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动物实验室智能化系统设计的基本要求与实践

动物实验室智能化系统设计的基本要求与实践

动物实验室智能化系统设计的基本要求与实践李杨锦福建省疾病预防控制中心福州350000摘要智能化系统是一种融合了计算机技术和一些其他技术(如通信与信息技术和传感技术)的系统,目的是将复杂的工作自动化。

应用智能化系统是保证动物实验室内环境稳定,从而保障实验动物、实验质量和实验室安全的现代化先进手段。

本文分别通过八个方面阐述动物实验室智能化系统设计的基本要求及笔者参与建成的动物实验室已实现的功能,以供同行设计参考。

关键词动物实验室智能化远程控制屏障环境文献标识码:A文章编号:1003-4331(2024)02-0036-04B asi c requi rem ent s and appl i cat i on of ani m all aborat ory i nt el l i gent s yst em s des i gnLiY angj i n(Fuj i an Cent er f or D i s eas e Cont r oland Pr event i on,Fuz hou350000)A bst ract I nt el l i gentsys t em s ar e s yst em s aut om at e com pl ex wor k wi t h com put er t echnol ogy and s om e ot her t echnol ogi es(s uch as com⁃m uni cat i on and i nf or m at i on t echnol ogy and sens or t echnol ogy).A ppl i cat i on ofi nt el l i gentsys t em s i s m oder n and advanced t o ensur e t he s t abi l i t y of t he ani m al l abor at or y envi r onm ent and t hus guar ant ee t he s af et y of exper i m ent al ani m al s,exper i m ent al qual i t y and l abor a⁃t or y s af et y.Thi s ar t i cl e di scus s8bas i c r equi r em ent s f or t he des i gn of i nt el l i gent s yst em s f or ani m al l abor at or i es,especi al l y t hos e al⁃r eady r eal i z ed i n ani m all abor at or y t hatt he aut hor has par t i ci pat ed i n bui l di ng,t o pr ovi de exper i ences f or l at er desi gner s.K ey w ords A ni m all abor at or y I nt el l i gence R em ot e cont r ol Speci f i c pat hogen f r ee随着科学技术不断发展,科学研究对实验动物等级的要求越发严格,早在《实验动物微生物学等级及监测》(G B14922.2-2011)标准中已经取消普通级实验小鼠和大鼠等级,2023年7月实施的《实验动物微生物学等级及监测》(G B14922-2022)中又取消了清洁级实验动物分类并增加环境要求[1]。

三维激光扫描技术获取高精度DTM的应用研究

三维激光扫描技术获取高精度DTM的应用研究

J ournal o f E ngineering G eology工程地质学报1004-9665/2007/15(03)-0428-05三维激光扫描技术获取高精度DT M的应用研究*董秀军(成都理工大学地质灾害防治与环境保护国家专业实验室成都610059)摘要三维激光扫描技术又被称为实景复制技术,是测绘领域继GPS技术之后的又一次技术革命,它突破了传统的单点测量方法,具有高效率、高精度的独特优势。

三维激光扫描技术能够提供扫描物体表面的三维点云数据,因此可以用于获取高精度高分辨率的数字地形模型。

本文将以一工程边坡为例讨论利用三维激光扫描技术快速获取数字地形模型的方法,着重论述三维点云数据的获取、拼接、坐标校正、去噪及数字高程模型的生成方法,由此得出在一定空间范围内利用三维激光扫描技术快速获取高精度高分辨率的数字地形模型具有可行性。

关键词三维激光扫描点云数字地形模型数字高程模型中图分类号:P285.4+3文献标识码:ARE S EARCH ON APPL ICATI ON OF3D LAS ER S CANN I NG TECHNOLOGY I N ACQU I R I NG DT M W ITH H I GH ACCURACY AND RES OLUTI ONDONG X i u j u n(T heN ational Laboratory of G eological H azard Preventi on&G eolog ical Environ m ent P rotection,Chengdu U ni ver sity of T echnology, Chengdu610059)Abst ract The three-d i m ensional laser scan technology.a lso na m ed the rea l-life scenery duplica ti o n techn i q ue, is ano t h er i m portan t techno l o g ica l revo l u ti o n i n survey i n g and m appi n g field a fter the G lobal Position Syste m(GPS) techno l o gy.It has h i g h effic iency and h i g h prec isi o n.The three-d i m ensional po i n t c l o ud data of the scanned ob-ject surface can be acqu ired by usi n g the t h ree-di m ensional laser scan technology.Therefore,the techno logy can be used i n ga i n i n g dig ita l terra i n m odels(DTM)w ith high accuracy and resolution.This paper w ill d i s cuss the m ethod o f usi n g the techno l o gy in quick l y gaining DTM.A cut slope pro j e ct is used as exa m ple.The m ethod i n-cludes acqu iri n g,align i n g,coor d i n ate ad j u sting,,de-no ising and for m ati n g o f digita l elevati o n m ode.l It i s feas-i b ility that the high accurate and reso l u ti o n d i g ital terrain m odel can be acquired usi n g the technology w ithin certa i n space.K ey w ords3D laser scann i n g syste m,Po int c l o ud,D i g ital terrain m ode,l D ig ita l elevati o n m ode,l Slope eng-i neer i n g*收稿日期:2007-03-14;收到修改稿日期:2007-04-10.作者简介:董秀军,主要从事地质工程方面的试验与研究工作.Em ai:l dongzb2002@to m.co m1引 言三维激光扫描技术是一门新兴的测绘技术,又称/实景复制技术0,能够完整并高精度地重建扫描实物及快速获得原始测绘数据。

