Dependence of 50- and 100-keV Bremsstrahlung on Target Thickness, Atomic Numberand Geometric Factors
DNA的复制课件-2023-2024学年高一下学期生物人教版(2019)必修2

C.这M个子代T₂噬菌体中,含32P的T₂噬菌体所占的比例为1/M
有2个,故其所占的比例为2/M,C 错误。培养足够长的时间,会出现 不含32P而含35S的T₂噬菌体,但一般不会出现含32P的大肠杆菌,D 错 误。
3 、在一个密闭的容器里,用含有同位素13C的脱氧核苷酸合成一个 DNA分子,然后加入普通的含12C的脱氧核苷酸,经n次复制后,所得DNA 分子中含¹2C的脱氧核苷酸链数与含13C的脱氧核苷酸链数之比是
特点 半保留复制;边解旋边复制;多起点复制;双向复制
结果 子链与母链结合,构成两个相同的新的DNA分子
意义 保持了遗传信息的连续性
总结规律
规律1:若 一 个DNA 复制n次。
1.在子代中共形成 2n 个DNA, 其中含有亲代
DNA链的DNA分子数 2 0 2.含有亲代DNA链的DNA分子数占DNA分子总
D . 含 1 0 0 个 碱 基 对 ( 其 中 胞 嘧 啶 6 0 个 ) 的 DNA复 制 3 次 共 需 要 2 8 0 个
2、用 DNA双链均被32P标记的一个T,噬菌体侵染被35S标记的大肠杆菌, 一段时间后释放出出了M个子代T₂噬菌体。下列有关叙述正确的是
()
A.用32P标记T₂噬菌体的方法与用35S标记大肠杆菌的方法相同
It has not eseaped our notice that the specife pairing we have postulated immediately guggests a p⁰ssible copying mechanism for the genetic materiaI.
Full details of the structure,including the conditions assumed in building it,together with a set of co-ordinatos for the atoms,will be published elsewhere.
中国MSM艾滋病流行情况与高危行为及干预措施

中国MSM艾滋病流行情况与高危行为及干预措施发布时间:2021-04-23T02:38:54.063Z 来源:《医药前沿》2020年35期作者:张谊[导读] 本文将对我国MSM的艾滋病流行情况、高危行为特别是重叠高危行为的发生、社会对MSM人群的态度、国家和社会团体对MSM人群所进行的干预等方面进行综述,为MSM人群艾滋病防治策略的制定提供科学依据。
(龙州县疾病预防控制中心广西龙州 532400)【摘要】随着性传播代替血液传播成为艾滋病的主要传播方式,男男性接触人群(men who have sex with men,MSM)逐渐成为艾滋病传播的桥梁人群,其突出的隐蔽性、流动性特征以及多发的重叠高危行为对艾滋病的传播起到了促进作用,且由于大部分群众对MSM人群的不接纳甚至歧视导致了MSM人群不能很好地接受艾滋病防治教育和相关措施的干预。
本文将对我国MSM的艾滋病流行情况、高危行为特别是重叠高危行为的发生、社会对MSM人群的态度、国家和社会团体对MSM人群所进行的干预等方面进行综述,为MSM人群艾滋病防治策略的制定提供科学依据。
【关键词】男男性接触人群;艾滋病;流行;高危行为【中图分类号】R512.91 【文献标识码】A 【文章编号】2095-1752(2020)35-0005-03HIV prevalence trends,risky behaviours and intervention measures among men who have sex with men in ChinaZhang YiLongzhou county Center for Disease Prevention and Control,Longzhou, Guangxi,532400,China【Abstract】With the spread of sexually transmitted instead of blood as the main mode of transmission of HIV/AIDS,the MSM becoming the spread of HIV/AIDS bridge population.It has played a catalytic role in the spread of HIV/AIDS because of the features of the concealment,the mobility and the overlapping risk behaviors.HIV/AIDS education and related intervention measures cannot be taken among the MSM as most of the people were not accepted even discriminated the population.This paper aims to reviews the overall epidemic trend,social attitudes towards MSM population and associated high-risk behaviours among Chinese MSM and to investigate the governmental and community responses to the epidemic.It will provide a scientific basis for HIV/AIDS prevention and control of strategy formulation.【Key words】Men who have sex with men,MSM; HIV/AIDS; Prevalent; Risky behaviours引言艾滋病是一种由HIV引起的,以免疫系统损害为主要特征的一组综合征。
2018考研英语拓展阅读:“超级基因”将使人类不患病

拓展阅读:超级基因将使人类不患病The study of nearly 600,000 people found 13 who should have developed debilitating diseases, but did not.The hope is discovering what, against the odds, keeps them healthy and if that could lead to new therapies.Experts said the approach, published in Nature Biotechnology, was "fascinating" but that it was still early days.Errors in our code of life - our DNA - can cause disease.Large numbers of studies have tried to understand these mutations by looking at people who become ill.But the international team of researchers tried the opposite approach - searching for people harbouring damaging mutations but who remain healthy."Millions of years of evolution have produced far more protective mechanisms than we currently understand," said Dr Eric Schadt from the Icahn School of Medicine at Mount Sinai Hospital in New York.He added: "Most genomic studies focus on finding the cause of a disease, but we see tremendous opportunity in figuring out what keeps people healthy."The researchers scoured DNA databases containing information on 589,306 people.They found 13 healthy people who should have developed one of eight genetic diseases: cystic fibrosis, Smith-Lemli-Opitz syndrome, familial dysautonomia, epidermolysis bullosa simplex, Pfeiffer syndrome, autoimmune polyendocrinopathy syndrome, acampomelic campomelic dysplasia and atelosteogenesis.The report said the diseases were so severe that it was "highly unlikely that such an individual would have manifested the disease without it being clearly annotated in their health records".Prof Stephen Friend, from the Icahn School of Medicine, said: "Finding these individuals is a starting point to searching for the other changes, eg in the genome, that