemical properties ;-fate and behaviour in the environment ;-ecotoxicology ;-mammalian toxicology ;-residues and analytical methods ;-regulatory questions.The meetings for this consultation were organised on behalf of the Commission by the Pesticide Safety Directorate (PSD) in York, United Kingdom, from September to December 1996.The report of the peer review (i.e. full report)was circulated, for further consultation, to Member States and the main data submitter on 13 January 1997 for comments and further clarification.In accordance with the provisions of Article 7(3) of Regulation (EEC) No 3600/92, the dossier, the draft assessment report, the peer review report (i.e. full report)and the comments and clarifications on the remaining issues, received after the peer review were referred to the Standing Committee on Plant Health, and specialised working groups of this Committee, for final examination, with participation of experts from the 15 Member States. This final examination took place from February 1998 to August 2000, and was finalised in the meeting of the Standing Committee on 19 October 2000.The present review report contains the conclusions of this final examination; given the importance of the draft assessment report, the peer review report (i.e. full report) and the comments and clarifications submitted after the peer review as basic information for the final examination process, these documents are considered respectively as background documents A, B and C to this review report and are part of it.These documents were also submitted to the Scientific Committee for Plants for separate consultation. The report of this Committee was formally adopted on 29 February 20005).2. Purposes of this review reportThis review report, including the background documents and appendices thereto, have been developed and finalised in support of the Directive 2000/80/EC concerning the placing of plant protection products on the market, so as to consolidate that Annex and include a further active substance (lambda-cyhalothrin), and to assist the Member States in decisions on individual plant protection products containing lambda-cyhalothrin they have to take in accordance with the provisions of that Directive, and in particular the provisions of article 4(1) and the uniform principles laid down in Annex VI.This review report provides also for the evaluation required under Section A.2.(b) of the above mentioned uniform principles, as well as under several specific sections of part B of these principles. In these sections it is provided that Member States, in evaluating applications and granting authorisations, shall take into account the information concerning the active substance in Annex II of the directive, submitted for the purpose of inclusion of the active substance in Annex I, as well as the result of the evaluation of those data.In accordance with the provisions of Article 7(6) of Regulation (EEC) No 3600/92, Member States will keep available or make available this review report for consultation by any interested parties or will make it available to them on their specific request. Moreover the Commission will send a copy of this review report (not including the background documents) to all operators having notified for this active substance under Article 4(1) of this Regulation.The information in this review report is, at least partly, based on information which is confidential and/or protected under the provisions of Directive 91/414/EEC. It is therefore recommended that this review report would not be accepted to support any registration outside the context of Directive 91/414/EEC, e.g. in third countries, for which the applicant has not demonstrated to have regulatory access to the information on which this review report is based.3.Overall conclusion in the context of Directive 91/414/EECThe overall conclusion from the evaluation is that it may be expected that plant protection products containing lambda-cyhalothrin will fulfil the safety requirements laid down in Article 5(1)(a) and (b) of Directive 91/414/EEC. This conclusion is however subject to compliance with the particular requirements in sections 4, 5, 6 and 7 of this report, as well as to the implementation of the provisions of Article 4(1) and the uniform