亚莫利说明书
格列美脲说明书
【药物名称】中文通用名称：格列美脲英文通用名称：Glimepiride其他名称：阿茉立、安多美、安尼平、迪北、佳和洛、科德平、力贻苹、普唐苹、瑞平、圣平、圣糖平、唐弗、唐苏、万苏平、亚莫利、伊瑞、佑苏、Amarel、Amaryl。
【临床应用】用于经饮食控制、体育锻炼及减轻体重均不能满意控制的2型糖尿病。
【药理】1.药效学本药是第三代口服磺酰脲(SU)类降血糖药。
作用机制与格列本脲相似，但本药是与SU受体上的65kDa亚基相结合，而不是与140kDa亚基相结合。
另外，本药有改善组织对胰岛素敏感性的作用，且较少引起严重低血糖，这一特点可能与其结合及离解SU受体的速度都较格列本脲快有关。
2.药动学本药口服吸收迅速而完全(100%在胃肠道吸收)，进食对药物吸收影响不明显。
服药后2-3小时达峰浓度，口服4mg后平均峰浓度约为300ng/ml。
半衰期为5-8小时。
本药在肝脏内通过细胞色素P450氧化，并全部代谢为环己羟甲基及羧基两类衍生物(分别为M1及M2)，M1可进一步代谢为M2，两者皆无降低血糖作用。
口服以14C标记的本药后7日内，约60%出现于尿中，其中M1和M2(占主要)占80%-90%；约40%出现于粪便中，其中M1和M2(占主要)约占70%，尿液及粪便中均未发现药物原形。
3.遗传与生殖毒性动物试验和临床观察证实磺酰脲类降血糖药可造成死胎和胎儿畸形。
【注意事项】1.禁忌症(1)对本药、其他磺酰脲类或磺胺类药过敏者。
(2)已确诊的1型糖尿病患者。
(3)严重肝、肾功能损害者。
(4)伴有酮症酸中毒、昏迷、严重烧伤、感染、外伤和重大手术等应激情况的2型糖尿病患者，或曾有糖尿病酮症酸中毒或糖尿病昏迷史者。
(5)白细胞减少者。
(6)孕产妇。
(7)哺乳妇女。
2.慎用(1)体质虚弱者。
(2)老年患者。
(3)肝、肾功能不全者。
(4)恶心、呕吐患者。
(5)肾上腺皮质功能或腺垂体功能减退，尤其是未经激素替代治疗者。
(6)高热患者。
亚莫利 (格列美脲片) 说明书
亚莫利（格列美脲片）说明书【亚莫利药品名称】通用名：格列美脲片(亚莫利)英文名：Glimepiride Tablets汉语拼音：GeliemeiniaoPian【亚莫利成分】亚莫利主要成份为：格列美脲。
其化学名称为：1-[4-[2-(3-乙基-4-甲基-2-氧代-3-吡咯啉-1-甲酰胺基)-乙基]-苯磺酰]-3-(反式-4-甲基环己基)-脲。
【亚莫利性状】亚莫利为白色片。
【亚莫利药理毒理】亚莫利为第二代磺酰脲类口服降血糖药，其降血糖作用的主要机理是刺激胰岛? 细胞分泌胰岛素，部分提高周围组织对胰岛素的敏感性。
亚莫利与胰岛素受体结合及离解的速度较格列本脲为快，较少引起较重低血糖。
【亚莫利药代动力学】亚莫利口服后迅速而完全吸收，空腹或进食时服用对亚莫利的吸收无明显影响，服后2～3小时达血药峰值，口服4mg平均峰值约为300ng/ml，t1/2约5～8小时，亚莫利在肝脏内经P450氧化物代谢成无降糖活性的代谢物，60%经尿排泄，40%经粪便排泄。
【亚莫利适应症】适用于食物、运动疗法及减轻体重均不能满意控制血糖的非胰岛素依赖型糖尿病。
【亚莫利用法用量】遵医嘱口服用药。
对于糖尿病患者，格列美脲或任何其他降糖药物都无固定剂量，必须定期测量空腹血糖和糖化血红蛋白以确定患者用药的小有效剂量；测定糖化血红蛋白水平以监测患者的治疗效果。
通常起始剂量：在初期治疗阶段，格列美脲的起始剂量为1～2mg每天一次，早餐时或次主餐时给药。
那些对降糖药敏感的患者应以1mg每天一次开始，且应谨慎调整剂量。
格列美脲与其他口服降糖药之间不存在的剂量关系。
格列美脲初始剂量不超过2mg。
通常维持剂量：通常维持剂量是1～4mg每天一次，推荐的维持量是6mg每天一次。
剂量达到2mg后，剂量的增加根据患者的血糖变化，每1～2周剂量上调不超过2mg。
【亚莫利不良反应】依据对格列美脲片及其它磺脲类药物的经验，应考虑下列不良反应：免疫系统：个别病例轻微的过敏反应可发展成导致威胁生命的严重情况，如呼吸困难、血压降低，有时发展为休克。
DYANAVEL XR（amphetamine）延长释放型口服悬液药液说明指南说明书
MEDICATION GUIDEMEDICATION GUIDE®DYANAVEL XR (dī-an-uh-vel)(amphetamine)extended-release oral suspension, CIIRead this Medication Guide that comes with DYANAVEL XR before you or your child starts taking it and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking to your doctor about your or your child’s treatment with DYANAVEL XR.What is the most important information I should know about DYANAVEL XR?DYANAVEL XR is a federally controlled substance (CII) because it can be abused or lead to dependence. Keep DYANAVEL XR in a safe place to prevent misuse and abuse. Selling or giving away DYANAVEL XR may harm others and is against the law.Tell your doctor if you or your child has ever abused or been dependent on alcohol, prescription medicines, or street drugs.DYANAVEL XR is a stimulant medicine. Some patients have had the following problems when taking stimulant medicines such as DYANAVEL XR.The following have been reported with use of methylphenidate hydrochloride and other stimulant medicines.1. Heart-related problems:•sudden death in patients who have heart problems or heart defects•sudden death, stroke and heart attack in adults•increased blood pressure and heart rateTell your doctor if you or your child have any heart problems, heart defects, high blood pressure, or a family history of these problems.Your doctor should check you or your child carefully for heart problems before starting DYANAVEL XR.Your doctor should check your or your child’s blood pressure and heart rate regularly during treatment with DYANAVEL XR.Call your doctor right away if you or your child have any signs of heart problems such as chest pain, shortness of breath, or fainting while taking DYANAVEL XR.2. Mental (Psychiatric) problems:All Patients•new or worse behavior and thought problems•new or worse bipolar illness•new psychotic symptoms (such as hearing voices, believing things that are not true, are suspicious) or new manic symptomsTell your doctor about any mental problems you or your child have, or about a family history of suicide, bipolar illness, or depression.Call your doctor right away if you have or your child has any new or worsening mental symptoms or problems while taking DYANAVEL XR, especially seeing or hearing things that are not real, believing things that are not real, or are suspicious.3. Circulation problems in fingers and toes [Peripheral vasculopathy, including Raynaud’s phenomenon]:•fingers or toes may feel numb, cool, painful•fingers or toes may change color from pale, to blue, to redTell your doctor if you have or your child has numbness, pain, skin color change, or sensitivity to temperature in your fingers or toes.Call your doctor right away if you have or your child has any signs of unexplained wounds appearing on fingers or toes while taking DYANAVEL XR.What is DYANAVEL XR?DYANAVEL XR is a central nervous system stimulant prescription medicine. It is used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). DYANAVEL XR may help increase attention and decrease impulsiveness and hyperactivity in patients with ADHD.It is not known if DYANAVEL XR is safe and effective in children under 6 years of age.Who should not take DYANAVEL XR?DYANAVEL XR should not be taken if you or your child:•are allergic to amphetamine, or any of the ingredients in DYANAVEL XR. See the end of this Medication Guide for a complete list of ingredients in DYANAVEL XR.