14oscillatory 2

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高频振荡通气

高频振荡通气

高频振荡通气高频通气(high frequency ventilation,HFV)是指通气频率超过150次/分(2.5 Hz, 1 Hz=60次/分)的通气方式。

高频通气是1959年由Emerson首次发展起来的新技术,随着时间的推移逐步衍生出多种高频通气方式。

一般按照其气体运动方式将高频通气分为五类:1.高频正压通气(high frequency positive pressure ventilation, HFPPV)2.高频喷射通气(High frequency jet ventilation,HFJV)3.高频振荡通气(high frequency oscillatory ventilation,HFOV)4.高频阻断通气(High frequency flow interruption ventilation,HFFI)5.高频叩击通气(High-frequency flow interruption ventilation,HFFI)高频振荡通气以其可清除CO2、不易引起气压伤、小潮气量、操作简便、副作用少的优点,在近年来逐渐成为高频通气的首选。

经过多年的经验积累,高频振荡通气在儿科已经成为儿科重症治疗的首选通气方案之一,在ARDS、支气管胸膜瘘等疾病的治疗中,也逐渐扮演着越来越重要的角色。

而其余四种通气方式由于各自的不足,在临床使用中越来越少见。

一、高频振荡通气(HFOV)概述1972年Lukeuheimer等人在心功能研究试验中发现,经器官的压力振动可以使狗在完全肌松的情况下维持时间氧合和动脉血二氧化碳分压正常;与此同时,加拿大多伦多儿童医院Bryan及Bohn等发现应用活塞驱动振荡器对健康狗进行研究时发现,在高频率、低潮气量及远端气道极低压力的时候,动物可维持正常的CO2分压及O2分压,由此开始了人们对高频振荡通气机制的探究。

早期的高频振荡通气仅仅直接在气道上加用振荡器,后来发现这种方法短时间内虽然可以保证氧合和通气,但是长时间使用会造成严重的二氧化碳潴留。

PLC说明书

PLC说明书

COM2(RS-485)通 讯 传 送 (Tx) 指 示灯
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区,万年历及停电保持寄存器)有可能会消失或被破坏。
13 扩展定位孔
14 DIN 轨糟﹝35mm﹞
S0~S9, 10 点(*1)
S10~S19, 10 点, 搭配 IST 指令使用(*1) S20~S511, 492 点(*1) S512~S895, 384 点(*3)
合计 1024 点
S896~S1023, 124 点(*3)
T0~T255, 256 点
C0~C199, 16 位计数器, 200 点 C200~C254, 32 位计数器, 50 点 D0~D199, 200 点(*1) D200~D999, 800 点(*3) D2000~D4999, 3000 点(*3) D1000~D1999, 1000 点 E0~E3, F0~F3, 8 点(*1) 0~1599(1600 点) (*4) N0~N7, 8 点 P0~P255, 256 点
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型号
200605-22
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普联技术有限公司TL-SG2422F工业级以太网交换机安装手册说明书

普联技术有限公司TL-SG2422F工业级以太网交换机安装手册说明书

Enterprise Networking Solution安装手册工业以太网交换机TL-SG2422F工业级声明Copyright © 2022 普联技术有限公司版权所有,保留所有权利未经普联技术有限公司明确书面许可,任何单位或个人不得擅自仿制、复制、誊抄或转译本手册部分或全部内容,且不得以营利为目的进行任何方式(电子、影印、录制等)的传播。

为普联技术有限公司注册商标。

本手册提及的所有商标,由各自所有人拥有。

本手册所提到的产品规格和资讯仅供参考,如有内容更新,恕不另行通知。

除非有特殊约定,本手册仅作为使用指导,所作陈述均不构成任何形式的担保。

I声明相关文档除本安装手册外,TP-LINK官网还提供了《用户手册》、《命令行手册》和《防雷安安装手册简介本安装手册主要介绍交换机的硬件特性、安装方法以及在安装过程中应注意事项。

本手册包括以下章节:第1章:产品介绍。

简述交换机的基本功能特性并详细介绍外观信息。

第2章:产品安装。

介绍交换机的硬件安装方法以及注意事项。

第3章:硬件连接。

介绍交换机与其他设备之间的连接及注意事项。

第4章:配置指南。

介绍本地WEB管理及云管理操作步骤。

附录A:常见故障处理。

附录B:技术参数规格。

II相关文档附录C:连接光口补充说明。

附录D:有毒有害物质含量声明。

产品保修卡。

附录E:本手册适合下列人员阅读:网络工程师网络管理员约定本手册中产品图片仅为示意,端口数量、类型和位置等请以实际机型为准。

本手册采用了如下几种醒目标志来表示操作过程中应该注意的地方,这些标志的III阅读对象目录第1章 产品介绍 ———————————011.1 产品简介 (01)1.2 产品外观 (01)第2章 产品安装 ———————————042.1 物品清单 (04)2.2 安装注意事项 (04)2.3 安装工具准备 (06)2.4 产品安装 (06)第3章 硬件连接 ———————————093.1 连接至RJ45端口 (09)3.2 连接SFP端口 (09)3.3 连接电源线 (10)3.4 电源模块的安装与拆卸 (10)3.5 设备初始化 (11)3.6 安装后检查 (11)第4章 配置指南 ———————————124.1 本地WEB管理 (12)4.2 云管理 (12)附录A 常见故障处理 —————————13附录B 技术参数规格 —————————14附录C 连接光口补充说明 ———————16附录D 有毒有害物质含量声明—————17附录E 产品保修卡 ——————————18IV目录01产品介绍工业以太网交换机第1章 产品介绍1.1 产品简介TP-LINK工业以太网交换机专为在恶劣的工业环境下可靠稳定的运行而设计,并提供了一套经济有效的解决方案。

物理公式1(英文版)

物理公式1(英文版)

小学六年级数学教研组工作计划模板一、指导思想本学期六年级数学教研组以学校教学工作计划为指导,加强课程理论学习,进一步转变教育观念,更新教学方式,提高自身的教育科研能力,提高课堂教学效率。

探索高效课堂下的课堂常规管理模式,提高课堂教学水平,使得教研组在课题研究和教学质量等方面进一步得到稳步提高。

创设高效、民主、合力的教育氛围,全面提升各位数学教师的教学质量。

二、工作目标1、把集体备课落到实处。

做好集体备课教案的二次修改和反思。

上好每一节课。

2、进一步提升教师的自身素质和业务水平努力,提升教师素养,提高教学水平。

3、注重学生兴趣的培养,提高学生的积极性,全面提高学生的综合素质。

4、重点做好毕业生思想健康方面的工作,确保学生安全健康的发展三、主要工作1、加大口算训练力度,努力提高学生计算水平。

口算是一切计算的基础,让口算训练体现在天天练中,每节数学课都训练一定数量的口算题,并在训练过程中逐步提高要求。

2、继续学习新课程理论,加强教育教学的理论学习本学期我们全体数学教师继续以高效为主要的学习内容。

组织切实有效的学习和讨论活动,用先进的教育理论,改变传统的教学模式。

要求教师们把高效课堂的理念渗透到教学中,教学注重以培养学生的合作交流意识和实践创新能力为主,注重尊重学生的需要,培养学生的自学能力。

3、精心备好每一节课本学期我们组备课力求体现学生的主体性,在备课中充分发挥团队的作用,做到资源共享。

充分利用集体研讨的时间,讨论交流一周工作的得与失,并对下一阶段教学提出自己的看法4、认真上好每一节课本学期根据学校要求,上好示范课、教研课和汇报课,做到各种课型都能上到。