人工智能在实验室应用的英语作文

人工智能在实验室应用的英语作文

人工智能在实验室应用的英语作文Artificial intelligence (AI) is a cutting-edge technology that has been making waves in various industries, including the field of scientific research. In laboratory settings, AI is being increasingly used to streamline processes, accelerate the pace of discovery, and help researchers make sense of large volumes of data. This essay will explore the applications of AI in laboratory settings and discuss the benefits and challenges associated with its use.One of the primary applications of AI in laboratories is in the field of data analysis. With the ever-increasing amount of data being generated in scientific research, traditional methods of data analysis are often insufficient to process and interpret the vast amounts of information. AI algorithms, on the other hand, are able to quickly analyze large datasets and identify patterns and trends that would be difficult for humans to detect. This can lead to faster and more accurate results, helping researchers make breakthroughs in their fields.Another area where AI is being utilized in laboratories is in the field of experimental design. By using machine learning algorithms, researchers can optimize experimental parameters and predict outcomes before conducting experiments. This notonly saves time and resources, but also helps researchers avoid costly mistakes and improve the quality of their experiments. Additionally, AI can be used to generate hypotheses based on existing data, leading to novel discoveries and insights that may have been overlooked using traditional methods.In addition to data analysis and experimental design, AI is also being used in laboratory automation. Robots equipped with AI technology can perform repetitive tasks such as sample processing, data collection, and instrument calibration, freeing up researchers to focus on more complex and creative aspects of their work. This not only increases efficiency and productivity in the lab, but also reduces the risk of human error and ensures the reproducibility of results.Despite the many benefits of using AI in laboratory settings, there are also challenges that must be addressed. One of the main challenges is the lack of interpretability of AI algorithms. While AI can generate accurate predictions and insights, it is often difficult to understand how these conclusions were reached. This lack of transparency can be a barrier to adoption, as researchers may be hesitant to trust and rely on AI-generated results without a clear understanding of the underlying processes.Another challenge is the potential for bias in AI algorithms. Like any technology, AI is only as good as the data it is trained on. If the training data is biased or incomplete, AI algorithms may generate inaccurate or unfair results. This is a significant concern in scientific research, where objectivity and impartiality are crucial. Researchers must be vigilant in ensuring that the data used to train AI models is diverse and representative of the population being studied.In conclusion, AI has the potential to revolutionize the way research is conducted in laboratory settings. By automating routine tasks, analyzing large datasets, and optimizing experimental design, AI can help researchers work more efficiently and effectively, leading to new discoveries and breakthroughs in a wide range of scientific fields. However, significant challenges remain in terms of interpretability, bias, and ethical considerations, which must be addressed to fully realize the potential of AI in the laboratory. With careful planning and oversight, AI can be a powerful tool for advancing scientific knowledge and driving innovation in research.。

创新研究实验室建设方案设计

创新研究实验室建设方案设计
• 采用智能化、自动化的实验设备
• 建立实验室信息化管理系统
• 实现实验室资源共享与协同
03
提供舒适的生活设施
• 设立舒适的实验室休息区
• 提供便捷的实验室餐饮设施
• 配备实验室运动设施,促进员工身心健康
实验室安全与环保措施
01
严格执行实验室安全规定
• 定期进行实验室安全培训
• 配备实验室安全防护用品
• 对实验室建设与运行的绩效进行实时监控
• 及时调整实验室建设与运行的策略与措施
• 保障实验室建设与运行的顺利进行与目标实现
奖励优秀实验室绩效
• 设立实验室绩效评价奖励机制
• 对优秀实验室建设与运行绩效进行表彰与奖励
• 激发实验室建设与运行的积极性与创造力

⌛️
CREATE TOGETHER
谢谢观看
• 申请政府实验室建设经费资助与政
• 争取政府实验室建设相关政策资源
与运行的政策支持
策优惠
与平台
• 研究实验室建设与运行的法律法规
Байду номын сангаас
• 申请政府实验室运行经费补贴与政
• 争取政府实验室运行相关政策资源
要求
策扶持
与平台
• 为实验室建设与运行提供政策指导
• 申请政府人才培养与交流经费资助
• 争取政府人才培养与交流相关政策
• 建立实验室应急预案,应对突发事件
02
加强实验室环保管理
• 垃圾分类处理,减少环境污染
• 采用环保实验方法,减少实验废弃物
• 建立实验室环保监测与评估体系
03
提高实验室安全意识
• 定期开展实验室安全检查
• 建立实验室安全激励机制

211262503_北京下苇甸地区新元古代景儿峪组–寒武纪府君山组界线硅质角砾形成模式

211262503_北京下苇甸地区新元古代景儿峪组–寒武纪府君山组界线硅质角砾形成模式

415国家自然科学基金(41402025)资助收稿日期: 2022–05–07; 修回日期: 2022–05–30北京大学学报(自然科学版) 第59卷 第3期 2023年5月Acta Scientiarum Naturalium Universitatis Pekinensis, Vol. 59, No. 3 (May 2023) doi: 10.13209/j.0479-8023.2023.017北京下苇甸地区新元古代景儿峪组–寒武纪府君山组界线硅质角砾形成模式李辰卿 董琳† 沈冰造山带与地壳演化教育部重点实验室, 北京大学地球与空间科学学院, 北京 100871;† 通信作者,E-mail:****************.cn摘要 为探讨华北板块在新元古代与寒武纪之间沉积间断后再次接受沉积的具体过程和环境变化, 选取北京西山地区下苇甸剖面青白口系景儿峪组和下寒武统府君山组的硅质沉积作为研究对象, 通过沉积学、岩石学及地球化学分析, 发现景儿峪组顶部硅质层及府君山组底部硅质条带角砾具有相似的接近海水的Ge/Si 比值和稀土配分特征, 揭示府君山组硅质条带角砾可能来自下伏景儿峪组。

