英语小讲课
英语老师讲课稿范文10篇
英语老师讲课稿范文10篇1. Good morning, everyone. Today, we will be discussing the importance of effective communication in the workplace. Communication is crucial in any organization as it allows employees to share information, collaborate on projects, and make effective decisions. Without proper communication, misunderstandings and conflicts are likely to arise, which can hinder productivity and overall success. Therefore, it is imperative for individuals to develop strong communication skills to thrive in their professional careers.2. Hello, class. In today's lesson, we will explore the concept of globalization and its impact on the world economy. Globalization refers to the increasing interconnectedness and interdependence of countries through the exchange of goods, services, capital, and information. It has led to significant changes in the way businesses operate, promoting international trade and creating more opportunities for growth. However, it has also brought challenges such as increased competition and the need for companies to adapt to different cultural norms. Therefore, understanding globalization is essential for anyone interested in the global marketplace.3. Welcome, students. Today, we will be discussing the benefits of regular exercise and a healthy lifestyle. Engaging in physical activity not only improves our physical fitness but also has numerous positive effects on our mental and emotional well-being. Regular exercise helps to reduce stress, improve mood, and boost self-confidence. Additionally, a balanced diet combined with exercise contributes to maintaining a healthy weight and preventing chronic diseases. It is important for us to prioritize ourhealth and well-being by incorporating regular exercise into our daily lives.4. Hi, everyone. In today's lesson, we will be delving into the concept of sustainable development. Sustainable development aims to meet the needs of the present without compromising the ability of future generations to meet their own needs. It considers economic, social, and environmental factors to promote long-term well-being. By implementing sustainable practices, such as conserving natural resources and reducing pollution, we can create a more equitable and environmentally-friendly world. As individuals, we have a responsibility to support sustainable development through our actions and lifestyle choices.5. Good day, class. Today, we will be discussing the factors that contribute to climate change. Climate change refers to long-term shifts in temperature and weather patterns due to human activities, such as the burning of fossil fuels and deforestation. These activities release greenhouse gases into the atmosphere, which trap heat and contribute to global warming. The consequences of climate change include rising sea levels, extreme weather events, and loss of biodiversity. It is crucial for us to understand and address these factors to mitigate the impacts of climate change and create a sustainable future.6. Hello, everyone. In today's lesson, we will be exploring the importance of financial literacy. Financial literacy refers to the knowledge and skills needed to make informed financial decisions. It includes understanding concepts such as budgeting, saving, investing, and managing debt. Developing financial literacy isessential for individuals to achieve financial independence and make smart financial choices. It empowers us to plan for our future, avoid financial pitfalls, and build a strong foundation for our financial well-being.7. Welcome, students. Today, we will be discussing the impact of technology on society. Technology has revolutionized the way we live, work, and communicate. It has brought numerous benefits, such as increased productivity, improved healthcare, and enhanced connectivity. However, it has also raised concerns about privacy, job displacement, and the digital divide. As technology continues to advance, it is important for us to understand its implications and navigate the ethical, social, and economic challenges it presents.8. Hi, everyone. In today's lesson, we will be exploring the concept of cultural diversity. Cultural diversity refers to the variety of cultures, traditions, and beliefs that exist within a society or organization. It enriches our experiences, promotes tolerance and understanding, and encourages creativity and innovation. Embracing cultural diversity is essential in fostering inclusive environments where all individuals feel valued and respected. By celebrating our differences, we can create a more