在评课时每位教师认真总结,积极写好案例。

5、做好培优补差工作,提高教学质量。

在大面积提高教学质量的同时,坚持不放弃每一个后进生,以良好的心态接纳他们,给他们以更多的关心和爱护,相信每一个学生都能学到自己适合的数学,让他们在数学学习上有所进步,以提高的数学成绩合格率。

MIC MECHANIC 2 简易电池驱动音频效果小盒子用户手册说明书

MIC MECHANIC 2 简易电池驱动音频效果小盒子用户手册说明书

MIC MECHANIC 2Ultra-Simple Battery-Powered Vocal Eff ects Stompbox with Echo, Reverb and Pitch CorrectionUser Manual2MIC MECHANIC 2 User ManualLEGAL DISCLAIMER LIMITED WARRANTY Terminals marked with this symbol carry electrical current of suffi cient magnitude to constitute risk of electric shock.Use only high-quality professional speaker cables with ¼" TS or twist-locking plugs pre-installed. All other installation or modifi cation should be performed only by qualifi ed personnel.This symbol, wherever it appears,alerts you to the presence of uninsulated dangerous voltage inside theenclosure - voltage that may be suffi cient to constitute a risk of shock.This symbol, wherever it appears, alerts you to important operating and maintenance instructions in theaccompanying literature. Please read the manual.CautionTo reduce the risk of electric shock, do not remove the top cover (or the rear section).No user serviceable parts inside. Refer servicing to qualifi ed personnel.CautionTo reduce the risk of fi re or electric shock, do not expose this appliance to rain andmoisture. The apparatus shall not be exposed to dripping or splashing liquids and no objects fi lled with liquids, such as vases, shall be placed on the apparatus.CautionThese service instructions are for use by qualifi ed service personnel only.To reduce the risk of electric shock do not perform any servicing other than that contained in the operation instructions. Repairs have to be performed by qualifi ed service personnel.1. Read these instructions.2. Keep these instructions.3. Heed all warnings.4. Follow all instructions.5. Do not use this apparatus near water.6. Clean only with dry cloth.7. Do not block any ventilation openings. Install in accordance with the manufacturer’s instructions.8. Do not install near any heat sources such as radiators, heat registers, stoves, or other apparatus (including amplifi ers) that produce heat.9. Do not defeat the safety purpose of the polarizedor grounding-type plug. A polarized plug has two bladeswith one wider than the other. A grounding-type plughas two blades and a third grounding prong. The wide blade or the third prong are provided for your safety. If the provided plug does not fi t into your outlet, consult an electrician for replacement of the obsolete outlet.10.Protect the power cord from being walked on orpinched particularly at plugs, convenience receptacles,and the point where they exit from the e only attachments/accessories specifi ed bythe manufacturer.e only with thecart, stand, tripod, bracket,or table specifi ed by themanufacturer, or sold withthe apparatus. When a cartis used, use caution whenmoving the cart/apparatuscombination to avoidinjury from tip-over.13.Unplug this apparatus during lightning storms or when unused for long periods of time.14.Refer all servicing to qualifi ed service personnel. Servicing is required when the apparatus has been damaged in any way, such as power supply cord or plug is damaged, liquid has been spilled or objects have fallen into the apparatus, the apparatus has been exposed to rain or moisture, does not operate normally, or has been dropped.15.The apparatus shall be connected to a MAINS socket outlet with a protective earthing connection.16.Where the MAINS plug or an appliance coupler is used as the disconnect device, the disconnect device shall remain readily operable.17.Correct disposal of this product: This symbol indicates that this product must not be disposed of with household waste, according to the WEEE Directive (2012/19/EU) and your national law. This productshould be taken to a collection center licensed for the recycling of waste electrical and electronic equipment (EEE). The mishandling of this type of waste could have a possible negative impact on the environment and human health due to potentially hazardous substances that are generally associated with EEE. At the same time, your cooperation in the correct disposal of this product will contribute to the effi cient use of natural resources. For more information about where you can take your waste equipment for recycling, please contact your local city offi ce, or your household waste collection service.18.Do not install in a confi ned space, such as a book case or similar unit.19.Do not place naked fl ame sources, such as lighted candles, on the apparatus.20.Please keep the environmental aspects of battery disposal in mind. Batteries must be disposed-of at a battery collection e this apparatus in tropical and/or moderate climates.MUSIC Group accepts no liability for any loss which may be suff ered by any person who relieseither wholly or in part upon any description, photograph, or statement contained herein. Technical specifi cations, appearances and otherinformation are subject to change without notice.All trademarks are the property of their respectiveowners. MIDAS, KLARK TEKNIK, LAB GRUPPEN, LAKE,TANNOY, TURBOSOUND, TC ELECTRONIC, TC HELICON,BEHRINGER, BUGERA and DDA are trademarksor registered trademarks of MUSIC Group IP Ltd.© MUSIC Group IP Ltd. 2016 All rights reserved.For the applicable warranty terms and conditionsand additional information regarding MUSIC Group’s Limited Warranty, please see complete details online at/warranty.3MIC MECHANIC 2 User Manual1.Controls(9)(10)(11)(12)(1)ECHO knob selects the type and amount of echo eff ect on your voice.Adjusting the knob within your preferred echo style determines how loud the echoes will be. Turning the knob fully counterclockwise turns the echo eff ect off. There are 3 types of echo available:• Tape – simulates the warm sound of analog tape echo• Digital – creates a pristine, exact replication of the original signal• Slap – creates a single, quick echo eff ect(2)REVERB knob selects the type and amount of reverb eff ect on your voice.The 3 types of reverb appear in order from the smallest space (Room) tothe largest (Hall). Adjusting the knob within your preferred reverb spacedetermines how pronounced the eff ect will be. Turning the knob fullycounterclockwise turns the reverb off.(3)CORRECTION knob adjusts the amount of pitch correction. With the knobat the center 12:00 position, the eff ect will provide subtle pitch supportwithout noticeable or unnatural artifacts. Turn the knob all the way up for a more aggressive eff ect, or fully counterclockwise to turn the eff ect off. (4)BATTERY LED indicates the battery level, with green showing full life,yellow being partial life, and red to alert that the batteriesshould be changed.(5)TONE button engages a preset combination of adaptive EQ, de-essing, andnoise gate. "Normal" and "Less Bright" settings can be toggled by holding the Tone button and pressing the footswitch.(6)ON/OFF LED lights when the eff ect is engaged, and fl ashes in rhythm to thedelay tempo when using the tap tempo function.(7)FOOTSWITCH bypasses the Reverb, Echo and Correction eff ects, but doesnot aff ect the Tone status. (8)USB input accepts a micro USB cable for connection to a computer.Use the VoiceSupport application to install fi rmware updates, and forother features depending on your product. Download VoiceSupport from /products/voicesupport/(9)ON/OFF switch powers the pedal on and off.(10) POWER input accepts a 9V power cable (not included).(11) OUT jack accepts a balanced XLR cable for connection to a mixer oractive speaker.(12) MIC input jack accepts a balanced XLR cable to connect your microphone.4MIC MECHANIC 2 User ManualConnection•Connect a microphone to the MIC jack•Connect the OUT jack to a mixer, interface or active speaker •Connect the power cable (optional)•Connect a micro USB cable to a computer (optional)Tap TempoThe echo tempo can be manually adjusted to match the song you’re performing. Simply hold the Footswitch down for about 2 seconds to enter Tap Mode. The on/off LED will fl ash in rhythm with the current tempo. Tap the footswitch a few times in rhythm with your desired tempo, and on the last tap, hold your foot on the switch for around 2 seconds to exit Tap Mode.Note – the pedal will not “time out” of Tap Mode, so you can keep this mode active if you intend to leave the eff ect on throughout a song or set, allowing you easier access to this function.Adjusting Echo FeedbackFeedback is the parameter that controls how many repeats are heard in the echo eff ect. By holding the Tone button and turning the Correction knob, you can adjust the feedback length. As soon as you release the Tone button, the Correction knob will resume its normal function. Changing the BatteriesThe Mic Mechanic 2 can operate on 4 AA batteries. Remove the single screw on the bottom of the pedal to open the battery door. Make sure to observe correct polarity when inserting the batteries.Auto GainMic Mechanic 2 will automatically adjust the gain setting for your microphone, eliminating the need for manual adjustments and ensuring that a good signal is passed to the mixer without any unwanted distortion.24V Phantom PowerPhantom power is always active on the Mic Mechanic 2. This will power condenser microphones, but will not aff ect dynamic mics either.Mic ControlMic Control allows you to control the eff ect's on/off status via an MP-75 microphone. Press and hold the footswitch while powering up the unit to toggle Mic Control.Note that when using a condenser microphone, Mic Control should be disabled to prevent unwanted on/off switching.2.Operation5MIC MECHANIC 2 User Manual3.Specifi cationsI nput Connector: XLR female, balanced Input Impedance: 3k4/1k7 Ohm SNR A Weighted:>1 dBOutput Connector: XLR male, impedance balanced, pin 2 hot Output Impedance: 200/100 Ohm Output Full Scale Level: Input to Output Freq Response:+0/-0.3 dB, 20 Hz to 20 kHzPower Supply (Optional ): 9 V / 670 mA Power Consumption:6 WOperating Temperature: 32°F to 122°F (0°C to 50°C)Storage Temperature: -22°F to 167°F (-30°C to 70°C)Humidity Max.:90 % non-condensingDimensions: 5.4" x 3.5" x 2.3" (140 x 90 x 60 mm) Weight: 0.92 lb. (420 g)For the applicable warranty terms and conditions and additional information regarding MUSIC Group’s Limited Warranty, please see complete details online at /warranty.Due to continuous development, these specifi cations are subject to change without noticeInput Clip Sensitivity: -1 dBu +7.5 dBuMIC MECHANIC 2 Ultra-Simple Battery-Powered Vocal Eff ects Stompbox with Reverb, Echo and Pitch Correction。