研究结果还表明, 府君山组底部含角砾白云岩不具有层理, 且其中角砾成分复杂, 磨圆分选程度较低, 排列杂乱, 可能代表一次冰川沉积。

关键词 景儿峪组; 府君山组; 古风化壳; Ge/Si; 稀土元素Formation of Chert Breccia from the Transitional Beddings between Neoproterozoic Jingeryu Formaiton and Cambrian FujunshanFormation in Xiaweidian Section, BeijingLI Chenqing, DONG Lin †, SHEN BingKey Laboratory of Orogenic Belts and Crustal Evolution (MOE), School of Earth and Space Sciences, Peking University,Beijing100871;†Correspondingauthor,E-mail:****************.cnAbstract To investigate the specific processes of deposition and environmental changes in the North China Block during Late Neoproterozoic to Early Cambrian when it received deposition again after a depositional hiatus, chert breccia of the Qingbaikou Series Jingeryu Formation and the Lower Cambrian Fujunshan Formation in the Xiaweidian section of Xishan area of Beijing was analyzed. Based on petrological and geochemical studies, chert layers in Jingeryu Formation and chert breccia in the bottom of the overlying Fujunshan Formation have similar Ge/Si ratios and rare earth element patterns. It indicates that Fujunshan chert breccia might originated from Jingeryu Formation. Breccia-bearing dolomite in the bottom of the Fujunshan Formation is block-shaped, without bedding. The breccia is mixed in component and size, with poor sorting and roundness, and disorderly arranged. Breccia-bearing dolomite in the bottom of Fujunshan Formation may represent glacial deposits. Key words Jingeryu Formation; Fujunshan Formation; paleo-regolith; Ge/Si; rare earth element前寒武纪与寒武纪之交是地质历史上重要的转折期[1–4]。

211166332_干细胞实验室设计——以树兰(济南)国际医院为例

211166332_干细胞实验室设计——以树兰(济南)国际医院为例

1引言临床干细胞实验室可应用于多种学科疾病细胞实验研究,包括女性生殖系统、男科、心血管内科、内分泌科、神经内科、免疫内科、肾内科、骨科、消化内科、整形科、呼吸科等。

2019年,聊城市人民医院对干细胞实验室进行标准化建设,用于干细胞临床前基础和临床转化研究。

[1]对临床干细胞实验室建设具有指导意义。

2021年9月,上海市人民政府发布《上海市建设具有全球影响力的科技创新中心“十四五”规划》,提出干细胞与再生医学的研究方向,用于推进细胞治疗和基因治疗产业发展,突破前沿重大科学问题和关键技术,打造干细胞再生医学中心及相关新兴技术产业集群。

[2]预示着干细胞治疗产业在国内将不断飞速发展,临床干细胞实验室的建设使医院临床与科研相结合,为形成中国研究型医院提供有力的平台支撑,有效推动中国医院转型发展。

[3]树兰(济南)国际医院项目目前处于在建阶段,投入运营后将形成医教研产一体化的社会化办医发展模式,整合各科平台资源,旨在济南建成具有国际水平的国内顶尖研究型综合医院。

[4]其中,干细胞实验室是树兰(济南)国际医院临床与科研的有效转化平台,为医院后期的发展提供有力的设施条件。

2干细胞实验室的平面布局临床干细胞实验室位于病房楼B22楼,紧邻中心实验室,为病房楼的顶楼,远离污染源和毒性制剂,选址符合GMP要求。

干细胞实验区总面积有1286m2(见图1),其中办公用房及公共走廊面积682.6m2,包括男女卫生间、主任办公、医生办公、会议室,机房设备用房146.34m2,实验室用房400m2。

办公用房和实验用房分开设置,保证实验室洁净环境和医护人员干细胞实验室设计———以树兰(济南)国际医院为例The Design of Stem Cell Laboratory———A Case Study of Shulan(Ji’nan)Hospital杜莉,付秀秀(中建八局第二建设有限公司,济南250000)DU Li,FU Xiu-xiu(The Second Construction Limited Company of China Construction Eighth Engineering Division,Ji’nan250000,China)【摘要】顺应国内综合性医院向研究型医院发展的趋势,将树兰(济南)国际医院定位为具有国际水平的国内顶尖研究型综合医院。

DAL数字建筑实验室跨界设计解读


折纸与 榫卯
2013北京设计 将传统木构 周 “ 数 字 现 转译为参数
实”展览装置 原型,在三
维空间叠加
自生成-原力场- 咖啡厅装置 装置回应场
形态-原型建构
地条件
卫生间
顶棚装置
2015 20天
徐丰、于雷(Laboratory for Creative Design)
互撑结构
室外咖啡亭 自承重系统
作为一种设计方法,数字化设计具有跨界性和实验性,它不仅适用于建筑设计,而且适用于城市规划、环艺、工业 设计、艺术设计等不同领域。在当代跨界设计的潮流愈演愈烈,设计学科向着“广义化”①迈进的过程中,“数字编码” 成为设计师手中强有力的工具,不断推动设计创新。
在这样的背景下,建筑设计教学应当以积极的姿态担当起知识传播和前沿探索的责任②。湖南大学在2009年成立 了DAL“数字建筑实验室”,立足于多学科平台开展与数字建筑相关的教学改革,通过与国内外领先团队学习交流,探 索数字化设计的生成逻辑与建构方法,设计实践涉及建筑设计、室内设计、工业设计等各个学科,并逐步总结一系列教 学经验。
雨棚
形态、结构 逻辑统一性
2012 12+15天
杜宇(DAL)Johannes Elias、万新宇 透明表皮 (Coop Himmelb(1)au Architects)
建筑学院门厅 室 内 光 环 室内遮阳吊顶 境 优 化 功

