仿生物电刺激对卵巢储备功能下降患者的短期治疗作用

仿生物电刺激对卵巢储备功能下降患者的短期治疗作用

作者：李雅丹

来源：《中外医学研究》2019年第35期

【摘要】目的：評价仿生物电刺激治疗对卵巢储备功能下降患者的短期疗效。方法：选择笔者所在医院2018年1-12月83例卵巢储备功能下降患者作为研究对象，采用隐匿数字随机法分为两组，对照组41例采用雌孕激素序贯治疗;观察组42例采用仿生物电刺激治疗，监测治疗前后临床症状及体征评分、阴道彩色多普勒参数，以及血清雌二醇（E2）、卵泡刺激素（FSH）和促黄体生成素（LH），比较两组疗效。结果：观察组治疗后LH、FSH水平为（26.17±1.65）U/L、（43.25±3.69）mIU/ml，分别低于治疗前的（38.16±1.80）U/L、

（54.14±4.77）mIU/ml，差异有统计学意义（P<0.05）。观察组治疗后E2水平为

（43.82±7.90）pg/ml，与治疗前的（41.16±4.27）pg/ml比较，差异无统计学意义（P>0.05）。

对照组治疗后E2水平较治疗前明显升高，且高于观察组治疗后E2水平，差异有统计学意义（P<0.05）。两组治疗后LH、FSH水平差异无统计学意义（P>0.05）。观察组治疗后PI、OAV、AFCs分别为（1.90±0.31）、（5.06±0.62）cm3、（2.18±0.34）个，均高于治疗前的（1.42±0.32）、（4.29±0.51）cm3、（1.55±0.28）个，差异有统计学意义（P<0.05）。两组治疗后PI、OAV、AFCs差异无统计学意义（P>0.05）。结论：仿生物电刺激治疗卵巢储备功能下降短期可达到雌孕激素治疗相同的疗效，长期疗效有待进一步观察。

【关键词】仿生物电刺激卵巢储备功能下降短期疗效

[Abstract] Objective： To evaluate the short-term efficacy of bionic bioelectrical stimulation in patients with decreased ovarian reserve function. Method： A total of 83 cases with decreased ovarian reserve function in our hospital from January to December 2018 were selected as research objects. The patients were randomly divided into two groups by hidden number method. The control group received sequential treatment with estrogen and progesterone. In the observation group， 42 patients were treated with bionic bioelectric stimulation. Clinical symptoms and signs scores， vaginal color Doppler parameters and serum estradiol （E2）， follicle-stimulating hormone （FSH） and luteinizing hormone （LH） before and after treatment were monitored in the observation group. Result： The levels of LH and FSH in the observation group were （26.17±1.65） U/L and

（43.25±3.69） mIU/ml， lower than （38.16±1.80） U/L and （54.14±4.77） mIU/ml before treatment， respectively， with statistically significant differences （P<0.05）. E2 level in the observation group was （43.82±7.90） pg/ml after treatment， and （41.16±4.27） pg/ml before treatment， there was no statistically significant difference （P>0.05）. After treatment， E2 level in the control group was significantly higher than that before treatment， and higher than that after treatment in the observation group， with statistically significant difference （P<0.05）. There was no significant difference in LH and FSH levels between the two groups after treatment （P>0.05）. After treatment， the number of PI， OAV and AFCs in the observation group was （1.90±0.31），（5.06±0.62） cm3 and （2.18±0.34）， which were all higher than （1.42±0.32），

（4.29±0.51） cm3 and （1.55±0.28） before treatment， and the differences were statistically significant （P<0.05）. There were no significant differences in PI， OAV and AFCs between the two groups after treatment （P>0.05）. Conclusion： Bionic bioelectrical stimulation can achieve the same short-term efficacy as estrogen and progesterone therapy in the treatment of decreased ovarian reserve function， while the long-term efficacy remains to be further observed.

卵巢是女性性腺，作用是产生女性激素和成熟卵细胞，并在维持女性月经、生育力和生殖生理等内分泌功能方面发挥重要作用[1-2]。受多种因素的影响，部分育龄女性会出现卵巢抑制素生成减少，卵巢储备功能下降，卵子质量的降低或窦卵泡数量减少，表现为月经稀少、紊乱、闭经及不孕，如不积极治疗在自然绝经前卵子耗竭导致卵巢早衰而失去治疗的机会[3-4]。目前临床对于卵巢储备功能下降的干预手段主要是激素替代疗法，可迅速改善性激素水平和临床症状，但副反应也十分明显，即长期应用可能会导致心血管事件及肝肾功能异常，而且还会