【US10517960B2】Bifunctionalpolypeptides【专利】
共轭聚合物 有机半导体 英文
共轭聚合物有机半导体英文英文回答：Conjugated polymers are a class of organic semiconductors that have alternating single and double bonds along their backbone. This unique structure gives conjugated polymers interesting electrical and optical properties, making them promising candidates for use in various electronic applications.Conjugated polymers are typically synthesized via chemical polymerization techniques, such as oxidative coupling or Heck reaction. The resulting polymers are typically soluble in organic solvents and can be processed into thin films using techniques such as spin coating or drop casting.The electrical properties of conjugated polymers are highly dependent on the degree of conjugation, which is the length of the alternating single and double bond sequence.Longer conjugation lengths lead to higher charge carrier mobility and lower bandgap, making the polymer more conductive and semiconducting, respectively.The optical properties of conjugated polymers are also affected by the degree of conjugation. Longer conjugation lengths lead to absorption and emission of light at longer wavelengths, resulting in a red shift in the polymer's absorption and emission spectra.Conjugated polymers have been used in a variety of electronic applications, including organic solar cells, organic light-emitting diodes (OLEDs), and transistors. In organic solar cells, conjugated polymers act as the active layer, absorbing light and generating charge carriers that are then collected by the electrodes. In OLEDs, conjugated polymers are used as the emitting layer, emitting light when an electric current is applied. In transistors, conjugated polymers are used as the semiconductor channel, controlling the flow of current between the source and drain electrodes.Conjugated polymers are a promising class of materials for use in electronic applications due to their unique electrical and optical properties. Further research is needed to improve the performance and stability of conjugated polymers, but they have the potential to revolutionize the field of electronics.中文回答：共轭聚合物是有机半导体的一种，其主链上交替排列着单键和双键。
b2plyp 双杂化泛函 -回复
b2plyp 双杂化泛函-回复b2plyp是一种常用于密度泛函理论计算的双杂化泛函。
在本文中，我们将一步一步地回答关于b2plyp的问题，从其定义和原理，到其在化学计算中的应用和优势。
首先，让我们来了解b2plyp的定义和原理。
b2plyp是一种双杂化泛函，其由Becke和Lee-Yang-Parr（LYP）泛函的线性组合构成。
Becke泛函用于处理交换能，而LYP泛函则用于处理相关能。
通过将这两个泛函结合在一起，b2plyp有效地综合了交换和相关效应，使其在计算化学中具有广泛的应用。
接下来，让我们看看b2plyp在化学计算中的应用。
b2plyp是一种相对精确的方法，可以用于计算分子的能量、结构和反应性质。
它通常被用于计算各种体系，包括有机分子、无机化合物以及配位化合物等。
与其他泛函相比，b2plyp在描述非键相互作用和电荷转移等现象方面具有一定的优势。
在实际使用b2plyp进行计算时，我们需要选择适当的基组。
基组的选择对计算结果的准确性和可靠性有着重要影响。
一般而言，大型基组可以提供更精确的结果，但计算成本也会相应增加。
因此，在选择基组时，需要权衡计算资源和精确性之间的关系。
此外，b2plyp还可以通过校正其参数来提高计算结果的精确性。
通过对实验数据进行拟合，可以得到更适合特定问题的参数。
这种参数校正的方法被称为微调（fine-tuning），可以进一步提高b2plyp的准确性。
在化学计算的实际应用中，b2plyp常常用于研究分子的电子结构和反应性质。
例如，它可以用于预测分子的电子亲和势、离子化势和键能等。
此外，b2plyp还可以用于研究反应的机理和速率常数等动力学性质。
它的应用范围涵盖了理论化学的各个领域。
最后，让我们总结一下b2plyp的优势。
作为一种双杂化泛函，b2plyp综合了交换和相关效应，具有一定的精确性。
它在计算分子的能量、结构和反应性质方面具有广泛的应用。
此外，通过微调参数和选择合适的基组，可以进一步提高其结果的准确性。
博士入学PPT模板
Results
2.2. Overexpressed of PTBP1 promotes migration of lung cancer cells
Results
2.3. Knockdown of PTBP1 inhibits levels of EMT-related proteins in lung cancer cells
Background
Seven alternative splicing (AS) subgroups: • Exon skipping accounts for nearly 40% of AS events; • alternative 3′ splice site (3′SS) selection (18.4%) and 5′SS
3. Dewei Niu, ******, Shanze Yi, Feng Wang*. Gene cloning, protein expression and functional analysis of a type 3 metallothionein gene from Sonneratia alba with biosorption potential. Polish Journal of Environmental Studies, Accepted. PJOES-00647-2017-02.