EMC测试报告

EMC测试报告

EMC测试报告EMC TEST REPORTReport No: TS12060041-EME Model No: RPI-H3, RPI-H2.5 Issued Date: Jan. 30, 2013Applicant: Address: DELTA ELECTRONICS INC.39 Sec. 2, Huandong Road, Shanhua Dist., Tainan city 74144, TaiwanTest Methods/ Standards: EN 301 489-17 V2.1.1/EN 301 489-1 V1.9.2EN 61000-6-3: 2007+A1: 2011 /EN 61000-6-1: 2007EN 61000-6-4: 2007+A1: 2011/EN 61000-6-2: 2005EN 61000-3-2: 2006+A1: 2009 +A2: 2009EN 61000-3-3: 2008IEC 61000-4-2: 2008/ EN 61000-4-2: 2009ICE 61000-4-3: 2010/ EN 61000-4-3:2006+A1:2008+A2:2010 ICE 61000-4-4 :2012/EN 61000-4-4: 2012IEC 61000-4-5: 2005/ EN 61000-4-5: 2006IEC 61000-4-6: 2008/ EN 61000-4-6: 2009IEC 61000-4-8: 2009/ EN 61000-4-8: 2010IEC 61000-4-11 :2004/EN 61000-4-11: 2004IEC 61000-4-16: 2011IEC 61000-4-18: 2011IEC 61000-4-29: 2000Test By: Intertek Testing Services Taiwan Ltd.,Hsinchu LaboratoryNo. 11, Lane 275, Ko-Nan 1 Street, Chia-Tung Li,Shiang-Shan District, Hsinchu City, TaiwanIt may be duplicated completely for legal use with the allowance of the applicant. It shall not be reproduced except in full, without the written approval of Intertek Laboratory. The test result(s) in this report only applies to the tested sample(s). The test report was prepared by: Sign on FileCandy Liu / AssistantThese measurements were taken by:Sign on FileAnson Lee / EngineerName Arthur TsaiTitle Senior EngineerTable of Contents1. General Information (6)1.1 Identification of the EUT (6)1.2 Additional information about the EUT (7)2. Test Summary (8)2.1 Test requirements (8)3. Test Specifications (11)3.1 Standards (11)3.2 Test Facility accreditation (12)3.3 Classification of ITE (12)3.4 External port (13)3.5 Performance verification (13)3.6 Mode of operation during the test (13)3.7 Peripheral equipment (14)4. Conducted Emission Test (15)4.1 Test arrangement (15)4.2 Photographs of the test arrangement (15)4.3 Test Procedures (15)4.4 Test Equipment (16)4.5 Conducted Emission Limit for AC mains port (16) 4.6 Uncertainty of Conducted Emission (16)4.7 Test Result: Pass (17)5. Radiated Emission Test (19)5.1 Test arrangement (19)5.2 Photographs of the test arrangement (19)5.3 Test Procedures (19)5.4 Test Equipment (20)5.5 Radiated Emission Limit (20)5.2.1 Test Procedure from 1 GHz to 6 GHz (23)5.2.2 Test Equipment (24)5.2.3 Radiated Emission Limit (24)5.2.4 Uncertainty of Radiated Emission (24)5.2.5 Radiated Emission Test Data from 1 GHz to 6 GHz (25)6. Harmonic Test (26)6.1 Test arrangement (26)6.2 Test Procedure & classification (26)6.3 Classification (26)6.4 Test Equipment (27)6.5 Uncertainty of Harmonic (27)6.6 Test Result (28)7. V oltage Fluctuations-Flicker Test (29)7.1 Test arrangement (29)7.2 Test Procedure (29)7.3 Test Equipment (30)7.4 Uncertainty of Flicker (30)7.5 Test result (30)8. Electrostatic Discharge Immunity Test (31)8.1 Test arrangement (31)8.2 Photographs of the test arrangement (31)8.3 Test Procedure (31)8.4 Test Specification (32)8.5 Test Equipment (33)8.6 Requirement (33)8.7 Test Result: Pass (34)9. Radiated Susceptibility Immunity Test (38)9.1 test arrangement (38)9.2 Photographs of the test arrangement (38)9.3 Test Procedure (38)9.7 Generation of the Electromagnetic Field (40)9.8 Test Results: Pass (41)10. Electrical Fast Transient/Burst Immunity Test (42)10.1 Test arrangement (for Main power) (42)10.2 Test arrangement (for DC port) (42)10.3 Test arrangement (for RS-485&RJ45port) (42)10.2 Photographs of the test arrangement (43)10.3 Test procedure (43)10.4 Test Specification (43)10.5 Test Equipment (44)10.6 Requirement (44)10.7 Test Results (45)11. Surge Immunity Test (46)11.1 Test arrangement (AC side) (46)11.2 Test arrangement (DC side) (46)11.3 Test arrangement (Signal port) (47)11.2 Photographs of the test arrangement (47)11.3 Test procedure (47)11.4 Test Specification (48)11.5 Test Equipment (48)11.6 Requirement (49)11.7 Test Results: Pass (50)11.7.1 Main power port (50)11.7.2 DC power port & Signal port (50)11.7.3 Signal port (50)12. Immunity to Conducted Disturbances, Inducted by Radio-Frequency Fields (51) 12.1 Test arrangement (51)12.2 Photographs of the test arrangement (51)12.3 Test procedure (51)12.7 Generation and Calibration of the Disturbance Signal (53)12.8 Test Results: Pass (54)13. Power Frequency Magnetic Field Immunity Test (55)13.1 Test arrangement (55)13.2 Photographs of the test arrangement (55)13.3 Test procedure (55)13.4 Test Specification (56)13.5 Test Equipment (56)13.6 Requirement (57)13.7 Test Result: Pass (57)14. V oltage Dips, Short Interruptions and V oltage Variations Immunity Test (58)14.1 Test arrangement (58)14.2 Photographs of the test arrangement (58)14.3 Test procedure (58)14.3 Test Specification (59)14.4 Test Equipment (59)14.5 Requirement (60)14.6 Test Result: Pass (61)15. Test for immunity to conducted, common mode disturbances in the frequency range (62) 15.1 Test arrangement (62)15.2 Photographs of the test arrangement (62)15.3 Test procedure (62)15.4 Test Specification (63)15.5 Test Equipment (63)15.6 Requirement (64)15.7 Test Results: Pass (64)16. Damped oscillatory wave test (65)16.1 Test arrangement (65)16.2 Photographs of the test arrangement (65)16.3 Test procedure (65)16.4 Test Specification (66)16.5 Test Equipment (66)17. V oltage dips, short interruptions and voltage variations on d.c. input power port immunity tests (70) 17.1 Test arrangement (70)17.2 Photographs of the test arrangement (70)17.3 Test procedure (70)17.4 Test Specification (71)17.5 Test Equipment (71)17.6 Requirement (72)17.7 Test Results: Pass (73)Appendix A1: External photo of EUT (74)Appendix B1: Conducted Emission Test Set-up (78)Appendix B2: Radiated Emission Test Set-up (79)Appendix B3: Harmonic and Flick Test Set-up (81)Appendix B4: Electrostatic Discharge (ESD) Test Set-up (82)Appendix B5: Radiated Susceptibility (RS) Test Set-up (83)Appendix B6: Electrical fast transient / burst (EFT) Test Set-up (84)Appendix B7: Surge Test Set-up (86)Appendix B8: Conducted disturbances (CS) Test Set-up (88)Appendix B9: Power frequency magnetic field (PFM) Test Set-up (89)Appendix B10: V oltage Dips Test Set-up (90)Appendix B11: Conducted, common mode disturbances in DC~150kHz Test Set-up (91)Appendix B12: Damped oscillatory wave test Set-up (92)Appendix B13: D.C Dip test set-up (93)1. General Information1.1 Identification of the EUTInverterProduct: PVModel No.: RPI-H3DC Input: 125~630 Vdc, Max 10 ARated Power:AC Output: 230 Vac, 50Hz/60Hz, 14.3 A, 3000V AMax. output power: 3000V AMax. output current: 14.3 APower Cord: 2C wires 1.8 meters cable1-Phase/3-Wire 3 meter cableSample receiving date: May. 30, 2012Sample condition: WorkableTesting date: May. 30, 2012 ~ Jan. 22, 2013Note 1: This report is for the exclusive use of Intertek's Client and is provided pursuant to the agreement between Intertek and its Client. Intertek's responsibility and liabilityare limited to the terms