2013 15天
赵明诚(湖南大学)
2014 20天
徐丰(WAX AADR) Nikolaus Wabnitz (WAX AAD iptoma)
不能达到构建完整的教学体系的目标,湖南大学已将数字建筑设计列入2017年《教学大纲》,届时将有更多不同专业 教学资源加入,真正形成跨界的教学体系和数字化平台。

中_英_美污染场地风险评估导则异同与启示

中、英、美污染场地风险评估导则异同与启示陈梦舫1,2,骆永明1,2,3,宋静1,2,李春平1,2,吴春发1,2,罗飞1,2,韦婧1,2(1.中国科学院土壤环境与污染修复重点实验室,南京土壤研究所,江苏 南京 210008;2.中国科学院研究生院,北京 100049;3.中国科学院烟台海岸带研究所,山东 烟台 264003)摘 要:近年来,随着国家 退二进三 旧城改造政策的实施,全国几乎所有的大中城市正面临着大批多种污染行业企业的关闭和搬迁,这些搬迁企业遗留场地都存在着不同程度的环境与健康风险。

开展定量评估人体健康与生态环境风险是建立我国工业污染场地管理体系不可缺少的技术手段,也是适合我国国情并走向可持续性(绿色)土壤与地下水修复及综合环境管理的必然发展方向。

包括美国和英国在内的许多发达国家都在利用一种多层次的基于风险的评估技术框架来鉴定和管理污染场地。

文章着重比较中、英、美场地风险评估技术导则的异同性及其对完善我国场地风险评估技术导则的启示。

关键词:污染场地暴露评估;通用评估基准;风险基础上的校正行动;污染场地风险评估技术导则中图分类号:X 820.4 文献标识码:A 文章编号:1006-2009(2011)03-0014-05Co mparison of U S A ,UK and Chi nese R isk A ssess m entGui deli nes and the I mp licati ons for Chi naC HE N M e ng fang 1,2*,L UO Yong m i n g 1,2,3,SONG Jing 1,2,LI Chun pi n g 1,2,WU Chun fa 1,2,L UO Fei 1,2,WE I Ji n g1,2(1.K ey Laborator y of So il Environm ent and Pollution R e m ed iation,Institute o f Soil Science ,Ch i n ese A cade my of Sciences ,N anjing,J iang s u 210008,China;2.G raduate Universit y of Chinese A cade my of S ciences ,B eijing 100049,China;3.Yantai Institute of C oast a l Z one R esearch,Chinese Acad e m y of Sciences ,Yantai ,Shandong 264003,China )Abst ract :In recent years num erous i n dustrial sites have been abandoned and are subject to re l o cating due to t h e i m p le m entation o f governm enta l policy kno w n as W ithdra w 2Fo r w ar d 3 that ai m s to m odern ize old cit ies .These sites have been conta m i n ated posing var i o us deg rees of hea lth and env ironm en tal risks .Quantitative risk assess m ents p lay a si g n ificant ro le i n the m anage m ent and regu lation o f conta m inated sites as they leads to a m ore susta i n ab l e (Green)so il and groundwa ter re m ediation .M any deve l o ped countries inc l u d i n g the USA and UK utilize a m ulti ti e red risk based fra m e w ork and relevant gu i d ance to m anage and regulate conta m i n ated sites .Th is paper provides detailed co m parisons ofUSA,UK and Chinese R isk A ssess m entGu i d eli n esw ith i m plicati o ns for Ch i n a be i n g g i v en.K ey w ords :Con ta m i n ated land exposure assess m ent (CLEA);Generic assess m ent criteria (GAC);R isk based co rrecti o n assess m ent (RBC A );Ch i n ese risk assess m ent guide li n es (C RAG )收稿日期:2011-04-25基金项目:中国科学院知识创新工程重要方向基金资助项目(KZCX2-YW -BR -19);国家环境保护公益性基金资助项目(2010467016,201009032,201109017)作者简介:陈梦舫(1964 ),男,湖北洪湖人,研究员,博士生导师,伦敦2012年奥运会高级环境顾问,C I W EM 全英污染场地网络顾问理事,主要从事工业污染场地管理、土壤及地下水污染调查与修复、定量环境与健康风险评估等研究工作。