inclusive and harmonious society.9. Good day, class. Today, we will be discussing the impact of social media on society. Social media platforms have revolutionized how we connect, communicate, and consume information. They have provided new opportunities for networking, social activism, and business promotion. However, they have also raised concerns about privacy, cyberbullying, and the spread ofmisinformation. It is important for us to understand the advantages and disadvantages of social media and use it responsibly to foster positive interactions and protect our well-being.10. Hello, everyone. In today's lesson, we will be exploring the benefits of lifelong learning. Lifelong learning refers to the continuous pursuit of knowledge and personal development throughout one's life. It helps to enhance our skills, broaden our perspectives, and adapt to societal changes. Lifelong learning also contributes to personal growth, career advancement, and overall fulfillment. It is essential for us to embrace a mindset of lifelong learning to thrive in an ever-evolving world and reach our full potential.。
十分钟英语微课教案模板
#### 教学目标1. 知识目标：- 学生能够听懂并正确使用以下短语：apply for a job, work as a ..., be good at, take care of, and look after。
- 学生能够识别并运用一般过去时态描述过去的工作经历。
2. 技能目标：- 学生能够通过听力练习提高英语听力理解能力。
- 学生能够通过角色扮演和小组讨论提高口语表达能力。
3. 情感目标：- 学生能够通过了解不同职业的工作内容，激发对职业探索的兴趣。
- 学生能够通过分享自己的经历，增强自信心和表达能力。
#### 教学重点与难点- 重点：短语“apply for a job”、“work as a ...”和一般过去时态的运用。
- 难点：一般过去时态的准确使用和句子结构的完整性。
#### 教学过程##### 一、导入（Warming Up）1. 活动：播放一段关于不同职业的视频片段，让学生猜测视频中人物的工作。
2. 目的：激发学生的学习兴趣，为接下来的教学做铺垫。
##### 二、新授（Presentation）1. 活动：教师展示单词卡片，引导学生说出与职业相关的短语。
2. 内容：apply for a job, work as a ..., be good at, take care of, and look after。
3. 目的：帮助学生理解和记忆新词汇和短语。
##### 三、练习（Practice）1. 活动：听力和跟读练习。
- 教师播放关于过去工作经历的听力材料，学生跟读并复述。
- 目的：提高学生的听力理解和口语表达能力。
2. 活动：角色扮演。
- 学生分组，每组扮演不同的角色，用英语描述自己的过去工作经历。
- 目的：提高学生的口语表达能力。
##### 四、巩固（Production）1. 活动：小组讨论。
- 学生讨论以下问题：- What did you do in your first job?- Why did you choose that job?- What did you learn from that job?- 目的：提高学生的口语表达能力，增强团队协作能力。
小学英语英文说课稿(共6篇)
篇一：小学英语说课稿模板万能小学英语说课稿（英文万能版）● good morning, my dear judges. i am_______, from____________.i’m glad to interpret my teaching design here.● the teaching content is part, of unit of pepprimary english, bookthis unit is mainly about now, i will explain the lesson from the following aspects.1. 教学内容（体现教材的整合）firstly, let’s focus on the analysis of teaching content.the lesson is a new one of unit .it includes and . insection 1, it mainly deals with these key words,2. 教学对象（根据不同年级的学生，描述其特点）secondly, it is about the students.our students are in gradethey are active and curious, interested in new things.after learning english for years, they have some basic englishbackground knowledge, so the teacher should attach importance to thethey have learnt english for years, and have already known it is not difficult for them to understand and use the language 3. 教学目标（根据具体内容定目标和要求）so, i set the following aims.by the end of the lesson, students will be able to read, recognize, and usethese words:and, these sentences:by the end of the lesson,ss can understand the and get useful information from the throughattentive listening / reading.ss are able to talk about ss can use to give suggestions onss’ abilities of listening and speaking will be developed.(affect; learning strategies; cultural awareness.)in this lesson, the emotional aim isto help students cultivate and foster their abilities of working ingroups.to foster ss’ consciousness of good-cooperation and properto help ss cultivate their abilities to analyze and solve problemsindependently.to foster ss’ initiative and creativeness.to make sure that ss can use correctlyskillfully.to develop ss’ interest in english.the difficult point is:the pronunciation of 教法学法fourthly, it talks about teaching methods.andin this lesson, i will mainly use “task-based teaching method”,and so on.4. 教学过程①具体steps 根据具体内容定；②板书steps ＋ purpose 说明；③如有可能，同时完成layout设计;next, let’s focus on the teaching procedures.i will finish the lesson in steps.it will cost about mins.after greeting with the ss, i will begin the lesson by singing the song together with the ss.purpose:the purpose of this is to form a better english learning surrounding forthe ss, and, at the same time, it provides situations to review the learnt knowledgefor the next step.it will cost about mins.with the help of the ppt, i set a situation of by to stimulate the ss’ interest of the lesson.by playing the ppt, iand then, (板书layout)the purpose of this is to present the new words and sentences in thesituation, which relates to the ss’ real life experiences, to help the ss understand the language easily and naturally.after presenting each new word (by the guessing game), i will impart theknowledge of pronunciation rules in teaching the new words.it is called phonics.it can facilitate the ss’ abilities to pronounce the words, and help them to remember the spelling of the words.