and conditions of the agreement. Intertek assumes no liability to any party, other than to the Client in accordance with the agreement, forany loss, expense or damage occasioned by the use of this report. Only the Clientis authorized to permit copying or distribution of this report and then only in itsentirety. Any use of the Intertek name or one of its marks for the sale or advertisement of the tested material, product or service must first be approved inwriting by Intertek. The observations and test results in this report are relevantonly to the sample tested. This report by itself does not imply that the material,product, or service is or has ever been under an Intertek certification program. Note 2: The test report only allows to be revised within three years from its original issued date unless further standard or the requirement was noticed.Note 3: When determining the test conclusion,the Measurement Uncertainty of test has been considered.1.2 Additional information about the EUTThe customer confirmed the models listed as below were series model to model Sunmaster RPI-H3 (EUT), the difference between main model and series model are listed as below. Model Number DifferenceRPI-H3 Input: 125-630 Vdc, Max. 10 AOutput V oltage: 230 Vac, 50/ 60 Hz,Output power: 3 kV A nom,Output current: 14.3 A maxRPI-H2.5 Input: 125-500 Vdc, Max. 10 A Output V oltage: 230 Vac, 50/ 60 Hz Output power: 2.5 kV A nom, Output current: 12 A max2. Test Summary2.1 Test requirementsStandard Test Type Enclosure AC side DC side Signal portConducted Test ×√×× EN 61000-6-3: 2007+A1: 2011 Radiated Test √×××EN 61000-3-2: 2006 +A1: 2009 +A2: 2009Harmonic currentemissions×√××EN 61000-3-3: 2008 V oltage fluctuation &flicker×√××IEC 61000-4-2: 2008 ESD test √××× IEC 61000-4-3: 2010 RS test √××× IEC 61000-4-4: 2012 EFT test ×√** IEC 61000-4-5: 2005 Surge test ×√** IEC 61000-4-6: 2008 CS test ×√×× IEC 61000-4-8: 2009 Magnetic Field test √×××IEC 61000-4-11: 2004Dip test ×√××IEC 61000-4-16: 2011CS test inDC~150KHz×√××IEC 61000-4-18: 2011Damped Oscillatorytest×√××IEC 61000-4-29: 2000 D.C. Dip test ××√× √: Applicable ×: Not applicable *: Require by client2.2 Test resultsEmission (EN 61000-6-3: 2007+A1: 2011)Standard TestTypeResult Remarks Conducted Test PASS Meet the requirementsEN 61000-6-3: 2007+A1: 2011 Radiated Test PASS Meet the requirementsEN 61000-3-2: 2006+A1: 2009 +A2: 2009Harmonic current emissions PASS Meet the requirementsStandard Test Type Minimum Criteria Result Test JudgmentIEC 61000-4-2: 2008 ESD test Criterion B PASS Meets the requirements of Performance Criterion B IEC 61000-4-3: 2010 RS test Criterion A PASS Meets the requirements of Performance Criterion A IEC61000-4-4: 2012 EFT test Criterion B PASS Meets the requirements of Performance Criterion A IEC 61000-4-5: 2005 Surge test Criterion B PASS Meets the requirements of Performance Criterion B IEC 61000-4-6: 2008 CS test Criterion A PASS Meets the requirements of Performance Criterion A IEC 61000-4-8: 2009 Magnetic FieldtestCriterion A PASSMeets the requirements ofPerformance Criterion AIEC 61000-4-11: 2004 Dip test 1. 100% reduction-Performance Criterion B2. 60% reduction-Performance Criterion C3. 30% reduction- Performance Criterion C4.100% reduction- Performance Criterion C PASSMeets the requirements ofV oltage Dips:1. 100 % reduction-Performance Criterion A2. 60 % reduction-Performance Criterion B3. 30 % reduction-Performance Criterion B4. 100 % reduction-Performance Criterion BIEC 61000-4-16:2011 CS inDC~150kHz testCriterion A PASSMeets the requirements ofPerformance Criterion AIEC 61000-4-18:2011 DampedMeets the requirements ofPerformance Criterion BIEC 61000-4-29:2000 D.C Dip test 1. 100% reduction-Performance Criterion A2. 60% reduction-Performance Criterion C3. 30% reduction-Performance Criterion C4.100% reduction-Performance Criterion CPASSMeets the requirements ofV oltage Dips:1. 100 % reduction-Performance Criterion A2. 60 % reduction-Performance Criterion A3. 30 % reduction-Performance Criterion A4. 100 % reduction-Performance Criterion CRemark:The test items of IEC 61000-4-16、IEC 61000-4-18、IEC 61000-4-29 in this report were conducted by provided by Electronics Testing Center, Taiwan.(EN 301 489-1/-17)EmissionStandard Test Type Result RemarksConducted EmissionPASS Meet Class B LimitISNN/A N/AV oltage fluctuation & FlickerPASSMeet the requirementsImmunityStandard Test Type Performance CriteriaResult Test JudgmentEN 61000-4-2: 2009 ESD test Criterion B PASSMeets the requirements ofPerformance Criterion B EN61000-4-3 2006+A1:2008+A2:2010RS test Criterion A PASSMeets the requirements of Performance Criterion A EN 61000-4-4: 2004 +A1: 2010 EFT test Criterion B PASS Meets the requirements ofPerformance Criterion AEN 61000-4-5: 2006 Surge test Criterion B PASSMeets the requirements ofPerformance Criterion B EN 61000-4-6: 2009 CS test Criterion A PASSMeets the requirements ofPerformance Criterion A EN 61000-4-11: 2004Dip test1. 100 % reduction- Performance Criterion B2. 100 % reduction- Performance Criterion C3. 30 % reduction- Performance Criterion B4. 100 % reduction- Performance Criterion CPASSMeets the requirements of V oltage Dips: 1. 100 % reduction-Performance Criterion A 2. 100 % reduction-Performance Criterion A 3. 30 % reduction-Performance Criterion B 4. 100 % reduction-Performance Criterion B3. Test Specifications3.1 StandardsEN 61000-6-1: 2007 Electromagnetic compatibility - Generic immunity standard-For Residential, commercial and light industry environments.EN 61000-6-2: 2005Generic standards – Immunity for industrial environmentsEN 61000-6-3: 2007+A1: 2011 Generic standards –Emission standard for residential, commercial and light-industrial environmentsEN 61000-6-4: 2007+A1: 2011Generic standards – Emission standard for industrial environments.EN 301 489-17 V2.2.1 Electromagnetic compatibility and Radio spectrum Matters (ERM); ElectroMagnetic Compatibility (EMC) standard for radio equipment; Part 17: Specific conditions for Broadband Data Transmission SystemsEN 301 489-1 V1.9.2 Electromagnetic compatibility and Radio spectrum Matters (ERM); Electromagnetic Compatibility (EMC) standard for radio equipment and services; Part 1: Common technical requirementsEN 61000-3-2: 2006+A1: 2009 +A2: 2009 Electromagnetic compatibility ─ Part 3. Limits. Section 2. Limits for harmonic current emissions (equipment input current ≤ 16 A per phase) EN 61000-3-3: 2008 Electromagnetic compatibility ─ Part 3. Limits. Section 3. Limitation of voltage fluctuations and flicker in low-voltage supply systems for equipment with rated current ≤ 16 A3.2 Test Facility accreditationIntertek Testing Services Taiwan Ltd., Hsinchu Laboratory is accredited in respect of laboratory and the accreditation criterion is ISO/IEC 17025: 2005.Certification Bureau Code AccreditationCriteria TAF 0597 ISO/IEC17025AccreditationCertificate