might give us clues to develop therapies."Study the healthy, don’t just study the sick."However, this is where the tantalising story ends. The scientists were unable to go out and find the lucky 13 because of the consent rules signed when their DNA sample was taken.It means they do not know what is protecting them against disease.It also leaves the team unable to prove that errors in testing, bad record keeping or mosaicism - in which the genetic defect affects only some cells in the body - are not behind their findings."Because of the inability to confirm the source or validity of the variants and the inability to recontact the individuals, this paper does not constitute a proof of principle," Dr Ada Hamosh, from Johns Hopkins University, argued.And while Dr Scott Hebbring, from the University of Wisconsin, described the study as "fascinating" he also cautioned that diseases can present very differently even between patients that have same mutations.Some may have few symptoms at all.在这项基于60万人的医学研究中,科学家发现有13人本应该患有衰弱性疾病,但是却并没有任何迹象显示他们曾有过类似病史。
关于抗老基金的英语作文

关于抗老基金的英语作文Here is an essay on the topic of an anti-aging fund, with the content written in English and the word count exceeding 1000 words.The Significance of an Anti-Aging Fund: Investing in a Healthier FutureAs we navigate the ever-evolving landscape of modern life, the concept of aging has become a multifaceted challenge that extends far beyond the physical realm. The relentless march of time not only takes a toll on our bodies but also impacts our emotional well-being, financial security, and societal integration. In this context, the establishment of an anti-aging fund emerges as a strategic and visionary approach to addressing the complexities of growing older.At the heart of the anti-aging fund lies a fundamental recognition that aging is not merely a natural process to be passively endured, but a dynamic challenge that can be proactively managed. By channeling resources into research, development, and the implementation of innovative solutions, this fund aims to redefine the very nature of aging, transforming it from a burden to an opportunity for enhanced longevity, vitality, and quality of life.One of the primary objectives of the anti-aging fund is to drive advancements in medical and scientific fields that hold the potential to delay the onset of age-related diseases and disabilities. Through targeted investments in cutting-edge technologies, groundbreaking therapies, and comprehensive preventative measures, the fund seeks to empower individuals to maintain their physical and cognitive capacities for longer periods. This not only enhances personal well-being but also has far-reaching societal implications, as a healthier and more productive aging population can contribute to economic growth, reduce the strain on healthcare systems, and foster a more inclusive and dynamic social fabric.Moreover, the anti-aging fund recognizes the importance of addressing the emotional and psychological aspects of growing older. As individuals navigate the transitions and challenges associated with aging, the fund aims to support the development of innovative programs and resources that promote mental health, social engagement, and personal fulfillment. By investing in initiatives that foster resilience, foster intergenerational connections, and cultivate a sense of purpose, the fund can help mitigate the isolation, anxiety, and depression that often accompany the aging process.In the realm of financial security, the anti-aging fund plays a crucialrole in ensuring that individuals can maintain their economic well-being as they age. Through strategic investments in retirement planning, long-term care solutions, and innovative financial products, the fund can help individuals and families plan for a future that is both financially stable and aligned with their evolving needs and aspirations. By addressing the complex interplay between physical, emotional, and financial well-being, the anti-aging fund can empower individuals to approach the later stages of life with confidence and a sense of control.Importantly, the anti-aging fund also recognizes the need for a holistic and inclusive approach to aging. By investing in the development of age-friendly communities, accessible infrastructure, and inclusive social policies, the fund can contribute to the creation of environments that support the diverse needs and