免疫学试题B卷及答案

The final examination of medical immunology for seven year students of Grade 2003(2005/12/6)Paper BI. Explain the following items (2 points for each, 18 points)1. McAb2. MAC3. Hapten4. TCR complex5. Hypersensitivity6. Clonal anergy7. Heterophile Ag8.ITAM9.PRRII. Choose all correct answers (1 point for each,15 points)1.Which of the following statement(s) about the spleen is(are) true:A. It filters antigens out of the blood.B. Lymphatic vessels draining the tissue spaces enter the spleenC. It contains germinal centersD. It functions to remove old and defective red blood cells2.Which kinds of Ig expressed mainly on the surface of matureB cells?A. mIgGB. mIg AC. mIgDD.mIgM3.Which can function as C3 convertase in activation of complement system?A.C4b2bB.C4b2b3bC.C3bBbD.C3bnBb4.About the characteristics of cytokines, which of the following(s) is (are) correct?A. One cytokine can act on different cells and play multiple biological effectsB. The cytokine produced by one cell only acts on neighbor cellsC. Combined with corresponding receptor to play roleD. One cytokine can inhibit or enhance effects of other cytokine5.Which of the following molecules can stimulate T cells activation?A. LPSB. PWMC. Con AD. PHA6.What are the functions of B cells?A. produce AbB. secrete cytokinesC. kill target cells directlyD. present Ag7.Which of the cytokines are secreted by Th1 cells?A. IL-4B. IL-2C. IL-10D. IFN-γ8.Which of the diseases belong to type Ⅲhypersensitivity?A. Transfusion reactionB. Arthus reactionC. Contact dermatitisD. Rheumatoid arthritis9.Which of the following is(are) correct about the characteristics of memory cells?A. Can come from either B cell or T cellB. Can respond to antigen at low consentrate effectivellyC. Only exist in HID. React to a second invasion of an antigen more rapidly and stronger10.What abilities do αβ+T cells gain after maturation?A. self-reactiveB. self-toleranceC. express functional TCRD. self MHC restriction11.Which of the followings are correct statements about dendritic cells?A. Can stimulate naïve T cell proliferationB. Express high level of MHC class II moleculesC. Express high level of MHC class I moleculesD. Mature dendritic cells with strong function of antigen-capture12.About AICD, which statements are correct?A. Can be mediated by FasL-Fas interactionB. Is a kind of cell death of activated T cellC. Play important roles in immunological regulationD. IL-4 can promote AICD13. The processes of antigen-activated B cells differentiation in germinal center include:A. Ig Class switchingB. Somatic hypermutation and Ig affinity maturationC. Differentiate into BmD. Apoptosis14.Which of the following factors affect the antigen immunogenecity?A. molecule weightB. foreignessC. conformationD. chemical composition15. About somatic hypermutation, which statements are correct?A. Occurs during B cells maturationB. Result in affinity maturation of antibodiesC. Mainly occurs in CDR regionD. Can occur during T cells maturationⅢ．Answer the following questions briefly (5 point for each, 30 points)1.Why do NK cells only kill tumor or virus-infected cells but not normal cells?you know.3. How to use immunologic tolerance in clinical medicine? Please give more than two examples.4. Which type of hypersensitivity does allergy asthma belong to? How does it take place?5.How was complement activated in early phage of infection?6.Where are the CDR regions located on the antibody molecule and what are their fuctions?IV. Answer following question (12 points)1.When microbes invade an individual from skin,how can thisindividual eliminate them? Please describe the overall process.The final examination of medical immunologyfor seven year students of Grade 2003（2005/12/6）Paper BⅠExplain the following items （2 points for each,18 points）1.McAbPrepared by hybridomas technique (1 point)Immunized spleen cells(B) hybride with myeloma cells hybridoma (1 point)2.MACC5b6789 complex is known as MAC which leads to formation of a hole in the membrane.(1 point)MAC mediates lysis of target cell.(1 point)3. HaptenSubstances which can combine with Ab, but cannot induce immune response independently.(1 point)In another word, hapten only possess immunoreactivity.(1 point)4.TCR complexa group of membrane molecules on T cells that can specially bind to the antigen and pass an activation signal into the cells (1 point) consisting of TCR, CD3 and (1 point)5.Hypersensitivitya harmful immune response that is heightened reactivity to an antigen is called hypersensitivity, (1 point) which causes tissue injury or functional disorder.(1 point)6.Clonal anergyfunctional inactivation without cell death(1 point) : lack co-stimulatory signal(1 point).7.Heterophile Ag(forssman Ag):common Ags are shared by different species-no specificity of species (1 point)- Significance : immunopathology ,Diagnosis (1 point)8.ITAMimmune receptor tyrosine-based activation motif (0.5 point)-----transduceactivation signals from TCR(1 point) composed of tyrosine residues separated by around 18 amino acid-----when antigen binds,the tyrosine become phosphorylated by the receptor associated tyrosne kinas to transduct activtory signal(0.5 point)9.PRRThe receptor on macrophage (1 point)which can recognize and bind specific molecular structure on some pathogens,injured or apoptotic cells.(1 point)II. Choose all correct answers (1 point for each, 15 points)Ⅲ。