BSMI SL2-IS-E-0024SL2-IN-E-0024SL2-A1-E-0024SL2-R2-E-0024SL2-R1-E-0024SL2-L1-E-0024ISO/IEC 17025FCC 93910 Test facility list& NSA DataIC 2042D-1, 2042D-2 Test facility list& NSA DataSite Filling Code :VCCI R-1534C-1618T-1586Test facility list& NSA DataNote 1: Each certificate can refer to attachment certification.pdf.Note 2: Each certificate is within the valid calibration period.3.3 Classification of ITEITE is subdivided into two categories denoted class A ITE and class B ITE.Class B ITEClass B ITE is a category of apparatus which satisfies the class B ITE disturbance limits. Class B ITE is intended primarily for use in the domestic environment and may include: — equipment with no fixed place of use; for example, portable equipment powered by built-in batteries;— telecommunication terminal equipment powered by a telecommunication network; — personal computers and auxiliary connected equipment.NOTE: The domestic environment is an environment where the use of broadcast radio and television receivers may be expected within a distance of 10 m of the apparatus concerned. Class A ITEClass A ITE is a category of all other ITE which satisfies the class A ITE limits but not the class B ITE limits. Such equipment should not be restricted in its sale but the following warning shall be included in the instructions for use:WARNINGThis is a class A product. In a domestic environment this product may cause radio interference in which case the user may be required to take adequate measures.3.4 External portItems SpecificationsDC input port +,-AC mains output port 1-Phase/3-Wire (L, N, PE)WiFi Communication RS-485,RJ45,EPO&Note 1: EPO stands for “Emergency Power Off”.3.5 Performance verificationThe EUT has been monitored based on manufacturer’s specification; the performance fulfilled the requirements of standard.3.6 Mode of operation during the testThe input power port of EUT is connected with DC source, the output power port of EUT is connected with AC source and load. After EUT joining with AC source, when the output power of EUT raises, the AC source power will decline but not to zero. The margin of EUT raised power is the same as the margin of AC source declined power.3.7 Peripheral equipmentPeripheralsBrandModel No.Serial No.Description of cablelengthSymbolDC power Chroma 62150H-1000S N/AN/ABatteries frame YUASA&GS UXH90-12& GPL 121000 N/A N/AAC Converter APC AFC-33030J F311040038N/A Load N/A N/A N/A N/ANotebook PC IBM 2609 BA-ZHNHNRS 232 Cable 1meterRS232 to RS-485 Coverter*TryCon TRP-C06NARJ-45 UTP Cat.5.03 meterN/A* The equipment is supplied by client.4. Conducted Emission Test4.1 Test arrangement4.2 Photographs of the test arrangementPlease refer to the appendix B1 of the present report.4.3 Test Procedures1. The EUT is set up per the test arrangement and simulate the typical usage based on the user’s manual.2. Equipment designed for wall-mounted operation shall be tested as tabletop EUT. The orientation of the equipment shall be consistent with normal installation practice.3. The EUT are placed on a 1.0 meter(W)×1.5meter(L) and 0.8 meter in height wooden table and the EUT was adjusted to maintain a 0.4meter space from a vertical reference plane.4. The rear of the arrangement shall be flush with the back of the supporting tabletop unless that would not be possible or typical of normal use.5. The EUT is connected to power mains through a Artificial Mains Network (AMN), which provided 50 ohm coupling impedance for measuring instrument and the chassis ground was bounded to the horizontal ground plane of shielded room.6. The AMN is placed 0.8 meters from the EUT, All other units of the EUT and associated equipment shall be at least 0.8 m from the AMN .7. The excess power cable between the EUT and the AMN was bundled. All connecting cables of EUT and peripherals weremoved to find the maximum emission8. If the measuring receiver is connected to the voltage probe, the AMN shall be terminated with 50 ?.9. If any, measure the conducted emissions on each phase of power line of the EUT’s power source by using the test receiver.10. Sweep the signal from 150kHz to 30MHz by using the receiver with the maximum-Peak detector.11. If the peak emission level is lower than the average limit, then the emission valuespresented will be the peak value only. Otherwise, both of Q.P. and average values shall be measured. Reference ground plane 80 cm4.4 Test EquipmentEquipment Brand Model No. Serial No. CalibrationDateNextCalibrationEMI Receiver Rohde & Schwarz ESCS30 833364/0112012/06/15 2013/06/15200-A Four-LineV-NetworkRohde&schwarz ENV4200 848411/0122012/10/17 2013/10/17Shield Room N/A N/A N/A N/A N/ANote: The above equipments are within the valid calibration period.4.5 Conducted Emission Limit for AC mains portFreq. MaximumRFLineV oltage (MHz) Class B (dBµV)Q.P.Ave.0.15~0.50 66-56 56-460.50~5.00 56 465~30.00 60 50 4.6 Uncertainty of Conducted EmissionExpanded uncertainty (k=2) of conducted emission measurement is ± 2.786 dB.4.7 Test Result: PassPhase: Line Temperature: 24 ℃ Model No.: RPI-H3 Relative Humidity: 53 % Test Date: Nov. 21, 2012 Atmospheric Pressure: 1008 hPa Remark: N/AInput voltage: 500 V Vdc Output voltage:1-Phase/3-Wire (L, N, PE)Frequency range: 0.15 MHz to 30 MHzRemark:1. Corr. Factor (dB) = AMN Factor (dB) + Cable Loss (dB)2. Margin (dB) = Level (dBuV) – Limit (dBuV)Note: 1. Q.P. stands for Quasi-peak.2. Correction factor = cable loss + insertion loss of AMN.3. Margin = Level - Limit.Class B Q.P. Class B Ave.Phase: Neutral Temperature: 24 ℃ Model No.: RPI-H3 Relative Humidity: 53 % Test Date: Nov. 21, 2012 Atmospheric Pressure: 1008 hPa Remark: N/AInput voltage: 500 V Vdc Output voltage:1-Phase/3-Wire (L, N, PE)Frequency range: 0.15 MHz to 30 MHzRemark:1. Corr. Factor (dB) = AMN Factor (dB) + Cable Loss (dB)2. Margin (dB) = Level (dBuV) – Limit (dBuV)Note: 1. Q.P. stands for Quasi-peak.2. Correction factor = cable loss + insertion loss of AMN.3. Margin = Level - Limit.Class B Q.P. Class B Ave.5. Radiated Emission Test5.1 Test arrangement5.2 Photographs of the test arrangementPlease refer to the appendix B2 of the present report.5.3 Test Procedures1. The EUT is set up per the test arrangement and simulate the typical usage based on the user’s manual.2. Equipment designed for wall-mounted operation shall be tested as tabletop EUT. The orientation of the equipment shall be consistent with normal installation practice.3. Radiated testing is placed on a wooden table with a height of 0.8 meters above thereference ground plane and 10 meters away from the reference point of the receiver antenna in the open area test site.4. The table rotates 360 degrees to determine the position of the highest radiation. The antenna height is varied between one meter and four meters above reference ground plane to find the maximum value of the field strength.。