数字化实验室20190605

本文将以药物研发领域的数字化实验室为例,介绍数字化实验室的组成、核心、历 史、现状和未来发展趋势。
组成
尽管技术在持续进步,但药物发现仍然存在一个漫长的过程,需要经过发现靶点、确 证靶点、化合物发现与优化、生物药代毒理等表征、临床数据采集等数百上千人的团队协 作,长达 10 年到 15 年时间才能完成。由于科学研究的不确定性和缺乏大数据积累等原 因,新药发现成功率很低。
原理 软件和硬件组成的数据采集、分析、交互中心
技术 实时测量、数据采集、数据分析等
适用 制药、精细化工、石油和煤化工、新材料、新能源、快消品等
定义
数字化实验室(Digitalized Laboratory,DL),是指在进行科学实验研究的实验室 中,实现全程数字化采集、监测、控制和分析挖掘的软硬件技术,包括但不限于:实验数 据采集电子化、仪器数据电子化、仪器监测和控制、实验智能模拟与预测、智能机器人等 技术。
LIMS:实验室信息管理系统(LIMS)是一个提供实验室信息管理功能的软件系统, 包括工作流和数据跟踪支持,支持在受监管环境中使用。LIMS 根据不断变化的业务要求 和流程进行定制和配置,专注于信息管理、存储和报告。
SDMS: 科学文档管理系统(SDMS)为所有类型的科学数据和文件提供科学的内容 管理、存储、检索和共享。
一般来说,ELN 适用于探索性新样品的研发和发现过程,主要用于研发类实验室;样 品被发现之后,部分样品受监管部门的监管,LIMS 适用于这些成分基本明确的样品分析 和质量验证过程,主要用于开发型实验室。
从区分和定位维度来看, ELN 主要对新样品(新物质、新化学品、新方法等)的发 现、合成、生物测试、分析测试过程进行记录管理,可以对实验的思路、方案、和结果进 行记录和整理,讨论和分享;LIMS 主要对已经发现的样品在实验室的流转进行全生命周 期的质量管理,侧重于记录和管理需要监管的数据。

实验室计量检定校准计划英文

实验室计量检定校准计划英文Calibration and Verification Plan for Laboratory Measurement InstrumentsAccurate and reliable measurement is crucial in scientific research, industrial processes, and various other applications. To ensure the integrity and traceability of measurement data, a comprehensive calibration and verification plan is essential for any well-equipped laboratory. This plan outlines the systematic procedures and protocols for maintaining the accuracy and precision of laboratory measurement instruments, ultimately supporting the reliability of the laboratory's work.The primary objective of a calibration and verification plan is to establish a structured framework for the periodic assessment and adjustment of measurement instruments, ensuring they consistently operate within the specified accuracy and tolerance limits. This plan typically encompasses a range of activities, including initial instrument qualification, routine calibration, performance verification, and documentation management.Initial Instrument QualificationWhen new measurement instruments are acquired or existing ones are brought into service, it is essential to conduct a thorough initial qualification process. This process verifies that the instrument meets the required specifications and is suitable for the intended applications. The qualification may involve a series of tests and evaluations, such as:- Visual inspection for any physical damage or defects- Functional testing to ensure the instrument operates as per the manufacturer's instructions- Comparison of the instrument's performance against known reference standards or certified materials- Determining the instrument's accuracy, precision, and linearity within the specified measurement ranges- Evaluating the instrument's environmental dependencies, such as temperature, humidity, or vibration effectsThe results of the initial qualification are documented and serve as a baseline for future calibration and verification activities.Routine CalibrationPeriodic calibration is a crucial component of the plan, as it ensures the ongoing accuracy and traceability of measurement data. The calibration schedule is typically determined based on the instrument's usage, manufacturer's recommendations, and the laboratory's own historical performance data. Common calibration intervals range from daily to annual, depending on the criticality ofthe instrument and the stability of its performance.The calibration process involves comparing the instrument's measured values against reference standards that are traceable to national or international metrological institutes. This comparison allows for the determination of any systematic errors or drift in the instrument's performance, which can then be corrected through adjustment or recalibration. The calibration results are thoroughly documented, including the applied procedures, environmental conditions, and any adjustments made to the instrument.Performance VerificationIn addition to routine calibration, the calibration and verification plan includes periodic performance verification checks. These checks are conducted at predetermined intervals, often between calibration cycles, to ensure the instrument's continued compliance with the specified accuracy and tolerance requirements.Performance verification may involve the use of independent reference standards or the comparison of the instrument's measurements against a secondary or cross-check reference. The results of these checks are documented and evaluated to identify any potential issues or trends that may require further investigation or corrective action.Documentation and Records ManagementComprehensive documentation and record-keeping are essential components of the calibration and verification plan. All activities related to instrument qualification, calibration, and performance verification are meticulously recorded, including:- Instrument identification and description- Calibration and verification procedures- Calibration and verification results, including any adjustments or repairs- Environmental conditions during calibration and verification- Traceability of reference standards used- Responsible personnel and dates of activities- Any deviations from the established protocols or non-conformancesThis robust documentation system not only supports the laboratory's quality management system but also provides a historical record of the instrument's performance, aiding in the identification of trends, troubleshooting, and decision-making for future maintenance or replacement.Continuous Improvement and Risk ManagementThe calibration and verification plan is a living document that is regularly reviewed and updated to address any changes in the laboratory's operations, new regulatory requirements, oradvancements in measurement technology. The plan should incorporate a continuous improvement process, where the effectiveness of the plan is periodically evaluated, and adjustments are made to streamline procedures, optimize resources, and mitigate potential risks.Risk management is an integral part of the plan, as it helps identify and address potential sources of error or uncertainty in the measurement process. This may include evaluating the impact of environmental factors, operator influences, or instrument-specific vulnerabilities. By proactively addressing these risks, the laboratory can enhance the reliability and traceability of its measurement data, ensuring the integrity and credibility of its scientific or technical work.ConclusionThe implementation of a comprehensive calibration and verification plan is a essential component of a well-functioning laboratory. This plan ensures the ongoing accuracy, precision, and traceability of measurement instruments, supporting the reliability and integrity of the laboratory's work. By following a structured and documented approach to instrument qualification, calibration, and performance verification, laboratories can maintain the highest standards of measurement quality, contributing to the overall confidence and trustworthiness of their research, analysis, and decision-making processes.。