（机械上口；有意义操练； let’s do; 课文对话表演;）it will cost mins, includingdue to the ss’ age, i make the purpose of this is to draw the whole ss’ attention to the spelling ofthe words.it is to help ss to learn through a true situation.in this step, i will give ss a free space to show their abilities.i willthen,used here.ability of cooperation will be well developed.making a new dialogue is to check if ss can use correctly and skillfully.（总结上课内容；德育渗透；作业布置；）in this step, i will guide the ss to conclude the key words and sentences and also, i will the purpose of this is to stimulate ss’ interest of learning english and5. 板书设计and, this is my layout design.that’s all for my teaching design. thank you a lot for listening. (gong) 篇二：小学英语说课稿：《what do you like》说课稿范文小学英语说课稿：《what do you like》unit 11 what do you like?说课稿1.说教材1.1教材内容本节教材的主要话题是food，功能为运用i like?.句型表达自己喜好什么食物，并在此基础上进行简单的语言交流。
小学英语试讲 全英文
小学英语试讲全英文Good morning, boys and girls. Today, I'm going to talk to you about different pets.Pets are animals that we keep at home for companionship. There are many different types of pets, such as dogs, cats, birds, and fish. Each type of pet has its own characteristics and needs.Dogs are known for being loyal and friendly. They require regular exercise, grooming, and love and attention from their owners. Cats are independent animals that like to explore and play. They also need food, water, and a litter box for their bathroom needs.Birds are colorful and can be very talkative. They need a cage with perches, toys, and regular cleaning. Fish are beautiful creatures that need a tank with clean water, filters, and regular feeding.Remember, having a pet is a big responsibility. We need to take care of them, love them, and provide for their needs. So, if you're thinking of getting a pet, make sure you are ready for the commitment.Thank you for listening, and I hope you learned something new about pets today. Have a great day!。
小学英语讲课通用逐字稿
小学英语讲课通用逐字稿### 教案#### 教学目标：1. 学生能够掌握本课的新单词和短语。
2. 学生能够理解并运用本课的重点句型。
3. 学生能够通过听说读写活动提高英语综合运用能力。
#### 教学重点：- 新单词和短语的正确发音和意义。
- 重点句型的灵活运用。
#### 教学难点：- 句型的灵活运用和实际对话中的自然表达。
#### 教学准备：- 多媒体课件- 单词卡片- 录音机和磁带（或MP3播放器和音频文件）- 小组活动材料#### 教学过程：Step 1: Warm-up (5 minutes)- Greeting: Start the class with a warm greeting and a quick review of the previous lesson.- Icebreaker: Play a simple English song to get the students in the mood for English learning.Step 2: Presentation (10 minutes)- Introduce new vocabulary and phrases using multimedia aids and real-life examples.- Use pictures, objects, or gestures to help students understand the meaning of new words.Step 3: Practice (15 minutes)- Individual Practice: Have students repeat the new words and phrases after you, emphasizing pronunciation.- Pair Work: Students practice using the new vocabulary in simple sentences with a partner.Step 4: Application (10 minutes)- Group Activity: Divide the class into small groups and have them create short dialogues using the new phrases.- Role Play: Select volunteers to act out the dialogues in front of the class.Step 5: Consolidation (10 minutes)- Listening Practice: Play a recording of a dialogue containing the new vocabulary and have students repeat it.- Reading Comprehension: Distribute a short passage with the new words and ask students to read it silently and answer comprehension questions.Step 6: Assessment (5 minutes)- Quick Quiz: Give a short quiz to assess students' understanding of the new vocabulary and phrases.- Feedback: Provide immediate feedback on the quiz to reinforce learning.Step 7: Wrap-up (5 minutes)- Summary: Briefly review the key points of the lesson.- Homework: Assign relevant homework that includes practicing the new vocabulary and phrases.#### 教学反思：- 反思学生在各个环节的参与度和掌握情况。
高中英语微型课全英讲课稿