高频震荡通气 Word 文档 (2)

关键词】高频振荡通气临床【中图号】TH 778Application of High Frequency Oscillatory Ventilation in Pediatrics1 历史与背景传统的呼吸机通气(Conventional Machanical Ventilation CMV)在严重疾病的治疗中给予重要的生命支持,使很多危重病人获得康复机会,其疗效是非常显著的,但这一治疗手段也有其严重的并发症,如气压性损伤,气漏综合症(ai r leak syndrome)以及肺间质反应性纤维化.对早产婴儿长时间呼吸机通气可造成肺损伤从而导致慢性肺泡-支气管发育不良综合征.1972年Lukenheimer及其同事在高频率通气(High Frequency Ventilation HFV)的基础上,对严重肺损伤CMV治疗无效的病人采用高频振荡通气(High Frequency Oscillatory Ventila tion HFOV)收到良好效果[1].引起了危重病医学界的高度重视.此后国际上广泛大量开展了HFOV的基础与临床方面的科学研究取得突破性进展.今天HFOV 已成为新生儿婴幼儿极危重症病人尤其是严重肺功能障碍CMV治疗无效的一种重要治疗手段,成为儿科生命支持技术的发展方向之一.2 高频振荡通气的原理传统的呼吸机通气依赖于有效的肺泡通气其通气原理为:V A =VT-VDVA……肺泡有效通气VT……潮气量VD……解剖死腔量潮气量VT 大于解剖死腔VD,才能出现有效肺泡通气.当VT接近VD时则VA接近0.VA 是决定CO2从肺内排出的因素.高频振荡通气时TT≤VD,则VA≤0按理无气体交换.上述原理无法解析HFOV.Lukenheimer[1,10]研制的高频振荡通气是在呼吸机封闭的管道系统内,给予一个持续气流并控制在一定压力内,用一个扬声器膜(Loudspeaker diaphram)产生高频振荡,频率范围在5~40Hz(300~2400bp m)其振荡通过持续气流传入病人肺内.在通气过程,没有峰压(PIP)与基线压(base line pressure)之分.只有平均气道(MAP)压力,且潮气量极少,VT <VD.以传统机械通气的原理不能解析高频通气时气体交换的存在.传统机械通气时VCO2=FVT,二氧化碳的排出取决于分钟通气量(即FVT)而高频振荡通气时:[2,10]VCO2=(F)x(VT)y公式中x=0.5~1 y=1.5~2.2由此可见高频通气时潮气量比频率更重要{(VT)y?(F)x}.HFOV时气体交换有五种学说解析其原理:[3,10]①Permutt及其同事提出的Transit Time profile学说.其主要原理为气管吸入气体到达肺泡的距离不同因而到达的时间不一致.这种时间差使不同肺单位产生容积性气体交换(bulk convection).②Otis et al 的Interregional Gas Mixing学说,其主要原理为不同部位的肺单位存在顺应性差异,致使不同肺单位充盈胀气与回缩排气不同步.这种因顺气性差异所引致的肺泡胀缩时相差,可使气体在不同部位间流动,混合,达到气体交换.③Aug mented Dispersion 又称Taylor Dispersion学说,1953年Taylor首先在研究流体力学时提出的理论,即在密闭管道内流动的气体(或液体)会沿纵轴形成层流同时又会作横向扩散运动(axial velocity profile and radial diffusion of gas in motion)并产生涡流(gas turbulence).高频通气时气体可通过这些原理达到气体交换.④Asymmetric Velocity Profiles学说Scherer及其同事首先描述气体在分枝系统内的不均匀扩散,在支气管树内的不同气体的流速,流量不同,并且高频振荡时即使是少量气体向远端轴向扩散时亦不会衰减甚至可迭加增强.这种气体扩散是气体交换的机制之一.Chang及其同事对此特征的研究结果是肯定的[4].⑤分子扩散原理:气体分子的自由运动也是HFOV时气体交换原理之一.3 高频振荡通气的临床应用高频振荡通气的特点:(1)无峰值压力和基线压力,只有MAP,可减轻肺组织切应力性损伤.(2)适当高的MAP可提高FRC,增加氧弥散面积,改善氧合状态.(3)连续的振荡气流形成主动排气过程使CO2得以主动排出,而非传统机械通气的靠胸廓和肺的弹性回缩排气.HFOV的临床指征:HFOV的目的主要是利用其气压性损伤小(无峰压)可改善弥散功能的特点.临床主要用于需限压的通气及常规呼吸机通气不能改善的情况.新生儿与儿科适应症也不同.新生儿适应症有:[4,8]①NRDS ②PPHN(Persistent Pulmonary Hypertension of Newborn) ③NMA S (Neonatal Meconium Aspiration Syndrome) ④先天性膈疝和新生儿肺发育不良.⑤新生儿肺间质气肿及气胸.儿科HFOV的适应症有:①急性肺损伤的AR DS.②儿科气漏综合征和肺间质气肿.Gutierrez et al报告HFOV用于治疗呼吸道合胞病毒伴轻中度呼吸道梗阻,出现ARDS样症状(ARDS-like symptoms)病人,可有效改善氧合和维持满意通气.大量临床研究表明上述严重病变常规呼吸机通气无效时HFOV可明显改善缺氧和显著提高存活率,其安全性也较好,因而不少研究者主张尽早使用以减轻并发症,降低死亡率,提高生存率.HFOV还应用于较大的外科手术期间的通气以及腹部损伤所致腹压明显增高导致呼吸衰竭CMV无效的病人[7].HFOV结合NO吸入治疗严重肺损伤伴持续肺动脉高压,可减少膜肺应用,还可缩短呼吸机通气时间及减轻并发症,缩短病程.Fort.P和Fa rmer C的研究显示:在重危病人HFOV频率在500~1000bpm时可明显改善气体交换,生存者的追踪观察,慢性肺部疾病发病率与常规呼吸机治疗者比较有显著差异.Araorld et al.发表了第一次的前瞻性、随机性HFOV与CMV用于儿科呼吸衰竭的研究结果,为FDA批准HFOV在美国临床应用的依据,在其指导的多中心研究中包括70名急性肺损伤和呼吸衰竭病人,年龄>1月体重<3.5kg.入选研究的金标准为氧指数(Oxygen Index)≥13/或有气漏综合症(air leak).随机分组分别进行HFOV和CMV治疗,结果显示HFOV组需较高Paw ;PaO2/PAO2增大(肺泡动脉氧分压差),在治疗30天结果:所需FiO2有显著差异(HFOV组FiO2=21%,CMV组FiO2=59%),单纯用HFOV治疗生存率达83%;而单纯用CMV治疗为30%.从CMV转为HFOV治疗和从HOVF转为CMV治疗不伴有严重肺损伤的病人其存活率分别为21%和0%.研究还表明HFOV治疗24小时无氧改善,OI>42者其疗效不佳,此组病人死亡率很高[8,9].近年大量儿科临床研究均证实HFOV对严重肺功能障碍、氧合情况差,如严重肺损伤(SLI)ARDS和气漏综合征(ALS)等,CMV治疗效果欠佳的病人疗效显著,可改善氧合,降低死亡率,缩短病程[13,14].4 高频振荡呼吸机的选择高频振荡通气的概念及初始研究源于1972年由Lukenheimer首先表述,九十年代初才大量进行临床研究,1995年获FDA通过.因此技术成熟的呼吸机不多,目前常用的有Sensor Medics 3100A; Drager Baby Log 8000;Metran Hum ming Bird V;Infant Star;Infant Star 950.Sensor Medics 3100A采用较小的膜式振动源;Infant Star;Drager Baby Log 8000和Infant Star 950 采用扬声器膜为振动源(Loud spesker diaphram),Hammingv Bird V采用喷射式振荡(piston).前二者为专用HFOV,余者为CMV配以HFOV.近两年新机型Stepha n也具有HFOV功能,但亦为piston式振荡源[1,13].1998年David Hatcher et al对上述五种HFOV机型进行动物实验比较,结果表明各具优点,操作上也有简繁之别,病情程度、使用者知识等均影响HFOV效果.作为专用机的SENSOR Med ics 3100A.可调节参数较多而灵活,具有技术优势.其他机型可结合CMV使用,用途较广.应依据不同疾病的不同病理生理状况及使用者的经验选用.5 高频振荡通气的研究现状与未来研究方向HFOV近年已广泛应用于新生儿婴儿严重肺功能障碍的病人,HFOV结合NO吸入疗法治疗婴儿持续性肺动脉高压的研究,治疗胎粪吸入综合征,先天性膈疝伴肺发育不良的病人等方面的临床研究逐渐增多,NO结合部分液体通气的动物实验研究也取得可喜的成果[17].HFOV本身可减轻机械通气的肺损伤,结合其他方法如NO吸入,液体通气等能否将这种损伤进一步降低,将极危重病人的疗效进一步提高,进一步降低死亡率,成为年近危重病治疗特别是机械通气的研究热门课题.尽早使用HFOV还是先用CMV,疗效不好才转用HFOV?直接从HFOV撤机还是转为CMV一段时间后再撤机?