Pharmacological Research 53 (2006) 113–122

美国ResearchDiets实验动物模型饲料D12492

Where NutriPhenomics Begins© 2006 Research Diets, Inc. All rights reserved. D12492--2-13DescriptionRodent Diet with 60% kcal% fat.Used in ResearchFatty Liver In ammation Obesity DiabetesPackagingProduct is packed in 12.5 kg box.Each box is identi ed with the product name, description, lot number and expiration date.Lead TimeIN-STOCK.Ready for next day shipment.Gamma-IrradiationYes. Add 10 days to delivery time.FormPellet, Powder, LiquidShelf LifeMost diets require storage in a cool dry environment. Stored correctly they should last 6 months.Because of the high fat content is best if kept frozen.Control DietsD12450B, D12450J, D12450KFormulaProduct #D12492gm%Protein 26.2Carbohydrate 26.3Fat 34.9 Total kcal/gm5.24IngredientgmCasein, 30 Mesh200L-Cystine3Corn Starch 0Maltodextrin 10 125Sucrose 68.8Cellulose, BW200 50Soybean Oil 25Lard*245Mineral Mix S10026 10DiCalcium Phosphate 13Calcium Carbonate5.5Potassium Citrate, 1 H2O 16.5Vitamin Mix V1000110Choline Bitartrate2FD&C Blue Dye #10.05Total773.85kcal%202060100kcal800120500275.2022********40004057Formulated by E. A. Ulman, Ph.D., Research Diets, Inc., 8/26/98and 3/11/99.*Typical analysis of cholesterol in lard = 0.72 mg/gram.Cholesterol (mg)/4057 kcal = 216.4Cholesterol (mg)/kg = 279.6D12450B, D12451, D12492 The "Original High Fat Diets"1. Van Heek M, et al. Diet-induced Obese Mice Develop Peripheral, but not CentralResistance to Leptin. J. Clin. Invest. 1997; 99:385-390.2. Taheri S, et al. Distribution and quantiﬁcation of immunoreactive orexin A in rat tissues.FEBS Lett. 1999 Aug 20; 457(1):157-61.3. Nonogaki K, et al. Leptin-independent hyperphagia and type 2 diabetes in mice witha mutated serotonin 5-HT2C receptor gene. Nature Medicine 1998; 4:1152-1156.4. El-Haschimi K, et al. T wo defects contribute to hypothalamic leptin resistance in micewith diet-induced obesity. J.Clin.Invest. 2000; 105:1827-1832.5. Bush EN, et al.(Metabolic Disease Research, Abbott Laboratories) Adiposity, LeptinResistance, Hyperrphagia, Hyperglycemia, Glucose Intolerance and Insulin Resistance in C57BL/6J Mice Fed High Fat Diets.Endocrine SocietyAnnual Meeting 2001,Poster Session.6. Shapiro ME, et al. (Metabolic Disease Research, Abbott Laboratories) Eﬀects ofT reatment of C57BL/6j Mice Fed High vs. Low Fat Diets with Metformin orRosiglitazone on Adiposity, Food Intake, Hyperglycemia and Insulin Resistance.Endocrine Society Annual Meeting 2001, Poster Session.7. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. AT ransgenic Model of Visceral Obesity and the Metabolic Syndrome. Science. 2001;294:2166-2170.8. Razani B, Combs TP, Wang XB, Frank PG, Park DS, Russell RG, Li M, Tang B, JelicksLA, Scherer PE, Lisanti MP. Caveolin-1 deﬁcient mice are lean, resistant to diet-induced obesity, and show hyper-triglyceridemia with adipocyte abnormalities. J. Biol. Chem.2001; (in press).9. Valet P, Grujic D, Wade J, Ito M, Zingaretti MC, Soloveva V, Ross SR, Graves RA,Cinti S, Lafontan M, and Lowell BB. Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deﬁcient mice promotes diet-induced obesity. J.Biol.Chem. 275: 34797-34802, 2000.10. Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J,Mootha V, Cortright R, Muoio DM, and Lowell BB. Energy metabolism in uncoupling protein 3 gene knockout mice. J.Biol.Chem. 275: 16258-16266, 2000.11. Ziotopoulou M, Mantzoros CS, Hileman SM, & Flier JS. Diﬀerential expression ofhypothalamic neuropeptides in the early phase of diet-induced obesity in mice.Am. J. Physiol. Endocrinol. Metab. 279:E383-E845, 2000.12. Scrocchi LA & Drucker DJ. Eﬀects of Aging and a High Fat Diet on Body Weight andGlucose T olerance in Glucagon-Like Peptide-1 Receptor -/- Mice.Endocrinology 139:3127- 3132, 1998.13. Ghibaudi L, Cook J, Farley C, Van Heek M, & Hwa J.Fat Intake Aﬀects Adiposity,Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats.Obes. Res. 10:956-963. 200214. Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS & Kalra SP. Central Leptin Geneerapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemeia, andHyperinsulinemia. Diabetes 51:1729-1736, 2001.15. Tang H, Vasselli JR, Wu EX, Boozer CN, & Gallagher D. High-Resolution MagneticResonance Imaging T racks Changes in Organ and Tissue Mass in Obese and Aging Rats.Am J Physiol (Regulatory Integrative Comp Physiol) 282:R890-R899, 2002.16. Bowen H, Mitchell TD, & Harris RBS (Dept. of Foods and Nutr, U of Georgia).Method of Leptin Dosing, Strain, and Group Housing Inﬂuence Leptin Sensitivity in High-Fet-Fed Weanling Mice. AJP-Regul Integr Comp Physiol 284:R87-R100, 2003. 17. Harris RBS, Mitchell TD, & Hebert S (Pennington Biomedical Research Center, BatonRouge, LA). Leptin-Induced Changes in Body Composition in High Fat-Fed Mice.AJPRegul Integr Comp Physiol 284:R87-R100, 2003.18. Anini, Y. and Brubaker, P. L. Role of Leptin in the Regulation of Glucagon-LikePeptide-1 Secretion. Diabetes 52:252-259, 2003.19. Bluher, S., Responsiveness to Peripherally Administered Melanocortins in Lean andObese Mice. Diabetes 53:82-90, 2004.20. Brunengraber, D. Z., et al. Inﬂuence of diet on the modeling of adipose tissuetriglycerides during growth. Am J Physiol Endocrinol Metab 285: E917-E925, 2003. 21. Challis, B. G., et al. Mice lacking pro-opiomelanocortin are sensitive to high-fat feedingbut respond normally to the acute anorectic eﬀects of peptide-YY3-36.PNAS 101: 13: 4695- 4700, 2004.22. Cohen, A. W., B. Razani, X. B. Wang, T. P. Combs, T. M. Williams, P. E. Scherer, andM. P. Lisanti. Caveolin-1-deﬁcient mice show insulin resistance and defectiveinsulin receptor protein expression in adipose tissue. Am J Physiol Cell Physiol 285: C222-C235, 2003.23. Combs, T. P., et al. A T ransgenic Mouse with a Deletion in the Collagenous Domain ofAdiponectin Displays Elevated Circulating Adiponectin and Improved InsulinSensitivity. Endocrinology 145:367-383, 2004.24. Conarello, S. L., et al. Mice lacking dipeptidyl peptidase IV are protected against obesityand insulin resistance. PNAS, 100:11: 6825-6830, 2003.25. Dhar, M. S., et al. Mice Heterozygous for Atp10c, a Putative Amphipath, Represent aNovel Model of Obesity and Type 2 Diabetes. J. Nutr. 134: 799-805, 2004.26. El-Haschimi, K., S. D. Dufresne, M. F. Hirshman, J. S. Flier, L. J. Goodyear, and C.Bjørbæk. Insulin Resistance and Lipodystrophy in Mice Lacking Ribosomal S6 Kinase 2.Diabetes 52:1340-1346, 2003.27. Felipe, F., M. L. Bonet, J. Ribot, and A. Palou. Modulation of Resistin Expression byRetinoic Acid and Vitamin A Status. Diabetes 53:882-889, 2004.28. Felipe, F., M.L. Bonet, J. Ribot and A. Palou. Up-regulation of muscle uncouplingprotein 3 gene expression in mice following high