principles laid down in Annex VI of Directive 91/414/EEC, for each lambda-cyhalothrin containing plant protection product for which Member States will grant or review the authorisation.Furthermore, these conclusions were reached within the framework of a range of uses, which were proposed and supported by the main data submitter, as outlined in Background documentC of this report.5 Opinion of the scientific Committee on Plants regarding the inclusion of lambda-cyhalothrin in Annex I to Council Directive 91/414/EEC concerning the placing of plant protection products on the market. SCP/LAMBDA/002-Final.Extension of the use pattern beyond those reviewed will require an evaluation at Member State level in order to establish whether the proposed extensions of use can satisfy the requirements of Article 4(1) and of the uniform principles laid down in Annex VI of Directive 91/414/EEC. With particular regard to residues, the review has established that the residues arising from the proposed uses, consequent on application consistent with good plant protection practice, have no harmful effects on human or animal health. The Theoretical Maximum Daily Intake (TMDI; excluding water and products of animal origin) for a 60 kg adult is 30 % of the Acceptable Daily Intake (ADI), based on the FAO/WHO European Diet (August 1994). Provisional estimates of acute dietary exposure of adults and toddlers revealed that the Acute Reference Dose (ARfD) might be exceeded for few, individual commodities6. These possible exceedances should be addressed in the framework of Council Directive 90/642/EEC on the setting of maximum residues of pesticides in fruit and vegetables.The review has identified several acceptable exposure scenarios for operators, workers and bystanders, which require however to be confirmed for each plant protection product in accordance with the relevant sections of the above mentioned uniform principles.The review has also concluded that under the proposed and supported conditions of use there are no unacceptable effects on the environment, as provided for in Article 4 (1) (b) (iv) and (v) of Directive 91/414/EEC, provided that certain conditions are taken into account as detailed in section 6 of this report.4.Identity and Physical/chemical propertiesThe main identity and the physical/chemical properties of lambda-cyhalothrin are given in Appendix I.The active substance shall comply with the FAO specification and there seem not to be reasons for deviating from that specification; the FAO specification is given in Appendix I of this report. The review has established that for the active substance notified by the main data submitter Zeneca Agrochemicals, none of the manufacturing impurities considered are, on the basis of information currently available, of toxicological or environmental concern.5.Endpoints and related informationIn order to facilitate Member States, in granting or reviewing authorisations, to apply adequately the provisions of Article 4(1) of Directive 91/414/EEC and the uniform principles laid down in Annex VI of that Directive, the most important endpoints as identified during the re-evaluation process are set out under point 1 above. These endpoints are listed in Appendix II.6Adults: Spinach; Toddlers: Apples, pears, grapes, spinach. Worst case estimates on the basis of provisional residue data.6.Particular conditions to be taken into account on short term basis by MemberStates in relation to the granting of authorisations of plant protection products containing lambda-cyhalothrinOn the basis of the proposed and supported uses, the following particular issues have been identified as requiring particular and short term attention from all Member States, in the framework of any authorisations to be granted, varied or withdrawn, as appropriate:- Member States in granting authorisations must pay particular attention to the operator safety and must ensure that the conditions of authorisation include appropriate protective measures.- Member states should observe the acute dietary exposure situation of consumers in view of future revisions of Maximum Residue Levels.- For the protection of aquatic organisms, risk mitigation measures should be applied where appropriate.