1,3-Dihydro-α-methyl-1-methylene-3-oxo-2H-isoindole-2-acetic_acid_DataSheet_MedChemExpress
地法替尼结构式
地法替尼结构式
地法替尼（Difertini）是一种口服的小分子靶向药物，属于酪氨酸激酶抑制剂的一种。
它的主要作用是抑制表皮生长因子受体（EGFR）和人类表皮生长因子受体2（HER2）的信号通路，从而抑制肿瘤细胞的生长和增殖。
地法替尼的结构式中包含了一个苯环和一个吡啶环，通过一个亚甲基（-CH2-）相连。
在苯环上有一个硝基（-NO2）和一个甲氧基（-OCH3）取代基，而吡啶环上则有一个氯原子（-Cl）和一个甲酰胺基（-CONH2）取代基。
这种结构式赋予了地法替尼特定的化学性质和药理学活性。
其中，苯环和吡啶环是该药物分子的核心结构，它们通过共轭体系相互作用，对药物的溶解度、亲脂性和生物利用度等产生影响。
硝基和甲氧基等取代基的存在可能会影响药物的药代动力学特性和生物活性。
地法替尼作为一种靶向药物，通过与EGFR 和HER2 受体的特定区域结合，阻断了它们的酪氨酸激酶活性，从而抑制了肿瘤细胞的增殖和转移。
这种作用机制使得地法替尼在治疗某些癌症类型方面具有潜在的应用价值。
需要注意的是，结构式只是描述药物分子的化学结构的一种方式，对于药物的药理学特性、临床应用和安全性等方面的了解还需要进一步的研究和临床试验。
在使用任何药物之前，都应该遵循医生的建议，并按照医嘱使用药物。
齐多夫定结构式
齐多夫定结构式一、齐多夫定基本信息齐多夫定（Zidovudine，AZT）是一种核苷类逆转录酶抑制剂，用于治疗艾滋病和某些癌症。
它是由美国制药公司开发，于1987年获美国食品药品监督管理局批准上市。
齐多夫定的化学名称为3'-叠氮-3'-脱氧胸腺嘧啶核苷，是一种白色结晶粉末，易溶于水。
二、化学结构式化学结构式为：化学式: C10H13N5O4分子量: 267.24结构式: 1-(3-叠氮-2,3-二脱氧-β-D-呋喃核糖基)-5-甲基嘧啶-2,4(1H,3H)-二酮三、合成路线齐多夫定的合成路线主要有两条：一条是以胸腺嘧啶为原料，经过还原、溴代、消除、氧化等步骤得到；另一条是以2',3'-二脱氧胸腺嘧啶核苷为原料，经过还原、溴代、消除、氧化等步骤得到。
具体合成过程较为复杂，涉及多步化学反应。
四、药理作用齐多夫定通过抑制逆转录酶活性，从而阻断病毒DNA的合成。
具体来说，它能够与逆转录酶结合，抑制酶的活性，从而阻止病毒DNA链的延长。
此外，齐多夫定还能掺入病毒DNA，阻止病毒DNA的复制。
五、药物代谢齐多夫定口服后易吸收，血药浓度达峰时间为0.5-1.5小时。
主要分布在细胞外液，易透过胎盘屏障。
在体内代谢为5'-单磷酸酯和3'-叠氮-5'-腺苷酸。
主要通过肾脏排泄，约40%-50%以原形排出，其余为代谢产物。
消除半衰期为1.1-1.9小时。
六、临床应用齐多夫定主要用于治疗艾滋病和某些癌症，如急性淋巴细胞性白血病等。
在艾滋病的治疗中，齐多夫定常与其他抗逆转录病毒药物联合使用，以抑制HIV 病毒的复制。
在某些癌症治疗中，齐多夫定可作为辅助治疗手段，与其他化疗药物联合使用。
七、不良反应齐多夫定的不良反应主要包括骨髓抑制、胃肠道反应、过敏反应等。
骨髓抑制表现为贫血、白细胞减少和血小板减少等。
胃肠道反应包括恶心、呕吐、腹泻等。
过敏反应表现为皮疹、荨麻疹等。
染发剂中非法添加色素名单(2010欧盟委员会)
List of 179 substances banned for use in hair dye products(Updated: February 2010)Ref. No.Annex IIto CDChemical Name / INCI - Name CAS No.289 Leadacetate 301-04-2 363 o-Phenylenediamine 95-54-5 364 2,4-Diaminotoluene 95-80-7 376 1-Methoxy-2,4-diaminobenzen 615-05-4 377 1-Methoxy-2,5-diaminobenzene 5307-02-8 380 Basic Violet 3 548-62-9383 2-Amino-4-nitrophenol 99-57-0 384 2-Amino-5-nitrophenol 121-88-0 386 CI42640 1694-09-3 387 Acid Yellow 36 587-98-4388 Basic Violet 1 8004-87-3398 CI 45170, CI 45170:1 81-88-9; 509-34-2 406 4-Ethoxy-2,4-diaminobenzene 5862-77-1 407 1-beta-Hydroxyethyl-2,4-diaminobenzene 14572-93-1 408 Catechol 120-80-9 409 Pyrogallicacid 87-66-1 412 4-Amino-2-nitrophenol 119-34-6 413 1-Methyl-2,6-diaminobenzen 823-40-5 700 Disperse Blue 1 2475-45-81055 Disperse Yellow 3 2832-40-81188 Basic Green 4 569-64-21204 m-Phenylenediamine 108-45-2 1212 6-Methoxy-2,3-pyridinediamineHCl 94166-62-8 1213 2,3-Naphthalenediol 92-44-4 1214 2,4-Diaminodiphenylamine 136-17-4 1215 2,6-Bis(2-hydroxyethoxy)-3,5-pyridinediamineHCl 117907-42-3 1216 2-Methoxymethyl-p-aminophenol HCl 29785-47-5 (HCl) 1217 4,5-Diamino-1-methylpyrazole HCl; sulfate 21616-59-1 HCl 1218 4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate 163183-00-4 1219 4-Chloro-2-aminophenol 95-85-2 1220 4-Hydroxyindole 2380-94-1 1221 4-Methoxytoluene-2,5-diamineHCl 56496-88-9 1222 5-Amino-4-fluoro-2-methylphenolsulfate 163183-01-5 1223 N,N-Diethylm-aminophenol 91-68-9 1224 N,N-Dimethyl-2,6-pyridinediamineHCl -1225 N-cyclopentyl-m-aminophenol 104903-49-3 1226 N-Methoxyethyl-p-phenylenediamineHCl 72584-59-9 1227 2,4-Diamino-5-methylphenetolHCl 113715-25-6 1228 1,7-Naphthalenediol 575-38-2 1229 3,4-Diaminobenzoicacid 619-05-61230 2-Aminomethyl-p-aminophenolHCL 135043-65-1; 79352-72-01231 SolventRed1 1229-55-61232 Acid Orange 24 1320-07-61233 Acid Red 73 5413-75-21234 PEG-3,2′,2′-di-p-Phenylenediamine 144644-13-3 1235 6-Nitro-o-Toluidine 570-24-11236 HC Yellow No 11 73388-54-21237 HC Orange No 3 81612-54-6 1238 HC Green No 1 52136-25-11239 HC Red No 8 and its salts 97404-14-3; 13556-29-11240 Tetrahydro-6-nitroquinoxaline and its salts 158006-54-3; 41959-35-71241 Disperse Red 15, except as impurity in Disperse Violet 1 116-85-81242 4-amino-3-fluorophenol 399-95-1 1244 1-Methyl-2,4,5-trihydroxybenzene and its salts 1124-09-0 1245 2,6-Dihydroxy-4-methylpyridine and its salts 4664-16-8 1246 5-Hydroxy-1,4-benzodioxane and its salts 10288-36-5 1247 3,4-Methylenedioxyphenol and its salts 533-31-31248 3,4-Methylenedioxyaniline and its salts 14268-66-7 1249 Hydroxypyridinone and its salts 822-89-91250 3-Nitro-4-aminophenoxyethanol and its salts 50982-74-6 1251 2-methoxy-4-nitrophenol (4-Nitroguaiacol) and its salts 3251-56-7 1252 C.I. Acid Black 131 and its salts 12219-01-1 1253 1,3,5-Trihydroxybenzene (Phloroglucinol) and its salts 108-73-61254 1,2,4-Benzenetriacetate and its salts 613-03-61255 Ethanol, 2,2'-iminobis-, reaction products with epichlorohydrinand 2-nitro-1,4-benzenediamine (HC Blue No. 5) and its salts68478-64-8;158571-58-51256 N-Methyl-1,4-diaminoanthraquinone, reaction products withepichlorohydrin and monoethanolamine (HC Blue No. 4) andits salts158571-57-41257 4-Aminobenzenesulfonic acid and its salts 121-57-31258 3,3'-(Sulfonylbis(2-nitro-4,1-phenylene)imino)bis(6-(phenylamino)) benzenesulfonic acid and its salts1259 3(or5)-((4-(Benzylmethylamino)phenyl)azo)-1,2-(or1,4)-dimethyl-1H-1,2,4-triazolium and its salts1260 2,2'-((3-Chloro-4-((2,6-dichloro-4-nitrophenyl)azo)phenyl)imino)bisethanol (Disperse Brown 1)and its salts23355-64-81261 Benzothiazolium, 2-[[4-[ethyl(2-hydroxyethyl)amino]phenyl]azo]-6-methoxy-3-methyl- and its salts1262 2-[(4-Chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutanamide (Pigment Yellow 73) and its salts13515-40-71263 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenylbutanamide] (Pigment Yellow 12) and its salts6358-85-61264 2,2'-(1,2-Ethenediyl)bis[5-((4-ethoxyphenyl)azo]benzenesulfonic acid) and its salts1265 2,3-Dihydro-2,2-dimethyl-6-[(4-(phenylazo)-1-naphthalenyl)azo]-1H-pyrimidine (Solvent Black 3) and itssalts4197-25-51266 3(or5)-[[4-[(7-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-1-naphthyl]azo]salicylic acid and its salts1267 2-Naphthalenesulfonic acid, 7-(benzoylamino)-4-hydroxy-3-[[4-[(4-sulfophenyl)azo]phenyl]azo]- and its salts1268 (µ-((7,7'-Iminobis(4-hydroxy-3-((2-hydroxy-5-(N-methylsulphamoyl)phenyl)azo)naphthalene-2-sulphonato))(6-)))dicuprate(2-) and its salts1269 3-[(4-(Acetylamino)phenyl)azo]-4-hydroxy-7-[[[[5-hydroxy-6-(phenylazo)-7-sulfo-2-naphthalenyl]amino]carbonyl]amino]-2-naphthalenesulfonic acid and its salts1270 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis(4-hydroxy-3-[[2-sulfo-4-[(4-sulfophenyl)azo]phenyl]azo]-, and itssalts25188-41-41271 Ethanaminium, N-(4-[bis[4-(diethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene)-N-ethyl- and its salts1272 3H-Indolium, 2-[[(4-methoxyphenyl)methylhydrazono]methyl]-1,3,3-trimethyl- and its salts1273 3H-Indolium, 2-(2-((2,4-dimethoxyphenyl)amino)ethenyl)-1,3,3-trimethyl- and its salts1274 Nigrosine spirit soluble (Solvent Black 5) 11099-03-9 1275 Phenoxazin-5-ium, 3,7-bis(diethylamino)-, and its salts 47367-75-9 1276 Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts1277 6-Amino-2-(2,4-dimethylphenyl)-1H-benz[de]isoquinoline-1,3(2H)-dione (Solvent Yellow 44) and its salts2478-20-81278 1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and itssalts12217-43-51279 Laccaic Acid (CI Natural Red 25 ) and its salts 60687-93-61280 Benzenesulfonic acid, 5-[(2,4-dinitrophenyl)amino]-2-(phenylamino)-, and its salts15347-52-11281 4-[(4-Nitrophenyl)azo]aniline (Disperse Orange 3) and its salts 730-40-5 1282 4-Nitro-m-phenylenediamine and its salts 5131-58-81283 1-Amino-4-(methylamino)-9,10-anthracenedione (DisperseViolet 4)and its salts1220-94-61284 N-Methyl-3-nitro-p-phenylenediamine and its salts 2973-21-91285 N1-(2-Hydroxyethyl)-4-nitro-o-phenylenediamine (HC YellowNo. 5)and its salts56932-44-61286 N1-(Tris(hydroxymethyl))methyl-4-nitro-1,2-phenylenediamine(HC Yellow No. 3)and its salts56932-45-71287 2-Nitro-N-hydroxyethyl-p-anisidine and its salts 57524-53-51288 N,N'-Dimethyl-N-Hydroxyethyl-3-nitro-p-phenylenediamine andits salts10228-03-21289 3-(N-Methyl-N-(4-methylamino-3-nitrophenyl)amino)propane-1,2-diol and its salts93633-79-51290 4-Ethylamino-3-nitrobenzoic acid (N-Ethyl-3-Nitro PABA)andits salts2788-74-11291 (8-[(4-Amino-2-nitrophenyl)azo]-7-hydroxy-2-naphthyl)trimethylammonium and its salts, except Basic Red 118(CAS 71134-97-9) as impurity in Basic Brown 171292 5-((4-(Dimethylamino)phenyl)azo)-1,4-dimethyl-1H-1,2,4-triazolium and its salts1293 m-Phenylenediamine, 4-(phenylazo)-, and its salts 495-54-5 1294 1,3-Benzenediamine, 4-methyl-6-(phenylazo)- and its salts1295 2,7-Naphthalenedisulfonic acid, 5-(acetylamino)-4-hydroxy-3-((2-methylphenyl)azo)- and its salts1296 4,4'-[(4-Methyl-1,3-phenylene)bis(azo)]bis[6-methyl-1,3-benzenediamine] (Basic Brown 4)and its salts4482-25-11297 Benzenaminium, 3-[[4-[[diamino(phenylazo)phenyl]azo]-2-methylphenyl]azo]-N,N,N-trimethyl- and its salts1298 Benzenaminium, 3-[[4-[[diamino(phenylazo)phenyl]azo]-1-naphthalenyl]azo]-N,N,N-trimethyl- and its salts1299 Ethanaminium, N-[4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl- and its salts1300 9,10-Anthracenedione, 1-[(2-hydroxyethyl)amino]-4-(methylamino)- and its derivatives and salts86722-66-91301 1,4-Diamino-2-methoxy-9,10-anthracenedione (Disperse Red11)and its salts2872-48-21302 1,4-Dihydroxy-5,8-bis[(2-hydroxyethyl)amino]anthraquinone(Disperse Blue 7)and its salts3179-90-61303 1-[(3-Aminopropyl)amino]-4-(methylamino)anthraquinone and its salts1304 N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No. 8)and its salts66612-11-11305 [6-[[3-Chloro-4-(methylamino)phenyl]imino]-4-methyl-3-oxocyclohexa-1,4-dien-1-yl]urea (HC Red No. 9)and its salts56330-88-21306 Phenothiazin-5-ium, 3,7-bis(dimethylamino)- and its salts1307 4,6-Bis(2-Hydroxyethoxy)-m-Phenylenediamine and its salts1308 5-Amino-2,6-Dimethoxy-3-Hydroxypyridine and its salts 104333-03-1 1309 4,4'-Diaminodiphenylamine and its salts 537-65-5 1310 4-Diethylamino-o-toluidine and its salts 148-71-0 1311 N,N-Diethyl-p-phenylenediamine and its salts 93-05-0 1312 N,N-Dimethyl-p-phenylenediamine and its salts 99-98-9 1313 Toluene-3,4-Diamine and its salts 496-72-0 1314 2,4-Diamino-5-methylphenoxyethanol and its salts 141614-05-3 1315 6-Amino-o-cresol