高中英语微型课全英讲课稿高中英语全英文说课稿Good morning, everyone! I’m glad to be here to give my lesson plan presentation. The lesson plan I am going to talk about is the reading part of Unit 4 Wildlife Protection in the book NSEFC BOOK1. Now I’ll explain my lesson plan from the following aspects——analysis of teaching material, learning condition, teaching objectives, important and difficult points, teaching methods, teaching procure and blackboarddesign.Analysis of teaching material and learning conditionFirst, let’s come to the analysis of teaching material. The reading material is entitled How Daisy Learned to Help Wildlife. It talks about how Daisy learned the importance of wildlife protection through her communication with some animals in her dream. It is closely connected with this unit’s topic——the importance of wildlife protection. The passage is clearly organized by Daisy’s 3 trips in which she communicates with several endangered animals, and there are not so much new words in this passageNow let’s move on to the analysis of learning condition, students must be very familiar with the topic and interested in all kinds of animals. Students have acquired the basic reading skills, such as skimming,scanning, etc to deal with different reading tasks, and they can do some discussion in English. However, they are not familiar with the organization WWF mentioned in the passage, not clear with the author’s purposes of writing some sentences, and they may find it difficult to deal with some real problems by themselves concerning with wildlife protection.Teaching objectivesBased on the analyses of the teaching material and the learning condition, I will show you the teaching objectives.(1) Language Skills:1. Students can get the needed information about Daisy’s trip by applying different reading skills.2. Students can summarize the main ideas of each paragraph through skimming.3. Students can analyze the author’s purpose of writing sentences like “No rainforest, no animals, no drugs” and “And there are always WWF.”(2) Language Knowledge:1. Students can know more about why some animals are in danger and how to protect them.2. Students can know how to use the new words, such as mercy, importance, contain, etc.(3) Affective objectives:Students can realize the importance of wildlife protection.(4) Culture awareness:Students can know something about the organization WWF.(5) Learning strategy:1. Students can improve their communication strategy by discussing with classmates about protecting animals.2.Students can refer to the Internet to know more about wildlife protection.Key point and difficult points:Key points:(1) Students can improve their reading skills, such as summarizing, skimming, scanning, etc.(2)Students can get the main idea of the passage.(3) Students can know how to use the new words in the passage.Difficult Points:1. Students can summarize the main ideas of each paragraph.2. Students can get the implied meaning of some sentences in the passage.Teaching methodsAs for teaching methods, I’ll follow the interactive model to deal with the reading material and communicative approach to put what the students have learned into use.Teaching procedure:Then I’ll talk about the most important part of my presentation——teaching procedure.Warming-upThe first step is warming-up. It will cost 3 minutes. First, I’ll show my students a short clip of video about the endangered wildlife. Then, I’ll ask the students to name the endangered animals in it together with me and list more. This step is aimed to arise the students’ interest and get the students familiar with the topic——wildlife.Pre-readingThe second step is pre-reading. It will cost about 5 minutes with 2 activities. In the first activity, I’ll introduce something about the organization WWF to the students. The second activity is to ask students to givetheir reasons to the question “Why are some animals in danger?”. The purpose of these activities is to let students have the background knowledge of the passage and get interested in reading the passage. And it is also in this step some new words like fur, protect, affect will be taught.While-readingThe third step is while-reading. It consists of 3 activities which will be finished in 20 minutes.The first activity is skimming. It will cost about 5 minutes. I’ll ask the students to skim the passage and work out the main ideas of each paragraph by themselves. It is the difficult point for the students, so I’ll give them hints such as key words or some answers to choose when necessary to help them to do the summarization. The purpose is the improve students’ reading ability——skimming and let them get the main ideas of the passage.The second activity is scanning. It will cost about 3 minutes. I’ll ask the students to read fast and do some True or False questions. The purpose of it is to get students know the detailed information about Daisy’s trip and wildlife protection and improve their scanning ability.The third activity is close reading. It will cost about 12 minutes. Students will be asked to read the passage paragraph by paragraph and fill in the form the needed information——name of the animals in Daisy’s trips, their situation, andresult. Then I’ll ask the students questions: “What does the author want to tell us from the first paragraph?”, “How the government help protect the elephants?”, and “How do you understand the sentences ‘No rainforest, no animals, no drugs.’ and ‘and there was always WWF.’?”. These 3 questions involve some implied meanings which may be difficult for students to work out, so I’ll give some key words as hints for them or ask some other related questions to guide them to work out the answers. The purpose of this activity is to make the students fully understand the reading material and try to analyze the author’s purpose of writing some sentences. And in these 3 activities, I can also teach students some new words like carpet, respond, powerful, etc.Post-readingThe fourth step is post-reading. It will cost about 10 minutes. I’ll ask the students to form groups of 4 and do the discussion based on the questions on page 27, and they can refer to the reading material to work out these answers. After the discussion, I’ll ask some students to report their answers, especially how to protect the endangered animals.HomeworkThe last step is homework. It will take about 2 minutes. The homework is to write a short passage entitled “How to Protect Wildlife”. They can surf the internet and try to find more ways about wildlifeprotection.Well, this is the blackboard design. In the middle, it’s the form for students to fill in, and on the 2 sides, there are the new words in the passage. Some of them, as I’ve mentioned, are taught in pre-reading. Most of them is taught in third-step while-reading.That’s all for my lesson plan presentation. Thank you for your attention. Thank you!Unit 4 How Daisy Learned to Help Wildlifeprotect Animal Situation Result carpetfur Para 1 antelope being hunt decrease powerfulaffect Para 2 respondin relief Para 3 importancemosquitoes appreciate。
英语零基础讲义
第三课第一部分音标单元音：/ ɜ:/ 嘴形扁平，上下齿微开，舌身平放，舌中部稍抬起。
/ə/ 嘴唇微微张开，舌身平放，舌中部稍抬起，口腔自然放松。
her[hɜː]她的; girl[gɜːl]女孩; skirt[skɜːt]裙子; bird[bɜːd]鸟; picture['pɪktʃə]图片; teacher'['tiːtʃə]老师; mother['mʌðə] 妈妈/ɔ:/ 嘴唇收的小而圆，并向前突出，舌身往后缩。
/ɒ/ 口腔打开，嘴张大，舌头向后缩，双唇稍收圆。
ball[bɔːl]球;wall[wɔːl]墙;water['wɔːtə]水;horse[hɔːs]马;coffee['kɒfɪ]咖啡;watch[wɒtʃ]表;dog[dɒg]狗;shop[ʃɒp]商店;/u:/ 嘴形小而圆，微微外突，舌头尽量外缩。
/ʊ/ 嘴唇张开略向前突，嘴形稍收圆并放松些，舌头后缩。
flute[fluːt]长笛;fruit fruːt]水果;food[fuːd]食物;shoes['ʃu:z]鞋子; wolf[wʊlf]狼;wood[wʊd]木头;bull[bʊl]公牛;bullet['bʊlɪt]子弹;双元音：1. /eɪ/ 由[e]和[i]两个单音组成，[e]重读，[i]轻读，口型由半开到合。
字母A就发这个音。
Cake[keɪk]蛋糕;gate[geɪt]门;rain[reɪn]雨;train[treɪn]火车2. /ɔɪ/ [כ][i]两个单音，前重后轻，双唇由圆到扁，口型从开到合。
oil[ɒɪl]油;coin[kɒɪn]硬币;boy[bɒɪ]男孩;soy[sɒɪ]酱油3./əʊ/ 由[ə]和[u]两个单音组成，发音也是一个过程，口型由半开到小，与字母O的发音是相同的。
nose[nəʊz]鼻子;rose[rəʊz]玫瑰;boat[bəʊt]船;soap[səʊp]肥皂4. /ɪə/ 由[i]和[ə]两个单音组成，[i]重读，[ə]轻读，双唇始终是半开的。
英文版英语课堂讲义稿
英文版英语课堂讲义稿目录- 第一节：课程介绍- 第二节：教学目标- 第三节：教学内容- 第四节：教学方法- 第五节：教学评估第一节：课程介绍本课程旨在帮助学生提高英语口语和写作能力。
通过丰富的课堂活动和练，学生将加强他们的语言交流技巧，并提高他们的英语组织和表达能力。
第二节：教学目标- 培养学生的听说能力，使他们能够流利地进行日常交流。
- 提高学生的写作技能，使他们能够写出清晰、连贯的英文文章。
- 培养学生的阅读理解能力，使他们能够理解和分析各种英文文本。
- 培养学生的语法和词汇能力，使他们能够正确运用英语语法规则和丰富的词汇。
第三节：教学内容本课程将涵盖以下主题：1. 日常交流：- 自我介绍和问候- 谈论家庭、朋友和兴趣爱好- 讨论日常生活中的问题和场景2. 写作技巧：- 写作结构和段落组织- 描述事件和经历- 写作练和反馈3. 阅读理解：- 阅读不同类型的英文文章- 提取关键信息和理解文章主旨- 分析和解释作者的意图和观点4. 语法和词汇：- 基本语法规则和常见错误- 常用词汇和短语- 句子构造和语法练第四节：教学方法为了实现教学目标，我们将采用以下教学方法：1. 情景对话练：- 学生将在不同场景下进行对话练，提高他们的口语表达能力。
2. 写作任务和反馈：- 学生将完成写作任务，并获得针对他们写作的反馈和建议，以进一步提高他们的写作技能。
3. 阅读和讨论：- 学生将阅读不同类型的英文文章，并与同学共同讨论文章的主题和观点。
4. 语法和词汇练：- 学生将参与语法和词汇练，巩固他们所学的语法规则和词汇知识。
第五节：教学评估为了评估学生的研究成果，我们将采用以下评估方式：1. 口头表达能力评估：- 学生将参与口头表达任务，展示他们的口语能力和交流效果。
2. 写作作业评估：- 学生的写作作业将被评估，并提供针对他们写作的反馈和评分。
3. 阅读理解测试：- 学生将完成阅读理解测试，以评估他们的阅读理解能力。
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Introduction
EBP50(also known as NHERF1) is a 55-k Da phosphopro-tein, which is a member of the family of PDZ scaffolding proteins. The main site of localization of EBP50 is at the apical plasma membrane in human epithelial tissues. The loss of normal apical membrane expres-sion of EBP50 and/or its distribution to the cytoplasm and nuclear overexpression have been observed in several types of human cancer. EBP50 has been indicated to be a tumor suppressor in several types of tumor. Previous studies conducted by the authors of the present study have demonstrated that the downregulation of EBP50 expres-sion promotes the growth of gastric and pancreatic cancer cells, and that the overexpression of EBP50 regulates the apoptosis of pancreatic cancer cells by decreasing the expression levels of Bcl-2.