目前仍无一致认识,多数应用者主张先CMV再HFOV撤机前复用CMV过渡[13,15].也有人主张从HFOV直接撤机(有成功报道).这些都是今后临床研究要解决的问题.对于HFOV的机理及其并发症的基础研究还需进一步深入.HFOV对机体生理的影响,HFOV配合NO吸入及液体通气方面的研究将会成为今后研究的方向,明确HFOV的临床应用指征也会成为今后研究热点.随着HFOV的广泛应用,新机型的研制,新原理的探索,HFOV同时溶入症状、病因治疗的其他手段等方面的研究必将使HFOV技术更完善,适应面更广,疗效更佳.曾其毅(广州市儿童医院广州510120)References1,Chatburn RL.:A new system for understanding ventilators. Respir Ca re 36:1991,11232,St.-John-Re.Lefrak-SS:Alternative modes of mechanical ventilation: On the aberration of inspiratory pressure and flow profiles. Int Crit Care Dig 1990,9:283,David Todres, John H.Fugates: Critical Care of infants and Childre n; Mechanical Ventilation chap,1996,16,1554,Jay P.goldsmith, Edward H.Karotkin:Assisted Ventilation of the Neo nate;High-Frequency Ventilation:chap.1996,16.1995,Jay P.Goldsmith, Edward H.Karolkin:Assisted Ventilation of the Neo nate,Special Ventilation Techniques Ⅱ: Liquid Ventilation, Nitric Ox ide Therapy, and Negative Pressure Ventilation.6,Peter Fort,Christopher Farmer,et al: High-frequency Oscillatory Ve ntilation for Adult Respiratory Distress Syndrome-A pilot study.7,Margaret S,Herridge,Arthar S.et al:Has high frequency ventilation been inappropriately discarded in adult acute respiratojry distress s yndrome; Crit Care Med 1998 Vol. 26,NO.128,Murthy-BV,Petros-AJ.: High-frequency oscillatory ventilation with intermittent mandatory ventilation in critical ill neonates and infan ts. Acta-Anaethesiol-scand.1996 Jul;40(6):6799,Maruyama-K;Koizumi-T:Systemic air embolism in an extremely low bir thweight infant treated with high-frequency oscillatory ventilation.A cta-Paediatr-Jpn.1996 Dec;38(6):68110,Randall C.Wetzel:High Frequency Wentilation, The Ped.Clin-North A merica;Intensive Care;1987 Feb;34:111,Bernard GR,Nilsson R,Grossman G,et al:The American-European consensus conference on ARDS-Definitions mechanisms,relevent outcomes and clinical trial coordination.Am J Respir Crit Care Med.1994;149:818 12,Lukenheimer PP,Praker J,Herandz L,et al:Intrapulmonaler Gaswechse l unter Simulierter Apnoe durch transtrachealen periodischen,intratho raken.Drickwechsel.Aneasthetist 22:23213,David Hatcher,Hiroshi Watanabe,Ted Ashbury,et al:Mechanical perfo rmence of clinical available,Neonatal,High-frequency.Osccilatory-type ventilations.Critical Care Med.1998.Vol.26,No.614,Ng-PC,Tsuno K,Prato P,et al:High Frequency Oscillatory Ventilatio n with Persistent Pulmonary Hypertension;Singapore-Med-J.1995 Oct;36 (5):5,2015,Shibata-Y;Okamoto-K,Loughnan PM,et al: The safety of a nitric oxi de inhalation system with high frequency oscillatory ventilation;Acta -Paediatric-Jpn.1997 Apr;39(2)16,Cheung-PY,.Miguet D,Claris O,et al: Rescue High Frequency Oscilla tory Ventilation for Preterm Infants,Biol-Neonate,1997;71(5):282 17,Kendra M.Smith,Slutsky AS,et al:Partial Liquid Ventilation: A com parison using conventional and high frequency technique in an animal model of acute respiratory failure.Crit Care Med 1997 Vol.25,NO.7 18,Wayne E.Hachey,Fabien G,et al:High-frequency oscillatory ventilat ion versus conventional ventilation in a piglet model of early meconi um aspiration.Crit Care Med 1988 Vol.26,No.319,Stephen Dolan,Venegas JG,Hales CA,et al: Tracheal gas insufflatio n combined with high-frequency oscillatory ventilation.Crit Care Med 1996 Vol.24,No.320,Harris P.Baden,Lachmann B,et al: High-frequency oscillatory venti lation with partial liquid ventioation in a midel of acute respirator y failure.Crit Care Med 1997 Vol.25,No.221,Kendra M.Smith,Dennis R,et al:Partial liquid ventilation:A comparison using conventional and high-frequency techniques in an animal mo del of acute respiratory failure. Crit Care Med 1997 Vol.25,No.7 22,Alison B.Froese:High-frequency oscillatory ventilation for adult respiratory distress syndrome:Let's get it right this time Crit Care Med 1997 Vol.25,No.623,Neil R.MacIntyre:High-frequency ventilation. Crit Care Med 1998 V ol 26,No.12。