fat diet, dietary vitamin Asupplementation and acute retinoic acid-treatment. International Journal of Obesity27: 60-69, 2003.29. Fu, J., et al. Oleylethanolamide regulates feeding and body weight through activationof the nuclear receptor PPAR. Nature 425:90-93, 2003.30. Gavrilova, O., et al. Liver Peroxisome Proliferator-activated Receptor Contributes toHepatic Steatosis, T riglyceride Clearance, and Regulation of Body Fat Mass.e Journal of Biological Chemistry 278:36:34268-34276, 2003.31. Haluzík, M., O. Gavrilova and D. LeRoith. Peroxisome Proliferator-ActivatedReceptor- Deﬁciency Does Not Alter Insulin Sensitivity in Mice Maintained onRegular or High-Fat Diet: Hyperinsulinemic-Euglycemic Clamp Studies.Endocrinology 145:1662-1667, 2004.32. Hancock, A.A. et al. Antiobesity eﬀects of A-331440, a novel non-imidazole histamineH3 receptor antagonist. European Journal of Pharmacology 487:183-197, 2004.33. Hennige, A. M., et al. Upregulation of insulin receptor substrate-2 in pancreatic b cellsprevents diabetes. J. Clin. Invest. 112:1521-1532, 2003.34.34. Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Validation of a high-resolutionX-ray computed tomography system to measure murine adipose tissue depot mass in situ and longitudinally. Journal of Pharmacological and T oxicological Methods47: 99- 106, 2002.35. Hileman, S. M., D.D. Pierroz, H. Masuzaki, C. Bjørbæk, K. El-Haschimi, W. A. Banks,and J. S. Flier. Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity.Endocrinology 143:775-783, 2002.36. Ishii, M., H. Fei, and J. M. Friedman. Targeted disruption of GPR7, the endogenousreceptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.PNAS 100:18:10540-10545, 2003.37. Joseph, J. W., V. Koshkin, C-Y Zhang, J. Wang, B. B. Lowell, C. B. Chan, and M.B.Wheeler. Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin SecretoryCapacity After a High-Fat Diet. Diabetes 51:3211-3219, 2002.38. Kim, S., et al. Eﬀects of High-Fat, Angiotensinogen (agt) Gene Inactivation, andTargeted Expression to Adipose Tissue on Lipid Metabolism and Renal Gene Expression.Horm Metab Res 34:721-725, 2002.39. Kumar, M. V., T. Shimokawa, T. R. Nagy, and M. D. Lane. Diﬀerential eﬀects of acentrally acting fatty acid synthase inhibitor in lean and obese mice.PNAS 99:4: 1921-1925, 2002.40. Lambert, P. D., et al. Ciliary neurotrophic factor activates leptin-like pathways andreduces body fat, without cachexia or rebound weight gain, even in leptin-resistantobesity. PNAS 98:8: 4652-4657, 2001.41. Le Laya, S., et al. Decreased Resistin Expression in Mice with Diﬀerent Sensitivities to aHigh-Fat Diet. Biochemical and Biophysical Research Communications289:2:564-567, 2001.42. Li, J., K. Takaishi, W. Cook, S. K. McCorkle, and R. H. Unger. Insig-1 ''brakes''lipogenesis in adipocytes and inhibits diﬀerentiation of preadipocytes.PNAS 100:16:9476-9481, 2003.43. Ludwig, D. S., et al. Melanin-concentrating hormone overexpression in transgenic miceleads to obesity and insulin resistance. J. Clin. Invest. 107:379-386, 2001.44. Moon, Y. S., et al. Mice Lacking Paternally Expressed Pref-1/Dlk1 Display GrowthRetardation and Accelerated Adiposity. Molecular And Cellular Biology22:15: 5585-5592, 2002.45. Murray, I., A. D. Sniderman, P. J. Havel, and K. Cianﬂonei. Acylation StimulatingProtein (ASP) Deﬁciency Alters Postprandial and Adipose Tissue Metabolism inMale Mice. e Journal Of Biological Chemistry 274:51:36219-36225, 1999.46. Phan,L. K., F. Lin, C. A. LeDuc, W. K. Chung, and R. L. Leibel. e mousemahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.J. Clin. Invest. 110:1449-1459, 2002.47. Pierroz, D. D., M. Ziotopoulou, L. Ungsunan, S. Moschos, J. S. Flier, and C. S.Mantzoros. Eﬀects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity. Diabetes 51:1337-1345, 2002.48. Rosenfeld, C. S., K. M. Grimm, K. A. Livingston, A. M. Brokman, W. E. Lamberson,and R. M. Roberts. Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate. PNAS 100:8:4628-4632, 2003. 49. Chirala, S. S., et al. Fatty acid synthesis is essential in embryonic development: Fatty acidsynthase null mutants and most of the heterozygotes die in utero.PNAS 100:11:6358-6363, 2003.50. Takahashi, N., et al. Divergent Eﬀects of Leptin in Mice Susceptible or Resistant toObesity. Horm Metab Res 34:691-697, 2002.51. upari, J. N., L. E. Landree, G. V. Ronnett, and F. P. Kuhajda. C75 increases peripheralenergy utilization and fatty acid oxidation in diet-induced obesity.PNAS 99:14:9498-9502, 2002.52. T ortoriello, D. V., J. Mcminn, and S. C. Chua. Dietary-Induced Obesity andHypothalamic Infertility in Female DBA/2J Mice.Endocrinology 145: 1238-1247, 2004.53. Weisberg, S. P., et al. Obesity is associated with macrophage accumulation in adiposetissue. J. Clin. Invest. 112:1796-1808, 2003.54. Xu, H. et al. Chronic inﬂammation in fat plays a crucial role in the development ofobesity related insulin resistance. J. Clin. Invest. 112:1821-1830, 2003.55. Yamashita, T., et al. Enhanced insulin sensitivity in mice lacking ganglioside GM3.PNAS 100:6:3445-3449, 2003.56. Bagnasco, M., M. G. Dube, A. Katz, P. S. Kalra, and S. P. Kalra. Leptin Expression InHypothalamic Pvn Reverses Dietary Obesity And Hyperinsulinemia But StimulatesGhrelin. Obes Res. 11:1463-1470, 2003.57. Borowsky, B., et al. Antidepressant, anxiolytic and anorectic eﬀects of amelaninconcentrating hormone-1 receptor antagonist.Nature Medicine 8:8:825-830, 2002.58. Chan, C. B., et al. Increased Uncoupling Protein-2 Levels in b-cells Are AssociatedWith Impaired Glucose-Stimulated Insulin Secretion. Diabetes 50:1302-1310, 2001. 59. Chen, L. and B. L. G. Nyomba. Glucose Intolerance and Resistin Expression in RatOﬀspring Exposed to Ethanol in Utero: Modulation by Postnatal High-Fat Diet.Endocrinology 144:500-508, 2003.60. Farley, C., J. A. Cook, B. D. Spar, T. M. Austin, and T. J. Kowalski. Meal PatternAnalysis Of Diet-Induced Obesity In Susceptible And Resistant Rats.Obes Res. 11:845-851, 2003.61. Gao, J., L. Ghibaudi, M. Van Heek, J. J. Hwa. Characterization of diet-induced obeserats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet. Brain Research 936:87-90, 2002.62. Ogilvie, K. M., R. Saladin, T. R. Nagy, M. S. Urcan, R. A. Heyman, and M. D.Leibowitz. Activation of the Retinoid X Receptor Suppresses Appetite in the Rat.Endocrinology 145:565-573, 2004.63. Shklyaev, S., et al. Sustained peripheral expression of transgene adiponectin oﬀsets thedevelopment of diet-induced obesity in rats. PNAS 100:24:14217-14222, 2003.64. Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Antiobesity eﬀects of chroniccannabinoid CB1 receptor antagonist treatment in diet-induced obese mice.European Journal of Pharmacology 462:125-132, 2003.。