A
B
A. PTBP1 expression was elevated in LUAD tissues (N=515) compared with normal lung tissues (N=59) according to TCGA database (p<0.01); B. Kaplan-Meier plots of patients with LUAD according to high (N=127) and low (N=375) PTBP1 expression from the TCGA database and compared by paired t-test, p<0.01.
多重微珠免疫法 英文缩写
多重微珠免疫法英文缩写英文回答：Multiplex bead immunoassay (MBIA) is a high-throughput technique used for the simultaneous quantification of multiple analytes in a single sample. It is based on the principle of flow cytometry, where beads coated with specific antibodies are incubated with the sample. The beads are then washed and analyzed using a flow cytometer, which measures the fluorescence intensity of each bead. The fluorescence intensity is proportional to the amount of analyte bound to the bead.MBIA has several advantages over traditional immunoassays. First, it is highly multiplexed, allowing for the simultaneous quantification of up to 100 analytes in a single sample. Second, it is sensitive, with a lower limit of detection in the picomolar range. Third, it is fast and efficient, with results available in less than an hour.MBIA is used in a wide variety of applications, including:Clinical diagnostics.Drug discovery.Food safety testing.Environmental monitoring.中文回答：多重微珠免疫法（MBIA）是一种高通量技术，用于在单个样品中同时定量分析多种分析物。
头颈部鳞癌的研究趋势及新进展
头颈部鳞癌的研究趋势及新进展张洪瑞，苏本香，庞艳，孙月茹呼伦贝尔职业技术学院口腔教研室，内蒙古呼伦贝尔021000[摘要]头颈部鳞癌（Head and Neck Squamous Cell Carcinoma, HNSCC）为发生于口腔、咽、喉黏膜上皮的鳞癌，吸烟、酗酒与促进口腔及喉部鳞癌形成存在相关性，咽部鳞癌与人类乳头状瘤病毒感染有关。
头颈部鳞癌有多种治疗方式，特别是以分子靶向治疗为代表的药物治疗快速发展。
本文具体探讨与分析了头颈部鳞癌的流行病学状况，阐述了头颈部鳞癌的形成机制，综述了头颈部鳞癌的分子靶向治疗进展：西妥昔单抗、免疫检查点分子抑制剂、贝伐珠单抗。
[关键词]头颈部鳞癌；分子靶向治疗；免疫检查点分子抑制剂；贝伐珠单抗；西妥昔单抗[中图分类号]R739.91 [文献标识码]A [文章编号]2096-1782（2024）01(b)-0194-05 Research Trends and New Advances in Head and Neck Squamous Cell CarcinomaZHANG Hongrui, SU Benxiang, PANG Yan, SUN YueruStomatology Department, Hulunbuir Vocational Technical College, Hulunbuir, Inner Mongolia Autonomous Region, 021000 China[Abstract] Head and neck squamous cell carcinoma (HNSCC) is a squamous carcinoma that occurs in the mucosal epithelium of the oral cavity, pharynx and larynx. Smoking and alcohol abuse are associated with the formation of squa‐mous carcinoma of the oral cavity and larynx, and squamous cell carcinoma of the pharynx is associated with human papillomavirus infection. There are various treatment modalities for head and neck squamous cell carcinoma, espe‐cially the rapid development of drug therapy represented by molecular targeted therapy. This article specifically dis‐cusses and analyzes the epidemiological status of head and neck squamous cell carcinoma, describes the formation mechanism of head and neck squamous cell carcinoma, and reviews the progress of molecular targeted therapy for head and neck squamous cell carcinoma: cetuximab, immune checkpoint molecular inhibitors, and bevacizumab. [Key words] Head and neck squamous cell carcinoma; Molecular targeted therapy; Immune checkpoint molecular inhibitors; Bevacizumab; Cetuximab头颈部鳞癌（Head and Neck Squamous Cell Car‐cinoma, HNSCC）是一组起源于口腔、咽、喉的鳞状上皮细胞的异质性肿瘤，当前其发病率逐年增加，且病死率一直居高不下[1]。
Endevco 8530C 绝对压力传感器说明书