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Analog System Performance Estimation in the VASE(VHDL-AMS Synthesis Environment) Ranga Vemuri, Adrian Nunez-Aldana, Nagu R. Dhanwada, Alex Doboli,Paul Campisi, Sree GanesanLaboratory for Digital Design Environments,Department of ECECS, P.O. Box - 210030,University of Cincinnati,Cincinnati, OH-45221-0030Phone: (513) 556-4784; Fax: (513) 556-7326;Email: Ranga.Vemuri@; URL: /~ddel/projects/vase/vase.html 1.INTRODUCTIONThe VHDL-AMS Synthesis Environment (VASE) is a vertically integrated collection of software tools for synthesis of CMOS mixed signal systems from specifications written in VHDL-AMS. As discussed and demonstrated at the 1997 EETimes Analog and Mixed Signal Applications Conference [1], three successive generations of VASE systems are being developed.Critical to the success of analog synthesis in VASE is the accuracy of analog performance estimation at various levels of abstraction. The analog performance estimator (APE) in VASE is used during mixed signal partitioning, analog behavior synthesis as well as analog circuit synthesis. APE is capable of accepting the design parameters (bias current) of an analog component as input and determines its performance parameters (UGF, slew rate, area) along with anticipated sizing for the circuit components.VASE APE is structured as a hierarchical estimation engine and contains performance models of analog circuits at various levels of abstraction. The levels include the basic circuit elements (MOS transistors, resistors, capacitors), basic analog components (current mirrors, V-I converters), operational amplifiers (in various configurations), analog library cells (integrators, filters, amplifiers) and the user-level analog structures which include series and parallel combinations of the library cells with or without feedback connections. APE uses SPICE models of analog circuit elements and performance composition equations for determining circuit performance at other levels of abstraction.APE provides fast and accurate estimates of analog system performance at various levels of abstraction. This presentation will focus on the analog performance estimator and how it is used by the constraint transformation and module selection tools in VASE. Specific emphasis will be placed on:•The hierarchical estimation techniques used in the APE.•Experimental results demonstrating the accuracy of the estimates provided by the APE.•The impact on the speed and quality of analog circuit synthesis when the APE is used in analog design-space exploration.2.Architecture of VASEFigure 1 shows the architecture of VASE. The input is a VHDL-AMS description of the mixed-signal system and the constraints on the system. After partitioning and performing mixed-signal constraint allocation, the digital behavior is subjected to digital high-level synthesis. The analog behavior is taken through analog behavioral synthesis to generate an analog system-level net-list. The constraint transformation and module selection step allocates constraints to the individual components in the system, and selects a suitable topology for the component from the component library. Finally, each of the selected topologies along with the allocated constraints is sized by the circuit synthesis tool to generate a sized transistor net-list. This step is followed by layout synthesis and layout integration steps to generate the final layout of the system. In the Figure 1, the usage of the analog performance estimator in the various stages of VASE is highlighted. In the final section, we elaborate on the role of the estimator in the different stages of mixed-signal synthesis.3.Analog Performance EstimatorOur performance estimation methodology is based on a hierarchical structure as shown in Figure 2. This methodology predicts the characteristics of an analog circuit and produces a roughly sized circuit. The inputs are a circuit topology and a set of constraints. The topology is a net-list of blocks selected from the analog component library, which behaves as the specification. The hierarchy goes from the CMOS Transistors to the User Application.3.1CMOS Transistor ModelsThe transistor models are useful in predicting the performance of the devices before they are fabricated. There are several device models in the market to be used with different simulation tools. As SPICE has become the industrial standard for analog integrated circuits simulation, the SPICE models are one of the most used. SPICE and SPICE-like simulators implement various levels of device models [2]. The first generation comes from mathematical models. The second generation of models is based on the Berkeley Short-Channel IGFET Model (BSIM), which use empirical parameters instead of analytic equations.A CMOS transistor’s operating characteristic can be classified into three modes of operation: cutoff, non-saturation and saturation regions, where each is characterized by a DC and an AC model. The DC model describes the voltages and currents through the transistor ports. The current drain-source I ds is a function of the voltage gate-source V gs, voltage drain-source V ds,voltage flat-band V fb, and the fabrication process parameters. The small signal equivalent circuit characterizes the CMOS transistor behavior for AC, where the transconductance is a function of I ds and the process parameters.The transistor sizing process involves solving these equations such that the constraints are met. It should be noted that, the sizing process depends on the fabrication process parameters, and the sizing accuracy is directly proportional to the precision of the transistor models.3.2Basic Analog ComponentsA library of basic components is the next level in the estimator hierarchy. Some of these components are DC-bias voltages, current sources, gain amplifiers, output buffers, differential amplifiers and differential-to-single-ended converters. The symbolic equations of these elements are kept in memory. For example, a Differential CMOS amplifier can be characterized by the differential-mode gain A dm, the common-mode gain A cm, and the common-mode rejection-ratio CMRR. Each of these parameters depends on the topology of the basic component and the sizes of the transistors. When a component is required, the component elements are sized according to the specifications. A list of performance estimated parameters are attached as attributes to the sized component.3.3Operational AmplifiersThe third level of the hierarchy consists of a set of Operational Amplifier topologies. The general structure of an op-amp is represented by three stages: (1) Differential input amplifier; (2) Level shift, differential to single ended converter and gain stage; (3) Output buffer. Each of these stages can be implemented with elements from the library of basic components. The op-amp behavior depends on the topology selected, the behavior of the basic analog components and the