金盏花药学研究概况(1)

［2］胡晓丹，谢笔钧．金盏菊花的营养成分分析［J］．食品研究与开发，2000， 21（ 6）： 37 － 39．
［3］ BORTOLO D P G，MARQUES P A A，PACHECO A C，et al． Flavonoid content and yield in marigold plant （ Calendula officinalis L．） cultivated under different irrigation depths ［J］． Revista Brasileira de Plantas Medicinais，2009，11（ 4）： 435 － 441．
Parente 研究发现金盏花可加速伤口愈合的过程，具有抗菌活性［22］。研究证明，金盏花对 TPA 诱发的小鼠耳廓炎症有抑制作用［23］。龚苏晓报道了金盏花有降血糖、抑制胃排空及保护胃黏膜的功能［24］。Silva 报道了金盏花对 Wistar 大鼠生
殖方面的影响，发现其对雄性的睾丸形态，生殖器官重量，生育指数和后代的数量等基本无影响，而对早期和中期的怀孕母鼠有导致栓塞的风险［25］。刘丽研究了金盏花总皂苷的提取及其抗氧化和降血脂的活性［26］。Parente 报道金盏花具有抗抑郁作用［27］。Bashir 研究金盏花对痉挛具有双重作用［28］。Jimenez 证明金盏花对肿瘤有双重作用［29］，Barajas 研究出金盏花在大鼠肝癌形成中也有着双重作用［30］。 3 临床应用
［17］ FRANKIC T，SALOBIR K，SALOBIR J． The comparison of in vivo antigenotoxic and antioxidative capacity of two propylene glycol extracts of Calendula officinalis （ marigold） and vitamin E in young growing pigs ［J］． Journal of Animal Physiology and Animal Nutrition，2009，93（ 6）： 688 － 694．