•are taking or have taken within the past 14 days an anti-depression medicine called monoamine oxidase inhibitor or MAOI.What should I tell my doctor before taking DYANAVEL XR?DYANAVEL XR may not be right for you or your child. Before starting DYANAVEL XR tell your or your child’s doctor about all health conditions (or a family history of) including:•heart problems, heart defects, or high blood pressure•mental problems including psychosis, mania, bipolar illness, or depression•circulation problems in fingers and toesTell your doctor:•if you or your child have any kidney problems. Your doctor may lower the dose.•if you are or your child is pregnant, or plan to become pregnant. It is not known if DYANAVEL XR will harm your unborn baby.•if you are or your child is breastfeeding or plan to breastfeed. DYANAVEL XR passes into breast milk.Discuss with your doctor before you breastfeed while you are taking DYANAVEL XR.Tell your doctor about all of the medicines that you or your child takes including prescription and over-the-counter medicines, vitamins, and herbal supplements. DYANAVEL XR and some medicines may interact with each other and cause serious side effects. Sometimes the doses of other medicines will need to be adjusted while taking DYANAVEL XR.Your doctor will decide whether DYANAVEL XR can be taken with other medicines.Especially tell your doctor if you or your child take:•anti-depression medicines including MAOIsKnow the medicines that you or your child take. Keep a list of your medicines with you to show your doctor and pharmacist.Do not start any new medicine while taking DYANAVEL XR without talking to your doctor first.How should DYANAVEL XR be taken?•Take DYANAVEL XR exactly as prescribed. Your doctor may adjust the dose until it is right for you or your child.•Take DYANAVEL XR oral suspension 1 time each day in the morning.•DYANAVEL XR can be taken with or without food.•Shake the DYANAVEL XR bottle well before you use it.•Use an oral dosing syringe or other measuring device to help you measure the right amount of DYANAVEL XR.•Your doctor may sometimes stop DYANAVEL XR treatment for a while to check your ADHD symptoms. •Your doctor may do regular checks of your or your child’s blood, heart, and blood pressure while taking DYANAVEL XR.•Children should have their height and weight checked often while taking DYANAVEL XR. DYANAVEL XR treatment may be stopped if a problem is found during these check-ups.•If you or your child take(s) too much DYANAVEL XR, call your doctor or poison control center at 1-800-222-1222 right away, or go to the nearest hospital emergency room.What should I avoid while taking DYANAVEL XR?•drinking alcoholWhat are possible side effects of DYANAVEL XR?DYANAVEL XRcan cause serious side effects, including:•See “What is the most important information I should know about DYANAVEL XR?” for information on reported heart and mental problems.•slowing of growth (height and weight) in childrenCommon side effects of amphetamine products include:•dry mouth •decreased appetite •weight loss •stomach pain•nausea•trouble sleeping•restlessness•extreme mood changes•dizziness•increased heart rateTalk to your doctor if you or your child have any side effects that bother you or do not go away.These are not all the possible side effects of DYANAVEL XR. Ask your doctor or pharmacist for more information.Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.How should I store DYANAVEL XR?•Store DYANAVEL XR at room temperature between 68°F to 77°F (20°C to 25°C).•Store DYANAVEL XR in a safe place, like a locked cabinet.•Dispose of remaining, unused, or expired DYANAVEL XR by a medicine take-back program at authorized collection sites such as retail pharmacies, hospital or clinic pharmacies, and law enforcement locations. If no take-back program or authorized collector is available, mix DYANAVEL XR with an undesirable, nontoxic substance such as dirt, cat litter, or used coffee grounds to make it less appealing to children and pets. Place the mixture in a container such as a sealed plastic bag and throw away DYANAVEL XR in the household trash. Keep DYANAVEL XR and all medicines out of the reach of children.General information about the safe and effective use of DYANAVEL XRMedicines are sometimes prescribed for purposes other than those listed in the Medication Guide. Do not use DYANAVEL XR for a condition for which it has not been prescribed. Do not give DYANAVEL XR to other people, even if they have the same condition. It may harm them and it is against the law.This Medication Guide summarizes the most important information about DYANAVEL XR. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about DYANAVEL XR that was written for healthcare professionals.For more information about DYANAVEL XR please contact Tris Pharma at 1-732-940-0358 or.What are the ingredients in DYANAVEL XR?Active Ingredient: amphetamine.Inactive Ingredients: anhydrous citric acid, bubblegum flavor, glycerin, methylparaben, modified food starch, polysorbate 80, povidone, polyvinyl acetate, propylparaben, sodium lauryl sulfate, sodium polystyrene sulfonate, sucralose, triacetin and xanthan gum.Manufactured by: Tris Pharma, Inc. Monmouth Junction, NJ 08852 LB8417 Rev. This Medication Guide has been approved by the U.S. Food and Drug Administration.03 01/17。
Roche MagNA Lyser 产品说明书