experiences of individuals across the aging spectrum. This includes addressing the unique challenges faced by marginalized populations, such as individuals with disabilities, low-income communities, and underrepresented minority groups, ensuring that the benefits of the anti-aging initiatives are equitably distributed.Furthermore, the anti-aging fund can play a pivotal role in shaping the narrative around aging, challenging the prevailing societal perceptions that often cast older adults as burdens or liabilities. By investing in public awareness campaigns, educational programs, andadvocacy efforts, the fund can help reframe aging as a positive and empowering experience, one that is characterized by wisdom, resilience, and the opportunity for continued growth and contribution.In conclusion, the establishment of an anti-aging fund represents a bold and visionary step towards a future where the challenges of growing older are met with innovative solutions, compassionate support, and a renewed sense of purpose. By investing in cutting-edge research, holistic well-being programs, and inclusive social policies, this fund has the potential to transform the very nature of aging, empowering individuals to live longer, healthier, and more fulfilling lives. As we navigate the complexities of the 21st century, the anti-aging fund stands as a testament to our collective commitment to creating a world where the golden years truly shine.。
科学家在研发有一天会保护公众对抗流感的治疗方法

Scientists Develop Therapy That Someday Might Protect Public Against Flu PandemicsJessica BermanMay 29, 2013Researchers have developed a gene therapy against pandemic influenza in laboratory animals, one that stops infection at the point of entry - the nose. The therapy could potentially thwart the most aggressive viral pathogens, saving the lives of an estimated 500,000 people who die worldwide each year from the flu.The genetic therapy developed by researchers at the University of Pennsylvania expresses so-called broadly neutralizing antibodies, giving lab mice and ferrets almost complete protection against a number of lethal avian influenza strains, including those isolated from the deadly 1918 and 2009 pandemics.Unlike conventional vaccines whic h stimulate the body’s natural immune system to fight an infection, broadly neutralizing antibodies halt a virus’s biological activity so it cannot make people sick by infecting cells in the first place. The antibodies can become effective in two to three days.The head of the University of Pennsylvania's Gene Therapy Program, James Wilson, says scientists created a nasal spray to introduce protective genes.“And create what I call a "bioshield" around the nose and the mouth to prevent the influenza viru s from replicating,” Wilson said.The genes, which engineer the tissue to produce protective antibodies, were delivered by a harmless cold virus in the nasal spray.The therapy uses a single gene that produces antibodies against many different flu strains, hence the term, "broadly neutralizing antibodies." Wilson says this broad-based strategy protected all mice exposed to lethal amounts of three strains of H5N1 and two strains of H1N1.But the microbes replicated or reproduced rapidly in untreated rodents. The nasal spray was also successfully tested in ferrets, a good model for human flu because the tiny, furry animals cough and sneeze when sick.Conventional vaccines to protect against seasonal influenza are not 100 percent effective in preventing illness. The viral strains mutate rapidly, so there is little or no immune-system protection stimulated by the previous year’s flu shot, and the pathogens can evade experts' predictions of what virus is likely to be in circulation during the coming flu season.Wilson says a different approach to flu protection is needed. Researchers are currently in discussions with U.S. drug regulators about quickly testing the therapy in humans using a safe flu strain. According to Wilson, they are aiming to manufacture and stockpile the drug in anticipation of a serious influenza pandemic.“So then there is a pretty direct path into first, in human safety and then efficacy studies, which we have charted out. And with the right resources, we could move very quickly on t hat,” Wilson said.Wilson says the U.S. government has also expressed an interest in using the broadly neutralizing antibody approach to protect against bioweapons, such as anthrax and other toxic agents.An article on the development of a gene therapy against pandemic influenza is published in Science Translational Medicine .。
