science translational medicine介绍
转化医学(英文)
！~医药科学专业解释：转化医学；转化医学就是希望将生物医学研究的关注点放在如何将实验室的研究发现转化导向为有利病人诊断、治疗方法的提高上。
2：网络释义：a--转化或转换医学（Translational Medicine）是近两三年来国际医学健康领域出现的新概念。
b--转译医学(Translational Medicine)c--转换医学（Translational Medicine），又叫转化医学是本世纪从循证医学发展而形成的一个医学实践和干预性流行病学的理念，它融汇基础科学、社会科学、政治科学于一体...d--阿斯利康中国创新中心(ICC)初期将着重进行癌症领域临床前到临床医学之间转化医学(translational medicine)的研究。
广义上讲，转化医学(转化科学)就是使病人直接受益的对基础科学研究的应用。
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转化医学
3.保障人民健康的必然要求 人口老龄化和生活方式改变所带来的健康 和疾病问题，对社会和家庭的影响和压力是巨 大的；传染病、慢性病没有国界，在国际化、 全球化背景下，其影响更不容忽视；我国糖尿 病等慢性病情况令人担忧；职业病、精神卫生、 心理健康等方面都有许多亟待解决的问题。应 对我国人民健康面临的严峻挑战，既需要改革 体制机制，同时也需要医学科学的进步与创新。
转化医学的意义及其价值已引起欧美国家的 高度重视并催生战略行动。在我国，转化医学 尚处于起步和探索阶段，但发展很快，全国一 些院校和科研单位都成立了转化医学研究中心， 为我国转化医学的进一步发展打下了坚实的基 础。我认为，除了注重药物研发、生物医学工 程等经典意义上的转化医学外，对于我国这样 一个人口大国，转化医学研究更应重视公共卫 生，重视基层，重视社区英国政府成立健康研究战略协调办公室（The Office for Strategic Coordination of Heath Research, OSCHR），整合医 学研究理事会（MRC）和国家健康研究所（NIHR）的研究工作， 构建英国健康研究新策略，确定MRC、NIHR、NHS研究主题和优 先领域。 OSCHR职责包括转化医学研究、公共卫生研究、电子健康档案研 究、方法学研究、人力资源发展等５个方面，明确提出基础研究 新发现，转化为新的治疗方法、服务于临床实践的医学研究战略。 成立了转化医学委员会（TMB）、电子健康档案研究委员会 （EHRRB）、公共卫生研究委员会（PHRB）。2007~2008年， OSCHR投入为14亿英镑，预计到2010~2011年将增加到17亿英镑， 其中转化医学研究预算1610万英镑，约占0.95%。
卫生部部长陈竺院士作了题为《推动转化医学 发展，应对人民健康挑战》的主题评述报告。 陈竺说，转化医学的目的是为了打破基础医学 与药物研发和临床医学之间固有的屏障，在其 间建立起直接的关联，从实验室到病床，把基 础研究获得的知识和成果快速转化为临床治疗 的新方法。陈竺强调，转化医学的核心，就是 在从事基础科学发现的研究者与了解病人实际 需求的医生之间建立起有效联系，特别集中在 基础分子生物医学研究向最有效和最适合的疾 病诊断、治疗和预防模式的转化。
免疫治疗在乳腺癌中的应用
临床进展CHINESE COMMUNITY DOCTORS中国社区医师2021年第37卷第2期国际癌症研究机构2018年统计表明，乳腺癌的发病率和死亡率位居第2位。
在女性人群中，乳腺癌不仅诊断率最高，并且致死率也十分惊人[1]。
因此，乳腺癌治疗方案的选择极其重要。
乳腺癌的免疫治疗通过人为调节机体的免疫功能以期减少乳腺癌的复发和转移。
目前，乳腺癌的免疫治疗在防治中的作用仍然有待探究。
本文着眼于乳腺癌免疫治疗的大型临床试验进展和应用，总括乳腺癌的免疫治疗方案，为临床工作提供指导和方向。
免疫生物标志物肿瘤浸润淋巴细胞(TILs)是一种免疫生物标志物。
在乳腺癌，尤其在三阴性和HER2阳性的乳腺癌亚型中，TILs 对乳腺癌转移的抑制和预后的改善较为明显。
NeoALTTO 临床试验证实，TILs 的增加与乳腺癌无进展生存期的延长有关[2]。
此外，在一些试验中，TILs 的增加被认为是预后良好的特异性指标。
然而在一些临床试验中结果却恰恰相反。
