755nm翠绿宝石皮秒激光治疗太田痣-中英文

Treatment of Nevus of Ota With a Picosecond 755-nm Alexandrite Laser755nm翠绿宝石皮秒激光治疗太田痣Nevus of Ota, also known as nevus fusco-caeruleus ophthalmo-maxillaris, is a benign dermal melanocytic condition mostly seen as blue–gray patches on the faces of more darkly pigmented individuals, especially Asians, but it has been observed in all races.1太田痣，也被称为眼上腭部褐青色痣，是一种存在于真皮层的良性色素斑块，多发于有色人种，在面部呈现蓝灰色斑块，特别多发于亚洲人种，但可发生于所有肤色人种。

Lesions of nevus of Ota have historically been a difficult problem to treat, but lasers have shown positive results. Through selective photothermolysis, the advent of Q-switched (QS) lasers with pulse durations as short as 10 nanoseconds (ns) allowed precise targeting of the melanosomes with reduced collateral damage.2,3 The 10-ns pulse duration of the QS lasers is much shorter than the 50- to 250-ns thermal relaxation times of the 500- to 1,000-nm diameter dermal melanosomes.4 However, many patients plateaubefore their desired end point, and that end point requires a large number of treatments.4太田痣一直以来被认为是很难治愈的疾病，但是激光治疗却显示除了积极的结果。

通过选择性光热作用，脉宽可达10ns的Q开关激光的出现，可以更加精确的锁定黑色素细胞，降低对周围组织的损伤。

10ns脉宽的Q开关激光相比于500-1000nm直径的黑色素细胞50-250ns的热弛豫时间来说更短，然而许多病人在达到他们期望的结果前就到了停滞期，然后如果想达到他们期待的结果则需要更多次的治疗。

Picosecond lasers were first shown to be effective in tattoo removal by Ross and colleagues5 in the 1990s.A commercially available and FDA-approved 755-nm alexandrite (Cynosure, Westford, MA) version became available in 2012 for treatment of tattoos but has not been reported for use with Nevus of Ota.20世纪90年代Ross和同事们最早发现皮秒激光对祛除纹身有效，2012年赛诺秀开始销售经FDA认证的755nm翠绿宝石激光，用于去除文身，但当时报告并没有说可以用于治疗太田痣。

Objective 目的Because both tattoos and nevus of Ota share a pigmented chromophore in the dermis, the authors hypothesized that a picosecond 755-nm alexandrite laser might show improvement in nevus of Ota lesions that had plateaued or were otherwise minimally responsive to QS laser treatment, just as it had with recalcitrant tattoos.由于纹身和太田痣都是存在于真皮层的色素团，像治疗顽固的纹身一样，作者假设755nm翠绿宝石皮秒激光可以改善经过Q开关治疗且已达停滞期的这些太田痣患者，或者对Q开关激光治疗不起作用的这些患者。

The authors now report results of the novel use of a picosecond 755-nm alexandrite laser in 3 patients with nevus of Ota lesions recalcitrant to QS laser or no longer responding to treatment.作者找到3位太田痣患者，这3位患者已经对Q开关激光治疗方法不再有效果，对他们进行755nm翠绿宝石皮秒激光进行治疗。

Materials and Methods 材料和方法Over 12 months, 3 patients (2 female and 1 male; age,24, 32, 34 years) were selected from a university’s academic practice. All patients were of skin Type IV and had nevus of Ota lesions that had 4 to 10 or more previous QS laser treatments but did not respond or were no longer responding to such treatments.Previous QS lasers consisted of 694-nm ruby, 755-nm alexandrite, and 1,064-nm Nd:YAG.通过在一所大学的学术实践，经过12个月选出了三个患者（2女一男，年龄分别为24岁，32岁，34岁）。

所有的患者皮肤类型均为四类皮肤，且患有的太田痣在之前都经过4-10次或者更多次的Q开关激光的治疗，之前治疗的Q开关激光包括694nm波长的红宝石激光，755nm波长的翠绿宝石激光和1064nm Nd:YAG激光。

A 750-picosecond pulse duration 755-nm alexandrite laser (Cynosure) was used to treat all patients. All patients had their previous histories obtained, and informed consent was obtained. Compounded 7% lidocaine, 7% tetracaine ointment was applied topically 1 hour before all treatments.此次治疗采用的赛诺秀脉宽为750皮秒的755nm波长翠绿宝石激光对上述三位患者进行治疗。

所有患者都知悉其病史，并签署知情同意书。

每次治疗前一小时在患处涂7%利多卡因和7%丁卡因复合麻醉膏。

One 32-year-old female patient with a lesion on her right forehead, temple, malar cheek, buccal cheek, lower eyelid, and nasal sidewall (Figure 1) had a history of minimal response to more than 10 previous treatments with QS 755-nm alexandrite and QS 1,064-nm Nd:YAG, was spot tested at 1.59 to 2.08 J/cm2 (4 and 3.5mmspot sizes, respectively), and then treated initially with 2.08 J/cm2 to the superior temple. Eight weeks later, the treatment was repeated with the same settings (Figure 2).一名32岁女性患者在其右前额，太阳穴，颧骨处，下眼睑，鼻侧翼部位患有太田痣，（如图1）之前曾有过10次以上的755nm翠绿宝石Q开关激光和1064-nm Nd:YAG Q开关激光治疗史，治疗基本没有效果，最开始用4mm和3.5mm单光班进行测试，能量密度范围1.59-2.08 J/cm2，之后采用2.08 J/cm2的能量密度首先对太阳穴处进行治疗，8星期以后以相同的参数进行重复治疗（图2）A second female patient, 34 years old,with a lesion near her medial canthus had previously responded to QS treatments with the 694-nm ruby, 755-nm alexandrite, and 1,064-nm Nd:YAG lasers but was experiencing a response plateau. She was treated with a 3-mm spot size (2.83 J/cm2) on 3 occasions over a 6-month period, with modest improvement.第二位女性患者，34岁，在内眦处患有太田痣，之前对694nm红宝石Q开关激光治疗方法，755nm翠绿宝石Q开关激光法和1064-nm Nd:YAG Q开关激光疗法有反应，但之后进入了停滞期。

此次对其采用3mm直径光斑，能量密度2.83 J/cm2，对3处病变位置进行治疗，经过6个月的治疗，对之前的太田痣有中度的改善。