Results
Overexpression of EBP50 inhibits cancer cell migration and invasion.
Results
Expression of EBP50 is decreased in pancreatic cancer tissues.
the RT-q PCR data indicated that EBP50 m RNA expression was significantly decreased in pancreatic cancer tissues compared with the levels in corresponding normal tissues
Introduction
The pathogenesis of pancreatic cancer has not been completely elucidated. It has been found to be associated with factors including the activation of oncogenes, dysfunction of tumor suppressor genes, and aberrant activation of signal transduction pathways.β -catenin, which is an important effector in the Wnt signaling pathway, has an important role in cell-cell adhesion. Membrane-associated proteins that are formed by the binding of Ecadherin to β -catenin are involved in the regulation and provision of cellular adhesion. In addition, cell motility, including metastasis and invasion, is also regulated by membrane-associated adhesion proteins. In association with the extracellular matrix and actin cytoskel-eton, membrane-associated adhesion proteins play crucial roles in numerous biological signal transduction pathways. Dysfunction of β -catenin and E-cadherin has been observed in various types of tumor, including breast cancer, colorectal cancer and pancreatic cancer
Introduction
In the present study, the aim was to explore the expression of EBP50 in pancreatic cancer tissue, the effect the overexpression of EBP50 played in pancreatic cancer cell growth and invasion and the underlying mechanism. The pBK-CMV-HA-EBP50 plasmid was used to upregulate EBP50 expression in pancreatic cancer cells and identify whether β -catenin/E-cadherin is directly targeted by its effects on the growth and invasion of pancreatic cancer cells.
EBP50 inhibits pancreatic cancer cell growth and invasion by targeting the β -catenin/E-cadherin pathway
2016-5-19
Abstract
EBP50 has previously been demonstrated to be associated with the malignant transformation of numerous types of human cancer.The aim of the present study was to investigate the effect of EBP50 overexpression on pancreatic cancer and the underlying mechanism.Reverse transcriptionquantitative polymerase chain reaction was used to detect the expression of EBP50 in human pancreatic cancer tissue specimens.Furthermore,pBK-CMVHA-EBP50 and the pBK-CMV-HA vectors were transfected into pancreatic cancer cells and the effect of EBP50 upregulation on the proliferation and invasion of the cells was investigated.In addition,the effect of EBP50 overexpression on β -catenin and E-cadherin expression was evaluated. The results revealed that overexpression of EBP50 suppressed cell growth and invasion in two human pancreatic cancer cell lines. Overexpression of EBP50 also suppressed β -catenin expression and increased E-cadherin expression. Thus, the present study demonstrated that EBP50 inhibits pancreatic cancer cell growth and invasion through targeting the β -catenin/E-cadherin pathway. The results suggest that EBP50 may function as a potential tumor suppressor and thus may serve as a potential therapeutic target
Introduction
Pancreatic cancer has an extremely poor survival rate; it ranks as the fourth most common cause of cancer-related mortality and has a five-year survival rate of ~5%.Surgery is effectively the only potential treatment for its eradication and is suitable for only 10-20% of surgical candidates. In the majority of patients, the opportunity to carry out surgery is lost for reasons such as metastatic potential and delayed diagnosis.The lack of a novel prognostic biomarker is the most important reason for the poor outcome of patients with pancreatic cancer. Therefore, the identification of efficient prognostic biomarkers is urgently required.