N9831临床试验显示，未接受曲妥珠单抗的患者有较多的TILs。
虽然在大多数癌症中，如卵巢癌、胃癌、结直肠癌等，TILs 对肿瘤的转移有抑制作用，但在乳腺癌中，TILs 的作用仍然有待探究。
CD39和CD73是腺苷途径中的关键酶，它们可能是乳腺癌未来极具价值的免疫生物标志物。
脂肪来源的间充质干细胞可能对调节性T 细胞的CD73和CD39受体具有诱导作用[3]。
CD39对实体瘤的发生发展具有重要作用。
目前已有研究表明，CD39的表达可以导致肿瘤浸润性CD8+T 细胞衰竭。
近年来，CD73被认为是乳腺癌发生发展中的关键外周核苷酸酶。
缺氧和促炎细胞因子等因素上调肿瘤微环境中的CD73基因，通过酶和非酶途径触发分子和细胞信号通路，最终将促进乳腺癌的侵袭[4]。
此外，靶向阻断CD73可以增强抗PD-1和抗CTLA-4单克隆抗体的治疗活性，因此可能增强针对免疫检查点抑制剂的治疗策略。
science translational medicine介绍
science translational medicine介绍
（原创版）
目录
1.Science Translational Medicine 的概述
2.Science Translational Medicine 的内容与领域
3.Science Translational Medicine 的重要性
4.Science Translational Medicine 的未来展望
正文
Science Translational Medicine（STM）是一本国际性的医学研究杂志，它致力于促进基础研究与临床医学之间的交流与转化。
这本杂志是由美国科学促进会（AAAS）出版的，同时也是《科学》杂志的一个分支。
Science Translational Medicine 的内容涵盖了广泛的医学领域，包括生物医学研究、临床研究、药物研发、公共卫生等。
这本杂志的特色在于，它不仅发表原创研究论文，还鼓励作者提交那些能够直接影响临床实践和公共卫生政策的研究成果。
Science Translational Medicine 的重要性体现在，它为全球的医学研究者和临床医生提供了一个交流的平台，使得基础研究能够更快地转化为临床应用。
这对于提高医疗服务的质量，推动医学科学的发展都具有重要的意义。
对于 Science Translational Medicine 的未来展望，我们相信，随着科技的发展，这本杂志将会在更多的领域发挥重要的作用。
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science translational medicine的影响因子
science translational medicine的影响因子【最新版】目录1.科学翻译医学的影响因子概述2.影响因子的计算方法3.科学翻译医学的影响因子排名4.科学翻译医学的影响因子与学术地位的关系5.科学翻译医学的影响因子对科研人员的意义正文1.科学翻译医学的影响因子概述“科学翻译医学”（Science Translational Medicine，简称 STM）是一本国际知名的学术期刊，旨在促进生物医学研究领域的知识传播与转化。
影响因子（Impact Factor，简称 IF）是衡量一个学术期刊影响力的重要指标，它反映了某个期刊中文章在一定时间内被引用的平均频次。
对于科学翻译医学这本刊物来说，了解其影响因子有助于我们评估其在学术界的地位和影响力。
2.影响因子的计算方法影响因子的计算方法是以某期刊前两年发表的文章在第三年被引用的总次数与该期刊前两年发表文章的总数之比。
例如，计算某期刊 2019 年的影响因子，需要统计 2017 年和 2018 年发表的文章在 2019 年被引用的次数，然后除以 2017 年和 2018 年的文章总数。
3.科学翻译医学的影响因子排名根据我国最新的学术期刊影响因子排名，科学翻译医学在我国生物医学领域具有较高的影响力，其影响因子排名位居前列。
这表明该期刊发表的文章具有较高的学术价值和实用价值，受到了国内外同行的广泛关注和认可。
4.科学翻译医学的影响因子与学术地位的关系影响因子是衡量学术期刊影响力的一个重要指标，但并非唯一的标准。
学术地位的评价还涉及到其他方面的因素，如学术声誉、编辑质量、作者群体等。
然而，影响因子在很大程度上反映了一个期刊的学术地位。