and its salts 17672-22-9 1316 Hydroxyethylaminomethyl-p-aminophenol and its salts 110952-46-0 1317 2-Amino-3-nitrophenol and its salts 603-85-01318 2-Chloro-5-nitro-N-hydroxyethyl-p-phenylenediamine and itssalts50610-28-11319 2-Nitro-p-phenylenediamine and its salts 5307-14-2 1320 Hydroxyethyl-2,6-dinitro-p-anisidine and its salts 122252-11-3 1321 6-Nitro-2,5-pyridinediamine and its salts 69825-83-8 1322 Phenazinium, 3,7-diamino-2,8-dimethyl-5-phenyl- and its salts1323 3-Hydroxy-4-[(2-hydroxynaphthyl)azo]-7-nitronaphthalene-1-sulphonic acid and its salts16279-54-21324 3-[(2-nitro-4-(trifluoromethyl)phenyl)amino]propane-1,2-diol(HC Yellow No. 6) and its salts104333-00-81325 2-[(4-chloro-2-nitrophenyl)amino]ethanol (HC Yellow No. 12)and its salts59320-13-71326 3-[[4-[(2-Hydroxyethyl)Methylamino]-2-Nitrophenyl]Amino]-1,2-Propanediol and its salts173994-75-71327 3-[[4-[Ethyl(2-Hydroxyethyl)Amino]-2-Nitrophenyl]Amino]-1,2-Propanediol and its salts114087-41-11328 Ethanaminium, N-[4-[[4-(diethylamino)phenyl][4-(ethylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl- and its salts1329 4-[(4-Aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-o-toluidine (CAS 3248-93-9; EINECS 221-832-2) and its hydrochloride salt (Basic Violet 14; CI 42510) (CAS 632-99-5; EINECS 211-189-6)1330 4-(2,4-Dihydroxyphenylazo)benzenesulphonic acid (CAS 2050-34-2; EINECS 218-087-0) and its sodium salt (Acid Orange 6; CI 14270) (CAS 547-57-9; EINECS 208-924-8)1331 3-Hydroxy-4-(phenylazo)-2-naphthoic acid (CAS 27757-79-5; EINECS 248-638-0) and its calcium salt (Pigment Red 64:1; CI 15800) (CAS 6371-76-2; EINECS 228-899-7)1332 2-(6-Hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid; Fluorescein (CAS 2321-07-5; EINECS 219-031-8) and its disodium salt (Acid yellow 73 sodium salt; CI 45350) (CAS 518-47-8; EINECS 208-253-0)1333 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one; 4',5'-Dibromofluorescein; (Solvent Red 72) (CAS 596-03-2; EINECS 209-876-0) and its disodium salt (CI 45370) (CAS 4372-02-5; EINECS 224-468-2)1334 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid; Fluorescein, 2',4',5',7'-tetrabromo-; (Solvent Red 43) (CAS 15086-94-9; EINECS 239-138-3), its disodium salt (Acid Red 87; CI 45380) (CAS 17372-87-1; EINECS 241-409-6) and its aluminium salt (Pigment Red 90:1 Aluminium lake) (CAS 15876-39-8; EINECS 240-005-7)1335 Xanthylium, 9-(2-carboxyphenyl)-3-(2-methylphenyl)amino)-6-((2-methyl-4-sulfophenyl)amino)-, inner salt (CAS 10213-95-3); and its sodium salt (Acid Violet 9; CI 45190) (CAS 6252-76-2; EINECS 228-377-9)1336 3',6'-Dihydroxy-4',5'-diiodospiro(isobenzofuran-1(3H),9'-[9H]xanthene)-3-one; (Solvent Red 73) (CAS 38577-97-8; EINECS 254-010-7) and its sodium salt (Acid Red 95; CI 45425) (CAS 33239-19-9; EINECS 251-419-2)1337 2',4',5',7'-Tetraiodofluorescein (CAS 15905-32-5; EINECS 240-046-0), its disodium salt (Acid Red 51; CI 45430) (CAS 16423-68-0; EINECS 240-474-8) and its aluminium salt (Pigment Red 172 Aluminium lake)(CAS 12227-78-0; EINECS 235-440-4)1338 1-Hydroxy-2,4-diaminobenzene (2,4-Diaminophenol) (CAS 95-86-3; EINECS 202-459-4 ) and its dihydrochloride salt (2,4-Diaminophenol HCl) (CAS 137-09-7; EINECS 205-279-4)1339 1,4-Dihydroxybenzene (Hydroquinone) (CAS 123-31-9; EINECS 204-617-8)1340 [4-[[4-anilino-1-naphthyl][4-(dimethylamino)phenyl]methylene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride (Basic Blue 26; CI 44045) (CAS 2580-56-5; EINECS 219-943-6)1341 Disodium 3-[(2,4-dimethyl-5-sulphonatophenyl)azo]-4-hydroxynaphthalene-1-sulphonate (Ponceau SX; CI 14700) (CAS 4548-53-2; EINECS 224-909-9)1342 Trisodium tris[5,6-dihydro-5-(hydroxyimino)-6-oxonaphthalene-2-sulphonato(2-)-N5,O6]ferrate(3-) (Acid Green 1; CI 10020) (CAS 19381-50-1; EINECS 243-010-2)1343 4-(Phenylazo)resorcinol (Solvent Orange 1; CI 11920) (CAS 2051-85-6; EINECS 218-131-9) and its salts1344 4-[(4-Ethoxyphenyl)azo]naphthol (Solvent Red 3; CI 12010) (CAS 6535-42-8; EINECS 229-439-8) and its salts1345 1-[(2-Chloro-4-nitrophenyl)azo]-2-naphthol (Pigment Red 4; CI 12085) (CAS 2814-77-9; EINECS 220-562-2) and its salts1346 3-Hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide (Pigment Red 112; CI 12370) (CAS 6535-46-2; EINECS 229-440-3) and its salts1347 N-(5-Chloro-2,4-dimethoxyphenyl)-4-[[5-[(diethylamino)sulphonyl]-2-methoxyphenyl]azo]-3-hydroxynaphthalene-2-carboxamide (Pigment Red 5; CI 12490) (CAS 6410-41-9; EINECS 229-107-2) and its salts1348 Disodium 4-[(5-chloro-4-methyl-2-sulphonatophenyl)azo]-3-hydroxy-2-naphthoate (Pigment Red 48; CI 15865) (CAS 3564-21-4; EINECS 222-642-2)1349 Calcium 3-hydroxy-4-[(1-sulphonato-2-naphthyl)azo]-2-naphthoate (Pigment Red 63:1; CI 15880) (CAS 6417-83-0; EINECS 229-142-3)1350 Trisodium 3-hydroxy-4-(4'-sulphonatonaphthylazo)naphthalene-2,7-disulphonate (Acid Red 27; CI 16185) (CAS 915-67-3; EINECS 213-022-2)1351 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] (Pigment Yellow 13; CI 21100) (CAS 5102-83-0; EINECS 225-822-9)1352 