- For the protection of bees Member States should prescribe appropriate risk mitigation measures (e.g. buffer zones) if products containing lambda-cyhalothrin are applied at high doses.- Depending on crop and application rate, Member States should prescribe appropriate risk mitigation measures to avoid unacceptable effects on non-target arthropods when authorisations are granted for plant protection products containing this active substance.7.List of studies to be generatedNo further studies were identified which at this stage were considered necessary in relation to the inclusion of lambda-cyhalothrin in Annex I under the current inclusion conditions.Some endpoints however may require the generation or submission of additional studies to be submitted to the Member States in order to ensure authorisations for use under certain conditions. This may particularly be the case for- residue data supporting the current critical GAP, and- further laboratory and/or field studies on bees and non-target arthropods.rmation on studies with claimed data protectionFor information of any interested parties, Appendix III gives information about the studies for which the main data submitter has claimed data protection and which during the re-evaluation process were considered as essential with a view to annex I inclusion. This information is only given to facilitate the operation of the provisions of Article 13 of Directive 91/414/EEC in the Member States. It is based on the best information available to the Commission services at the time this review report was prepared; but it does not prejudice any rights or obligations of Member States or operators with regard to its uses in the implementation of the provisions of Article 13 of the Directive 91/414/EEC neither does it commit the Commission.9.Updating of this review reportThe technical information in this report may require to be updated from time to time in order to take account of technical and scientific developments as well as of the results of the examination of any information referred to the Commission in the framework of Articles 7, 10 or 11 of Directive 91/414/EEC. Such adaptations will be examined and finalised in the Standing Committee on Plant Health, in connection with any amendment of the inclusion conditions for lambda-cyhalothrin in Annex I of the Directive.APPENDIX IIdentity, physical and chemical properties lambda-CYHALOTHRINMelting point49.2 °C (322.4 K)Boiling point No measurable boiling point (decomposes) Appearance Beige solid without any characteristic odour (technicalgrade)Relative density 1.33 g/cm3 (1330 kg/m3) at 25 °CVapour pressure 2 · 10-7 Pa at 20 °C (extrapolated)Henry's law constant0.02 Pa⋅m3·mol-1 at 20 °CSolubility in water At 20 °C:pH 5: 4 · 10-3 mg/lpH 6.5: 5 · 10-3 mg/lpH 9.2: 4 · 10-3 mg/lSolubility in organic solvents At 21 °C:hexane, toluene, dichloromethane, methanol, acetoneand ethyl acetate: > 500 g/lPartition co-efficient (log P OW)log P OW = 7.0Hydrolytic stability (DT50)There is no significant hydrolysis at pH 5.2 and 6.9.After 7 days at pH 9.0, 43 – 45 % of PP321 remainsintact, thus half-life is approximately 7 days. Dissociation constant Not applicable0.092 (at wavelengths 270-290 nm)Quantum yield of direct photo-transformation in water:acetonitrileFlammability Flammability, in terms of flash point: 83 ± 2ºC(substance heated before test)Explosive properties Not explosive (expert judgement based on structure) UV/VIS absorption (max.)Two absorption maxima, at 210 nm and 275-280 nm,with an absorption tail up to 300 nm.Photostability (DT50)Indicated DT50 in water 13 days (latitudes 40 and 50°N).Average quantum yield at 270-290 nm 0.092.Calculated DT50 in European waters 5 days (summer) to75 days (winter).Calculated photochemical oxidative DT50 in air 4.1 h.10 November 2000APPENDIX IIEND POINTS AND RELATED INFORMATIONlambda-CYHALOTHRIN1 Toxicology and metabolismAbsorption, distribution, excretion and metabolism in mammalsRate and extent of absorption:Oral, < 2 d man, 50 %Distribution:Wide, with concentration in adipose tissuePotential for accumulation:Half-life: 23 dRate and extent of excretion: 2 d, 90 %Toxicologically significant compounds:ParentMetabolism in animals:Mainly by cleavage of ester bond and furthertransformation to conjugated metabolitesAcute toxicityRat