科普书的英文作文怎么写

科普书的英文作文怎么写Science is amazing. It helps us understand the world around us and unravel the mysteries of the universe. From the tiniest particles to the vastness of space, science is constantly expanding our knowledge. It's like a never-ending adventure that keeps us curious and excited.Have you ever wondered how the Earth was formed? Well, billions of years ago, a cloud of gas and dust collapsed under its own gravity and formed our planet. It'sincredible to think that we are made up of the same elements that were present at the birth of the universe. We are all stardust!Speaking of elements, did you know that there are over 100 different ones? They make up everything we see and touch. From the oxygen we breathe to the iron in our blood, elements are the building blocks of life. It's fascinating how they combine and interact to create the world as we know it.Let's talk about animals now. Did you know that some animals can regenerate their body parts? Take the starfish, for example. If it loses an arm, it can grow a new one.Isn't that incredible? Imagine if humans had that ability. We could regrow limbs and heal ourselves in a matter of weeks. Science is constantly studying these amazingabilities and trying to unlock their secrets.Now, let's dive into the world of medicine. Have you ever heard of antibiotics? They are powerful drugs that can kill bacteria and cure infections. Before their discovery, a simple cut could lead to a deadly infection. Thanks to science, we now have the means to fight off these harmful bacteria and save lives. It's truly a medical breakthrough.Speaking of breakthroughs, have you heard of the CRISPR gene-editing technology? It's like something out of a science fiction movie. Scientists can now edit genes and potentially cure genetic diseases. Imagine a world where we can eradicate diseases like cancer or Alzheimer's. It may seem like a distant dream, but science is making incredibleprogress every day.In conclusion, science is a never-ending journey of discovery. It's a way for us to understand the world and push the boundaries of what is possible. From the formation of our planet to the mysteries of the human body, science is always there, guiding us forward. So, let's embrace the wonders of science and continue to explore, learn, and be amazed.。
On the intrinsic limitation of the Rosenbluth method at large momentum transfer

a rXiv:h ep-ph/412216v115Dec24On the intrinsic limitation of the Rosenbluth method at large Q 2.E.Tomasi-Gustafsson DAPNIA/SPhN,CEA/Saclay,91191Gif-sur-Yvette Cedex,France ∗(Dated:February 2,2008)Abstract Correlations in the elastic electron proton scattering data show that the Rosenbluth method is not reliable for the extraction of the electric proton form factors at large momentum transfer,where the magnetic term dominates,due to the size and the ǫdependence of the radiative corrections.PACS numbers:25.30.Bf,13.40.-f,13.60.-Hb,13.88.+eThe determination of the elastic proton electromagnetic form factors(FFs)at large mo-mentum transfer is a very actual problem,due to the availability of electron beams in the GeV range,with high intensity and high polarization,large acceptance spectrometers, hadron polarized targets,hadron polarimeters.The possibility to extend the measurements of such fundamental quantities,which contain dynamical information on the nucleon struc-ture,inspired experimental programs at JLab,Frascati and at future machines,as GSI,both in the space-like and in the time-like regions.The traditional way to measure electromagnetic proton form factors consists in the de-termination of theǫdependence of the reduced elastic differential cross section,which can be written,assuming that the interaction occurs through the exchange of one-photon,as[1]:σred=ǫ(1+τ) 1+2Eα2cos2(θ/2)dσ•strong monotonical decreasing from polarization transfer measurements.R(Q2)==1−0.13(Q2[GeV2]−0.04).