2,2'-[Cyclohexylidenebis[(2-methyl-4,1-phenylene)azo]]bis[4-cyclohexylphenol] (Solvent Yellow 29; CI 21230) (CAS 6706-82-7; EINECS 229-754-0)1353 1-((4-Phenylazo)phenylazo)-2-naphthol (Solvent Red 23; CI 26100) (CAS 85-86-9; EINECS 201-638-4)1354 Tetrasodium 6-amino-4-hydroxy-3-[[7-sulphonato-4-[(4-sulphonatophenyl)azo]-1-naphthyl]azo]naphthalene-2,7-disulphonate (Food Black 2; CI 27755) (CAS 2118-39-0; EINECS 218-326-9)1355 Ethanaminium, N-(4-((4-(diethylamino)phenyl)(2,4-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-ethyl-, hydroxide, inner salt, sodium salt (Acid Blue 1; CI 42045) (CAS 129-17-9; EINECS 204-934-1)1356 Ethanaminium, N-(4-((4-(diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-ethyl-, hydroxide, inner salt, calcium salt (2:1) (Acid Blue 3; CI 42051) (CAS 3536-49-0; EINECS 222-573-8)1357 Benzenemethanaminium, N-ethyl-N-(4-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)(4-hydroxy-2-sulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-3-sulfo-, hydroxide, inner salt, disodium salt (Fast Green FCF; CI 42053) (CAS 2353-45-9; EINECS 219-091-5)1358 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) (CAS 8003-22-3; EINECS 232-318-2)1359 Nigrosine (CI 50420) (CAS 8005-03-6)1360 8,18-Dichloro-5,15-diethyl-5,15-dihydrodiindolo[3,2-b:3',2'-m]triphenodioxazine (Pigment Violet 23; CI 51319) (CAS 6358-30-1; EINECS 228-767-9)1361 1,2-Dihydroxyanthraquinone (Pigment Red 83; CI 58000) (CAS 72-48-0; EINECS 200-782-5)1362 Trisodium 8-hydroxypyrene-1,3,6-trisulphonate (Solvent Green 7; CI 59040) (CAS 6358-69-6; EINECS 228-783-6)1363 1-Hydroxy-4-(p-toluidino)anthraquinone (Solvent Violet 13; CI 60725) (CAS 81-48-1; EINECS 201-353-5),1364 1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) (CAS 128-80-3; EINECS 204-909-5)1365 6-Chloro-2-(6-chloro-4-methyl-3-oxobenzo[b]thien-2(3H)-ylidene)-4-methylbenzo[b]thiophene-3(2H)-one (VAT Red 1; CI 73360) (CAS 2379-74-0; EINECS 219-163-6)1366 5,12-Dihydroquino[2,3-b]acridine-7,14-dione (Pigment Violet 19; CI 73900) (CAS 1047-16-1; EINECS 213-879-2)1367 (29H,31H-Phthalocyaninato(2-)-N29,N30,N31,N32)copper (Pigment Blue 15; CI 74160) (CAS 147-14-8; EINECS 205-685-1)1368 Disodium [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cuprate(2-) (Direct Blue 86; CI 74180) (CAS 1330-38-7; EINECS 215-537-8)1369 Polychloro copper phthalocyanine (Pigment Green 7; CI 74260) (CAS 1328-53-6; EINECS 215-524-7)。
阿齐沙坦及片
阿齐沙坦片阿齐沙坦（又称阿齐沙坦酯，英语：Azilsartan）（INN）是治疗高血压症的血管紧张素II受体拮抗剂药物，多用于治疗高血压症，也是血管紧张素II受体拮抗剂（沙坦类）药物。
作为前体药物的阿齐沙坦酯（azilsartan medoxomil、INN、代码 TAK-491），2010年4月28日，日本武田制药公司（Takeda）所研发的该药物完成了三期临床试验，2011年获得美国FDA批准，该药物为一种血管紧张素II受体拮抗剂，可单独使用或与其它降血压药物一起使用，被视作坎地沙坦酯的下一代产品。
中文名: 阿齐沙坦英文名：Azilsartan商品名： Edarbi (Azilsartan medoxomil) 依达比化学英文名(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl2-ethoxy-1-([2'-(5-oxo-4,5-dihy dro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl)-1H-benzimidazole-7-car boxylateCAS号863031-21-4分子式化学式 C30H24N4O8分子量 568.5临床实验: 阿齐沙坦酯对于降低血压有着较为显著的疗效，一项1291位病人参与、长达六星期的实验比较40毫克、80毫克的阿齐沙坦酯和40毫克的奥美沙坦酯（Benicar®、由第一制药三共株式会社研发）或320毫克的缬沙坦的效果，结果40毫克的阿齐沙坦酯可降低13.4mmHg的血压、80毫克的阿齐沙坦酯则是14.5mmHg、40毫克的Benicar是12mmHg、320公克的缬沙坦则是10.2mmHg。
另有一项为期六周的实验，将20毫克、40毫克、80毫克的阿齐沙坦酯和40毫克的奥美沙坦酯进行了比较，共有1272位病人参与。
结果显示，20毫克的阿齐沙坦酯能降血压10.8mmHg、40毫克的阿齐沙坦酯则是12.1mmHg、80毫克的阿齐沙坦酯是13.2mmHg、40毫克的奥美沙坦酯则为11.2mmHg。
麻醉药品和精神药品品种目录
二甲噻丁
38
吗苯丁酯
39
地芬诺酯 *
40
地匹哌酮
41
羟蒂巴酚
42
芽子碱
43
乙甲噻丁
44
依托尼秦
45
埃托啡
46
依托利定
47
芬太尼 *
48
呋替啶
49
海洛因
Beta-hydroxy-3-methylfentany l Betameprodine Betamethadol Betaprodine Bezitramide Cannabis and Cannabis Resin and Extracts and Tinctures of Cannabis Clonitazene Coca Leaf Cocaine Codoxime Concentrate of Poppy Straw
PMA
thylamine
21
赛洛新
Psilocine
520-53-6
22
赛洛西宾
Psilocybine
520-52-5
23
咯环利定
Rolicyclidine
2201-39-0
PHP
24
二甲氧基甲苯异丙胺
2,5-Dimethoxy- alpha ,4-dimet 15588-95-1
STP
hylphenethylamine
90
苯吗庚酮
Phenadoxone
91
非那丙胺
Phenampromide
92
非那佐辛
Phenazocine
93
1- 苯乙基 -4- 苯基 -4- 哌啶 1-Phenethyl-4-phenyl-4-piper
有机化合物缩写大全
Chemical Name
BINOL
1,1'-bi-2,2'-naphthol
Bip bipy BLA
biphenyl-4-sulfonyl 2,2'-bipyridyl
Brönsted acid assisted chiral Lewis acid
bmin BMS Bn
BNAH
H OMe
N
N
DHQD
(DHQD)2PHAL
DIAD DIB (BAIB or PIDA)
dihydroquinidine
bis(dihydroquinidino)phthalazine diisopropyl azodicarboxylate (diacetoxyiodo)benzene
2,2'-dihydroxy-1,1'-binaphthyl lithium aluminum hydride
(R) (R)
(R)
Ph2P
(R)
PPh2
OH
O
Al H
Li
BINAP
2,2'-bis(diphenylphosphino)-1,1'-binaphthyl
PPh2
PPh2
xviii
TABLE OF CONTENTS
BOP-Cl bp BPD
bis(2-oxo-3-oxazolidinyl)phosphinic chloride boiling point
bis(pinacolato)diboron
BPO BPS (TBDPS)
benzoyl peroxide t-butyldiphenylsilyl
白胡椒成分