sizes of the transistors. The differential gain, common gain, slew rate, common-mode rejection-ratio, unity gain frequency, input impedance and output impedance describe the performance of an op-amp. The op-amp estimation procedure uses the attributes of the basic components after being sized and the equations, which relate these attributes to the op-amp behavior. Then, the sized op-amp is marked with its performance attributes.3.4Analog ModulesThe library of components is the fourth level of the hierarchy. This library is constructed with op-amps, resistors, capacitors and transistors. The library consists of circuits such as inverting amplifiers, integrators, comparators, analog-to-digital converters, digital-to-analog converters, filters and sample-and-hold circuits. The performance of each element depends on its topology and the sizes of the op-amp used. As each of the components describe different analog circuits, the performance parameters are specific for each analog module. The performance estimation ofthese components is done using the operational amplifier estimation attributes and the component library information.3.5User ApplicationsThe User Application is the highest level in the hierarchy. At this level, the specification is a structural definition of the analog system. The system is defined as a net-list of library components. The net-list is built with four configurations: serial, fork, join, and feedback. Each configuration consists of blocks, where the blocks are elements of the analog module library or one of the four configurations. In the serial configuration, the output of a block is the input of the next block. In the fork configuration, an input goes to two blocks, where each block has its own output. A block with two inputs and one output creates the split configuration. In the feedback configuration, the output of a block is fed-back through another block to the input of the first block. The performance estimator uses the library estimation and the relation of the four configurations to estimate a system net-list.3.6APE Experimental ResultsTo illustrate the effectiveness of APE, the performance of an Analog-to-Digital Acquisition System (see Figure 3) was estimated. For all components, the MOSIS HP 0.8µm CMOS26G n-well, triple metal, run N58A process was chosen. The input to the system is an analog signal, and the output is a 4-bit digital signal. The input is a sinusoidal signal with 10mV peak and a bandwidth of 300Hz to 3.3Khz (Telephone bandwidth). The first stage has a gain of 100, so that the output is a 1V peak. The sampling frequency used was 8KHz, with a 50% duty cycle TTL sampling signal. The ADC implemented was a 4-bit Flash Analog-To-Digital Converter. ASTRX/OBLX [5] tool was used to perform the circuit synthesis. (ASTRX/OBLX is an automated synthesis tool developed at the Carnegie Mellon University, which can size a pre-defined circuit topology. The circuit topology is specified on a SPICE-deck format, where the transistor sizes and bias points are set as unknowns [6].)It was observed that ASTRX/OBLX was unable to converge when the input description did not have knowledge of the solution space. The input file was then modified such that the intervals were reduced and the starting points were set using the APE’s estimated transistor-sizing information. A functional circuit was produced by ASTRX/OBLX using this modified input. Table 1 compares the estimation and SPICE simulation results after the circuit was synthesized.4Analog Performance Estimator in the context of VASEIn this section, we discuss the analog performance estimator in the context of mixed-signal synthesis in VASE.4.1Application of APE for Behavioral Synthesis of Mixed-Signal SystemsThe VASE APE is used during solution space exploration for behavioral synthesis of mixed-signal systems. In our CAD environment, mixed-signal systems are specified in VHDL-AMS [9] by describing their behavior. The specification is compiled into an internal representation. After this, the exploration step for system-level topology selection is performed. This is done by extensively using information offered by APE. Topology selection explores possible component interconnections that realize the specified functionality. The topologies represent different “solvers” for the defined DAE. The solvers are ranked for synthesis according to the performance information provided by VASE-APE at the architectural level. For each topology that proves to be eligible for further analysis, a constraint transformation and component selection step follows.4.2Analog System Level Constraint TransformationThe task of transforming the high-level specifications onto module level parameters is called constraint transformation. The constraint transformation and topology selection step in VASE takes as input the analog system level net-list and the constraints on the analog system. It generates the set of design/performance constraints on the individual modules in the system and selects a suitable topology for the module from the component library. The selected topology along with the constraints is used by the underlying circuit synthesis tool to generate a sized transistor net-list that is followed by the layout synthesis step. Typically, the circuit synthesis process involves searching the parameter space of the circuit in order to find the values of the widths and lengths of the transistors that satisfy the constraints. This search space is large because of the number of variables involved. The constraint transformation mechanism in VASE explores the parameter space at the system level to find ranges for the module design/performance parameters. During the exploration step, the performance estimator that is used by the constraint transformation engine generates approximate sizing solutions, which are used to limit the search space of the circuit synthesis tool. The constraint transformation method consists of an Interval Genetic Algorithm core interacting with the hierarchical performance estimator.4.2.1Genetic AlgorithmsGenetic Algorithms (GA) are stochastic search techniques based on the mechanism of natural selection and genetics [8]. They start with an initial set of random solutions called a population. Each individual solution being called a chromosome, which represents a candidate solution to the problem being solved. The chromosomes evolve through successive iterations, called generations by using genetic operators, like crossover and mutation. Each chromosome is evaluated using some measure of fitness, to determine which of them are used to form new ones.4.2.2Constraint Transformation using Genetic AlgorithmsConstraint transformation as mentioned earlier involves computing values for the component design parameters, while topology selection is the task of selecting a suitable implementation forthe component from the set of available components in the library. The solution encoding