(2)The ratio deviates from unity,as Q2increasing,reaching a value of≃0.34at Q2≃5.5GeV2 [10].This puzzle has given rise to many speculations and different interpretations[11,12,13], suggesting expensive experiments.In particular,it has been suggested that the2γexchange could solve this discrepancy through its interference with the the main mechanism(the1γexchange).In a previous paper[14]it has been shown that the present data do not show any evidence of the presence of the2γmechanism,in the limit of the experimental errors.The main reason is that,if one takes into account C-invariance and crossing symmetry,the2γmechanism introduces a non linear,very specificǫdependence of the reduced cross section [15,16,17],whereas the data does not show any deviation from linearity.Before analyzing the data in a different perspective,we stress the following points:•No experimental bias has been found in both types of measurements,the experimental observables being the differential cross section on one side,and the polarization of the outgoing proton in the scattering plane(more precisely the ratio between the longitudinal and the transverse polarization),on the other side.•The discrepancy is not at the level of these observables:it has been shown that constraining the ratio R from polarization measurements and extracting G Mp from the measured cross section leads to a renormalization of2-3%with respect to the Rosenbluth data,well inside the error bars[10].•The inconsistency arises at the level of the slope of theǫdependence of the reduced cross section,which is directly related to G Ep,i.e.,the derivative of the differential cross section,with respect toǫ.The difference of such slope,derived from the two methods above,appears particularly in the last and precise data[6].One should note that the discrepancy appears in the ratio G E/G M,whereas G M,for example,decreases more than one order of magnitude from Q2=1to5GeV2.The starting point of this work is the observation of a correlation,which appears in the published FFs data extracted with the Rosenbluth method:the larger is G2E,the smallerFIG.1:Dependence of G2E/G2D versus G2M/µ2G2D:(a)for Q2≥2GeV2from Refs.[6](triangles), [7](stars)and[18](squares);(b)for Q2≤2GeV2from Refs.[19](circles),and[20](squares).G2M.This is especially visible in the most recent and precise experiments,at large Q2.The dependence of G2E/G2D versus G2M/µ2G2D is shown in Fig.1a for three recent data sets,at Q2≥2GeV2[6,7,18].In Fig.1b two data sets at low Q2(Q2≤2GeV2)are shown[19,20]. Whereas at low Q2,G2E/G2D seems constant and quite independent from G2M/µ2G2D,at large Q2an evident correlation appears.Polarization data show also a linearity of the ratio G E/G M,but with an opposite trend. In this case,the ratio is measured directly,whereas according to the Rosenbluth method, one extracts two(independent)parameters from a linearfit.A correlation between the two parameters could be induced by the procedure itself or could be a physical effect and have a dynamical origin.In the last case,it should not depend on the experiment.In order to analyze this question in a quantitative way we have done a statistical study of the Rosenbluth data for several experiments.First of all,at large Q2,the contribution of the electric term to the cross section becomes very small,as the magnetic part is amplified by the kinematical factorτ.This is illustrated in Fig.2,where the ratio of the electric part(F E=ǫG2Ep)to the reduced cross section isshown as a function of Q2.The different curves correspond to different values ofǫ,assuming FFs scaling or in the hypothesis of the linear dependence(2).In the second case,one can see that,for example,forǫ=0.2,the electric contribution becomes lower than3%starting from2GeV2.This number should be compared with the uncertainty on the cross section measurement.When this contribution is larger or is of the same order,the sensitivity of the measurement to the electric term is lost and the extraction of G Ep becomes meaningless.Secondly,since thefirst measurements[21],the electromagnetic probes are traditionally preferred to the hadronic beams,as the electromagnetic interaction is exactly calculable in QED,and one can safely extract the information from the hadronic vertex.However,one has to introduce the radiative corrections,which become very large as the momentum transfer squared,Q2,increases.Radiative corrections werefirstly calculated by Schwinger[22]and are important for the discussion of the experimental determination of the differential cross section.The measured elastic cross section,is corrected by a global factor C R,according to the prescription following[23]:(3)σred=C RσmeasredThe factor C R contains a largeǫdependence,and a smooth Q2dependence,and it is common for the electric and magnetic