Ordering Information Cat. No. Product ***********MagNA Lyser Instrument (230 Volt)***********MagNA Lyser Instrument (110 Volt)(Instruments supplied with rotor and rotor cooling block)***********MagNA Lyser Green Beads (100 tubes)Related Products Cat. No. Product***********MagNA Pure LC DNA Isolation Kit II (Tissue)***********MagNA Pure LC mRNA Isolation Kit II (Tissue)03 330 591 001MagNA Pure LC RNA Isolation Kit III (Tissue)***********MagNA Pure LC DNA Isolation Kit III (Bacteria, Fungi)***********MagNA Pure LC RNA Isolation Tissue Lysis Buffer – Refill (70 ml)System DescriptionHomogenize up to 16 samples in just a few seconds.Save valuable lab space with a small benchtop instrument.Reduce hands-on time by replacing the mortar and pestle and other manual methods.Integrate your workflow with the automated nucleic acid isolation of the MagNA Pure LC Instrument.Perform consistent and reproducible sample disruption.Process many different sample types.Prevent nucleic acid degradation with the benchtop cooling unit.Ease your setup with a removable rotor and prefilled disposable vials.Automate with an easy-to-use instrumentVersatile, efficient, and rapid pre-preparationFigure 71. Add your sample and lysis buffer to the MagNA Lyser Green Beads.2. Homogenize with the MagNA Lyser Instrument.3. Centrifuge to pellet the debris.4. Proceeed with the supernatant to prepare nucleic acids or proteins.For detailed information,visit or contact your local representative.Trademarks:MagNA Pure, MagNA Lyser, LightCycler, and the MagNA Pure Logo are trademarks of a member of the Roche Group.The technology used for the LightCycler System is licensed from Idaho Technology Inc., Salt Lake City, UT, USA.Fully automated sample preparationon the PCR Workflow SystemRoche Diagnostics GmbH Roche Applied Science Nonnenwald 282372 Penzberg Germany0000Roche Applied Science Part of Roche DiagnosticsMagNA Lyser InstrumentStart the Ball Rollingwith Automated Tissue HomogenizationᕤᕣᕢᕡFigure 6Components of the system.The MagNA Lyser InstrumentAutomated tissue homogenizationProcessing conditionsRefer to the following tables for guidelines on setting up your homogenizationSample material(10 mg)*Time settings(seconds)Cooling(between the runs)Speed Average yield(µg)***Average purity(OD 280/260 nm)***Spleen 2 x 25 906,00030–40 1.9Liver 25-6,00016–18 1.8Lung 2 x 25906,00025 1.8Kidney25-6,000201.8Maize leaves **20-5,00010n.d.Maize polenta **20-5,0008n.d.Tortilla chips **20-5,0001n.d.*Aliqout containing 10 mg sample material (here mouse and food samples) was taken for the DNA purificationusing the MagNA Pure LC DNA Isolation Kit II (Tissue), (see pack insert)**Centrifugation after the homogenization for 5 minutes at 2,200 x g*** Yield and purity strongly depend on the condition of the sample material n.d.not determinedData kindly provided by Dr. Peterhänsel, RWTH Aachen, GermanyFigure 1Gel electrophoresis from genomic DNA isolated from tissue homogenized with the MagNA LyserInstrument, using the MagNA Pure LC DNA Kit II (Tissue).Marker: DNA Marker III*Aliquot containing 10 mg sample material (here mouse and human research samples) was taken to purify RNAeither with the MagNA Pure LC RNA Isolation Kit III (Tissue) or the MagNA Pure LC mRNA Isolation Kit II (Tissue) homogenized with the MagNA Lyser Instrument.** Yield and purity strongly depend on the condition of the sample material. The yield for mRNA was not determined.Sample material(10 mg)*Time settings(cycles/seconds)Cooling(between/afterthe runs in seconds)SpeedAverage yield (mg)(total RNA)**Average purity(OD 280/260 nm)**RNA/mRNARarely expressed targets in small numbers of target cells,as seen in experiments about minimalresidual diseases,are difficult to detect.Increasing the cell number can improve sensitivity and lead to accurate results.Without the MagNA Lyser pre-processing,the MagNA Pure mRNA HS Kit can efficiently obtain mRNA from a maximum of 1 x 107white blood cells (WBCs),as shown in research studies with human samples.However,using greater cell numbers results in a saturation effect with quantitative assays (Figure 3).Homogenization of the lysate with the MagNA Lyser Instrument prior to the purification eliminatesthe amplification saturation at 1 x 107cells and allows the use of up to 2.5 x 107WBCs (Figure 4 and 5),enhancing the analytical sensitivity of the assay.Eliminate sensitivity barriers with increased sample inputFigure 3mRNA was purified from different amounts of human white blood cells with the MagNA Pure mRNA HS Kit. G6PDH was amplified using the LightCycler t(9;22) Quantification Kit (see text beside).Figure 4mRNA was purified from different amounts of human white blood cells with the MagNA Pure mRNA HS Kit. The lysates from 2.5 x 107cells and 5 x 107cells were homogenized with the MagNA Lyser Instrument (2x50 seconds with 90 seconds cooling in between) prior to the mRNA purification. G6PDH was amplified using the LightCycler t(9;22) Quantification Kit (see text beside).Figure 5Scalability from 1 x 106cells to 2.5 x 107cells is represented in the graph and the table of the relationship between crossing points and cell numbers. The limitation of cell input is indicated by no change in crossing point with increased cell number (see text beside).Cell number 5 x 1072.5 x 1071 x 1075 x 1061 x 106Log (cell number)7.77.47.06.76.0Crossing point 20.320.321.822.424.4crossingpointLog(cell number)252423222120195.86.36.87.37.8Figure 2Gel electrophoresis from total RNA isolated from tissue homogenized with the MagNA Lyser Instrument, using the MagNA Pure LC RNA Kit III (Tissue).Ma r k e rS p l e e nL i v e rL u n gK i d n e yM a r k e rMa i z e l e a v e sMa i z e l e a v e sS p l e e nL i v e r11 kb5 kb5 kb28 S rRNA 18 S rRNASpleen 2 x 50 90 6,500–7,000 30–40 1.9Liver 50 - 6,500–7,000 13–17 2.0Thymoid tissue60906,500n.d.n.d.Heart 60 90 6,500 n.d. n.d.Abdominal fat 60 90 6,500 n.d. n.d.Aorta 60 90 6,500 n.d. n.d. Other samples1+n x 50 90 6,500–7,000- -1 x 105 x 101 x 10- 5 x 101 x 105 x 105 x 10- 5 x 102.5 x 10 5 x 10。
