制药工程专业英语考试题目与答案

专业英语考试内容：单词10分句子翻译24分根据课文回答问题24分英译汉药品说明书21分翻译汉译英摘要21分Unit 11 Tablet (The Pharmaceutical Tablets Dosage Form)药片（医药片剂剂型）Role in TherapyA: The oral route of drug admininistration is the most important method of administering drugs ofr systemic effects.Except in cases of Insulin therapy.the parenteral route is not routinely used for self-administration of medication.The topical route of administration has only recently been employed to deliver drugs to the body for systemic effects,with two classes of marketed products:Nitroglycerin for the treatmint of angina and scopolamine for the treatment of motion sickness.Other drugs are certain to follow,but the topical route of administration is limited in its ability to allow effective drug absorption for systemic drug action.A:口服给药是全身效应用药方法中最为重要的。

除了胰岛素治疗，非肠道药途径不常用在自我服药方面。

局部给药途径只是最近才被应用到身体药物输送达到系统效应。

有两类上市药物（应用到该方法）：治疗心绞痛药物的硝酸甘油和治疗眩晕病的莨菪胺。

其他药粉也效用此法，但局部给药途径受系统药物作用的药物有效吸收能力的限制。

B:The parenteral roue of administration is important in treating medical emergencies in which a subject os comatose or cannot swallow,and in providing various types of maintenance therapy for hospitalized patients.B:注射给药在处理病人昏迷或者不能吞咽的紧急情况和各种保守治疗的就医病人时十分重要。

Nevertheless,it is probable that at least 90% of all drugs used to produce systemic effects are addministered by the oral rote .C:When a new drug is discovered,one of the first quedtions a pharmaceutical company asks is whether or not drug can be effectively administered for its intdended effect by the oral route.If it cannot,the drug is primarily relegated to administration in a hospital setting or physician’s office.If patient self-admnistration cannot be achieved,the sales of the drug constitute only a small fraction of what the market would be otherwise.C:当一种新药被研制出来，制药公司首先考虑的一个问题就是，这种药物是否可以口服。

如果这种药物不能口服，它将被交给医院或医师来管理。

如果病人不能自己服药，这种药物的市场前景会比口服小得多。

Of drugs that are addministred orally,solid oral dosge forms represent the preferred class of product.The reasons for this preference are asQ1:How many kinks of the route of drug administration are there?Can you present these usual dosage form of the drug that are administered orally?Q2:Why does the solid oral dosage form represent the preferred class of drugs that are administered orally?Q3:Why do people make liquid dosage form of drug?addition ,liquids are less portable and require much more space per number of dosage on the pharmacist’s shelf.D:Drugs are in general less stable (both chemically and physically)in liquid form than in a dry state and expiration dates tend to be shorter .Careful attention is required to assure that the product will not allow a heavy microbiologic burden to develop on standing or under or under normal conditions of use once opened(preseration requirements).D:一般来说，药物在液态比固态片剂更不稳定（无论是化学性质还是物理性质），保质期都缩短。

需要特别注意的是确保产品一旦打开后，在存放时或常规使用下避免受到严重的微生物污染。

PropertiesQ4:What is the bjective of design and manufacture of the sompressed tablet?Q5:What is important aside from the physical and chemical propertices of the medicinical agent(s) to the formulated into a tablet?E:E:设计和制造扁平药片的目的是通过口服给药，把正确剂量适当形态的药物在适当的（或维持适当的）时间范围内送到指定的目标位置并保持其化学稳定性。

Aside from the physical and chemical properties of the medicinal agent(s) to be formulate into a tabletQ6:What physical properties should tablet have?How the physical properties effect on bioavailability?F:药物科学家现在认识到，片剂的不同物理性质会通过改变药物周围的环境或压力条件显著地影响生物药效率，这样一些药物作用体系中物理稳定性比化学稳定性更加重要和需要关注。

Q7:How to arrange the medicine effects and physical aspects?On the other hand , the tablet(1) must be able to release the medicinal agent(s) in the body in a predictable and reprouducible mannerexample of this point ,Meyer and associates present informantion on 14 Nitrofurantoin products,all of this which passed the compendia physical requirements,but showed statistially,significant bioavailbility differences.1、Why do people make liqaid dosage form of drug in Unit 11?Unit 12 Manufacture of Tablets 药片的生产制造Tablet Design and Formulatiom 药片的设计与制造A: The three basic methods of tablet manufacture have been previously detailed,the desirable properties and required features of granulations(成粒) and tablets defined,and the interrelationships（相互关系）between manyof these properties and the processing and machine variables（变量）noted.A:先前已经详细介绍了三种基本的片剂制造方法，对成粒和成片中适合的、必须的特性作了详细说明，对这些要素之间的关系，处理过程各机械变量进行了注解。

Q1:what are the nondrug components in tablets and what are their functions?B:Some tablet formulations may additionally require a flow promoter.B:一些药片还需要流动性促进剂。