part.At the largest Q2considered here,this factor can reach 30-40%,getting larger when the resolution is higher.If one made a linear approximation for the uncorrected data,one might evenfind a negative slope starting from Q2≥3GeV2[14].In Fig.3we show the C R dependence onǫ,for different Q2and from different set of data.One can see that C R increases withǫ,arising very fast asǫ→1.It may be different in different experiments,because its calculation requires an integration on the experimental acceptance.The Rosenbluth separation consists in a linearfit of the reduced cross section atfixed Q2, where the two parameters are G2E and G2M.Multiplying by a common factor,which depends strongly onǫ,the electric and magnetic term in(2)may induce a correlation between these two parameters.In order to test this hypothesis,we have built the error matrix for the Rosenbluthfits for different sets of data available in literature.Atfixed Q2,the reduced cross section,normalized to G2D,has been parametrized by a linearǫdependence:σred/G2D=aǫ+b.The two parameters,a and b,have been determined for each set of data as well as their errorsσa,σb and the covariance,cov(a,b).The correlationFIG.2:Contribution of the G E dependent term to the reduced cross section(in percent)for ǫ=0.2(solid line),ǫ=0.5(dashed line),ǫ=0.8(dash-dotted line),in the hypothesis of FF scaling(thin lines)or following Eq.(2)(thick lines).coefficientξ,is defined asξ=cov(a,b)/σaσb and is shown in Fig.4as a function of the average of the radiative correction factor<C R>,weighted overǫ.As the radiative corrections become larger,the correlation between the two parametersFIG.3:Radiative correction factor applied to the data at Q2=3GeV2(squares)from Ref.[18], at Q2=4GeV2(triangles)and5GeV2(inverted triangles)from Ref.[5],and at Q2=0.32GeV2 from Ref.[20](circles).The lines are drawn to drive the eyes.becomes also larger,reaching values near its maximum(in absolute value).Full correlation means that the two parameters are related through a constraint,i.e.,it is possible tofind a one-parameter description of the data.This does not necessarily means that the reducedcross section becomesflat,as a function ofǫ,but that the slope is related to a kinematical effect,not to a dynamical one.The data shown here correspond to three sets of experiments,where the necessary infor-mation on the radiative corrections is available.The correlation coefficient can be calculated for a larger number of data and one could plot the correlation as a function of Q2.However, different experiments,at the same Q2,have been done at different angles and energy,i.e., at differentǫ,and the radiative corrections which enter in the determination of a and b are different.Such plot would be not easy to interprete.At low Q2a correlation still exists,but it is smaller.For the data from Ref.[20]the radiative corrections are of the order of15%,seldom exceed25%and correspond toǫ<0.8. This allows a more safe extraction of the FFs.Fig.4shows that,for each Q2,the extraction of FFs by a two parametersfit,may be biased by theǫdependence induced by the radiative corrections.Whatever the precision on the individual measurement is,the slope of the reduced cross section is not sensitive to G Ep at large Q2,which,therefore,can not be extracted from the data.The Q2dependence is therefore driven by G Mp,which follows a dipole form.For each Q2, a nonzero value of the ratio G Ep/G Mp will lead to an apparent dipole dependence of G Ep.To summarize,we reanalyzed the Rosenbluth data with particular attention to the radia-tive corrections applied to the measured cross section,and we showed,from the(published) data themselves that,at large Q2the contribution of G E to the cross section is so small that it can not be safely extracted.The method itself is biased,at large momentum transfer because the electric contribution to the measured cross section is in competition with the size of theǫdependent corrections.When plotting the reduced cross section as a function ofǫ,one,indeed,sees a nonzero slope,but it is due to theǫdependence contained in the radiative corrections,and it is no more primarily related to the inner structure of the proton.Therefore,the Rosenbluth method can not be used to extract the nucleon FFs at large momentum transfer,due to an intrinsic limitation deriving from the large size of the radia-tive corrections,compared to the electric contribution to the differential cross section,and especially to their steepǫdependence.In other words,there is a type of systematic error which becomes dominant and has never been included in the data,preventing the extrac-tion of G Ep.We confirm the conclusion of a previous paper[4],whichfirstly suggested the polarization method for the determination of G Ep,due to the increased sensitivity of theFIG.4:Correlation coefficient,ξ,as a function of the radiative correction factor<C R>,averaged overǫ,for different sets of data:from Ref.