尼克萨里鸟控制产品说明书
Effective Installations Don't Just Happen...They Are Planned.Thorough planning,proper instal-lation,follow-up maintenance in the first weeks and periodic inspection of the mounting sys-tem,are the keys to a successful plan for Nixalite Bird Control.Always study the building carefully .Nixalite must be installed on all areas where birds alight,roost or build nests.All areas above,from which birds can drop nesting materials,as well as areas where birds can fly above the installation to drop materi-als,must be protected with Nixalite.Even though stainless steel has a very low rate of corrosion or reaction with other metals,it is still recommended to apply a protective coating or sealer on dissimilar metal surfaces before installing Nixalite to prevent any gal-vanic action.When installing Nixalite in small pieces or on a complicated surface,cut and fit each piece carefully .Be patient and thorough when applying Nixalite,being sure to cover all con-tours and angles closely .Do not jam the Nixalite together .Before deciding on the proper amount of Nixalite to be used,there are some specific figures to consider .Take time to establish the proper position and amount of the Nixalite by referring to the Surface Depth and charts on .Too much Nixalite can be as ineffective as too little."Space-i-fication"page 4All exposed edges,as well as the inte-rior of flat surfaces,must be covered.On inside corners,particularly cornice returns and similarly protected areas,it may be necessary to make a screen or special device with Nixalite to close off the protected area.In some areas,the Nixalite should be installed both on the surface and upside down on the surface directly above.Nixalite can be used on pipes,sup-ports and similar areas.It is also used as a deterrent for climbing ani-mals,rodents and humans.Clean the surface thoroughly with a disinfectant.The scent of bird drop-pings can encourage the birds to come back.Birds will fight hard to retain their old roosts.Before installing Nixalite remove all overhanging branches and similar foliage where birds can land to drop nesting materials.A free consultation service is pro-vided by our planning depart-ment.Submit drawings with exact measurements for recommendations.On site consultation is available by request.However ,there is a charge for this service.In cases where the accumulation ofQuestions About Y our Installation?Ph:800-624-1189or 309-755-8771Fax:800-624-1196or 309-755-0077E-mail:*********************Website:www For your protection ,wear goggles,gloves and a protective mask to help protect you against the health haz-ards associated with the bird debris.bird dung is heavy ,it may be neces-sary to use a bactericide to kill the dis-ease carrying bacteria.1.Carefully measure the depth and length of the surface,then refer to the Surface Depth Specification Charts page 4on for the number of rows needed.It is sometimes necessary to measure for height clearance when installing Nixalite in tight spaces.Proper placement and quantity of Nixalite starts with accurate mea-surements of the surface.Installing Nixalite StripsNOTE:Make sure the dimensionsyou record are accurate .Do not guess or estimate dimensions from a distance.Accurate dimensions are essential for an effective Nixalite installation.The Guide To Success121819gaw - new mhdBefore installing the Nixalite strips into the mounting hard-ware,there are some important guidelines that must be followed.2.Do not leave gaps in the Nixalite coverage.Cover all possible land-ing areas above,behind or next to the installation areas.1.Be sure the Nixalite strips will fit the area properly .The Nixalite base strip must follow the installa-tion surface closely .3.At the exposed ends of a surface ,run the strips over the ends.Make sure the of the strip is the or wire at all exposed surface ends.Make sure the strip wires extend at least over the outside edges.1/2"tallest wire first last 1/4"2.Mark where the Nixalite base strip will be positioned.To help you space the Nixalite on the surface correctly ,refer to the "Space-i-fications "chart on page 4.Steel or IronMounting Hardware InstructionsAll Nixalite mounting hardware is made of high grade stainless steel or weather resistant materials. If you have any questions or need more information, contact Nixalite or go to .4.Slip Nixalite base strip into mount-ing clips.3.Drive flush with hammer .MasonryWood &Sheet Metal4.Slip Nixalite base strip into mount-ing clips.1.Drill 11/64"diameter holes,at least 1/2"deep or through the steel.2.Blow out debris,insert anchors.3.Insert sheet metal screws through the mounting clips and drive flush into anchors with a screw driver .1.If necessary ,make small guide holes with a drill,punch,etc.2.Insert stainless steel sheet metal screw