全国自考《英语(二)》高频词汇

全国自考《英语(二)》高频词汇anizational a.组织(上)的2.goal n.目的，目标;得分进球，球门3.objective n.目标，目的 a.客观的;无偏见的4.accomplish vt.完成(任务等)5.predict vt./vi.预言;预示6.accompany vt.伴随，陪同;为…伴奏7.implement vt.实现;完成;履行8.constraint n.强制;强制因素，制约条件9.precedent n.先例，前例10.simplify vt.简化11.tendency n.趋势，倾向12.managerial a.经理的，管理人的;管理上的，经营上的13.maker n.制造者;制造商14.achievement n.完成，达到;成就，成绩15.attain vt.达到;完成16.optimal a.最适宜的;最理想的17.suboptimization n.局部最优化，次优化18.trade-off n.(对不能同时兼顾的因素)权衡;物物交换19.argue vt./vi.争辨，争论，辩论;说服20.budget n.预算 vt.把…编入预算;安排，预定21.scheme n.计划;方案 vt./vi.计划，策划22.define vt.解释，给…下定义;限定，规定23.multiple a.多样的，复合的 n.倍数24.profitability n.赚钱，获得25.correctness n.正确，正确性26.unintended a.非计划中的，非故意的27.ongoing a.进行中的，前进的28.entity n.存在，实体;统一性29.skilled a.熟练的;有技能的30.in the way 挡路;碍事31.make a guess at 猜测32.and the like 等等，诸如此类33.research into 研究34.speculation about 关于…猜测35.swallow up 吞没，耗尽36.make use of 利用37.Star of Bethlehem 圣诞星38.White Dwarf [天]白矮星39.Albert Einstein 爱因斯坦(美籍德国理论物理学家)ky Way 银河;银河系(=Milky Way galaxy)41.planet n.行星42.revolve vi.旋转;绕转43.solar a.太阳的，日光的;利用太阳光的rgely ad.大量地;主要地45.glitter vi.闪闪发光，闪烁 n.闪光46.cloudless a.无云的，晴朗的47.unlikely a.未必可能的;靠不住的48.astronaut n.宇航员49.thrilling a.令人激动的;颤动的，震颤的50.outer a.外部的51.whereas conj.而，却;反之52.lesser a.较小的;更少的;次要的53.concerned a.有关的;关切的，担心的54.microscopic a.显微镜的;微观的;微小的，细微的55.whilst conj.(=while)当…时;然而;虽然，尽管56.plateau n.([复]plateaus或plateaux)高原57.tropical a.热带的;炎热的58.coloured a.有色的59.religion n.宗教;宗教信仰60.circumstance n.[pl.]情况，环境;境遇61.a great many 很多62.above all 首先，首要63.as a rule 通常;一般说来64.euthanasia n.无痛楚的死亡;安乐死65.weaken vt.削弱，减弱 vi.变弱66.Dutchman n.([复]Dutchmen)荷兰人67.deteriorate vt./vi.(使)恶化68.lethal a.致死的69.injection n.注射;注射剂，针剂70.amount to 达到，总计;相当于，等于71.on average 平均72.blame…fo r 为…责备某人来自73.by nature 生来，天生，就其本性而言74.be worth doing 值得做75.Oxbridge 牛津大学和剑桥大学;该校之学生76.Oxford 牛津;牛津大学77.Cambridge 剑桥;剑桥大学78.Westminster 威斯敏斯特79.France 法兰西，法国80.Ivy League 常春藤联合会;名牌大学的81.Harvard (美国)哈佛大学82.Yale (美国)耶鲁大学83.Princeton (美国)普林斯顿大学84.Stanford (美国)斯坦福大学85.Berkeley 伯克利;加利福尼亚大学伯克利分校86.John Major 约翰?梅杰(前英国首相)87.slavery n.奴隶制度，奴役;奴隶身份88.domestic adj.家庭的，家务的;国内的n.家仆，佣人89.Briton n.大不列颠人;英国人90.statistics n.统计数字，统计资料;[用作单]统计学91.diplomat a.外交家;外交官92.abroad ad.到国外;在国外93.exploit vt.开发，开采;利用;剥削94.abuse vt./n.滥用，妄用;虐待，凌辱95.campaign n.战役;运动 v.参加运动，参加竞选活动96.sexually ad.在性方面97.passport n.护照98.Filipino n.菲律宾人(语) a.菲律宾人的;菲律宾的99.maid n.少女;侍女，女仆100.execute vt.实行，执行，完成，贯彻;将…处死101.convict vt.证明…有罪(of);宣判 n.罪犯102.despite prep.尽管，任凭103.guilt n.有罪;内疚104.deserving a.应得的，值得的(of)105.Saudi n.沙特阿拉伯人 a.沙特阿拉伯(人或语)的106.breadwinner n.养家糊口的人107.shelf n.(壁橱，书橱内)搁板;架子108.minimum n.最小量;最低限度 a.最小的;最低的109.employee n.雇员，雇工110.leaflet n.小叶，嫩叶;传单，活页111.incidence n.影响程度，影响范围;发生率112.immigrant a.移民的，侨民的 n.移民，侨民113.status n.情形，状况;地位，身份114.kingdom n.王国;领域115.concession n.让步;特许权;租界，租界地116.immigration n.移居;外来的移民117.foreigner n.外国人118.deport vt.驱逐出境119.bring over 把…带来;使转变120.painstaking a.苦干的;费力的121.traditionalist n.传统主义者;因循守旧者122.thematic a.题目的，主题的;主旋律的123.conception n.概念，观念124.well-established a.固定下来的;得到确认的125.temper vt.[治]使回火，锻炼;调合126.well-tempered 脾气好的;(键盘乐器)调到平均律的127.clavichord n.(音)击弦古钢琴128.mold n.(=mould)模子;模型 vt.用模子做，浇铸129.sake n.缘故pleteness n.完整，圆满;完成，结束131.summarize vt./vi.概述，总结132.diversified a.多样化的133.conventional a.惯例的，常规的;(艺术等)因袭的134.experimental a.实验的;经验的135.harmony n.协调，和谐;融洽，一致136.sonority n.响亮，洪亮137.evident a.明显的，明白的138.in other words 换句话说139.in a sense 在某种意义上140.at a stretch 连续不断地141.serve as 适合142.belong in 应归入(类别、范畴等)143.in advance 在前面;预先144.It goes without saying that 不言而喻，理所当然145.for the sake of 为了…之好处;为了…的目的146.Franz Schubert 舒伯特(奥地利作曲家)147.Hugo Wolf 沃尔夫(奥地利作曲家)148.Beethoven 贝多芬(德国作曲家)149.Palestrina 帕莱斯特里纳(意大利作曲家)150.Bach 巴赫(德国作曲家)151.Well Tempered Clavichord (巴赫)《平均律钢琴曲集》152.take to 开始从事;养成…的习惯;培养对…的爱好153.put……to use 使用;利用154.be relevant to 与…有关155.on the part of 就…而言156.set……as objective 把…作为目标157.elusive a.躲避的;难以捉摸的，难以理解的158.tricky a.狡猾的，耍花招的;难以处理的159.slip vi.滑动，滑过;溜，溜走 vt.使滑动160.quicksand n.流沙161.oversupply vt./n.过多供应162.wayside n.路边 a.路边的163.flexible a.柔韧的，柔顺的;可变通的，灵活的164.readjustment n.再整理，再调整165.project n.设计，规划;项目 vt.方案，计划;投射166.appointment n.任命;约会167.weekly a.每周的ad.每周(一次) n.周刊，周报168.adjustment n.调整169.realistic a.现实的，实际的;现实主义的170.underestimate vt.低估;看轻171.overestimate vt.过高估计;过高评价172.emergency n.紧急情况;突发事件173.routine n.日常工作 a.日常的;例行的;常规的174.crash a.紧急的，速成的175.inflexible a.不可弯曲的;不可改变的，固执的176.adjust vt.调整，调节;校准177.deem vt.认为，相信178.assignment n.分配，委派;任务，(课外)作业179.freshman n.新手，生手;大学一年级学生180.kid vt./vi./n.戏弄，开玩笑;欺骗，哄骗181.faithfully ad.忠诚地;如实地182.temptation n.引诱，诱惑183.look ahead to 向前看;展望未来184.allocate……for 分配给…;配给185.fall by the wayside 半途而废，中途退出186.hang up 把…挂起来;挂断(电话);延迟，拖延187.throw off 扔掉;摆脱188.work out 作出;制定出189.up to date 最新的，新式的;切合目前情况的190.kid……into doing 欺骗…去做…191.Wales 威尔士192.esteem vt./n.尊敬，尊重193.cope vi.对付，妥善处理(with)194.parenting n.父母对孩子的养育195.tone n.音调，音色;腔调，语气;声调，语调196.infant n.婴儿，幼儿 a.婴儿的，幼儿的197.lovable a.可爱的，讨人喜欢的198.manageable a.易管理的199.unlovable a.不可爱的;不讨人喜爱的200.worthless a.无价值的，无用的;不足道的，不可取的201.ultimately ad.最后，最终地202.crisis n.危机;决定性时刻203.withdraw vt.收回，提取;撤退 vi.撤退;退缩204.inconsiderate a.不替别人考虑的;不体谅人的205.outcome n.结果，结局;出路，出口206.reinforcement n.增强，加固;强化207.tangible a.可触摸的，可感知的;确实的，真实的208.attribute n.属性，特征;vt.把…归因与(to)209.fold vt./vi.折叠;对折 n.褶(痕)210.appropriate a.适合的，恰当的，相宜的211.cope with 对付;处理212.no other……than 除…外没有，只有;正是，就是213.take advantage of 利用;占…便宜214.act out 将…表演出来;(用行动)表示出来215.election n.选举;选举权216.presidential a.总统(校长)的;总统(校长)职务的217.winner n.获胜者，优胜者;成功者218.republican a.共和国的;共和党的 n.共和党党员219.democratic a.民主的，民主主义的220.nominee n.被提名者;被任命者221.vote n.选举，投票;票，选票 vi.投票，选举222.certainty n.一定;必定223.nomination n.提名;任命224.loyalty n.忠诚;忠心225.delightful a.令人高兴的;讨人喜欢的226.humanity n.个性，博爱，仁慈;人类中华考试网(www.Examw。