Key featuresn15, 50 and 100 psia ranges n225 mV full scalen Absolute reference DescriptionModel 8530C is a miniature, high sensitivity piezoresistive pressure transducer for measuring absolute pressure. The volume behind the diaphragm is evacuated and glass sealed to provide an absolute pressure reference. Full scale output is 225 mV with high overload capability and high frequency response. It is available in ranges from 15 psia to 100 psia. 8530B is available for higher pressure ranges.Endevco pressure transducers feature a four-arm strain gage bridge ion implanted into a unique sculptured silicon diaphragm for maximum sensitivity and wideband frequency response. Self-contained hybrid temperature compensation provides stable performance over the temperature range of 0°F to 200°F (-18°C to +93°C). Endevco transducers also feature excellent linearity (even to 3X range), high shock resistance, and high stability during temperature transients.8530C has been used successfully in many blast test situations. For this application, a protective coating is recommended to eliminate photoflash sensitivity and provide particle impingement protection. This coating does not degrade the superior dynamic response characteristics of the sensor.8530C is available with metric M5 mounting thread as 8530C-XXM5 on special order. See “other options.”Recommended electronics for signal conditioning and power supply are model 126 and 136 general purpose three channel conditioners, ultra low noise 4430A conditioner, or the 4990A-X (Oasis) multi-channel rack mount system.Piezoresistive pressure transducer Model 8530C -15, -50, -100The following performance specifications conform to ISA-RP-37.2 (1964) and are typical values, referenced at +75˚F (+24˚C) and 100 Hz, unless otherwise noted. Calibration data, traceable to National Institute of Standards and Technology (NIST), is supplied.Notes1. 1 psi = 6.895 kPa = 0.069 bar.2. FSO (Full Scale Output) is defined as transducer output change from 0 psia to + full scale pressure.3. Zero Measurand Output (ZMO) is the transducer output with 0 psia applied.4. Significantly higher thermal transient errors occur if the excitation voltage exceeds 10 Vdc. For sensitive phase change studies, manyusers reduce the excitation to 5 Vdc or even 1 Vdc.5. Per ISA-S37.10, Para.6.7, Proc. II. The metal screen partially shields the silicon diaphragm from incident radiation. Accordingly, lightincident at acute angles to the screen generally increases the error by a factor of 2 or 3.6. Warm-up time is defined as elapsed time from excitation voltage “turn on” until the transducer output is within ±1% of reading accuracy.7. Case pressure identifies media containment pressure in the event of diaphragm rupture.8. For best results when using excitation voltages other than 10.0 Vdc, it is recommended that the transducer be calibrated at the desiredexcitation during manufacture. Otherwise larger thermal errors may occur, especially at voltages above 10 Vdc.9. O-ring, EHR93 Parker 5-125, compound V747-75 (Viton®) is supplied unless otherwise specified on purchase order. FluorosiliconeO-ring, EHR96 Parker material L677-70, for leak tight operation below 0°F is available on special order.10. Maintain high levels of precision and accuracy using Endevco’s factory calibration services. Call Endevco’s inside sales force at866-ENDEVCO for recommended intervals, pricing and turn-around time for these services as well as for quotations on our standard products.Other optionsM1 “A” screen, black greaseM2 “B” screen, black greaseM5 Metric