through the mounting clip and washer (in that order ,top to bottom).1.Drill 3/16”diameter holes,1"deep.4.Slip Nixalite base strip into mount-ing clips.Optional:Fill drilled holes with silicone sealer before installing hardware.This provides protection against water damage2.Insert stainless steel drive screws with mounting clips and washers (in that order ,top to bottom)into drilled holes.Fill drilled holes with silicone sealer before inserting anchors.This provides protection against water damage.Optional:Use the Mounting HardwareSpacing Chart on page 4to find the proper mounting hardware spacing.e a screw driver to drive screws,clips and washers flush to surface.The "hook"end of the mounting clip should point to the closest out-side edge of the surface.e the Mounting HardwareSpacing Chart on ,to deter-mine the proper mounting hard-ware spacing.Make a mark for each mounting hardware unit,or use an installation template.Call Nixalite for installation template details.page 43.Mounting hardware is installed 7/8"from Nixalite base strip.Mark the surface where the mounting hardware units are to be placed.MasonryWood/Sheet MetalNixalite Mounting Hardware UnitsQuestions About Y our Installation?Ph:800-624-1189 or 309-755-8771 Fax:800-624-1196 or 309-755-0077Wire Tie and Adhesive2.Apply adhesive to the bottom of the Nixalite base strip and to the installation surface.Recommended for fastening the Nixalite strips to suspended struc-tures,such as pipe,cables,etc.Follow the adhesive manufacturers direc-tions printed on the container .1.Clean the surface thoroughly ."Non-removable"Method1.Clean the surface thoroughly .2.By following manufacturers direc-tions printed on the adhesive con-tainer ,apply adhesive to surface where clips are to be attached.Put clips into the adhesive,making sure not to get any adhesive into the hook end of the clip.The clip hook should point to the closest out-side edge of the surface.3.Cover the eyelet end of the clip with adhesive.Make sure not to get adhesive into the hook end of the mounting clip.5.It is absolutely necessary to allow the adhesive holding the mounting clips to cure for at least 24hours before inserting the Nixalite strips.Removable MethodKeeping TabsWhen the use of supplied mounting hardware is not possible,a removable adhesive installation can be done.However ,it is recommended to use one mounting hardware unit at each end of the Nixalite strip to ensure solid mounting.1.Clean the surface thoroughly .2.By following manufacturers direc-tions printed on the adhesive con-tainer ,apply adhesive to surface where clips are to be attached.Put clips into this adhesive,making sure not to get any adhesive into the hook end of the clip.The hook end of clip should point toward the closest outside edge of the surface (see sketch #2at left).3.Cover the eyelet of the mounting clip with adhesive making sure not to get adhesive in the hook end of the clip (see sketch #3at left).4.It is absolutely necessary to allow the adhesive holding the mounting clips to cure for at least 24hours before inserting the Nixalite strips.By setting up a bi-annual visualinspection of the installation,you can keep an eye out for any debris that may get caught in the needles of the strips.Also inspect the mounting hard-ware system at this time.This allows re-securing the strips in the unlikely event that the strips have come loose from the hardware.Bear in mind that the birds may fight to retain their nesting and roosting places.Credit the birds for being cun-ning,persistent and tenacious.Sufficient Nixalite must be installed to do the job effectively .Careful observa-tion before the installation is neces-sary to locate all the problem areas.Remember that birds will try to drop sticks and other nesting materials into the Nixalite in an attempt to.....continued next pageIn Closing...3.Press the Nixalite strip into the sur-face adhesive.4.Wrap the wire tie around the strip and the suspended surface.Twist the loop ends with wire tying tool until tight.Space the wire ties in accordance with the Mounting Hardware Spacing Chart on page 4of this guideline.Adhesive Installation InstructionsWhen the use of supplied mounting hardware is not possible,an adhesive installation can be done.It is recom-mended to use one mounting hard-ware unit at each end of the Nixalite strip to ensure solid mounting.Always follow instructions printed on the adhesive container .4.After the adhesive holding the clips has cured,apply adhesive to the bottom of the Nixalite base strip and the installation surface.Slip the Nixalite strip into the mounting clips.For More Information or Planning AssistanceE-mail:*********************Careful thought and planning are required to make the installation suc-cessful.We can furnish the material,render it useless.That is why the areas above the installation must be pro-tected with Nixalite strips.but it must be installed with skill and ingenuity .Naturally ,since there are so many dif-ferent factors to be considered,we make no warranties,guarantees or representations,expressed or implied.Surface Depth Specification ChartsDetails to Remember:Nixalite "Space-i-fication" ChartsMounting Hardware Spacing Chart*½row indicates the use of Model H Nixalite.Whole number indicate the use of full row models S Nixalite.charts apply to .If using Model W ,review the Installing Model W Nixalite pages from Nixalite.Download this brochure from www or contact Nixalite for a free copy .NOTE:Model W Nixalite DO NOT A Always measure from the of the Nixalite base strip.center C1¾”(4.4cm)max.from the outsiderow .B5”(12.7cm)max.and 3½”(8.9cm)min.between two rows of Nixalite.2½”(6.4cm)max.and 2”(5.1cm)min.between models H and S Nixalite.E Extend Nixalite base strip at least ½”(1.3cm)over ends of surface.D 2¼”(5.7cm)max.from inside wall to the center of the inside row of Nixalite.FNixalite needles must extend over the outside edge at least ¼”(0.6cm).48"6units -one at each end,four spaced evenly between 16"2units -one at each end.Strip length Mounting Hardware Spacing12"2units -one at each end.24"3units -one at each end,one inmiddle Outside Corners &Exposed Edges:At outside corners,space the strips as shown below .At exposed ends,the tallest wire of the strip is always the first and/or last wire.Make sure there are no gaps where Nixalite strips meet walls or other objects,or where two Nixalite strips butt together end-to-end.Gaps:When two Nixalite strips are butted together in a row ,make sure the Nixalite wire pattern continues from one strip to the next strip.No gaps.Butting Strips:Single ExposedSurface DepthInchesCentimetersRows Required 8.5 - 13.50 - 3.53.5 - 5.55.5 - 8.513.5 - 18.518.5 - 23.523.5 - 28.528.5 - 33.533.5 - 38.538.5 - 43.534.3 - 47.00 - 8.98.9 - 14.014.0 - 21.621.6 - 34.372.4 - 81.597.8 - 110.547.0 - 59.759.7 - 72.481.5 - 97.8 3 rows 1 row 6 rows 7 rows 9 rows4 rows 8 rows 2 rows5 rows 1½ row*½ row*1 row 4 rows 2 rows 8 rows1½ rows 3 rows 6 rows 7 rows 5 rows 73.7 - 86.45.2 - 10.20 - 5.161.0 - 73.710.3 - 15.322.9 - 35.635.6 - 48.348.3 - 61.086.4 - 99.115.3 - 22.90 - 22 - 44 - 66 - 99 - 1414 - 1919 - 2429 - 3424 - 2934 - 39Double ExposedSurface DepthInchesCentimetersRows Required Need Help?U.S.\Canada - Ph:800-624-1189 Fax:800-624-1196E-mail Web :******************: Nixalite is open 8:00 a.m. to 4:30 p.m. Central Time,Monday through Friday . Fax or E-mail anytime.International - Ph:309-755-8771 Fax:309-755-0077Never use less than 2hardware units per strip,no matter how short the strip may be.Copyright© 2008 - 2019 by Nixalite® of America Inc. All rights reserved.Nixalite® is a registered trademark of Nixalite® of America Inc. Printed with pride in the .USA 1025 16th Avenue East Moline,. 61244IL Nixalite of America Inc®Experts In Architectural Bird Control Since 1950P_GuideToSuccess100219gaw .cdr - mhd new。
贝利莫电子无压依赖特性控制阀说明书
BACnet PICS Energy ValveEnergy ValveContentsProtocol Implementation Conformance Statement – PICS 2 BACnet Object Description 4General information Date26.01.2018Vendor Name BELIMO Automation AGVendor ID423Product Name Energy ValveProduct Model Number EV..R+(K)BAC, EV..R3+BAC, EV..F+(K)BACApplikations Software Version03.02-0000Firmware Revision12.25BACnet Protocol Revision 1.12Product Description Electronic pressure-independent characterisedcontrol valve with energy monitoringBACnet Standard Device Profile BACnet Application Specific Controller (B-ASC)Segmentation capability NoData Link Layer Options MS/TP masterBACnet IP, (Annex J)BACnet IP, (Annex J), Foreign DeviceDevice Address Binding No static device binding supportedNetworking Options NoneCharacter Sets Supported ISO 10646 (UTF-8)Gateway Options NoneNetwork Security Options Non-secure deviceConformance Listed by BTLBACnet Interoperability Building Blockssupported BIBBs Data sharing – ReadProperty-B (DS-RP-B)Data sharing – ReadPropertyMultiple-B (DS-RPM-B)Data sharing – WriteProperty-B (DS-WP-B)Data sharing – COV-B (DS-COV-B)Device management – DynamicDeviceBinding-B (DM-DDB-B) Device management – DynamicObjectBinding-B (DM-DOB-B) Device management – DeviceCommunicationControl-B (DM-DCC-B)BACnet MS/TP Baud rates9’600, 19’200, 38’400, 76’800 (Default: 38’400) Address0...127 (Default: 1)Number of nodes Max 32 (without repeater), 1 full busloadTerminating resistor120 ΩBACnet IP Port open (Default: 47’808)Parameterisation Tool through the integrated webserver !All writeable objects with instance number ≥ 90 are persistent and are not supposed to be written on a regular base.Standard Object Types Supported Objekt type Optional properties Writeable propertiesDevice DescriptionLocationActive COV SubscriptionsMax MasterMax Info FramesProfile Name Object IdentifierObject NameLocationDescriptionAPDU Timeout (1’000…60’000) Number of APDU Retries (0...10) Max Master (1...127)Max Info Frames (1...255)Analog Input [AI]DescriptionCOV IncrementAnalog Output [AO]DescriptionCOV IncrementPresent ValueAnalog Value [AV]Description Present ValueBinary Input [BI]DescriptionActive textInactive TextBinary Valve [BV]DescriptionActive textInactive TextPrresent ValueMulti-state Input [MI]DescriptionState TextMulti-state Output [MO]DescriptionState TextPresent ValueMulti-state Value [MV]DescriptionState TextPresent ValueThe device does not support the services CreateObject and DeleteObject.The specified maximum length of writable strings is based on single-byte characters andsupport up to 252 characters.Service processing The device supports the DeviceCommunicationControl and ReinitializeDevice services. No password is required.A maximum of 5 active COV subscriptions with a lifetime of 1…43‘200 sec. (12 hours) aresupported.Object Name Object