白胡椒成分(+-)-1-(ACETOXY)-2-(1-BROMOETHYL)-3-METHOXYANTHRAQUINONE(1S*,4R*,5S*,8R*,9S*,10S*)-N-PHENYL-8-METHYL-9-METHOXY-9-(PHENYLTHIO)-10-CHLO RO-11-OXATRICYCLO[6.2.1.0(2,7)]UNDEC-2(7)-ENE-4,5-DICARBOXIMIDE(1SR,5RS,9SR,13RS,18RS)-18-ALLYLHEXACYCLO[16.3.0.0(15).0(5,9).0(9,13).0(13,17 ]HENICOS-16-ENE(2,3-DIMETHOXYPHENYL)TRIMETHYLSILANE(2,5-DIMETHOXYPHENYL)TRIMETHYLSILANE(2R(*),3AR(*),7AR(*))-HEXAHYDRO-2-((BENZOYLOXY)METHYL)-4(2H)-BENZOFURANONE (2S,4AS,5S,8AS)-2-(T-BUTYL)-PERHYDRO-5-METHYL-2H,4H-[1,3]BENZODIOXIN-4-ONE (3S,5R)-3-(HYDROXYMETHYL)-1,4,4,5-TETRAMETHYLCYCLOPENTENE(4R,8S)-P-MENTH-1-ENE-8,9-DIOL(4RS,5SR,6RS)-6-HYDROXY-4,5-(ISOPROPYLIDENEDIOXY)CYCLOHEX-2-EN-1-ONE(E)-1,4-DIMETHYL-1,3-HEPTADIEN-5-IN-1-YL-TRIFLATE(E)-2,6,6,10-TETRAMETHYL-8,10-UNDECADIEN-3,7-DIONE(E)-2-ETHOXY-3-PHENYLSULFONYL-5,6,7,8-TETRAHYDROAZOCINE(E)-3-HYDROXY-2,2,4,4-TETRAMETHYL-3-(3'-METHYL-1',3'-BUTADIENYL)CYCLOHEXANONE (E)-DI-T-BUTYL [2-((E)-2-BUTENYLOXY)-2-BUTENYL]-PHOSPHONATE(E,E)-6-(DIMETHYLAMINO)-3-METHYL-3,5-HEXADIEN-2-ONE(S)-(+)-5-SEC-BUTYL-2-PYRIMIDINOL(Z)-2-(1-(METHOXYCARBONYL)ETHYLIDENE)-.GAMMA.-BUTYROLACTONE(Z)-3,3-DIETHOXY-1-(2-FURYL)-1-PROPENE(Z)-8-Hydroxy-4,7-dimethyl-oct-6-enoic acid lactone.ALPHA.-SANTALAN-12-ONE[2-(2,4-CYCLOHEXADIENYL)ETHYL]AMMONIUM CHLORIDE[METHYL 3-(4-METHOXYCYCLOHEXA-1,3-DIENYL)PROPANOATE]1-(1(Z)-1-METHYLTHIO-1,3-BUTADIEN-1-YL)-6,6-DIMETHYL-2-METHYLENECYCLOHEXANE 1,1,1,3,5,5,5-Heptamethyltrisiloxane1,1-DICHLORO-4-[(TRIMETHYLSILYL)OXY]-4-PHENYLBUT-1-ENE1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHYLPROPYL) ESTER (CAS)1,2-BENZENEDICARBOXYLIC ACID, DIBUTYL ESTER (CAS)1,2-BENZENEDICARBOXYLIC ACID, DICYCLOHEXYL ESTER (CAS)1,2-BENZENEDICARBOXYLIC ACID, DIISOOCTYL ESTER (CAS)1,2-Dihydro-2,4-diphenyl-quinazoline1,2-DIHYDROXY-4-(1-PROPYL)BENZENE1,3-Benzenediol, 2-methyl-1,4-BENZENEDICARBOXYLIC ACID, METHYL ESTER (CAS)1,4-Benzenediol, 2-methyl-1,5-Cyclohexadiene-1-carboxylic acid, 3,4-dihydroxy-, methyl ester, trans-1-AMINO-1-ORTHO-CHLOROPHENYL-2-(2-QUINOXALINYL)ETHENE1-BUTOXY-1-(TRIMETHYLSILOXY)ETHYLENE1-Cyclohexenyl-cyclohexanol1-DECYLAMINOMETHYL-1,2,3,4-TETRA-HYDROISOQUINOLINE1-Hexyl-2-nitrocyclohexane1-PHENYL-4-METHYL-1,3-PENTANEDIOL BISTRIMETHYLSILYL ETHER1-TRIMETHYLSILYLOXY-2.BETA.H-6-[(TRIMETHYLSILYLOXY)(PHENYL)METHYL]-3,4,5,6-TE TRAHYDROBENZENE2(1H)-Pyridinone, 1,4,6-trimethyl-2-(2,3-EPOXYPROPYL)-TETRAHYDROFURANE2-(2-HYDROXY-2-PHENYLACETAMIDO)-2-METHYLPROPIONIC ACID2-(2-METHOXYCARBONYLETHYL)-3-(2-THIENYL)-4- AND-5-METHOXYCARBONYLISOXAZOLIDINE2-(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID METHYL ESTER2-(4-NITROPHENYL)-3-(2-NITROPHENYL)-3-OXO-1-PROPANAL2-(BENZYLCARBONYL)AMINO-BENZOTHIAZOLE2,3:5,6-DIEPOXY-2,3,4,5,6-PENTAMETHYL-4-VINYLCYCLOHEXANONE2,4-HEPTADIENAL2-ACETYLTETRAHYDROFURAN2-Cyclopentene-1-thione, 3,4-dimethyl-2-HYDROXY-2-PHENYL-1,3-PROPANEDIOL DICARBAMATE2-Isopropyl-2-phenyl-1,3-dithiane2-METHOXY[1]BENZOTHIENO[2,3-C]QUINOLIN-6(5H)-ONE2-METHOXYMETHOXYMETHYL-2-METHYLCYCLOHEXANONE3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACID3,4-DIHYDROXY-L-PHENYLALANINE3,4-DIMETHOXYBENZENE-1,2-DIOL3,7,11-(3-METHYL-TRIDEUTERIO)-TRIMETHYL-(4,4-DIDEUTERIO)DODECA-1,6,10-TRIEN-3 -OL3-BROMO-4-HYDROXY-PENTADECA-6(Z),9(Z)-DIENE3-BUTENOIC ACID, 2,2-DIETHYL-3-METHYL- (CAS)4-(TRIMETHYLSILYL)DIBENZOFURAN4-IODO-4,5-ETHANOSPIRO(2.3)HEXANE4-Tolyl trifluoromethanesulfonate5-AMINO-2-METHYL-2-PHENYL-2,3-DIHYDRO[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZINE 5-AMINO-2-PHENYL-2-METHYL-2H-[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZINE5-AMINO-3,4-DIHYDRO-4-(1-METHOXYETHYL)-3-METHYL-2H-PYRROL-2-ONE5-ETHENYL-5-(1-METHYLBUTYL)BARBITURIC ACID6,10,13-TRIMETHYL-17-ACETYL-17-ACETOXY-3-OXO-ESTRA-4,6-DIENE6-ISOPROPYLTRICYCLO[4.1.0.0(2,7)]HEPT-4-EN-3-ONE7-(2-BROMO-2-PROPENYL)-5-METHOXY-2-METHYLBENZOFURAN7-(TRIMETHYLSILYLMETHOXY)BICYCLO[4.1.0]HEPTANE9-DEUTERIO-2,2,8,8,10(S)-PENTAMETHYL-TRANS-1-DECALONEá-(4-Hydroxy-3-methoxyphenyl)propionic acidARABITOL-1,2,3,4,5-PENTAACETATEArsenous acid, tris(trimethylsilyl) esterARSENOUS ACID, TRIS(TRIMETHYLSILYL) ESTER (CAS)Benzaldehyde, 2-hydroxy-Benzaldehyde, 2-hydroxy-, oximeBENZALDEHYDE, 4-HYDROXY- (CAS)Benzeneethanol, 3-hydroxy-BENZENEETHANOL, 3-HYDROXY- (CAS)Benzeneethanol, 4-hydroxy-Benzenemethanol, 3-hydroxy-Benzoic acid, 4-hydroxy-3,5-dimethoxy-BENZOIC ACID, 4-HYDROXY-3,5-DIMETHOXY- (CAS)BIS(2-ETHYLHEXYL) PHTHALATEBUTANOIC ACID, 3-OXO-, PHENYLMETHYL ESTER (CAS)BUTYL (2,2-DIFLUOROBUTYL) ETHERCyclohexene, 1,5,5-trimethyl-6-(2-propenylidene)-Cyclopentasiloxane, decamethyl-Cyclotetrasiloxane, octamethyl-Cyclotrisiloxane, hexamethyl-CYCLOTRISILOXANE, HEXAMETHYL- (CAS)DI-DEUTERIO-3,4,9-TRIMETHYL-DECA-4,6,8-TRIENE-2-OLDIHYDRO-5-HYDROXY-5-[(8-PENTYL-2-OXOCANYL)ACETYL]-2(3H)-FURANONEERYTHRO-1-HYDROXY-1-PHENYL-2,4,4-TRIMETHYL-3-PENTANONEETHYL1-[1-(TRIMETHYLSILYLOXY)-1,2-DIPHENYLETHYLOXY]-7-AZABICYCLO[4.1.0]HEPTAN-7-CA RBOXYLATEEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENEHEXADECANOIC ACID, TRIMETHYLSILYL ESTER (CAS)HOTRIENOLISOLYRATOLMETHOXYMETHYL-2 METHYL-1 [ETHYLOXYCARBONYLMETHYLENE]-3 CYCLOPENTENE-1 METHYL(2E,4E)-4-(2,3,5,6-TETRAHYDRO-3-OXOIMIDAZO[2,1-B]THIAZOL-2-YLIDENE)BUT-2-EN-1 -OATEMETHYL (2S,3R)-2,3-DIHYDROXY-3-(4-METHOXYPHENYL)PROPANOATEMETHYL (3R,5Z)-3-(TRIISOPROPYLSILYLOXY)DEC-5-ENOATEMETHYL 2-PHENYL-2,3-DIHYDROXY-3-BENZYLBUTANOATEMETHYL 