[20](circles),from Ref.[5](triangles)and from Ref.[18](squares).cross section to the magnetic term,at large Q2:’Thus,there exist a number of polarization experiments which are more effective for determining the proton charge form factor than isthe measurement of the differential cross section for unpolarized particles’.This work was inspired by stimulating discussions with M.P.Rekalo.Thanks are due to J.L.Charvet,G.I.Gakh and B.Tatischefffor useful suggestions and a careful reading of the manuscript.[1]M.N.Rosenbluth,Phys.Rev.79,615(1950).[2]M.K.Jones et al.[Jefferson Lab Hall A Collaboration],Phys.Rev.Lett.84,1398(2000).[3]O.Gayou et al.[Jefferson Lab Hall A Collaboration],Phys.Rev.Lett.88,092301(2002).[4] A.Akhiezer and M.P.Rekalo,Dokl.Akad.Nauk USSR,180,1081(1968);Sov.J.Part.Nucl.4,277(1974).[5]L.Andivahis et al.,Phys.Rev.D50,5491(1994).[6]I.A.Qattan et al.,arXiv:nucl-ex/0410010.[7]M.E.Christy et al.[E94110Collaboration],Phys.Rev.C70,015206(2004).[8]J.Arrington,Phys.Rev.C68,034325(2003).[9]R.G.Arnold et al.,Phys.Rev.Lett.35,776(1975).[10] E.J.Brash,A.Kozlov,S.Li and G.M.Huber,Phys.Rev.C65(2002)051001.[11]P.G.Blunden,W.Melnitchouk and J.A.Tjon,Phys.Rev.Lett.91,142304(2003).[12]P.A.M.Guichon and M.Vanderhaeghen,Phys.Rev.Lett.91,142303(2003).[13]Y.C.Chen,A.Afanasev,S.J.Brodsky,C.E.Carlson and M.Vanderhaeghen,Phys.Rev.Lett.93,122301(2004).[14] E.Tomasi-Gustafsson and G.I.Gakh,arXiv:hep-ph/0412137.[15]M.P.Rekalo and E.Tomasi-Gustafsson,Eur.Phys.J.A.22,331(2004).[16]M.P.Rekalo and E.Tomasi-Gustafsson,Nucl.Phys.A740,271(2004).[17]M.P.Rekalo and E.Tomasi-Gustafsson,Nucl.Phys.A742,322(2004).[18]R.C.Walker et al.,Phys.Rev.D49,5671(1994).[19]Ch.Berger,V.Burkert,G.Knop,ngenbeck and K.Rith Phys.Lett.b1,87(1971).[20]T.Janssens,R.Hofstadter,E.B.Hughes and M.R.Yerian,Phys.Rev.142,922(1966).[21]R.Hofstadter,F Bumiller and M.Yearian,Rev.Mod.Phys.30,482(1958).[22]J.S.Schwinger,Phys.Rev.76,790(1949).[23]L.W.Mo and Y.S.Tsai,Rev.Mod.Phys.41,205(1969).。
金转停Genistein金雀异黄素可抑制人乳腺癌细胞的生长

金转停Genistein金雀异黄素可抑制人乳腺癌细胞的生长作者:G 彼得森,S 巴恩斯摘要:已经检查了金雀异黄素对人乳腺癌细胞系MDA-468(雌激素受体阴性)以及MCF-7 和MCF-7-D-40(雌激素受体阳性)生长的影响。
金雀异黄素是每种细胞系生长的有效抑制剂(IC50 值为6.5 至12.0 μg/ml),而biochanin A 和大豆苷元是较弱的生长抑制剂(IC50 值为20 至34 μg/ml)。
金雀异黄素β-葡萄糖苷,genistin和daidzin,对生长几乎没有影响(IC50值大于100μg/ml)。
金雀异黄素不需要雌激素受体的存在来抑制肿瘤细胞生长(MDA-468 与MCF-7 细胞)。
此外,金雀异黄素和生物素A的作用不会因多重耐药基因产物(MCF-7-D40 与MCF-7 细胞)的过表达而减弱。
收起关键词:精胺色氨酸抗氧化剂电子喷射自由基年份:1991Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene作者:G Peterson,S Barnes摘要:The effect of isoflavones on the growth of the human breast carcinoma cell lines, MDA-468 (estrogen receptor negative), and MCF-7 and MCF-7-D-40 (estrogen receptor positive), has been examined.Genistein is a potent inhibitor of the growth of each cell line (IC50 values from 6.5 to 12.0 micrograms/ml), whereas biochanin A and daidzein are weaker growth inhibitors (IC50 values from 20 to 34 micrograms/ml). The isoflavone beta-glucosides, genistin and daidzin, have little effect on growth (IC50 values greater than 100 micrograms/ml). The presence of the estrogen receptor is not required for the isoflavones to inhibit tumor cell growth (MDA-468 vs MCF-7 cells). In addition, the effects of genistein and biochanin A are not attenuated by overexpression of the multi-drug resistance gene product (MCF-7-D40 vs MCF-7 cells).关键词:SPERMINE TRYPTOPHAN ANTIOXIDANT ELECTRON EJECTION FREE RADICALS年份:1991。
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JOURNAL OF APPLIED PHYSICS
H. W. Koch and J. W. Motz, Rev. Mod. Phys. 31, 920 (1959). S. T. Stephenson, in Handbuch der Physik., Vol. 30, p. 22. 3 H. A. Kramers, Phil. Mag. 46, 836 (1923). • P. Kirkpatrick and L. Wiedmann, Phys. Rev. 67, 321 (1945). 5A. Sommerfeld, Ann. Physik 11, 257 (1931). 6 M. J. Berger and S. Seltzer, to be published. Preliminary results were published in "Proceedings of the Second Symposium on Protection Against Radiations in Space," Gatlinburg, Tenn. (1964) .