LD50 oral:LD50 = 56 (f) - 79 (m) mg/kg bw R25 Rat LD50 dermal:LD50 = 632 (m) – 696 (f) mg/kg bw R21 Rat LC50 inhalation:LC50 = 0.06 mg/l R26 Skin irritation:Slight irritation. Non-irritant according to criteria. Eye irritation:Slight irritation. Non-irritant according to criteria.Sensitisation (test method used and result):Not sensitising at a 1% challenge dose. Higher doses not possible due to paraesthesiaGuinea pig maximisation testShort term toxicityTarget / critical effect:Organs liver, CNSLowest relevant oral NOAEL / NOEL:0.5 mg/kg bw/d, oral, 1 y dog Lowest relevant dermal NOAEL /NOEL:No study available10 November 2000 Lowest relevant inhalation NOAEL /NOEL:No study availableGenotoxicity NegativeLong term toxicity and carcinogenicityTarget / critical effect:LiverLowest relevant NOAEL:NOEL 1.7 mg/kg bw/d, 2 y rat (cyhalothrin) Carcinogenicity:NegativeReproductive toxicityTarget / critical effect - Reproduction:Negative. Parental, slightly reduced bw gain andslightly reduced bw gain of the pups.Lowest relevant reproductive NOAEL / NOEL:NOEL 1.5 mg/kg bw/d (parental) NOEL 1.5 mg/kg bw/d (foetal)Target / critical effect - Developmental toxicity:Negative. No treatment related embryotoxic or teratogenic effects were observed.Lowest relevant developmental NOAEL / NOEL:NOEL 10 mg/kg bw/d based on maternal toxicity (decreased bw gain and loss of limb coordination).Delayed neurotoxicity Not relevantOther toxicological studies NoneMedical data Information suppliedSummaryValue Study Safety factor ADI:0.005 mg/kgbw/d1 y dog100AOEL systemic:0.0025 mg/kgbw/d 1 y dog(50 % oral absorption)100AOEL inhalation:AOEL dermal:ARfD (acute reference dose):0.0075 mg/kg bw6-week oral dogstudy; NOEL0.75 mg/kg bw1001. Toxicology and metabolism10 November 2000 Dermal absorption12 % EC formulation, in-use dilution: 4 %, in vivo rat5 % EC formulation, in-use dilution: <0.3%, in vivoman5 % EC formulation, in-use dilution: 0.055%, in vitroman0.3% used for model calculations (concentrate anddilution) (See Doc. 5684/VI/97-app.4)23 November 20002 Fate and behaviour in the environment2.1 Fate and behaviour in soil Route of degradationAerobic:Mineralization after 100 days:Non-extractable residues after 100 days:Relevant metabolites above 10 % of applied active substance: name and/or code % of applied rate (range and maximum)Supplemental studies Anaerobic:Soil photolysis:NegligibleRemarks:Rate of degradationLaboratory studies7Compound XV: (RS)-α-cyano-3-(4-hydroxyphenoxy)benzyl-(Z)-(1RS)-cis-3-(2-chloro-3, 3, 3-trifluoropropenyl)-2, 2-dimethylcyclopropanecarboxylate. (IUPAC)8Compound Ia (cyclopropane acid): (Z)-3-(2-chloro-3, 3, 3-trifluoropropenyl)-2, 2-dimethylcyclopropanecarboxylic acid. (IUPAC)9Compound V: 3-phenoxybenzoic acid. (IUPAC)23 November 2000DT 50lab (20 °C, aerobic):DT 90lab (20 °C, aerobic):DT 50lab (10 °C, aerobic):DT 50lab (20 °C, anaerobic):Field studies (country or region)US and Germany:Detected in the upper 10 cm of soil,< 4 % below 5 cm depthDT 50f from soil dissipation studies:Germany: 6, 26, 28, 40 d (best fit model)US study I: 2, 37 d (best fit model)US study II: 19, 20, 21, 35 d (best fit model)Mean 23 d (n=10)DT 90f from soil dissipation studies:Germany: 68, 85, 92, 207 d (best fit model)US study I: approx. 30, > 279 d (graphical)US study II: 62, 67, 108, 117d (best fit model)Mean 112 days (n=10)Soil accumulation studies:Not submitted, not required Soil residue studies:Not submitted, not requiredRemarksUS study I used 14C-cyclopropane and 14C-phenyl label; bound residues as 22-32% after 115 days,and as 17-27% after 279 days.Adsorption/desorptionK f / K oc :K dpH dependence:Mobility10DT 50s for soil metabolite XV inserted as agreed by Working Group Legislation, October 2000. Data provided by CTB (The Netherlands), not evaluated by the RMS. DT 50s in original report were 4, 3 and 4 days but recalculated into the figures in the table by CTB, assuming first order kinetics (r 2 0.75-0.96).11Kom values for soil metabolite XV inserted as agreed by Working Group Legislation, October 2000. Data provided by CTB (The Netherlands), not evaluated by the RMS. Koc values in original report were 60000, 67000,68000, 75000, 78000 and 110000, but recalculated into the values in the table by CTB.23 November 2000Laboratory studies:Column