threadM37Integral connectorM58 “B” screenM57No screen, gelM59 No screen8530C − XXX − YYY − EExcitation voltage (if no voltage is specified the default is 10 Vdc)A=2 Vdc, B=2.5 Vdc, C=3.3 Vdc, D=5 Vdc, E=7, F=7.5Cable length in inches (ie 8530C-100-200 has a length of 200 inches)If no dash number is specified the default is 30 inches.For lengths ≤ 10 ft specify 1 ft increments (12”, 24”...120”)For lengths ≤ 10 ft specify 5 ft increments (180”, 240”...etc)Pressure range (psia)-15, -50, -100Basic model number10869 NC Highway 903, Halifax, NC 27839 USA |*****************| 866 363 3826© 2022 PCB Piezotronics - all rights reserved. PCB Piezotronics is a wholly-owned subsidiary of Amphenol Corporation. Endevco is an assumed name of PCB Piezotronics of North Carolina, Inc., which is a wholly-owned subsidiary of PCB Piezotronics, Inc. Accumetrics, Inc. and The Modal Shop, Inc. are wholly-owned subsidiaries of PCB Piezotronics, Inc. IMI Sensors and Larson Davis are Divisions of PCB Piezotronics, Inc. Except for any third party marks for which attribution is provided herein, the。
恩格列净联合二甲双胍治疗2型糖尿病的效果评价
恩格列净联合二甲双胍治疗2型糖尿病的效果评价林智化厦门大学附属第一医院同安院区（厦门市第三医院）内分泌科，福建厦门361100[摘要]目的分析恩格列净联合二甲双胍治疗2型糖尿病的效果。
方法选取2021年3月—2022年4月厦门大学附属第一医院同安院区（厦门市第三医院）收治的98例2型糖尿病患者为研究对象，按照随机数表法分为观察组和对照组，每组49例。
两组均予以二甲双胍治疗，同时观察组加行恩格列净治疗。
比较两组血糖水平、血脂水平、胰岛β细胞功能、不良反应发生率以及临床疗效。
结果治疗6个月后，与对照组相比，观察组血糖水平、血脂水平均较低，胰岛β细胞功能的改善情况较好，差异有统计学意义（P<0.05）。
观察组不良反应发生率8.16%与对照组6.12%对比，差异无统计学意义（P>0.05）。
观察组治疗总有效率95.92%较对照组83.67%更高，差异有统计学意义（P<0.05）。
结论应用恩格列净联合二甲双胍治疗，效果突出，可有效调节糖脂代谢，纠正胰岛β细胞功能。
[关键词] 恩格列净；二甲双胍；2型糖尿病；糖脂代谢；胰岛β细胞功能[中图分类号] R446.1 [文献标识码] A [文章编号] 1672-4062（2023）08（a）-0087-04 Efficacy Evaluation of Empagliflozin Combined with Metformin in the Treatment of Type 2 Diabetes MellitusLIN ZhihuaDepartment of Endocrinology, Tong'an District of the First Affiliated Hospital of Xiamen University (Xiamen Third Hospital), Xiamen, Fujian Province, 361100 China[Abstract] Objective To analyze the effect of Empagliflozin combined with metformin in the treatment of type 2 dia⁃betes mellitus. Methods From March 2021 to April 2022, 98 patients with type 2 diabetes treated in Tong 'an District the First Affiliated Hospital of Xiamen University (Xiamen Third Hospital) were selected as the research objects. Ac⁃cording to the random number table method, they were divided into observation group and control group, 49 cases in each group. Both groups were treated with metformin, while the observation group was treated with empagliflozin. The blood glucose level, blood lipid level, islet β cell function, incidence of adverse reactions and clinical efficacy were compared between the two groups. Results After 6 months of treatment, compared with the control group, the blood glucose level and blood lipid level in the observation group were lower, and the improvement of islet β cell function was better, the difference was statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group (8.16%) and the control group (6.12%) (P>0.05). The to⁃tal effective rate of treatment in the observation group was 95.92% higher than that in the control group (83.67%), and the difference was statistically significant (P<0.05). Conclusion The treatment of Empagliflozin combined with metfor⁃min has a remarkable effect, which can effectively regulate the metabolism of glucose and lipid and correct the func⁃tion of islet beta cells.[Key words] Empagliflozin; Metformin; Type 2 diabetes; Glycolipid metabolism; Islet beta cell function2型糖尿病是最为常见的糖尿病类型，由于多发于成年，故又称成人发病型糖尿病，疾病早期症状不典型，随着疾病进展，患者可出现多饮、多食、多尿、消瘦或短期内体质量减轻等典型症状[1]。