科学翻译医学较高的影响因子表明其在学术界具有较高的地位和声望。
5.科学翻译医学的影响因子对科研人员的意义科学翻译医学的影响因子对科研人员具有重要的参考价值。
首先，高影响因子表明该期刊发表的文章具有较高的学术价值，科研人员可以从中获取最新的研究动态和科研成果。
science translational medicine介绍
science translational medicine介绍
Science Translational Medicine 是一份同行评审的科学期刊，由美国科学家出版，主要刊登将基础研究成果转化为临床应用的科学论文。
该期刊于2009年创刊，每周出版一期。
其宗旨是
推动基础科学研究与临床医学之间的桥梁，加速科学发现在疾病诊断、治疗和预防领域的转化。
Science Translational Medicine 发表的论文涵盖了各个研究领域，包括生物学、生物化学、生理学、药理学、临床医学等。
这些论文通常介绍了新的疗法、技术、药物、诊断工具，以及疾病机制的新认识等。
期刊的编辑团队由经验丰富的科学家和医生组成，以确保发表的文章具有高质量和科学可信度。
Science Translational Medicine 推崇跨学科合作和应用导向研究，并鼓励作者在论文中提供实验数据、临床试验结果和相关的数据分析，以使读者能够更好地理解研究的重要性和潜在的临床应用。
该期刊还注重社会影响和伦理问题，对于涉及人类和动物实验的研究，作者需提供相应的伦理批准和知情同意的文件。
Science Translational Medicine 的文章具有高影响力和引用率，被广泛阅读和引用。
它为研究人员、临床医生和生物制药行业提供了一个宝贵的资源，促进了研究和应用之间的互动和合作。
(最新至2013.10)纳米技术与生物学交叉领域研究进展(中文简报)
目录1. 亮点研究揭示纳米技术助力人类疾病研究 (2)2. ACS Nano：美科学家研发出新的抗癌技术 (12)3. Biomaterials：科学家发现纳米金棒抗癌分子表型 (15)4. Science Translational Medicine:纳米涂层能将移植物与骨结合 (17)5. Nature Communications：新技术可引导两种不同胶体自动组装 (19)7. Nano Lett.：借助纳米材料控制雄性动物避孕新法 (22)8. Scientific Reports：DNA纳米材料研究新进展 (24)9. Science：DNA纳米技术新进展 (26)10. Small ：DNA可控自组装贵金属纳米结构研究获进展 (28)11. Nanoscale：MRI造影剂材料研究获进展 (31)12. Nat Nano：科学家研发药物降低醉酒小鼠血液酒精浓度 (33)13. ACIE：稀土掺杂无序结构晶体材料光物理研究获进展 (34)14. Nano Lett.:科学家利用电子显微镜首次拍到DNA照片 (36)15. ACS Nano：一种新颖的多任务模式可调式等离子体纳米泡 (38)16. Nanomedicine：利用纳米颗粒开发出新的膀胱癌药物运送系统 (41)17. ACS Nano：自组装纳米丝加强药物运送能力 (42)18. Angew Chem：首次开发出自组装的纳米颗粒进行抗肿瘤的热化疗 (45)19. Nat Methods：利用磁性纳米颗粒同时控制上千个细胞 (46)20. Adv Mater：纳米颗粒形状在基因疗法中发挥着重要作用 (49)21. PNAS：利用硅片计算工具揭示纳米颗粒抑制胰腺癌转移机制 (51)22. ACS Nano：开发出快速检测疾病发生的DNA纳米探针技术 (53)23. Materials Today：一种保护医疗器械生物功效的纳米涂层新技术 (54)24. PNAS：纳米颗粒提高药物疗效 (56)25. Nat Med：利用纳米颗粒开发出治疗深层癌症的光动力疗法 (58)26. PNAS:研究开发出混合纳米纤维生物材料 (60)27. Sci Rep:金纳米粒子对果蝇代谢信号通路的调控作用 (63)28. JACS：一种聚合物纳米膜或可替代蛋白质水化膜 (65)29. Small：日开发出伸缩自如柔软胶囊 (66)30. Plant Cell：林金星等在拟南芥中发现脂筏蛋白介导胞吞的新途径 (68)31. PNAS：邱志刚等发现纳米材料可促进耐药基因在细菌之间转移 (70)32. ENVIRON SCI TECHNOL：纳米粒可能增加植物DNA损伤 (72)33. ACS Nano：纳米注射器递送靶向治疗脑癌的化合物 (75)34. Biomaterials：纳米泡加化疗等于靶向单个癌细胞 (76)35. Sci Transl Med：纳米微粒投药可明显改善化疗效果 (78)36. JACS ：新催化剂——更价廉、更绿色的药物 (81)37. J Am Chem Soc:金纳米粒--开启免疫系统的钥匙 (83)38. Nanoscale：纳米―森林‖可将光和水转化为氢燃料 (85)39. Nano. Lett：纳米技术或可控制蛋白性质 (87)40. Nano Lett.：德发明新方法无需标记即可检测蛋白分子 (88)（最新至2013.10）纳米技术与生物学交叉领域研究进展（中文简报）1. 亮点研究揭示纳米技术助力人类疾病研究2013-9-30 0:15:20关键词：纳米颗粒HIV 癌症药物运输电子皮肤纳米技术（Nanotechnology）也称毫微技术，是研究结构尺寸在1纳米至100纳米范围内材料的性质和应用的一种技术。
医学核心期刊目录2020
医学核心期刊目录2020引言医学核心期刊是指在医学领域具有重要影响力和学术价值的期刊，被广泛认可和引用。
医学核心期刊向医学专业人士提供了最新的科研成果和学术论文，对医学研究和临床实践具有重要意义。
本文将介绍2020年医学核心期刊目录，并对其中一些具有代表性的期刊进行简要介绍。
2020年医学核心期刊目录以下是2020年医学核心期刊目录的一些代表性期刊：1.New England Journal of Medicine（NEJM）2.The Lancet3.JAMA - Journal of the American Medical Association4.British Medical Journal（BMJ）5.Nature Medicine6.Cell7.Science Translational Medicine8.PLoS Medicine9.Clinical Cancer Research10.Circulation11.Diabetes Care12.Neurology13.Journal of Clinical Oncology14.Annals of Internal Medicine15.American Journal of Respiratory and Critical Care Medicine代表性期刊简介1. New England Journal of Medicine（NEJM）New England Journal of Medicine（NEJM）成立于1812年，是医学领域最古老和最具影响力的期刊之一。
NEJM发表了许多临床研究、基础医学研究和公共卫生研究的重要成果。
它涵盖了各个医学领域，包括内科、外科、儿科、神经科学等。
NEJM的审稿严格，质量高，被广泛认可和引用。
2. The LancetThe Lancet成立于1823年，是一本国际性医学期刊，涵盖了各个医学领域。
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science translational medicine介绍
摘要：
一、科学转化医学的定义与背景
二、科学转化医学的主要研究领域
三、科学转化医学在我国的发展现状
四、科学转化医学的意义及挑战
五、结论
正文：
科学转化医学是一门将基础科学研究成果应用于临床实践，以解决实际医疗问题的学科。
它旨在促进基础研究与临床医学之间的沟通与协作，为患者提供更有效的治疗手段。
近年来，随着科学技术的飞速发展，科学转化医学逐渐成为医学研究的重要方向。
科学转化医学的主要研究领域包括基因编辑、生物材料、药物研发、疾病模型等。
其中，基因编辑技术如CRISPR-Cas9 系统为遗传病治疗带来了新希望；生物材料研究为组织修复与再生提供了支持；药物研发领域的个体化治疗和精准医疗逐渐成为现实。
在我国，科学转化医学得到了政府和企业的大力支持，发展迅速。
近年来，我国在基因编辑、肿瘤免疫治疗等领域取得了一系列突破性成果，为全球医学发展做出了贡献。
然而，我国科学转化医学仍面临许多挑战，如基础研究水平有待提高、临床试验体系亟待完善等。
总之，科学转化医学为提高人类健康水平提供了重要支撑。