柴胡疏肝散合左金丸治疗肝胃郁热型反流性食管炎的研究进展

Traditional Chinese Medicine 中医学, 2023, 12(4), 760-764 Published Online April 2023 in Hans. https:///journal/tcm https:///10.12677/tcm.2023.124116柴胡疏肝散合左金丸治疗肝胃郁热型反流性食管炎的研究进展李合鹏1，胡运莲2*1湖北中医药大学第一临床学院，湖北武汉 2湖北省中医院(湖北中医药大学第一附属医院)脾胃病科，湖北武汉收稿日期：2023年3月10日；录用日期：2023年4月11日；发布日期：2023年4月24日摘要近年来随着人们生活水平的提高，和生活的不规律，导致反流性食管炎的发病率逐年升高，虽然西医在治疗本病取得了一定进步，但仍然没有突破性进展，长期用药或停药后有其局限性。

经过文献查询，发现在中医学中，反流性食管炎主要以肝胃郁热型为主，同时发现柴胡疏肝散合左金丸对于肝胃郁热型有良好的治疗效果，但缺乏对文献的整理，导致合方的价值没能被进一步地挖掘。

因此本文从肝胃郁热型反流性食管炎的病因病机、治疗方法，和柴胡疏肝散合左金丸的临床研究、药理分析出发，总结合方治疗上述疾病的文献支持。

关键词中医药联合西药治疗，反流性食管炎，综述Research Progress of Chaihu Shugan San Combined with Zuojinwan in Treating Reflux Esophagitis of Liver and Stomach Stagnation Heat TypeHepeng Li 1, Yunlian Hu 2*1College of First Clinical, Hubei University of Traditional Chinese Medicine, Wuhan Hubei 2Spleen and Stomach Disease Department, Hubei Provincial Hospital of Traditional Chinese Medicine (First Affiliated Hospital of Hubei University of Traditional Chinese Medicine), Wuhan Hubei Received: Mar. 10th , 2023; accepted: Apr. 11th , 2023; published: Apr. 24th , 2023*通讯作者。

珍贵树种观光木研究现状及展望

珍贵树种观光木研究现状及展望李松海;谢安德;贲丽云;王凌晖【摘要】The present paper described the morphological and biological characteristics of precious tree species Tsoongiodendron odorum. The research progresses in propagation technology, biomass conservation, biodiversity, eco-physiology, chemical composition and pharmacology of T. odorum have been reviewed in this paper. Focusing on the researches on asexual reproduction technology, cultivation techniques of introduced species and pharmacological properties of T. odorum have been suggested for future studies in order to protect the T. odorum plants and make their use for the ecological, economic and social benefits.%文章介绍了珍贵树种观光木形态特征和生物学特性,对其繁育技术、生物量、生物多样性、生理生态、化学成分及药理分析等面研究进展进行综述,提出今后应加强其无性繁殖技术、引种栽培技术及药理特性等面研究,重点解决资源濒危问题,从而实现生态效益、经济效益和社会效益共赢,促进人与自然和谐发展.【期刊名称】《南方农业学报》【年(卷),期】2011(042)008【总页数】4页(P968-971)【关键词】珍贵树种;观光木;研究现状;展望【作者】李松海;谢安德;贲丽云;王凌晖【作者单位】广西国营高峰林场,南宁530001;广西大学林学院,南宁530005;广西国营七坡林场,南宁530225;广西大学林学院,南宁530005【正文语种】中文【中图分类】S687观光木（Tsoongiodendron odorumChun）又名香花木、宿轴木兰，为木兰科观光木属，是我国特有的属、种，为我国南方著名的珍稀濒危树种，已被列为国家二级保护植物。