2-TRIDEUTERIOMETHYL-3,4-DI-O-METHYL-.BETA.,L-ARABOPYRANOSIDEMETHYL(+-)-M-METHOXYMANDELATEN-(3-HYDROXYPHENYLETHYL)-TRIFLUOROACETYLAMIDEN-METHYL-N,N-DI[2-(4-PYRIDYL)ETHYL]-(2-PYRIDYL)ETHYLAMINENoradrenaline tetraTMSO-NITROPIVALOPHENONEPhenol, 2,2'-[(hydroxyimino)bis(4,5-dihydro-5,3-isoxazolediyl)]bis- PHENOL, 4,4'-(1-METHYLETHYLIDENE)BIS- (CAS)Pyrrolidine, 1-(m-methoxycinnamoyl)-PYRROLIDINE, 1-(M-METHOXYCINNAMOYL)- (CAS)REL-(1R,4R)-4-ACETYL-6-MORPHOLINOTETRACYCLO[6.4.0.0(2,4).0(3,7)]DODECA-8,10,1 2-TRIENE-6-CARBONITRILESELINEN-11-EN-4-OLSILANE,[[4-[1,2-BIS[(TRIMETHYLSILYL)OXY]ETHYL]-1,2-PHENYLENE]BIS(OXY)]BIS[TRIMETHYL-(CAS)Silane, trimethyl(1-methylethoxy)-SPIRO[2,5]OCT-6-ENE-4-ACETALDEHYDESYM-TETRAMETHYLDIMETHOXYDISILOXANETERT BUTYL1,6,8-TRI-TERT-BUTYL-3,4-(TETRACHLOROBENZO)-2,5-DIOXABICYCLO[4.2.0]OCTA-3,7-D IENE-7-CARBOXYLATETRANS-1-(PHENYLTHIO)-6-OXO-4-OXAHEPT-1-ENETRIMETHYLSILYL DERIVATIVE OF 4-NITROSOPHENOLUROTERPENOLWAITZIACUMINONEZ-ISOMER, 2-(2-HYDROXYETHYLIDENE)-3-METHOXYNORBORNANEArsenous acid, tris(trimethylsilyl) ester3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACIDCyclotrisiloxane, hexamethyl-3-(1'-ETHOXYETHOXY)-1-BUTANOLPropane, 1-(1-ethoxyethoxy)-1,3-BIS(TRIMETHYLSILYL)-4,4-DICARBOMETHOXY-1,8-NONADIENE2-METHOXY[1]BENZOTHIENO[2,3-C]QUINOLIN-6(5H)-ONECyclotetrasiloxane, octamethyl-3-Butoxy-1,1,1,5,5,5-hexamethyl-3-(trimethylsiloxy)trisiloxane DIHEXYLSULFIDENIZATIDINE1,2-Dihydro-2,4-diphenyl-quinazolineNitric acid, ethyl esterTRANS-3-CHLOROALLYL 2,3-EPOXYPROPYL ETHERD,L-1,4-PHENYLENE-BIS{[(T-BUTYLTHIO)THIOXOMETHYLTHIO]ACETIC ACID} HOTRIENOLButanedioic acidCyclopentanol, 2-methyl-, cis-[(TERT-BUTYL)DIMETHYLSILYL]CYCLOPROPYLMETHANOLCIS-2-(7-OCTYNYL)CYCLOHEXANOL2-(ALLYLTHIO)-1-NITROBUTANESalicyl AlcoholBENZENEMETHANOL, 2-HYDROXY- (CAS)BUTANOIC ACID, 3-METHYL-, 2-METHYLPROPYL ESTER (CAS)Butanoic acid, 3-oxo-, 1-methylpropyl ester(Z)-7-(TETRAHYDROPYRANYLOXY)-3-[(TRIMETHYLSILY)-METHYL]-2-METHYL-3-HEPTEN-2-O LN-[3-(2-CARBOXYPHENOXY)PROPYL]-3,4-DIHYDROXYPHENYLACETAMIDEMETHYL22-(TRIMETHYLSILOXY)DOCOSAN-4(Z),7(Z),10(Z),13(Z),16(Z),19(Z)-HEXAENOATE(1R,2R,4R)-p-Menthane-1,2,8-triol3-BROMO-4-HYDROXY-PENTADECA-6(Z),9(Z)-DIENE2-Cyclopentene-1-thione, 3,4-dimethyl-2,4-HEPTADIENAL2-(2,3-EPOXYPROPYL)-TETRAHYDROFURANE2-ACETYLTETRAHYDROFURANBenzenemethanol, 3-hydroxy-1,4-Benzenediol, 2-methyl-1,3-Benzenediol, 2-methyl-4-(PHENYLTHIOXOMETHYL)MORPHOLINE(2S,3R,4S,5R,6R,7R)-2,3-EPOXY-1-IODO-5,6-ISOPROPYLIDENE-DIOXY-7-(4-METHOXYBEN ZYLOXY)-2,4,6-TRIMETHYLNONANENIZATIDINE(E)-DI-T-BUTYL [2-((E)-2-BUTENYLOXY)-2-BUTENYL]-PHOSPHONATE1,3-Benzodioxole-5-methanol5,5'-BIS(2,2-DIMETHYL-(5H)-1,3-PYRONE)ETHER2H-Pyran-2-one, tetrahydro-6-(2-pentenyl)-3-(2-pyridinylsulfinyl)-(1.ALPHA.,2.BETA.,4.ALPHA.)-1-[4-(1,1-DIMETHYLETHYL)-2-(2-PROPENYL)CYCLOPENTY L]ETHANONE1-[[(P-TOLYLSULFONYL)OXY]METHYL]TRICYCLO[5.4.0.0(2,6)]-8-UNDECANONE3-METHOXY-1-TOSYL-1-CYCLOHEXANEBenzeneethanol, 4-hydroxy-Benzeneethanol, 3-hydroxy-BENZENEETHANOL, 3-HYDROXY- (CAS)UROTERPENOL(4R,8S)-P-MENTH-1-ENE-8,9-DIOL6-(3-Methyl-3-cyclohexenyl)-2-methyl-2,6-heptadienol1-METHYL-2-METHYLENE-TRANS-4-DEUTERODECALIN3-O-BENZYL-4,5-O-CARBONYL-D-FRUCTOSE1,2-Dihydro-2,4-diphenyl-quinazolineCHLORO-9-FORMYLACRIDINE1-BENZYL-6,7-DIMETHOXY-3-ISOCROMANONE2-Cyclohexen-1-one, 3-(3-hydroxy-1-butenyl)-2,4,4,5-tetramethyl-2,6-DIMETHOXYBENZALDEHYDE(2,3-DIMETHOXYPHENYL)TRIMETHYLSILANE(2,5-DIMETHOXYPHENYL)TRIMETHYLSILANEBENZOIC ACID, 3-HYDROXY- (CAS)Ethanone, 1-(4-hydroxyphenyl)-2-phenyl-Isobutyl p-hydroxybenzoateHomovanillyl alcohol4-HYDROXY-3-METHOXYBENZYL METHYL ETHER2-(2-HYDROXYETHYL)-3-METHOXY-TRICYCLO(2.2.21.0*2,6)HEPTANE4-TERT-BUTYL-CHLOROBENZENEBenzoic acid, 4-hydroxy-3-methoxy-4'-CHLORO-2'-METHYL-ACETOPHENONE6-ISOPROPYLTRICYCLO[4.1.0.0(2,7)]HEPT-4-EN-3-ONE1-TOSYLCYCLOHEXA-1,3-DIENEBICYCLO[3.1.1]HEPT-2-ENE-2-CARBOXALDEHYDE, 6,6-DIMETHYL- (CAS)BIS (2-CHLOROISOPROPYL) ETHER(2R,6R)-6-METHYL-2-PHENYL-1,3-DIOXANE-4-ONE3,5-O-BENZYLIDENE-1-DEOXY-D-THREO-2-PENTULOSE1-TRIMETHYLSILYLOXY-2.BETA.H-6-[(TRIMETHYLSILYLOXY)(PHENYL)METHYL]-3,4,5,6-TE TRAHYDROBENZENEEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENEERYTHRO-1-HYDROXY-1-PHENYL-2,4,4-TRIMETHYL-3-PENTANONE1-TRIMETHYLSILYLOXY-2.BETA.H-6-[(TRIMETHYLSILYLOXY)(PHENYL)METHYL]-3,4,5,6-TE TRAHYDROBENZENETRIMETHYLSILYL DERIVATIVE OF 4-NITROSOPHENOLEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENEBenzene, 1-(1,1-dimethylethoxy)-2-methyl-L-TYROSINE (CAS)2-Cyclohexen-1-one, 4-(3-hydroxy-1-butenyl)-3,5,5-trimethyl-3-BUTENOIC ACID, 2,2-DIETHYL-3-METHYL- (CAS)3,4-DIMETHOXYBENZENE-1,2-DIOLREL-(1R,4R)-4-ACETYL-6-MORPHOLINOTETRACYCLO[6.4.0.0(2,4).0(3,7)]DODECA-8,10,1 2-TRIENE-6-CARBONITRILE2-(3',4'-DIHYDROXYPHENYL)-3-HYDROXY-6-(2''-HYDROXYETHYL)-2,3-DIHYDRO-1,4-BENZ ODIOXIN2,4-Pentadiyn-1-one, 1-phenyl-5-ETHENYL-5-(1-METHYLBUTYL)BARBITURIC ACID1-PHENYL-1,1-DIMETHOXY-2,2-DIFLUOROPENTANE1,3-Benzenediol, 4-propyl-1-METHYL-2-CYANO-2-DEUTERIO-3-ETHYL-3-PIPERIDEINE4-(5'-T-BUTYLCYCLOHEX-1'-ENYL)BUT-1-ENE5-EXO-METHYL-5-ENDO-NITROBICYCLO-[2.2.1]HEPTAN-2-ONE8,8-DIDERITERIOCAMPHENE1-(2-METHYLPHENYL)-3-CYANO-2(1H)-PYRIDINETHONE5-ACETYL-2-DIMETHYLAMINO-4-T-BUTYLTHIAZOLE1-TRIMETHYLSILYL-1-(2-NAPHTHYL)ETHYLENEá-(4-Hydroxy-3-methoxyphenyl)propionic acid2-(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID METHYL ESTERMETHYL(+-)-P-METHOXYMANDELATE2-HYDROXY-2-PHENYL-1,3-PROPANEDIOL DICARBAMATEtert-Butyl-benzyl-dimethylaminomethyl-phosphine1-Cyclohexenyl-cyclohexanol(1RS,2SR)-[2,2-DIMETHYL-6-(PHENYLSELENYL)METHYLCYCLOHEXANE-1-CARBOXYLIC ACID (2S,4AS,5S,8AS)-2-(T-BUTYL)-PERHYDRO-5-METHYL-2H,4H-[1,3]BENZODIOXIN-4-ONE (4RS,5SR,6RS)-6-HYDROXY-4,5-(ISOPROPYLIDENEDIOXY)CYCLOHEX-2-EN-1-ONE(2A.ALPHA.,5A.BETA.,8A.ALPHA.,8B.ALPHA.)