b2plyp 双杂化泛函 -回复
b2plyp 双杂化泛函-回复什么是B2PLYP双杂化泛函？B2PLYP双杂化泛函是一种用于量子化学计算的密度泛函理论方法。
它结合了双电子相关（B2）和杂化泛函（PLYP），具有高精度和较低的计算成本。
在理论计算中，双电子相关性是指电子之间相互作用的一种考虑方式，而杂化泛函则是将属于不同泛函类型的组分结合在一起以提高计算的准确性。
B2PLYP双杂化泛函的产生和发展B2PLYP双杂化泛函最早由Grimme等人于2006年提出，其目的是克服传统杂化泛函在处理非共线自旋体系时的问题。
该方法的发展得益于量子化学计算领域的不断进步和理论研究的不断深入。
B2PLYP双杂化泛函的基本原理B2PLYP双杂化泛函是基于密度泛函理论的方法，其基本原理可以概括为以下几点：1. 双电子相关性：B2PLYP双杂化泛函通过使用密度泛函理论的双电子相关项，考虑了电子之间的相互作用。
这使得该方法能够更准确地描述复杂的化学反应和分子间相互作用。
2. 杂化泛函：B2PLYP方法同时采用了两种不同的泛函类型，即杂化泛函。
其中一个泛函用于描述电子的相关性，而另一个泛函用于描述电子的无关性。
这种结合可以提供更高的计算精度和可靠性。
3. 非局域密度泛函：B2PLYP双杂化泛函采用了非局域密度泛函的特点，即引入了距离相关的修正项。
这个修正项可以更好地描述分子在不同空间区域中的行为，从而提高计算的精度。
B2PLYP双杂化泛函的优点和应用B2PLYP双杂化泛函具有以下几个优点，使其成为理论计算中广泛应用的方法：1. 高计算精度：B2PLYP双杂化泛函能够在保持较低计算成本的同时，提供与更高级别方法相近甚至更高的计算精度。
这使得该方法在研究复杂化学反应和分子间相互作用时具有较高的可靠性。
2. 适用范围广：B2PLYP双杂化泛函适用于处理不同类型的分子和体系，包括有机分子、无机分子和生物分子等。
它可以用于计算能量、电子结构、反应路径等多项性质。
3. 可扩展性强：B2PLYP双杂化泛函可以与其他计算方法相结合，如分子力场、分子动力学模拟等。
OLYMPUS iScope 1053-PLMi PLPOLR 金属科学观察仪说明书
with iris diaphragm
FOCUSING
• Coaxial coarse and fine adjustments, 200 graduations, 1 μm per graduation, 200 μm per rotation, total travel approximately 24 mm and is supplied with an adjustable rack stop to prevent damage to sample and objectives.
NOSEPIECE
Revolving quintuple reversed nosepiece on ball bearings
OBJECTIVES
• Plan PLMi infinity corrected objectives for material observation • All optics are anti-fungus treated and anti-reflection coated for maximum
ICARE SENSOR
• The unique iCare Sensor is developed to avoid unnecessary loss of energy • The illumination of the microscope automatically switches off shortly after
STANDARD CONDENSERS
• Standard height adjustable Abbe N.A. 1.25 condenser with iris diaphragm • Suitable for slider with darkfield stop for magnifications up to
多糖疫苗和结合疫苗2013
综述doi:10.3969/j.issn.1009-0002.2013.05.026病原细菌多糖疫苗和多糖结合疫苗研究进展潘超，朱力，王恒樑军事医学科学院生物工程研究所，病原微生物生物安全国家重点实验室，北京100071［摘要］在许多病原细菌中，荚膜多糖和O抗原多糖能够刺激机体产生保护性抗体，因此利用病原细菌的多糖制成的疫苗能有效预防传染病，同时避免了病原细菌耐药性的出现。
此类疫苗包括多糖疫苗和多糖结合疫苗。
细菌体内糖基化的发现，使得利用生物法生产多糖结合疫苗成了多糖结合疫苗生产的热门方向。
我们简要综述了多糖疫苗和多糖结合疫苗在研究和应用方面的主要进展。
［关键词］多糖疫苗；多糖结合疫苗；病原细菌［中图分类号］R392.1［文献标识码］A［文章编号］1009-0002（2013）05-0705-05 Progress on Polysaccharide Vaccines and Glycoconjugate Vaccines of BacteriaPAN Chao,ZHU Li,WANG Heng-Liang*State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Biotechnology,Beijing100071,China*Corresponding author,E-mail:wanghl@［Abstract］Capsular polysaccharide and O-antigen polysaccharide of pathogens can stimulate the body to produce protective antibodies.The vaccines made by pathogenic bacterial polysaccharide can effectively address the preven⁃tion of infectious diseases and avoid the resistance to antibiotics.This kind of vaccines include polysaccharide vac⁃cines and glycoconjugate vaccines.The discovery of protein glycosylation pathway in bacteria has been evoking the enthusiasm of researchers to develop glycoconjugate vaccines by bio-engineering technology.The research and appli⁃cation of polysaccharide vaccines and glycoconjugate vaccines were reviewed here.[Key words]polysaccharide vaccines;glycoconjugate vaccines;pathogen由病原微生物引起的传染病是人类患病的主要因素，其中以婴幼儿和老人感染最为严重，尤其在发展中国家这种状况更加明显，这其中包括一些重要的病原菌如肺炎链球菌、脑膜炎奈瑟球菌、流感嗜血杆菌、沙门菌、志贺菌、霍乱弧菌等[1]。