美国ResearchDiets实验动物模型饲料D12492

Where NutriPhenomics Begins© 2006 Research Diets, Inc. All rights reserved. D12492--2-13DescriptionRodent Diet with 60% kcal% fat.Used in ResearchFatty Liver In ammation Obesity DiabetesPackagingProduct is packed in 12.5 kg box.Each box is identi ed with the product name, description, lot number and expiration date.Lead TimeIN-STOCK.Ready for next day shipment.Gamma-IrradiationYes. Add 10 days to delivery time.FormPellet, Powder, LiquidShelf LifeMost diets require storage in a cool dry environment. Stored correctly they should last 6 months.Because of the high fat content is best if kept frozen.Control DietsD12450B, D12450J, D12450KFormulaProduct #D12492gm%Protein 26.2Carbohydrate 26.3Fat 34.9 Total kcal/gm5.24IngredientgmCasein, 30 Mesh200L-Cystine3Corn Starch 0Maltodextrin 10 125Sucrose 68.8Cellulose, BW200 50Soybean Oil 25Lard*245Mineral Mix S10026 10DiCalcium Phosphate 13Calcium Carbonate5.5Potassium Citrate, 1 H2O 16.5Vitamin Mix V1000110Choline Bitartrate2FD&C Blue Dye #10.05Total773.85kcal%202060100kcal800120500275.2022********40004057Formulated by E. A. Ulman, Ph.D., Research Diets, Inc., 8/26/98and 3/11/99.*Typical analysis of cholesterol in lard = 0.72 mg/gram.Cholesterol (mg)/4057 kcal = 216.4Cholesterol (mg)/kg = 279.6D12450B, D12451, D12492 The "Original High Fat Diets"1. Van Heek M, et al. Diet-induced Obese Mice Develop Peripheral, but not CentralResistance to Leptin. J. Clin. Invest. 1997; 99:385-390.2. Taheri S, et al. Distribution and quantiﬁcation of immunoreactive orexin A in rat tissues.FEBS Lett. 1999 Aug 20; 457(1):157-61.3. Nonogaki K, et al. Leptin-independent hyperphagia and type 2 diabetes in mice witha mutated serotonin 5-HT2C receptor gene. Nature Medicine 1998; 4:1152-1156.4. El-Haschimi K, et al. T wo defects contribute to hypothalamic leptin resistance in micewith diet-induced obesity. J.Clin.Invest. 2000; 105:1827-1832.5. Bush EN, et al.(Metabolic Disease Research, Abbott Laboratories) Adiposity, LeptinResistance, Hyperrphagia, Hyperglycemia, Glucose Intolerance and Insulin Resistance in C57BL/6J Mice Fed High Fat Diets.Endocrine SocietyAnnual Meeting 2001,Poster Session.6. Shapiro ME, et al. (Metabolic Disease Research, Abbott Laboratories) Eﬀects ofT reatment of C57BL/6j Mice Fed High vs. Low Fat Diets with Metformin orRosiglitazone on Adiposity, Food Intake, Hyperglycemia and Insulin Resistance.Endocrine Society Annual Meeting 2001, Poster Session.7. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. AT ransgenic Model of Visceral Obesity and the Metabolic Syndrome. Science. 2001;294:2166-2170.8. Razani B, Combs TP, Wang XB, Frank PG, Park DS, Russell RG, Li M, Tang B, JelicksLA, Scherer PE, Lisanti MP. Caveolin-1 deﬁcient mice are lean, resistant to diet-induced obesity, and show hyper-triglyceridemia with adipocyte abnormalities. J. Biol. Chem.2001; (in press).9. Valet P, Grujic D, Wade J, Ito M, Zingaretti MC, Soloveva V, Ross SR, Graves RA,Cinti S, Lafontan M, and Lowell BB. Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deﬁcient mice promotes diet-induced obesity. J.Biol.Chem. 275: 34797-34802, 2000.10. Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J,Mootha V, Cortright R, Muoio DM, and Lowell BB. Energy metabolism in uncoupling protein 3 gene knockout mice. J.Biol.Chem. 275: 16258-16266, 2000.11. Ziotopoulou M, Mantzoros CS, Hileman SM, & Flier JS. Diﬀerential expression ofhypothalamic neuropeptides in the early phase of diet-induced obesity in mice.Am. J. Physiol. Endocrinol. Metab. 279:E383-E845, 2000.12. Scrocchi LA & Drucker DJ. Eﬀects of Aging and a High Fat Diet on Body Weight andGlucose T olerance in Glucagon-Like Peptide-1 Receptor -/- Mice.Endocrinology 139:3127- 3132, 1998.13. Ghibaudi L, Cook J, Farley C, Van Heek M, & Hwa J.Fat Intake Aﬀects Adiposity,Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats.Obes. Res. 10:956-963. 200214. Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS & Kalra SP. Central Leptin Geneerapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemeia, andHyperinsulinemia. Diabetes 51:1729-1736, 2001.15. Tang H, Vasselli JR, Wu EX, Boozer CN, & Gallagher D. High-Resolution MagneticResonance Imaging T racks Changes in Organ and Tissue Mass in Obese and Aging Rats.Am J Physiol (Regulatory Integrative Comp Physiol) 282:R890-R899, 2002.16. Bowen H, Mitchell TD, & Harris RBS (Dept. of Foods and Nutr, U of Georgia).Method of Leptin Dosing, Strain, and Group Housing Inﬂuence Leptin Sensitivity in High-Fet-Fed Weanling Mice. AJP-Regul Integr Comp Physiol 284:R87-R100, 2003. 17. Harris RBS, Mitchell TD, & Hebert S (Pennington Biomedical Research Center, BatonRouge, LA). Leptin-Induced Changes in Body Composition in High Fat-Fed Mice.AJPRegul Integr Comp Physiol 284:R87-R100, 2003.18. Anini, Y. and Brubaker, P. L. Role of Leptin in the Regulation of Glucagon-LikePeptide-1 Secretion. Diabetes 52:252-259, 2003.19. Bluher, S., Responsiveness to Peripherally Administered Melanocortins in Lean andObese Mice. Diabetes 53:82-90, 2004.20. Brunengraber, D. Z., et al. Inﬂuence of diet on the modeling of adipose tissuetriglycerides during growth. Am J Physiol Endocrinol Metab 285: E917-E925, 2003. 21. Challis, B. G., et al. Mice lacking pro-opiomelanocortin are sensitive to high-fat feedingbut respond normally to the acute anorectic eﬀects of peptide-YY3-36.PNAS 101: 13: 4695- 4700, 2004.22. Cohen, A. W., B. Razani, X. B. Wang, T. P. Combs, T. M. Williams, P. E. Scherer, andM. P. Lisanti. Caveolin-1-deﬁcient mice show insulin resistance and defectiveinsulin receptor protein expression in adipose tissue. Am J Physiol Cell Physiol 285: C222-C235, 2003.23. Combs, T. P., et al. A T ransgenic Mouse with a Deletion in the Collagenous Domain ofAdiponectin Displays Elevated Circulating Adiponectin and Improved InsulinSensitivity. Endocrinology 145:367-383, 2004.24. Conarello, S. L., et al. Mice lacking dipeptidyl peptidase IV are protected against obesityand insulin resistance. PNAS, 100:11: 6825-6830, 2003.25. Dhar, M. S., et al. Mice Heterozygous for Atp10c, a Putative Amphipath, Represent aNovel Model of Obesity and Type 2 Diabetes. J. Nutr. 134: 799-805, 2004.26. El-Haschimi, K., S. D. Dufresne, M. F. Hirshman, J. S. Flier, L. J. Goodyear, and C.Bjørbæk. Insulin Resistance and Lipodystrophy in Mice Lacking Ribosomal S6 Kinase 2.Diabetes 52:1340-1346, 2003.27. Felipe, F., M. L. Bonet, J. Ribot, and A. Palou. Modulation of Resistin Expression byRetinoic Acid and Vitamin A Status. Diabetes 53:882-889, 2004.28. Felipe, F., M.L. Bonet, J. Ribot and A. Palou. Up-regulation of muscle uncouplingprotein 3 gene expression in mice following high fat diet, dietary vitamin Asupplementation and acute retinoic acid-treatment. International Journal of Obesity27: 60-69, 2003.29. Fu, J., et al. Oleylethanolamide regulates feeding and body weight through activationof the nuclear receptor PPAR. Nature 425:90-93, 2003.30. Gavrilova, O., et al. Liver Peroxisome Proliferator-activated Receptor Contributes toHepatic Steatosis, T riglyceride Clearance, and Regulation of Body Fat Mass.e Journal of Biological Chemistry 278:36:34268-34276, 2003.31. Haluzík, M., O. Gavrilova and D. LeRoith. Peroxisome Proliferator-ActivatedReceptor- Deﬁciency Does Not Alter Insulin Sensitivity in Mice Maintained onRegular or High-Fat Diet: Hyperinsulinemic-Euglycemic Clamp Studies.Endocrinology 145:1662-1667, 2004.32. Hancock, A.A. et al. Antiobesity eﬀects of A-331440, a novel non-imidazole histamineH3 receptor antagonist. European Journal of Pharmacology 487:183-197, 2004.33. Hennige, A. M., et al. Upregulation of insulin receptor substrate-2 in pancreatic b cellsprevents diabetes. J. Clin. Invest. 112:1521-1532, 2003.34.34. Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Validation of a high-resolutionX-ray computed tomography system to measure murine adipose tissue depot mass in situ and longitudinally. Journal of Pharmacological and T oxicological Methods47: 99- 106, 2002.35. Hileman, S. M., D.D. Pierroz, H. Masuzaki, C. Bjørbæk, K. El-Haschimi, W. A. Banks,and J. S. Flier. Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity.Endocrinology 143:775-783, 2002.36. Ishii, M., H. Fei, and J. M. Friedman. Targeted disruption of GPR7, the endogenousreceptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.PNAS 100:18:10540-10545, 2003.37. Joseph, J. W., V. Koshkin, C-Y Zhang, J. Wang, B. B. Lowell, C. B. Chan, and M.B.Wheeler. Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin SecretoryCapacity After a High-Fat Diet. Diabetes 51:3211-3219, 2002.38. Kim, S., et al. Eﬀects of High-Fat, Angiotensinogen (agt) Gene Inactivation, andTargeted Expression to Adipose Tissue on Lipid Metabolism and Renal Gene Expression.Horm Metab Res 34:721-725, 2002.39. Kumar, M. V., T. Shimokawa, T. R. Nagy, and M. D. Lane. Diﬀerential eﬀects of acentrally acting fatty acid synthase inhibitor in lean and obese mice.PNAS 99:4: 1921-1925, 2002.40. Lambert, P. D., et al. Ciliary neurotrophic factor activates leptin-like pathways andreduces body fat, without cachexia or rebound weight gain, even in leptin-resistantobesity. PNAS 98:8: 4652-4657, 2001.41. Le Laya, S., et al. Decreased Resistin Expression in Mice with Diﬀerent Sensitivities to aHigh-Fat Diet. Biochemical and Biophysical Research Communications289:2:564-567, 2001.42. Li, J., K. Takaishi, W. Cook, S. K. McCorkle, and R. H. Unger. Insig-1 ''brakes''lipogenesis in adipocytes and inhibits diﬀerentiation of preadipocytes.PNAS 100:16:9476-9481, 2003.43. Ludwig, D. S., et al. Melanin-concentrating hormone overexpression in transgenic miceleads to obesity and insulin resistance. J. Clin. Invest. 107:379-386, 2001.44. Moon, Y. S., et al. Mice Lacking Paternally Expressed Pref-1/Dlk1 Display GrowthRetardation and Accelerated Adiposity. Molecular And Cellular Biology22:15: 5585-5592, 2002.45. Murray, I., A. D. Sniderman, P. J. Havel, and K. Cianﬂonei. Acylation StimulatingProtein (ASP) Deﬁciency Alters Postprandial and Adipose Tissue Metabolism inMale Mice. e Journal Of Biological Chemistry 274:51:36219-36225, 1999.46. Phan,L. K., F. Lin, C. A. LeDuc, W. K. Chung, and R. L. Leibel. e mousemahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.J. Clin. Invest. 110:1449-1459, 2002.47. Pierroz, D. D., M. Ziotopoulou, L. Ungsunan, S. Moschos, J. S. Flier, and C. S.Mantzoros. Eﬀects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity. Diabetes 51:1337-1345, 2002.48. Rosenfeld, C. S., K. M. Grimm, K. A. Livingston, A. M. Brokman, W. E. Lamberson,and R. M. Roberts. Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate. PNAS 100:8:4628-4632, 2003. 49. Chirala, S. S., et al. Fatty acid synthesis is essential in embryonic development: Fatty acidsynthase null mutants and most of the heterozygotes die in utero.PNAS 100:11:6358-6363, 2003.50. Takahashi, N., et al. Divergent Eﬀects of Leptin in Mice Susceptible or Resistant toObesity. Horm Metab Res 34:691-697, 2002.51. upari, J. N., L. E. Landree, G. V. Ronnett, and F. P. Kuhajda. C75 increases peripheralenergy utilization and fatty acid oxidation in diet-induced obesity.PNAS 99:14:9498-9502, 2002.52. T ortoriello, D. V., J. Mcminn, and S. C. Chua. Dietary-Induced Obesity andHypothalamic Infertility in Female DBA/2J Mice.Endocrinology 145: 1238-1247, 2004.53. Weisberg, S. P., et al. Obesity is associated with macrophage accumulation in adiposetissue. J. Clin. Invest. 112:1796-1808, 2003.54. Xu, H. et al. Chronic inﬂammation in fat plays a crucial role in the development ofobesity related insulin resistance. J. Clin. Invest. 112:1821-1830, 2003.55. Yamashita, T., et al. Enhanced insulin sensitivity in mice lacking ganglioside GM3.PNAS 100:6:3445-3449, 2003.56. Bagnasco, M., M. G. Dube, A. Katz, P. S. Kalra, and S. P. Kalra. Leptin Expression InHypothalamic Pvn Reverses Dietary Obesity And Hyperinsulinemia But StimulatesGhrelin. Obes Res. 11:1463-1470, 2003.57. Borowsky, B., et al. Antidepressant, anxiolytic and anorectic eﬀects of amelaninconcentrating hormone-1 receptor antagonist.Nature Medicine 8:8:825-830, 2002.58. Chan, C. B., et al. Increased Uncoupling Protein-2 Levels in b-cells Are AssociatedWith Impaired Glucose-Stimulated Insulin Secretion. Diabetes 50:1302-1310, 2001. 59. Chen, L. and B. L. G. Nyomba. Glucose Intolerance and Resistin Expression in RatOﬀspring Exposed to Ethanol in Utero: Modulation by Postnatal High-Fat Diet.Endocrinology 144:500-508, 2003.60. Farley, C., J. A. Cook, B. D. Spar, T. M. Austin, and T. J. Kowalski. Meal PatternAnalysis Of Diet-Induced Obesity In Susceptible And Resistant Rats.Obes Res. 11:845-851, 2003.61. Gao, J., L. Ghibaudi, M. Van Heek, J. J. Hwa. Characterization of diet-induced obeserats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet. Brain Research 936:87-90, 2002.62. Ogilvie, K. M., R. Saladin, T. R. Nagy, M. S. Urcan, R. A. Heyman, and M. D.Leibowitz. Activation of the Retinoid X Receptor Suppresses Appetite in the Rat.Endocrinology 145:565-573, 2004.63. Shklyaev, S., et al. Sustained peripheral expression of transgene adiponectin oﬀsets thedevelopment of diet-induced obesity in rats. PNAS 100:24:14217-14222, 2003.64. Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Antiobesity eﬀects of chroniccannabinoid CB1 receptor antagonist treatment in diet-induced obese mice.European Journal of Pharmacology 462:125-132, 2003.。