I. INTRODUCTION
1"l.
ALTHOUGH a considerable amount of information is available on the bremsstrahlung process,1·2 accurate predictions on thick-target bremsstrahlung production are especially difficult to make in the low energy region where the initial electron kinetic energies are less than a few MeV. This difficulty arises in part from the uncertainties in the bremsstrahlung cross section in this energy region and in part from the complicated calculations required to account for multiple scattering effects in the target. Among the early theoretical thick-target bremsstrahlung studies in the low-energy region, below a few hundred keV, are the calculations by Kramers,3 and by Kirkpatrick and Wiedmann. 4 The Kramers calculations estimate the bremsstrahlung energy spectrum integrated over the photon direction, and are based on a nonrelativistic, semiclassical treatment, while the Kirkpatrick and Wiedmann calculations estimate the efficiency for the total bremsstrahlung production on the basis of the nonrelativistic Sommerfeld5 cross section. However, the calculations by Kramers and by Kirkpatrick and Wiedmann have the following limitations: (1) Electron scattering effects (including backscattering from targets) are neglected and therefore the results apply to the case where electrons lose energy in an infinite medium. (2) No corrections are given for the photon attenuation in the target. Because of these limitations, these calculations cannot be directly compared with experimental results which apply to the bremsstrahlung emitted from a target and which are critically dependent on geometric conditions of the measurement. On the other hand, Berger and Seltzer6 recently have
VOLUME 38, NUMBER 5
APRIL 7
Dependence of 50- and 100-keV Bremsstrahlung on Target Thickness, Atomic Number, and Geometric Factors
R. C. PLACIOUS National Bureau of Standards, Washington, D. C. (Received 28 November 1966; in final form 16 January 1967)
Experimental data have been obtained for the bremsstrahlung spectra produced with 50- and lOO-keV electrons incident on different targets. The spectrum per unit solid angle per incident electron is measured for photon emission angles of 30, 70, and llO deg, for normal and oblique incidence of the electrons on the targets having atomic numbers of 13, 50, and 79, and for four target thicknesses equal to different fractions of the electron range in the given material. Also, results are given for the bremsstrahlung production efficiencies per unit solid angle at a given emission angle. The experimental results at normal incidence show good agreement with the theoretical predictions of Berger and Seltzer, which are based on thin-target bremsstrahlung cross sections and which employ Monte Carlo calculations to account for multiple scattering and energy-loss effects. Similar calculations for other geometries should produce reliable estimates of the emitted bremsstrahlung spectra in this same energy region.
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1
2
carried out Monte Carlo calculations which predict the energy and angular distribution of the bremsstrahlung emitted from thick targets and which can be directly compared with experimental results. These calculations, which are based on the Bethe-Heitler7 cross section with an empirical correction factor discussed by Koch and Motz,1 account for energy loss and multiple elastic scattering of the electron and absorption and multiple Compton scattering of the photon in specific slab geometries. References are also available1 •2 on previous experimental low-energy thick-target bremsstrahlung production. Some of these works give data in terms of relative photon intensities8 while others give data in terms of absolute photon intensities9 per incident electron. Most of these papers make comparisons with the predictions of Kramers or Kirkpatrick and Wiedmann, which may not give accurate estimates for the case of targets with finite size. Therefore, the present measurements were undertaken in order to provide more experimental data on thick-target bremsstrahlung production in the low energy region, which can be directly compared to the calculations of Berger and Seltzer, without uncertain correction factors for geometry and photon attenuation. These measurements are made with initial electron kinetic energies of SO and 100 keV. For each electron energy, the photon energy spectrum per unit solid angle per incident electron is obtained as a function of the photon emission angle, the target thickness, and the target atomic number. Also, these spectra are integrated over the photon energies and estimates are made for the bremsstrahlung production efficiency per unit solid angle for a given photon emission angle and a given electron angle of incidence, as defined in Sec. III.2.