leaching:No significant leachingAged residue leaching:No significant leachingField studies:Lysimeter/Field leaching studies:Not submitted, not requestedNo leaching in field dissipation studies Remarks:None2.2 Fate and behaviour in waterAbiotic degradationHydrolytic degradation:Relevant metabolites:Photolytic degradation:Relevant metabolites:Biological degradationReady biological degradability:Not submitted, not requestedWater/sediment study:DT50 water:DT50 whole system:DT90 water:DT90 whole system:Distribution in water / sediment systems (active substance)at 20 °C, 2 systems, pH 7.2-7.8:5 and 11 h15 and 7 days3.3 and4.6 days151 and 45 daysParent compound, as % of applied radioactivity in the two water/sed. systems:Day 0Day 1Day 7 Water72/4910/13 3.7/2.6 Sediment14/3070/3053/4312Compound Ia (cyclopropane acid): (Z)-3-(2-chloro-3, 3, 3-trifluoropropenyl)2, 2-dimethylcyclopropanecarboxylic acid. (IUPAC).13Compound IV: 3-phenoxybenzaldehyde. (IUPAC)14Compound V: 3-phenoxybenzoic acid. (IUPAC)23 November 2000(metabolites)Accumulation in water and/or sediment:Degradation in the saturated zone Not submitted, not requestedRemarks:None2.3 Fate and behaviour in airVolatilityVapour pressure: 2 · 10-7 Pa at 20 °C (extrapolated)Henry's law constant:0.02 Pa m3·mol-1 at 20 °CPhotolytic degradationDirect photolysis in air:Not submitted and not requested, but possibletheoretically due to absorption ”tail” to 300 nm. Photochemical oxidative degradation in air:DT50 4.1 h (calculated)Volatilisation:Volatilisation from soil not significant, fromleaves low rate of volatilisation observed (88% ofapplied amount remaining on leaves after 24hours).15Compound VI: 3-phenoxybenzylalcohol. (IUPAC)16Compound XV (hydroxylated lambda-cyhalothrin): (RS)-α-cyano-3-(4-hydroxyphenoxy)benzyl-(Z)-(1RS)-cis-3-(2-chloro-3, 3, 3-trifluoropropenyl)-2, 2-dimethylcyclopropanecarboxylate. (IUPAC)23 November 2000 Remarks:None24 October 2000 3 EcotoxicologyTerrestrial VertebratesAcute toxicity to mammals:LD50 = 20 mg/kg bw (mice)Acute toxicity to birds:LD50 > 3950 mg/kg bw (mallard duck)Dietary toxicity to birds:LC50 > 5300 mg/kg food (bobwhite quail) Reproductive toxicity to birds:NOEC > 30 mg/kg food (mallard duck)Short term oral toxicity to mammals:NOEL = 0.7 mg/kg bw/day (male rat, 90-day) Aquatic OrganismsAcute toxicity fish:Long term toxicity fish:Bioaccumulation fish:Acute toxicity invertebrate:Acute toxicity algae:Chronic toxicity sediment dwellingorganism:17Compound Ia (cyclopropane acid): (Z)-3-(2-chloro-3, 3, 3-trifluoropropenyl)2, 2-dimethylcyclopropanecarboxylic acid. (IUPAC).18Compound V: 3-phenoxybenzoic acid. (IUPAC)24 October 2000Results from mesocosm studies:Mesocosm study I (UK):Gammaridae most sensitive taxa:LOEC: 4 events of overspray at 0.17 g/haChironomidae, less sensitive:NOEC: 4 events of overspray at 1.7 g/ha Mesocosm study II (US):Insecta most sensitive taxa:NOAEC: 12 events of overspray at 0.017 g/ha +6 events of run-off at 0.05 g/haFish, L. macrochirus, and sedentary chironomidswere less sensitive:NOEC: 12 events of overspray at 1.7 g/ha + 6events of run-off at 5 g/haHoneybeesAcute oral toxicity:LD50 (48 h) = 0.91 µg/beeAcute contact toxicity:LD50 (48 h) = 0.038 µg/beeField study in cereals:Preliminary results indicate NOAEC = 20 g/haOther arthropod speciesFoliage dwellers:Rhopalosiphum padi LD50 (6 d) 0.004 µg/g bw, contact exposure Leptyphantes spp. (m)LD50 (6 d) 0.097 µg/g bw, contact exposure Leptyphantes spp. (f)LD50 (6 d) 0.132 µg/g bw, contact exposure Bathyphantes spp. (f)LD50 (6 d) 0.012 µg/g bw, contact exposure Oedothorax spp. (m)LD50 (6 d) 0.058 µg/g bw, contact exposure Panonychus ulmi LD50 (48 h) 1.9 g/haTyphlodromus pyri LD50 (48 h) 0.2 g/haEpisyrphus balteatus27% larval mortality after 6 days at 9 g/haSoil dwellers:Trechus quadristriatus LD50 (6 d) 12.1 µg/g bw, contact exposure Pterostichus melanarius23% mortality after 28 days at 7.5 g/ha Poecilus cupreus0-10% mortality after 28 days at 7.5 g/ha Pardosa sp.90% mortality after 14 days at 7.5 g/ha Pardosa spp.83-87% mortality after 14 days at 7.5 g/ha24 October 2000Field study, autumn application in cereals, UK, at 5 g/ha:Mean depression in abundance of affected species was 20-60% and lasted for 4-5 weeks.Field study, summer application in cereals, UK, at 7 g/ha:Mean