-1,2,2A,3,4,5,5A,8,8A,8B-DECAHYDRO-1-OXO-1H-CYCLOPENTA[CD]INDENE-3,3-DI(METHOXYCARBONYL)ACENAPHTHYLENE1,1-DIMETHYL-4-PHENYLSEMICARBAZIDE6-HYDROXY-1,4-DICHLORO-5-DECANONEDIMETHYL [3-(TERT-BUTYLACETOXY)-3-METHYL-2-OXOBUTYL]PHOSPHONATE-(18)O VOMIFOLIOLN-METHYLMETHANESULFONAMIDO-2-CYCLOHEXENE-2-ONEBENZOIC ACID, 4-HYDROXY-3,5-DIMETHOXY- (CAS)3-Hydroxy-4,5-dimethoxybenzoic acidTRANS-1-(PHENYLTHIO)-6-OXO-4-OXAHEPT-1-ENE1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHYLPROPYL) ESTER (CAS)N-METHYL-N,N-DI[2-(4-PYRIDYL)ETHYL]-(2-PYRIDYL)ETHYLAMINEBenzoic acid, 2,4-dihydroxy-3,6-dimethyl-, methyl ester1,6-Dimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyrimidine6,8-Dimethyl-5-oxo-2,3,5,8-tetrahydroimidazo[1,2-a]pyrimidine3-(1-BROMOCYCLOPENTYL)-2-BUTENOLIDE(4ARS,5SR,6RS,7RS)-7-(DIMETHYLAMINO)-1,2,3,4,4A,5,6,7-OCTAHY-DRONAPHTHALENE-5 ,6-DICARBOXYLATE2-TERT-BUTYLADAMANTAN-2-OL(+-)-5.BETA.-HYDROXY-2.BETA.-DIMETHOXYMETHYL-3.BETA.-TERT-BUTYLDIMETHYLSILYLO XYCYCLOPENTYL-1.ALPHA.-ACETIC ACID METHYL ESTERETHYL6-O-ACETYL-2,3,4-TRIDEOXY-4-PIPERIDINO-.ALPHA.-D-ERYTHRO-HEX-2-ENOPYRANOSIDE P-PHENYLPHENACYL [2-DEUTERIO)ISOBUTYRATETRANS-1-(PHENYLTHIO)-6-OXO-4-OXAHEPT-1-ENE1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHYLPROPYL) ESTER (CAS)N-METHYL-N,N-DI[2-(4-PYRIDYL)ETHYL]-(2-PYRIDYL)ETHYLAMINE2-Azafluorenone3-AZAFLUORENONEEthanone, 1-(4-hydroxy-3,5-dimethoxyphenyl)-1,3-BENZENEDICARBOXYLIC ACID (CAS)1,4-BENZENEDICARBOXYLIC ACID (CAS)3,4-MethylenedioxybenzhydrazidePyrrolidine, 1-(m-methoxycinnamoyl)-Phenol, 2,2'-[(hydroxyimino)bis(4,5-dihydro-5,3-isoxazolediyl)]bis-N-HEXYLDI-N-PROPOXYMETHYLSILANE1,3-DIACETOXYPROPA-2-ONE1,1,1,3,5,5,5-Heptamethyltrisiloxane1-(1'-CYCLOHEXENYL)-3-(TRIMETHYLSILYL)-2-BUTEN-1-ONE2-[(TRIMETHYLSILYL)METHYL]-1-[1-HYDROXY-4-(TERT-BUTYLDIMETHYLSILOXY)BUTYL]CYC LOPROPANE1,3-DIACETOXYPROPA-2-ONE1-(1'-CYCLOHEXENYL)-3-(TRIMETHYLSILYL)-2-BUTEN-1-OL3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACID2,5-Pyrrolidinedione, 3-ethylidene-4-methyl-Cyclotrisiloxane, hexamethyl-3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACIDCYCLOTRISILOXANE, HEXAMETHYL- (CAS)3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACID(+-)-1-(ACETOXY)-2-(1-BROMOETHYL)-3-METHOXYANTHRAQUINONE6,10,13-TRIMETHYL-17-ACETYL-17-ACETOXY-3-OXO-ESTRA-4,6-DIENE(1SR,5RS,9SR,13RS,18RS)-18-ALLYLHEXACYCLO[16.3.0.0(15).0(5,9).0(9,13).0(13,17 ]HENICOS-16-ENE2-METHOXY[1]BENZOTHIENO[2,3-C]QUINOLIN-6(5H)-ONECyclotetrasiloxane, octamethyl-1-AMINO-1-ORTHO-CHLOROPHENYL-2-(2-QUINOXALINYL)ETHENE4-[[6-(ETHOXYCARBONYL)-TRANS-5-HEXENYL]OXY]-6-METHYL-2-PYRONE3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACIDArsenous acid, tris(trimethylsilyl) ester(+,-)-2-HYDROXY-1,5-DIMETHYL-6,8-DIOXABICYCLO[3.2.1]OCTANE PermethylspermidineBUTYL 4-OXOOCTANOATEBIS(TRIMETHYLSILYL)[9-(TRIMETHYLSILYL)-9-FLUORENYL]SILANOL1,1,3,3,5,5,7,7,9,9,11,11,13,13-TETRADECAMETHYLHEPTASILOXANENIZATIDINE1-METHYL-1-(METHOXYCARBONYLAMINO-HYDROXY-METHYL)-CYCLOHEXA-3-ENETRANS-4-(T-BUTYL)-1-ETHENYL-1-(DIMETHYLAMINOCARBONYLOXY)CYCLOHEXANETRANS-CISOID-TRANS-TRICYCLO[9.3.0.0(3,7)]TETRADECANE-2,9-DIONE Benzeneethanol, 4-hydroxy-5-CYCLOPROPYL-3,3A,4,5,6,7-HEXAHYDROISOXAZOLO[4,3-C]PYRIDINE Benzaldehyde, 3,4-dimethoxy-1,3-Benzodioxole-5-carboxylic acid1-TRIMETHYLSILYLOXY-2.BETA.H-6-[(TRIMETHYLSILYLOXY)(PHENYL)METHYL]-3,4,5,6-TE TRAHYDROBENZENEEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENEERYTHRO-1-HYDROXY-1-PHENYL-2,4,4-TRIMETHYL-3-PENTANONETRIMETHYLSILYL DERIVATIVE OF 4-NITROSOPHENOLEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENE[(T-BUTYL)DIMETHYLSILYL] 5-PHENYLVALERIANATE2,2-BIS(3',3'-DIMETHYLBUTOXY)ADAMANTANEO-NITROPIVALOPHENONEBenzeneacetic acid, 3-hydroxy-, ethyl esterSILANE, TRIMETHYL[[5-METHYL-2-(1-METHYLETHENYL)-1-CYCLOHEXEN-1-YL]OXY]-2,6,6-TRIMETHYL-4-(TRIMETHYLSILOXY)-2,4-CYCLOHEXADIEN-1-ONEDIETHYL ESTER OF HYDROXY(4-METHOXY-3-METHYLPHENYL)-PROPANEDIOIC ACID DIETHYL ACETOXY(4-METHOXY-3-METHYLPHENYL)PROPANEDIOATESYN-(4,5)-4-METHYL-5-PHENYL-5-TRIMETHYLSILOXY-1-PENTEN-3-ONE1-TRIMETHYLSILYLOXY-2.BETA.H-6-[(TRIMETHYLSILYLOXY)(PHENYL)METHYL]-3,4,5,6-TE TRAHYDROBENZENEERYTHRO-1-HYDROXY-1-PHENYL-2,4,4-TRIMETHYL-3-PENTANONEEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENETHREO-2-BROMO-3,4-EPOXYOCTANE2-FORMYL-2',5,5'-TRIMETHYLPYRROLIDINE-N-OXYLERYTHRO-2-BROMO-3,4-EPOXYOCTANE2,4-Pentadiyn-1-one, 1-phenyl-(3S,5R)-3-(HYDROXYMETHYL)-1,4,4,5-TETRAMETHYLCYCLOPENTENE5-ETHENYL-5-(1-METHYLBUTYL)BARBITURIC ACID(9R)-9-HYDROXY-4-MEGASTIGMEN-3-ONE1-(CYANO-ACETOXYMETHYLENE)-2-CYCLOHEXENE3-OXO-7,8-DIHYDRO-.ALPHA.