Type[Instance]DescriptionCommentStatus_FlagsValues COV Increment AccessDevice Device[Inst.Nr]0…4’194’302Default: 1–WRelPos AI[1]Relative Position in %0...1005R AbsPos AI[2]Absolute Position in degree0...905R SpAnalog_V AI[5]Analog Setpoint in Volt0...10.001R RelFlow AI[10]Relative Flow in %0...1005R AbsFlow_lmin AI[11]Absolute Flow in l/min0...100’0001R AbsFlow_m3h AI[12]Absolute Flow in m3/h0...6000.1R AbsFlow_gpm AI[13]Absolute Flow in gpm0...100’0001R AbsFlow_ls AI[14]Absolute Flow in l/s0...100’0000.1R AbsFlow_lh AI[15]Absolute Flow in l/h0...100’000100R T1_C AI[20]Temperature 1 (remote) in C-10 (1201)T2_C AI[21]Temperature 2 (embedded) in C-10 (1201)DeltaT_K AI[22]Delta Temperature in K0...1301R T1_F AI[25]Temperature 1 (remote) in F14...2481R T2_F AI[26]Temperature 2 (embedded) in F14...2481R DeltaT_F AI[27]Delta Temperature in F0...2661R AbsPower_kW AI[30]Power in kW0...2.147e+610R E_Cooling_kWh AI[31]Cooling Energy in kWh0...2.147e+910R E_Heating_kWh AI[32]Heating Energy in kWh0...2.147e+910R E_Cooling_MJ AI[33]Cooling Energy in MJ0...2.147e+910R E_Heating_MJ AI[34]Heating Energy in MJ0...2.147e+910R AbsPower_kBTUh AI[35]Power in kBTU/h0...2.147e+610R E_Cooling_kBTU AI[36]Cooling Energy in kBTU0...2.147e+910R E_Heating_kBTU AI[37]Heating Energy in kBTU0...2.147e+910R RelPower AI[40]Relative Power in %0...3005R AbsPower_ton AI[45]Power in ton refrigeration0...2.147e+61R E_Cooling_tonh AI[46]Cooling Energy in ton*h0...2.147e+91R E_Heating_tonh AI[47]Heating Energy in ton*h0...2.147e+91R E_CoolReset_kWh AI[50]Cooling Energy in kWh, resettable with BV[31]0...2.147e+91R E_HeatReset_kWh AI[51]Heating Energy in kWh, resettable with BV[32]0...2.147e+91R E_CoolReset_kBTU AI[52]Cooling Energy in kBTU, resettable with BV[31]0...2.147e+91R E_HeatReset_kBTU AI[53]Heating Energy in kBTU, resettable with BV[32]0...2.147e+91RGlycolConcentration AI[60]Glycol concentration in %Measured value or override value from webserver Measured value: 0 (40)Override value: 0 (80)1RErrorState 1)AI[100]Error StateError Sensor T1: Error with remote temperature sensorError Sensor T2: Error with embedded temperature sensorError Flow Sensor: Error with the flow sensorActuator can‘t move: Mechanical overload due to blocked valve, etc.Flow with closed valve: Flow is measured but position of valve is closedAirbubbles: Air bubbles in the hydronic systemFlow not reached: Setpoint cannot be reached within 3min during flow controlPower not realized: Setpoint cannot be reached within 3min during power controlGear disengagement active: Gear disengaged button is pressedReverse flow detected: Reverse flow is detectedMP communication faulty: Internal communication between sensor and actuatorfaultyFreeze warning: Measured temperature & glycol concentration indicate thatgrease ice can build upBit 0: Error Sensor T1Bit 1: Error Sensor T2Bit 2: Error Flow SensorBit 3: Actuator cannot moveBit 4: Flow with closed valveBit 5: Air bubblesBit 6: Flow not reachedBit 7: Power not realizedBit 8: Gear disengagedBit 9: Reverse flow detectedBit 10: MP communicationfaultyBit 11: Freeze warning1RSpAbsFlow_lmin AI[111]Setpoint Absolute Flow in l/min0...100’0001R SpAbsFlow_m3h AI[112]Setpoint Absolute Flow in m3/h0...6000.1R SpAbsFlow_gpm AI[113]Setpoint Absolute Flow in gpm0...100’0001R SpAbsFlow_ls AI[114]Setpoint Absolute Flow in l/s0...100’0000.1R SpAbsFlow_lh AI[115]Setpoint Absolute Flow in l/h0...600100RSpRel AO[1]Setpoint Relative in %The set point is related either to the position, the flow (of Vmax) or the power(of Pmax).See ControlMode for more information → MV[100]0 (100)Default: 01CVmax_lmin AV[90]Maximum Flow Limit in l/min30%Vnom…VnomDefault: Vnom-WVmax_gpm AV [91]Maximum Flow Limit in gpm30%Vnom…VnomDefault: Vnom-WPmax_kW AV [95]Maximum Power Limit in kW0.5%Pnom…PnomDefault: Pnom-WObject Name Object Type[Instance]DescriptionCommentStatus_FlagsValues AccessSpPosReached BI [1]Setpoint Position reached0: No1: YesRSummaryStatus BI [101]Summary StatusSummarizes all status from MI 103 - 1070: OK1: Not OKRRstCoolEnergy BV [31]Reset Cooling EnergySets the Cooling Energy (AI[50] / AI[52]) to zero 0: None1: ResetWRstHeatEnergy BV [32]Reset Heating EnergySets the Heating Energy (AI[51] / AI[53]) to zero 0: None1: ResetWRstErrCount BV [100]Reset Error Counters0: None1: ResetWDeltaT_ MgrStatus MI [102]DeltaT Manager StatusNot selected: dT-Manager deactivatedStandby: dT-Manager activated but not activeActive: dT-Manager activeScaling standby: dT-Manager active with no limitation to the flowScaling active: dT-Manager active with limitation to the flow → AV[108]1: Not selected2: Standby3: Active4: Scaling standby5: Scaling activeRStatusSensor MI [103]Status SensorIndicates informations within the flow sensor and both temperature sensors 1: OK2: Flow sensor not OK3: T1 not OK4: T2 not OKRStatusFlow MI [104]Status FlowReverse flow detected: Energy Valves detected a reverse flowFlow not reached: Setpoint cannot be reached within 3min during flow controlFlow in closed position: Flow is measured but position of valve is closed 1: OK2: Reverse flow detected3: Flow not reached4: Flow in closed positionRStatusMedia MI [105]Status MediaAirbubbles: Airbubbles in the hydronic system. As long as there are airbubblesin the system, position control mode is active, regardless off control modesetting (ControlMode MV[100]).Freeze