depression in abundance of affected species was 75% and lasted for 27±6 days.Field study, summer application in cereals, UK, at 2.5, 5 and 10 g/ha:Depression in abundance of the species affected lasted for 1-7 weeks with no statistically significant effects remaining 7 weeks after spraying. Increased selectivity was seen at reduced rates.Field studies in non-European countries:Recovery after 3 weeks.EarthwormsAcute toxicity:LC50 (14 d) > 1000 mg/kg soilNOEC = 100 mg/kg soilReproductive toxicity:Not submitted, not requestedSoil micro-organismsNitrogen mineralization:< 21% effect on ammonification/nitrification at1.25 kg/haCarbon mineralization:No significant effects at 1.25 kg/haList of studies24 October 2000APPENDIX IIIlambda-CYHALOTHRINList of studies for which the main submitter has claimed data protection and which during the re-evaluation process were considered as essential for the evaluation with a view to Annex I inclusion19.B.1 Identity, B.2 Physical and chemical properties, B.3 Data on application and further information,B.4 Proposals for classification and labelling, B.5 Methods of analysis19List based on a detailed analysis from Sweden in its submission of XX/XX/XX (background document C).20 Reports received from the notifier at the date of finalisation of the present review report (not exhaustive).Annex point/ reference number Author(s)Year TitleSource (where different from company)Company, Report No.GLP or GEP status (where relevant)Published or notReports20 onprevious use ingranting nationalauthorizationsAII 2.9.1 AII 7.2.1.1Collis WMD andLeahey JP1984PP321: Hydrolysis in Water at pH 5, 7 and 9.ICI Report series RJ 0338B.GLP studyNot publishedAustria (18/7/91),Germany(25/10/90),UK (14/2/1990),the Netherlands.AII 2.9.2 AII 2.9.3 AII 7.2.1.2Moffatt F1994lambda-Cyhalothrin: Environmental Half-lifeand Quantum Yield for DirectPhototransformation in Aqueous Solution.Zeneca Report Series RJ 1617B.GLP studyNot publishedAII 2.9.2 AII 7.2.1.2Priestley DB andLeahey JP1988PP321: Aqueous Photolysis at pH 5.ICI Report Series RJ 0605B.GLP studyNot publishedGermany(25/10/90),the Netherlands.AII 2.10Hayes SE1998Lambda-cyhalothrin - calculation of half-life byreaction with atmospheric hydroxyl radicals.Zeneca G:\AOP+lambda-cyhalothrin.AOP.GLP not relevantNot publishedAII 4.1Duffin MR1994The determination of lambda-cyhalothrin andassociated impurities in technical material bycapillary gas chromatography.Zeneca Agrochemicals Analytical MethodPAM 721/3.Not GLP studyNot publishedAII 4.2Hadfield ST, SadlerJ andBolygo E 1989The determination of residues of PP321 in water following sampling by a solid-phaseextraction technique.ICI Agrochemical Residue Analytical MethodNumber 125b.Not GLP studyNot publishedAII 4.2Marsh JR1995Determination of lambda-cyhalothrin in humanblood.Zeneca Central Toxicology Laboratory ReportNo. CTL/R/1241.Not GLP studyNot publishedAII 4.2Ryan J and Sapiets A1993Lambda-cyhalothrin: Validation of a steppedmodel to determine residues in air.Zeneca Agrochemicals Jealott´s Hill ResearchStation Report No. RJ1525B.GLP studyNot published。
夯裕农药适用清单
喷雾
艾法迪
氰氟虫腙
22％悬浮剂
70－80g/ mu
2
甘蓝5
喷雾
除尽 垄歌 辛硫磷 敌百虫
虫螨腈 氟虫双酰胺 辛硫磷 敌百虫
10%悬浮剂 20％水分散粒剂 3%颗粒剂 90%原药
33-50g/mu 15－17g/mu 1500-2000g/mu 50-100g/mu
2 3 2 2
甘蓝14 白菜3 14 14
戊唑醇
430g/l悬浮剂
15-18ml/mu
2
大白菜14
软腐病
喷雾
农药登记证号：PD20110287; 执行标 拜耳作物科学（中国） 准号：Q/GB-JV53-2009; 生产许可证 有限公司 号：HNP46887-D9021
龙克菌
噻菌铜
20-30g/mu
3
7
普力克
霜霉威盐酸盐
722g克/升水剂
3000倍
氯虫苯甲酰胺
200g/l悬浮剂
3
1
小菜蛾、棉铃 虫、菜青虫 甜菜夜蛾
喷雾
鹰虫1号
苜蓿银纹夜蛾核 10亿PIB/ml悬浮 型多角体病毒 剂 高氯·甲维盐 5％微乳剂
1000-1500倍
2
3
喷雾
优钻
20－30g/ mu
1
甘蓝 14
甜菜夜蛾 小菜蛾、甜菜 夜蛾 甜菜夜蛾、小 菜蛾 甜菜夜蛾、小 菜蛾 地下害虫 地下害虫
安打
茚虫威
150g/l悬浮剂
10-18ml/mu（甜 菜叶蛾、小菜 蛾）；510ml/mu（菜青 虫） 10ml/mu
3
7
菜青虫、甜菜 夜蛾、小菜蛾
喷雾
美国杜邦公司
农药登记证号：PD20101189; 执行标 准号： Q/DDDA 64-2008 生产许可 证号：HNP 31024-A7491
高效氯氟氰菊酯MSDS
化学品安全数据单一、标识
四、急救措施
九、物理及化学性质
十、稳定及反应性
十三、处置考虑
注1：当产品为含有两种以上危险物质的混合物时，应依据其混合后的危险性，制作安全数据单。
注2：制造商/供应商应根据实际情况确保安全数据单所含信息的正确性，并适时更新。
注3：如由于产品特性而不存在或不可得某些信息时（如固体不存在沸点），应在表格中以“/”标识。
第1页，共5页Chemical Safety Data Sheet
Note 1: When products contain two or more hazardous substances, Safety Data Sheets should be prepared based on the risk of the mixture.
Note 2: Manufacturer / supplier should ensure the correctness of the information contained in the safety data sheets, and updated in a timely manner.