小檗碱对炎症性肠病的调控机制

小檗碱对炎症性肠病的调控机制郭乙冰;汪水平;刘国威;周承福【摘要】炎症性肠病(IBD)是一种易复发的慢性肠道炎症疾病,对人和动物危害极大,迄今没有可根治的药物.作为一种天然产物,小檗碱具有丰富的生理功能和独特的药理特性,治疗IBD的能力不俗,具有防治IBD的潜在优势.本文介绍小檗碱的种类和性质、IBD的基本特征,探讨小檗碱对IBD的调控机制,为其在实践中的应用提供科学依据.【期刊名称】《动物营养学报》【年(卷),期】2018(030)011【总页数】6页(P4363-4368)【关键词】小檗碱;炎症性肠病;调控机制【作者】郭乙冰;汪水平;刘国威;周承福【作者单位】西南大学动物科学学院,重庆 402460;西南大学动物科学学院,重庆402460;西南大学动物科学学院,重庆 402460;西南大学动物科学学院,重庆402460【正文语种】中文【中图分类】S816.7作为中药黄连的主要成分，小檗碱因其清热燥湿、泻火解毒的药性，在中医上常内服用于湿热、呕吐、泻痢、黄疸、高热神昏、心火亢盛、心烦不寐、目赤、牙痛、消渴及痈肿疔疮等症候，外敷用于湿疹、湿疮及耳道流脓等症候[1]。

近年来，小檗碱被发现在治疗肿瘤、癌症、糖尿病、心血管病、高血脂症、炎症、细菌和病毒感染、脑缺血性损伤、精神失调、神经障碍、阿尔茨海默病及骨质疏松等具有药理作用[2]。

炎症性肠病(inflammatory bowel disease，IBD)是一种易复发的慢性肠道炎症疾病，可导致人和动物出现腹痛、腹泻及排出黏稠或带血粪便等症状，不易根治。