warning: Measured temperature & glycol concentration indicate thatgrease ice can build up 1: OK2: Airbubbles3: Freeze warningRStatusActuator MI [106]Status ActuatorActuator cannot move: Mechanical overload due to blocked valve, etc.Gear disengaged: Gear disengaged button is pressed 1: OK2: Actuator cannot move3: Gear disengagedRStatusPower MI [107]Status PowerPower not reached: Setpoint cannot be reached within 3min during powercontrol 1: OK2: Power not reachedRObject Name Object Type[Instance]DescriptionCommentStatus_FlagsValues COV Increment AccessPmax_kBTUh AV [96]Maximum Power Limit in kBTU/h0.5%Pnom…PnomDefault: Pnom-WVmax AV [100]Maximum Flow Limit in %30 (100)Default: 100-W Vnom_lmin AV [101]Nominal Volume Flow in l/min Vnom-W Vnom_gpm AV [102]Nominal Volume Flow in gpm Vnom-W SpDeltaT_K AV [103]Setpoint DeltaT in K1 (55)Default: 10-WSpDeltaT_F AV [104]Setpoint DeltaT inF2 (100)Default: 18-WPmax AV [105]Maximum Power Limit in %0.5 (100)Default: 100-W Pnom_kW AV [106]Nominal Power in kW Pnom-R Pnom_kBTUh AV [107]Nominal Power in kBTU/h Pnom-R SpFlow_DeltaT lmin AV [108]Setpoint Flow at DeltaT in l/min0...VnomDefault:Vnom-WSpFlow_DeltaT gpm AV [109]Setpoint Flow at DeltaT in gpm0...VnomDefault:Vnom-WElectronic pressure-independent characterised control valvewith energy monitoringOverride MO [1]Override ControlOverrides setpoint with defined valves. It will change back to None (1) after2 hours.1: None2: Close3: Open4: Vnom5: Vmax6: MotStop7: Pnom8: PmaxDefault: None(1)CControlMode MV [100]Control ModeThis value defines the interpretation of the setpoint 1: Position Control2: Flow Control3: Power ControlDefault: Flow control(2)WDeltaT_Limitation MV [101]DeltaT LimitationDisabled: dT-Manager not activedT-Manager: dT-Manager active with no restriction to flowdT-Manager scaling: dT-Manager active with restriction of flow → AV 108]1: Disabled2: dT-Manager3: dT-Manager scalingDefault: Disabled(1)WSpSource MV [122]Setpoint SourceIf Analog(1) then actuator is controlled by analog signal 0...10 V on wire 3.If Bus(2) then setpoint via bus SpRel AO[1]1: Analog2: BusDefault: Analog(1)W。
说明书万苏平格列美脲片
患者血管并发症的作用。
有823例患者被随机分配到四个治疗组中一组（Diabetes， 19supp2：747－830，1970）。
UGDP报导经饮食加固定剂量甲苯磺丁脲治疗（每天）5～8年的患者，其心血管事件死亡率是单纯饮食治疗患者的约－2倍。
由于心血管事件死亡率的升高而中断了甲苯磺丁脲的使用，总死亡率显着升高尚未被观察到。
这样就限制了研究整体死亡率增高的机会，尽管这些结果有争议，但UGDP的研究为这个警告提供了足够的依据。
应该告诉患者使用格列美脲的潜在危险、益处以及治疗选择模式。
尽管这项研究只涉及一个磺酰脲类药物（甲苯磺丁脲），但考虑这类药物化学结构和作用模式十分近似，从安全方面考虑这个警告也适用于这类药物的其他口服降糖药。
二、一般的注意事项： 1. 对于2型糖尿病，控制饮食和运动是初始的治疗方法。
2. 控制热量、减轻体重和运动对肥胖型糖尿病患者是必要的。
适当的饮食控制和运动对控制血糖和改善高血糖症状方面是有效的。
除了有规律的体力活动外，心血管危险因素一旦发现应采取措施予以纠正。
3. 医生和患者除了考虑饮食和运动疗法外，应考虑应用格列美脲，且不应该把格列美脲视为饮食和运动疗法的替代和避免饮食控制的便利途径。
此外，单纯饮食控制和运动疗法降低血糖是暂时的，因此要求短期服用格列美脲。
4. 在维持治疗方案中，如果不能有效地降低血糖，格列美脲的单纯治疗应该中断。
应根据临床和实验室指标来判断。
5. 对于无症状病人采用格列美脲治疗，有效控制2型糖尿病患者的血糖对预防长期糖尿病所致心血管和神经系统并发症方面的作用尚未被确认。
然而，控制糖尿病和并发症试验（DCCT）表明糖化血红蛋白和血糖的控制与胰岛素依赖型患者的视网膜病变、神经系统病变和肾病的降低有关。
6. 低血糖反应：所有的磺酰脲类药物均可导致低血糖反应。
选择合适的病人和剂量、正确的用药对避免低血糖反应是重要的。
在治疗的最初几周内，出现低血糖的危险性可能增加，需要鉴于特别观察。
格列美脲片说明书.pdf_1694279553.4315429
核准日期：2007年02月修改日期：2007年08月2008年05月2009年06月2012年12月2013年03月2016年01月07日2016年05月04日2017年03月13日2019年11月12日2020年01月03日2020年08月04日2020年10月15日格列美脲片说明书请仔细阅读说明书并在医师指导下使用【药品名称】通用名称：格列美脲片商品名称：亚莫利英文名称：Glimepiride Tablets汉语拼音：Geliemeiniao Pian【成份】本品主要成份为格列美脲化学名称：1－[4-[2-(3-乙基－4－甲基－2－氧代－3－吡咯啉－1－甲酰胺基)乙基]苯磺酰]－3－（反式－4－甲基环己基）－脲化学结构式：分子式：C24H34N4O5S分子量：490.6【性状】绿色异形片【适应症】适用于控制饮食、运动疗法及减轻体重均不能充分控制血糖的2型糖尿病。
格列美脲片不适用于1型糖尿病（例如，有酮症酸中毒病史的糖尿病患者的治疗）、糖尿病酮症酸中毒或糖尿病前驱昏迷或昏迷的治疗。
【规格】2 mg【用法用量】用量原则上，应根据目标血糖水平调整格列美脲片的剂量。
格列美脲片的剂量必须是足以达到目标代谢控制的最低剂量。
应用格列美脲片治疗过程中，必须定期测定血糖和尿糖水平。
另外，建议定期测定糖化血红蛋白。
如果发生如漏服的错误，不得通过之后服用更大剂量的药物来纠正。
用于处理无法在规定时间服药（尤其是忘记服药或不进餐）或各种原因下无法按时服药情况的措施必须由医生和病人双方讨论并同意。
•起始剂量和剂量调整起始剂量为每日1 mg格列美脲片。
如有必要，可增加每日剂量。
建议通过定期监测血糖进行剂量调整，建议剂量应逐渐增加，例如每隔1-2个星期，逐步增加剂量至每日2 mg、3 mg、4 mg、6mg。
•糖尿病控制良好的患者的剂量范围糖尿病控制良好的患者，通常每日剂量为1mg至4 mg 格列美脲片。
每日剂量大于6mg仅对少数患者更有效。
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【药品名称】
通用名称：格列美脲片
商品名称：格列美脲片(亚莫利)
英文名称：Glimepiride Tablets
拼音全码：GeLieMeiNiaoPian(YaMoLi)
【主要成份】本品主要成分为格列美脲。
化学名：1-[4-[2-(3-乙基-4-甲基-2-氧代-3-吡咯啉-1-甲酰胺基)-乙基]-苯磺酰]-3-(反式-4-甲基环己基)-脲。
【成份】
分子式：C24H34N4O5S
分子量：490.62
【性状】绿色异形片。
【适应症/功能主治】适用于饮食控制、运动疗法及减轻体重均不能充分控制血糖的2型糖尿病。
【规格型号】2mg*15s
【用法用量】遵医嘱口服用药。
对于糖尿病患者，格列美脲或任何其他降糖药物都无固定剂量，必须定期测量空腹血糖和糖化血红蛋白以确定患者用药的最小有效剂量；测定糖化血红蛋白水平以监测患者的治疗效果。
通常起始剂量：在初期治疗阶段，格列美脲的起始剂量为1～2mg每天一次，早餐时或第一次主餐时给药。
那些对降糖药敏感的患者应以1mg每天一次开始，且应谨慎调整剂量。
格列美脲与其他口服降糖药之间不存在精确的剂量关系。
格列美脲最大初始剂量不超过2mg。
通常维持剂量：通常维持剂量是1～4mg每天一次，推荐的最大维持量是6mg每天一次。
【不良反应】 1.低血糖，本品可引起低血糖症，尤其老年体弱患者在治疗初期，不规则进食，饮酒及肝肾功能损害患者，据报道，发生率为2%。
2.消化系统症状：恶心呕吐，腹泻、腹痛少见。
3.有个别病例报道血清肝脏转氨酶升高。
4.皮肤过敏反应，瘙痒、红斑、荨麻疹少见。
5.其他：头痛、乏力、头晕少见。
【禁忌】1.已知对格列美脲有过敏史者禁用。
2.糖尿病酮症酸中毒伴或不伴昏迷者禁用，这种情况应用胰岛素治疗。
3.孕妇、分娩妇女、哺乳期妇女禁用。
【注意事项】1.病人用药时应遵医嘱，注意饮食，运动和用药时间。
2.治疗中应注意早期出现的低血糖症状，如头痛、兴奋、失眠、震颤和大量出汗，以便及时采取措施，严重者应静脉滴注葡萄糖液，对有创伤、术后，感染或发热病人应给与胰岛素维持正常血糖代谢。
3.避免饮酒，以免引起类戒断反应。
4.过量服用，患者会突发低血糖反应。
【儿童用药】尚不明确。
【老年患者用药】尚不明确。
【孕妇及哺乳期妇女用药】怀孕及哺乳期间禁用。
【药物相互作用】 1.与水杨酸类，磺胺类，保泰松类，抗结核病药，四环素类，单胺氧化酶抑制剂，β受体阻滞剂，氯霉素，香豆素类和环磷酰胺等合用可增强本品作用。
2.氯丙嗪，拟交感神经药，皮质激素类，甲状腺激素，口服避孕药和烟酸制剂等可降低本品降血糖作用。
3.本品可以减弱病人对酒精的耐受力，而酒精亦可能加强药物的降血糖作用。
【药物过量】过量服用，患者会突发低血糖反应。
【药理毒理】格列美脲属口服磺脲类降糖药，主要通过刺激胰岛β细胞释放胰岛素发挥作用，这一作用主要基于增加胰岛β细胞对生理浓度葡萄糖的反应性。
此外，格列美脲也有胰外降血糖作用。
【药代动力学】吸收：格列美脲口服给药后的生物利用度是完全的。
进餐时服用不影响吸收度，仅稍微减低吸收速率。
口服给药后大约2.5小时达最大血清浓度(Cmax)(每日4mg多次
给药血清浓度平均值为0.3μg/ml)。
【贮藏】密闭，250C以下保
【包装】铝塑包装，15片/盒。
【有效期】36 月
【执行标准】YBH26392005
【批准文号】国药准字H20057672
【生产企业】赛诺菲(北京)制药有限公司。