Note 3: As a result of product features without the existence of certain information (such as boiling point does not exist for the solid) in the table with "/" logo.。
高效氯氰菊酯(MSDS)
呼吸系统防护：空气中浓度超标时，必须佩戴自吸过滤式防毒面具（半面罩）。紧急事态抢救或撤离时，应该佩戴空气呼吸器。
眼睛防护：戴化学安全防护眼镜。
身体防护：穿防毒物渗透工作服。
手防护：戴橡胶手套。
其他防护：工作场所禁止吸烟、进食和饮水，饭前要洗手。工作完毕，淋浴更衣。保持良好的卫生习惯。
（6）柑橘红蜡蚧：在卵孵化盛期防治。用4.5%乳油加水稀释900倍均匀喷雾。
（7）茶尺蠖：于2-3龄幼虫盛发期施药，每亩用4.5%乳油2540毫升，加水60～75?，均匀喷雾。
（8）烟青虫：于 2-3龄幼虫期施药，每亩用4.5%乳油25-40毫升，加水 60-75?，均匀喷雾。
（9）各种松毛虫、杨树舟娥、美国白娥在2-3龄幼虫发生期，用4.5%乳油4000-8000倍液喷雾， 飞机喷雾每公倾用量60-150毫升。
第十五部分：法规信息
国内化学品安全管理法规：化学危险物品安全管理条例(1987年2月17日国务院发布)，危险化学品安全管理条例(2002年3月15日国务院发布)。化学危险物品安全管理条例实施细则(化劳发[1992] 677号)，工作场所安全使用化学品规定([1996]劳部发423号)等法规，针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定；常用危险化学品的分类及标志(GB 13690-92)将该物质划为第6.1类毒害品。
第七部分：操作处置与储存
操作注意事项：密闭操作，局部排风。防止蒸气泄漏到工作场所空气中。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防毒面具（半面罩），戴化学安全防护眼镜，穿防毒物渗透工作服，戴橡胶手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。在清除液体和蒸气前不能进行焊接、切割等作业。避免产生烟雾。避免与氧化剂、碱类接触。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。
高效氯氟氰菊酯—搜狗百科
高效氯氟氰菊酯—搜狗百科化学名称：3-(2-氯-3,3,3-三氟丙烯基)-2,2-二甲基环丙烷羧酸α-氰基-3-苯氧苄基酯曾用名：高效氯氟氰菊酯、毒特星、功乐、攻关、功千、功勋、功禾、功锐、功星、功令、功浚、功特、攻猎、功将、功倒、攻索、功高、攻害、功力、功灿、功卡、功灭、金功、银功、立功、顶渺、好功、美功、森功、闪功、展功、广功、澳功、捷功、尊功、领功、稳功、爱功、极功、硬功、迅功、神功、易攻、至功、胜功、炫功、玄宝功、傲功、扑功、强攻、强弩、当关、飞红、红箭、惊彩、彩地、日高防、高发、高兰、高福、共福、泰龙、彪、劲彪、彪戈、英瑞、连斗、斗盎、斗魁、雷帅、碧宝、喷金、金登、金菊、鑫碧、氟虎、暂星、铁骑、铁腕、美赛、赛镖、擒敌、更富、荣茂、闪点、万凯、万祥、万巧、巧克、巧杀、砍杀、统杀、统宁、冲锋、巅逢、封害、狂纵、多击、击破、击断、米格、翠浓、务农、天戟、天矛、天弓、天菊、无患、刚劲、劲跑、劲夫、胜夫、夫伏、强悍、强镇、丝抑、顶秀、希利、真迅、迅拿、迅奇、奇猛、怒猛、蔬香、添翼、力鼎、透拿、速征、森戈、稼尊、震死、植喜、傲申、跃成、方捕、朗穗、朗星、健祥、黑雾、诱敌、闪平、联扑、妙胜、东晟、定生、定剑、乐剑、重歼、射手、单挑、双盾、通惠、惠择、大康、小康、康夫、消卷、穿纵、丰野、稳定杀、四面击、好本事、好农夫、好渗达、好乐士、圣斗士、金锐宁、黄金甲、恒功清、见虫卡、专整虫、虫垮台、绿青丹、雷司令、如雷贯、功得乐、特鲁伊、华夏龙、寒风刀、秋风扫、死翘翘、洽益鹏、百千浪、百业新、金秋风扫、菜茶帮手、苏化正功、丰山农富、上格治服、瑞德丰瑞功。