因具有抗菌、抗炎、抗氧化及调节免疫等生理功能，小檗碱有益于IBD的预防和治疗。

本文介绍小檗碱的种类和性质、IBD的基本特征，探讨小檗碱对IBD的调控机制，为其在实践中的应用提供科学依据。

1 小檗碱的种类和性质小檗碱是小檗科、罂粟科、毛茛科、芸香科、防己科及鼠李科等药用植物的根、茎及皮所含的主要活性成分，常见的有黄连、黄柏、冬青叶小檗、刺檗及印度小檗等。

鹿药药学研究概况

２６（３）：１６７．
前对其的研究和利用还不够，相关中成药研究也比较少。随着对鹿药的养生价值认识的进一步加深，鹿药在未来会被应用到更多的养生保健相关行业中。
参考文献
［１］葛宝福，张绪成，苏峰，等．集安市山野菜植物名录［Ｊ］．中国园艺文摘，
２０１Ｉ（９）：５６．
［２］安晓云，慈嘉，申琼．鹿药组织培养的研究［Ｊ］．中国园艺文摘，２０１０（１０）：１４．［３］王盛民，张瑛，刘亮忠．鹿药的生药鉴定［Ｊ］．陕西中医学院学报，１９９９，
等氨基酸和铝、镁、钙、磷、钛、钡等无机元素∞。７１。其氨基
酸、蛋白质和无机元素含量较丰富，而糖类和脂肪含量却非
药理研究表明，鹿药具有抗真菌和抗肿瘤活性¨“。鹿
药具有一定的抗氧化涪睦，并有抑制人肺腺癌ＳＰＣ—Ａ－Ｉ细胞
生长活性的作用；对人肝癌细胞（ＳＭＭＣ－７２２１）和人结直肠腺癌细胞（ＤＬＤ一１）亦有抑制作用。鹿药含有黄酮类化合物，对羟基自由基（ＯＨ・）有一定的清除能力¨０｜。赵淑杰从鹿药根茎中分离得到１个新的呋甾皂苷，具有抑制人肺腺癌ＳＰＣ— Ａ一１细胞生长的活性ｕ４｜，对人肝癌细胞（ＳＭＭＣ－７２２１）和人结直肠腺癌细胞（ＤＬＤ．１）有抑制作用，但无抗细菌作用¨“。
诸冷而益老起阳也”。
鉴定为（２５Ｓ）－５ｅｔ一螺甾烷－９（１１）一烯－３ｐ一醇３－０－ｐ－Ｄ－吡喃葡萄
基金项目西部资源生物与现代生物技术教育部重点实验室基金（编号：ＫＨ０９０３０）；西藏自治区科技厅重大科技专项基金（编号：２００９１０１２）；陕西省教育厅科学研究项目（编号：
２０１０ＪＫ８６２）。
鹿药（ＳｍｉｌａｃｉｎａｊａｐｏｎｉｃａＡ．Ｇｒａｙ）为百合科（Ｌｉｌｉａｃｅａｅ）鹿药属（ＳｍｉｌａｃｉｎａＤｅｓｆ．）多年生草本植物，别名山糜子等。鹿

Elabscience γ-谷氨酰转肽酶（GGT γ-GT）比色法测试盒说明书

（本试剂盒仅供体外研究使用，不用于临床诊断！）Elabscience®γ-谷氨酰转肽酶（GGT/γ-GT）比色法测试盒γ-Glutamyl Transferase (GGT/γ-GT)Activity Assay Kit产品货号：E-BC-K126-M产品规格：48T(32 samples)/96T(80 samples)检测仪器：酶标仪(405 nm)使用前请仔细阅读说明书。

如果有任何问题，请通过以下方式联系我们：销售部电话************，************技术部电话131****6790具体保质期请见试剂盒外包装标签。

请在保质期内使用试剂盒。

联系时请提供产品批号(见试剂盒标签)，以便我们更高效地为您服务。

用途本试剂盒适用于检测血清、血浆等液体样本及动物组织样本中的γ-谷氨酰转肽酶（γ-GT）的活性。

检测原理γ-谷氨酰转肽酶（γ-GT）催化γ-谷氨酰对硝基苯胺中γ-谷氨酰基转移给N-甘氨酰甘氨酸，生成对硝基苯胺，在405 nm有特征光吸收，通过测定405 nm波长处吸光度的增加速率，来计算γ-GT酶活性。

本试剂盒检测组织样本时，需测定总蛋白浓度，推荐使用本公司BCA试剂盒（货号E-BC-K318-M）进行测定。

提供试剂和物品说明：试剂严格按上表中的保存条件保存，不同测试盒中的试剂不能混用。

对于体积较少的试剂，使用前请先离心，以免量取不到足够量的试剂。

所需自备物品仪器：酶标仪(405 nm)试剂准备①所有试剂平衡至室温后方可使用，试剂四和试剂五可提前放至37℃恒温箱中预热20 min，以保证其完全融化；②试剂二应用液的配制：取一支试剂二粉剂，用3 mL的试剂五溶解，临用前配制，2-8℃条件下可分装保存7天。

③反应工作液的配制：将试剂一和试剂二应用液按照4：1的比例混匀，现配现用。

标准品工作液的配制：标准品按稀释表稀释后，再将试剂一与不同浓度的标准品溶液按4：1的比例混匀，现配现用。

芭蕉化学成分和药理活性的研究进展

Traditional Chinese Medicine 中医学, 2021, 10(1), 14-27Published Online January 2021 in Hans. /journal/tcmhttps:///10.12677/tcm.2021.101002芭蕉化学成分和药理活性的研究进展徐锋1，韦秀娟1，杨冲冲1，张梅1，陈滕1，吴红梅1，王祥培2*1贵州中医药大学药学院，贵州贵阳2贵州民族大学药学院，贵州贵阳收稿日期：2020年11月19日；录用日期：2020年12月31日；发布日期：2021年1月13日摘要芭蕉的多个部位(根、茎、叶、花)均作药用，具有丰富的传统功效和较高的药用价值。

目前，芭蕉中已鉴别出化合物300多个，主要是酮类、醇类、醛类、烯烃和酸类化合物等成分，具有抗糖尿病、抗炎镇痛、抗氧化、抗菌等多种药理活性。

本文对芭蕉的化学成分和药理活性进行梳理、归纳，以期为芭蕉进一步的研究、开发提供参考和依据。

关键词芭蕉，芭蕉根，芭蕉油，芭蕉花，芭蕉叶，化学成分，药理活性Research Progress on ChemicalConstituents and PharmacologicalActivities of Musa basjooFeng Xu1, Xiujuan Wei1, Chongchong Yang1, Mei Zhang1, Teng Chen1, Hongmei Wu1,Xiangpei Wang2*1Department of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang Guizhou2Department of Pharmacy, Guizhou Minzu University, Guiyang GuizhouReceived: Nov. 19th, 2020; accepted: Dec. 31st, 2020; published: Jan. 13th, 2021AbstractMany parts of Musa basjoo (rhizome, pseudostem, leaf, flower) are used for medicinal purposes *通讯作者。