-IONOLà-Ethyl-O-methoxybenzyl alcohol1,1,1,3,5,5,5-HeptamethyltrisiloxaneArsenous acid, tris(trimethylsilyl) esterCYCLOTRISILOXANE, HEXAMETHYL- (CAS)3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACID2-TRIMETHYLSILYL(ISOPROPOXYDIMETHYLSILYL)BENZENE1,2-BIS{(4S)-4-ISOPROPYL-2-OXAZOLIN-2-YL} ETHANE(+-)-N-(1-METHYL-3,3-DIPHENYLPROPYL)FORMAMIDE(+)-[1R-(1.BETA.,2.BETA.,3.BETA.,7.ALPHA.,10.ALPHA.)]-3-[1'-METHYL-1'-HYDROXY ETHYL]-6-METHYLIDENE-10-METHYLBICYCLO[5.3.0]DECAN-2-OLTricyclo[4.4.0.02,7]dec-3-ene-3-methanol, 1-methyl-8-(1-methylethyl)-.BETA.-CHENOPODIOL(6)MONOACETATE2-METHYL-1-OXASPIRO[5.5]UNDECANE-2-CARBONITRILE(1RS,5SR,8ARS)-1-(3-FURYL)-5,8A-DIMETHYL-1,5,6,7,8,8A-HEXAHYDRO-3H-2-BENZOPYR AN-3-ONE5-(1-CHLOR-1-METHYLETHYL)-3,5-DIMETHYL-2-CYCLOPENTEN-1-ONE1-Propanone, 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-BIS(ETHYLTHIO)(PHENYL)METHANE1-PROPANONE, 3-HYDROXY-1-(4-HYDROXY-3-METHOXYPHENYL)- (CAS) Cyclotrisiloxane, hexamethyl-ETHYL ESTER OF 3-OXO-4-(TRIMETHYLSILYL)CYCLOHEXANEACETIC ACID1,2-Dihydro-2,4-diphenyl-quinazolineTRANS-1-(PHENYLTHIO)-6-OXO-4-OXAHEPT-1-ENE1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHYLPROPYL) ESTER (CAS)N-METHYL-N,N-DI[2-(4-PYRIDYL)ETHYL]-(2-PYRIDYL)ETHYLAMINEMETHYL (2S,3R)-2,3-DIHYDROXY-3-(4-METHOXYPHENYL)PROPANOATE1-(4'-METHOXYPHENYL)-2-METHYLPROPANE-1-OL(E)-4-(2',6',6'-TRIMETHYL-1',2'-EPOXYCYCLOHEXYL)-3-PENTEN-2-ONE3,7,11-(3-METHYL-TRIDEUTERIO)-TRIMETHYL-(4,4-DIDEUTERIO)DODECA-1,6,10-TRIEN-3 -OL1,10-DICYANO-DECANE(+)-1-ISOPROPYL-7-METHOXY-4-METHYLSPIRO(4.5)DEC-6-EN-8-ONE1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHYLPROPYL) ESTER (CAS)2-METHYL-6-.BETA.-D-RIBOFURANOSYLIMIDAZO[1,2-C]PYRIMIDIN-5(6H)-ONEDibutyl phthalatePALMITOLEIC ACID 1TMSPalmitelaidic acid, trimethylsilyl esterPALMITELAIDIC ACID 1TMS1-DECYLAMINOMETHYL-1,2,3,4-TETRA-HYDROISOQUINOLINEHexadecanoic acid, trimethylsilyl esterMETHYL (3R,5Z)-3-(TRIISOPROPYLSILYLOXY)DEC-5-ENOATE(2S,3R)-3-DIMETHYL-T-BUTYLSILOXY-2,4-DIMETHYLPENTAN-1-OL(E)-3-ALLYL-2-DIMETHYLPHENYLSILYL-1-CYCLONONENE4-(1,3-BENZODIOXOL-5-YLMETHYL)-4,5-DIHYDROFURAN-2(3H)-ONE1-Hexyl-1-nitrocyclohexane1-Hexyl-2-nitrocyclohexaneBROMOCYCLODODECANE1-PHENYL-6-DEUTEROMETHYL-5,7-DIDEUTEROHEPTA-1,6-DIEN-3-ONE(E)-(1,3-DIMETHYL-5-PYRAZOYL) 3-PHENYL-2-PROPENOATEPyrrolidine, 1-cinnamoyl-1-Hexyl-2-nitrocyclohexaneETHYL 2,2-DIFLUORO-4-IODO-12-HYDROXYDODECANOATE9-OCTADECENOIC ACID (Z)-, ETHYL ESTER (CAS)(MESO)-3,4-DIHYDROXYMETHYL-3,4-DIMETHYLHEXANE(1,3-DIISOPROPYLCYCLOPENTADIENYL)DIMETHYL(TRIMETHYLPHOSPHAN)-COBALT(III) .GAMMA.-OCTADECALACTONE5-AMINO-2-PHENYL-2-METHYL-2H-[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZINE5-AMINO-2-METHYL-2-PHENYL-2,3-DIHYDRO[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZINE PHENOL, 4,4'-(1-METHYLETHYLIDENE)BIS- (CAS)(E)-DIHYDRO-3-CARBOMETHOXYMETHYLENE-4,4,5,5-TETRAMETHYL-2(3H)-FURANONE TRANS-3-ACETOXY-6,6-DIMETHYL BICYCLO(3.1.1)HEPTAN-2-ONE2.ALPHA.-ACETOXY-1.ALPHA.,3,3-TRIMETHYLCYCLOHEXANOLN-HEXYLDI-N-PROPOXYMETHYLSILANEPyrrolidine, 1-(m-methoxycinnamoyl)-PYRROLIDINE, 1-(M-METHOXYCINNAMOYL)- (CAS)BIS(3-METHYLPHTHALIDYL)PEROXIDEETHANONE, 1,1'-(1,4-PHENYLENE)BIS- (CAS)Benzene, 1-(1,1-dimethylethyl)-3-ethyl-1-Hexyl-1-nitrocyclohexane8-METHYL-HEXACOSANOL1-Hexyl-2-nitrocyclohexane1-BROMO-8-METHYLHEXACOSANEMethyl (1s*,2s*,5R*)-1,5-dimethyl-2-ethenyl-cyclohexane-1-carboxylate (E)-3-HYDROXY-2,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-PROPENSAURE-BENZYLESTER(2R,5E)-2,12-EPOXYCARYOPHYLL-5-ENEMETHYL 2,5-BIS(METHOXYCARBONYL)-3-(TOSYLMETHYL)ADIPATE3.ALPHA.,17,19-TRIACETOXYSPONGIA-13(16),14-DIEN-2-ONE1,2-BENZENEDICARBOXYLIC ACID, DIISOOCTYL ESTER (CAS)1,2-BENZENEDICARBOXYLIC ACID, DICYCLOHEXYL ESTER (CAS)BIS(2-ETHYLHEXYL) PHTHALATE4-METHYL-1,2,4-TRIAZOLINE-3,5-DIONE ADDUCT WITH NOPADIENE1-CYCLOPROPYL-4-ETHOXY-3-METHOXYBENZENE1-CYCLOHEPTYL-2,2-HEXAMETHYLENE-1H-PYRROL-3(2H)-ONE1-Hexyl-2-nitrocyclohexaneDIHYDRO-5-HYDROXY-5-[(8-PENTYL-2-OXOCANYL)ACETYL]-2(3H)-FURANONE3,7,11-(3-METHYL-TRIDEUTERIO)-TRIMETHYL-(4,4-DIDEUTERIO)DODECA-1,6,10-TRIEN-3 -OL。
盐酸吡格列酮合成工艺路线
盐酸吡格列酮合成工艺路线
吡格列酮是一种口服降糖药物，其化学名称为(2S)-1-{2-[(6S)-2,4-dioxo-3,4-dihydro-1(2H)-pyridinyl]ethyl}-3-[3,5-dihydroxy-4-(1,2,3-trihydroxypropyl)oxolan-2-yl]pyrrolidine-2-carboxamide。
下面是盐酸吡格列酮的合成工艺路线：
1. 吡格列酮的合成是以吡嗪-2,4-二酮为原料。
首先将吡嗪-2,4-二酮进行锂盐化处理，得到相应的锂盐。
2. 将锂盐与1,2-环己二醇反应，生成环己二醇盐酸盐。
然后与二溴甲烷在碱性条件下反应，发生取代反应生成2,2'-二甲基环己三烯-1,5-二酮。
3. 将2,2'-二甲基环己三烯-1,5-二酮与氨反应，发生加成反应合成(2S)-1-{2-[(6S)-2,4-dioxo-3,4-dihydro-1(2H)-pyridinyl]ethyl}-3-[3,5-dihydroxy-4-(1,2,3-trihydroxypropyl)oxolan-2-
yl]pyrrolidine-2-carboxamide。
4. 最后，将合成得到的吡格列酮中间体与盐酸反应生成盐酸吡格列酮。
这个反应可以通过向反应体系中加入盐酸或通过滴定来完成。
值得注意的是，合成吡格列酮及其中间体的反应条件和操作方法需根据具体的实验室条件和酌情调整。
合成吡格列酮需要严格控制反应温度、反应时间和反应物的添加顺序，以及使用适当的溶剂和催化剂。
此外，由于吡格列酮是一种药物，其合成工艺路线也需要符合相关法规和标准。