for the constraint transformation problem consists of a two dimensional array of real numbers. The first row represents the center of the interval being computed and the second row, a delta value that gives the width of the interval. The representation consists of two parts, the first part representing the values to be assumed by the design parameters and the second part represents the topology information. Figure 5 shows the fitness evaluation technique that uses the analog performance estimator (APE). In a solution, the design parameters and the topology information corresponding to each of the component in the system level net-list are used to evaluate the performance of the component by calling the performance estimator. The component performances corresponding to the current set of design parameters are stored in an intermediate performance array. With this set of performances, the APE is invoked at the user application level to evaluate the performance of the entire system. At the User Application level APE estimates the performance of the entire system, given the performances of the individual blocks constituting the system. The objective function is a two level one, the local objective function verifies whether all the constraints satisfy the user specified ones, and the global one checks whether all the solutions in the region are constraint satisfying. The GA works towards minimizing the objective function. The global objective function returns a value of zero only if all the points in the region are constraint satisfying. Uniform crossover and non-uniform mutation operators were defined for the representation. The GA generates a solution that best satisfies the user asserted constraints. The solution gives us the values for the design parameters and a topology for each of the component in the system level net-list.4.3Analog Circuit SynthesisThe analog circuit synthesis process typically consists of three steps: topology selection, circuit sizing and design verification [3],[4]. Topology selection is the process of choosing an architecture that performs the desired behavior. The circuit-sizing phase determines the physical dimensions, bias points, and element values to meet user constraints. Typically, the circuit sizing process employs an algorithm to search through the design-space until converges at a design that is likely to meet the user constraints. The speed of convergence and the quality of the design produced depend on the initial design point as well as the design-space exploration algorithm used. Finally, the design verification phase is typically performed by a circuit simulator such as SPICE.Some of the analog circuit synthesis tools starts with a pre-selected topology and attempt to size it until the constraints are satisfied. Other tools try to select an architecture from a pre-defined database. The verification process involves many iterations through the design process, and a backtracking methodology is generally used. The circuit synthesis tool ASTRX/OBLX assumes a fixed topology and uses a simulating annealing process to size the analog cells.ASTRX/OBLX requires several conditions to converge. The simulation is performed in two phases, the DC analysis, which evaluates the bias point, and the AC analysis, which evaluates the small signal behavior. The cost function is evaluated using these analyses and it is compared against the constraints, objectives and specifications. A proper test-bench becomes critical to find a functional design. However, it may take an expert analog designer to decide a proper testbench. Besides, The convergence time and the accuracy of results are improved when the unknowns intervals are kept small and the number of unknowns, specifications, objectives and constraints are as minimum as possible. Therefore, an initial knowledge of the transistor sizes, operating points, and small signal characteristics can speed up the process of convergence successfully. The Analog Performance Estimator presented in this paper provides a way to generate such initial design conditions.4.4Analog Component LibraryThe analog cell library consists of a set of components such as current mirrors, opamps, differentiators, integrators, adders, multipliers, dividers, sample and hold circuits, analog to digital converters, and digital to analog converter. Each component describes just the circuit topology at the CMOS transistor level; no sizing information is obtained from the library. The goal is to have a retargetable library that doesn’t depend on the fabrication process parameters and the functional constraints. However, having a library in this format requires extra information to guide the synthesis process. The performance of each library component depends on the fabrication process parameters, the sizes and the environment in which is used. The analog performance estimator presented in this paper can generate such information.5.Conclusion and Future plansThe analog performance estimator (APE) presented in this paper uses a hierarchical approach to analog circuit performance and size estimation. These size estimates could be used effectively as a starting point for analog circuit synthesis. The APE was discussed in the context of a mixed-signal synthesis system (VASE). The application of APE in performing constraint transformation was also presented. Currently we are trying to characterize the error of the estimator and use this to improve the accuracy of the constraint transformation process. Work is also directed towards extending the estimator for use in analog behavioral synthesis. ACKNOWLEDGEMENTSThis research is sponsored by the USAF, Wright Laboratories, Wright Patterson Air Force Base under contract number F33615-96-C-1911.REFERENCES[1]R. Vemuri, N. Dhanwada, A. Nunez, P. Campisi, "VASE: VHDL-AMS SynthesisEnvironment: Tools for Mixed-Signal Systems," proc. EETimes Conference on Analog and Mixed-Signal applications, pp. 1C:77-1C:84, July 1997.[2]Daniel Foty, “MOSFET Modeling with SPICE”, Prentice Hall, chapter 2, pp. 6-17,1997.[3]L. R. Carley, G.E. Gielen, R. A. Rutenbar, W. Sansen, ``Synthesis Tools for Mixed-Signal ICs: Progress on Frontend and Backend Strategies'', Proceedings of the DAC 1996, pp 298-303, June 1996.[4] B.A. Antao, A.J. Brodersen, ``Techniques for Synthesis of Analog Integrated Circuits'', IEEE Design & Test of Computers, pp 8-18, March 1992.[5] E. S. Ochotta, R. A. Rutenbar, L. R. Carley, ``Synthesis of high-performance analogcircuits in ASTRX/OBLX'', IEEE Trans. CAD, Vol. 15, pp. 273-294, Mar. 1996.[6]ACACIA 2.0 Release, User Guides; ACACIA Group, 1994.[7]L.T. Pillage, R.A. Rohrer, ``Asymptotic Waveform Evaluation for Timing Analysis'',IEEE Trans. CAD, vol 9. No. 4, pp. 352-366 Apr. 1990.[8]M. Gen and R. Cheng, “Genetic Algorithms and Engineering Design”, John Wiley andsons, 1997.[9]VHDL-AMS (1076.1) Language Reference Manual.。

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