分析方法：液谱法(Anal.Methods. Pestic. Plant Growth. Regul. 1984.13,9)理化性质纯品为白色固体，黄色至棕色粘稠油状液体(工业品)，沸点187－190℃/0.2mmHg，蒸气压约0.001mPa(20℃)，密度1.25(25℃)，溶解度水中0.004ppb(20℃)，溶于丙酮，二氯甲烷，甲醇，乙醚，乙酸乙酯，己烷，甲苯均>500g/L(20℃)，50℃黑暗处存放2年不分解，光下稳定，275℃分解，光下pH7－9缓慢分解，pH>9加快分解。
高效氯氢菊酯原药
Ａ ｍＥ ，
， … “二 ， 诵 “ … （１ ） ”． ““… … …
式中： ， 标样溶液中高效级氛菊酸（ Ａ— 高效顺式十商效反式） 蜂面积的平均值； Ａ — 试样溶液中高效级很菊附（ ， 高效顺式十商效反式） 峰面积的平均值。 ， — 高效级氛菊酣标样的质Ｉ＋ｔ １ ｔｇ ｍ — 试样的质盈，； Ｅ ９
１ 范围 本标准规定 了高效抓氛菊醋原药的要求、 试验方法以及标志、 标签、 包装 、 贮运。
本 标 准适 用 于 由 高效 抓 佩 菊 醋及 其 生 产 中产生 的杂 质组 成 的高 效 氮银 菊 醋 原 药 。 ２ 引 用标 准
下列标准所包含的条文 ， 通过在本标准 中引用而构成为本标准的条文 。本标准出版时 ， 所示版本均
Ｇ ３９ －１ ８ 农药包装通则 Ｂ ６ ９ ３ ７ ３ 要求
３ １ 外观： ． 白色至浅黄色结晶粉末。 ３２ 高效抓氛菊防原药应符合表 １ ． 要求 。 表 １ 高效扳佩菊醋原药控制项 目指标
指 项 目 标 合格 品
９． ２０ ０５ ． ４０ ６０ ．＾ ．
１５ ２７
中华人民共和国化工行业标准
高效氯氛菊酉原药 旨
Ｂ ｔ－ｙ ｅｍｅｈ ｉ ｔｃ ｎｃｌ ｅａｃｐ ｒ ｔｒ ｅｈ ｉ ｎ ａ
ＨＧ ６ ９ １９ ３ ２－ ９ ９
高效锐氛菊醋其他名称、 结构式和基本物化参数如下：
Ｉ Ｓ Ｏ通用名称：ｅ － ｐｒ ｅ ｒ Ｂｔ ｃ ｅ ｔ ｉ ａ ｙ ｍ ｈｎ
４ ２ 鉴别试验 ．
４２ ， 高效液相色谱法： ．． 本鉴别试验可与高效抓氛菊醋含ｆ的测定同时进行。在相同的色谱操作条件 下， 试样溶液中某二个色谱峰的保留时间与试样溶液中高效抓氛菊酸的高顺体和高反体色谱 峰的保留 时间， 其相对差值应在 １５ ． ％以内。 ４２２ 红外光谱法： ．． 试样与标样在 ４ ＾４０ ‘ ００ － ｃ 波数范围内的红外光谱图， ０ ０ ｍ－ 应没有明显差异（ 见图
《GB2019高效氯氟氰菊酯原药》编制说明
O
H
CN
F3C
O
O Cl
H
H
H3C
CH3
(1R,3R)-((S)-cyano(3-phenoxyphenyl)methyl) 3-((Z)-2-chloro-3,3,3-trifluoroprop-1-
enyl)-2,2-dimethylcyclopropanecarboxylate
H
H
Cl
O
CN
O
2019 年 6 月～8 月，开展高效氯氟氰菊酯原药的分析方法的实验研究工作， 对原国标中高效氯氟氰菊酯分析方法进行修订讨论，并确定各项技术指标及相应 的检验方法。
2019 年 9 月～10 月，编写高效氯氟氰菊酯原药国家标准征求意见稿和编制 说明，对标准征求意见稿广泛征求意见。
2019 年 10～11 月，根据各单位反馈意见对标准进行修改，完成标准送审稿。 2019 年 11 月，召开标准审查会，对标准进行了审查。 3. 质量控制项目和指标值的确定 本标准是对高效氯氟氰菊酯原药的国家标准 GB/T 20695-2006 的修订。原药 是制剂的活性成分，其质量直接影响制剂产品的质量。原国标规定了外观、高效 氯氟氰菊酯质量分数、水分、丙酮不溶物、酸度控制项目，并规定了验收期。FAO 于 2015 年发布了高效氯氟氰菊酯的产品规格，FAO Specification 463/TC (August 2015)。本标准是在原国家标准基础上，充分参考了 FAO 规格，并结合产品的实 际生产情况，修订了丙酮不溶物等控制项目，并增加了质量保证期。