921 Voltage Controlled Oscillator 快速启动向导说明书

快速启动向导921 VOLTAGE CONTROLLED OSCILLATOR Legendary Analog VCO Modulefor Eurorack(CN) 控制项(1) FREQUENCY – 使用此旋钮设置振荡器频率。

此旋钮的频率设置由 COARSE RNG 和 SCALE 拨动开关以及 RANGE 旋转开关控制。

(2) RANGE – 该旋钮以八度音阶为单位设置振荡器的总体频率范围,然后可以使用FREQUENCY 旋钮向上或向下调节。

(3) SCALE – 此开关控制频率旋钮的音阶是 ±6八度音阶还是 ±12 半音,从而可以进行更精细的频率控制。

(4) COARSE RNG – 此开关控制振荡器频率是在音频范围内起作用还是在音频阈值以下的较低频率范围内起作用。

(5) RECTANGULAR WIDTH – 使用此旋钮为矩形波形设置默认宽度。

然后,可以通过通过CNTRL IN 插孔输入的控制电压进一步控制和改变宽度。

(6) CNTRL IN – 这些总和插孔允许通过带有 3.5毫米 TS 连接器的电缆为矩形波形提供控制电压和调制信号。

(7) CLAMPING POINT – 使用此旋钮设置振荡器波形复位的点。

(8) TRIG (V / S) – 这些插孔允许通过带有 3.5 mmTS 连接器的电缆将夹紧点的控制信号引入。

夹紧点可以通过 V 插孔通过 V-Trig (电压触发) 信号触发,也可以通过 S 插孔通过 S-Trig (开关触发) 信号触发。

(9) AUX OUT WAVEFORM – 使用此旋钮选择辅助输出信号的波形,包括正弦波,三角波,锯齿波,倒锯齿波,方波和方波。

(10) AUX OUT LEVEL – 使用此旋钮调节 AUXILIARYOUTPUT 插孔的输出电平。

(11) AUXILIARY OUTPUTS – 使用这些插孔通过带有 3.5 毫米 TS 连接器的电缆将辅助波形信号引出模块。

Grid cells and cortical representation

Idealists argue that the hexagonal rooms are the necessary shape of absolute space, or at least of our perception of space. The Library of Babel, Jorge Luis Borges The nervous system has evolved to enable adaptive decision making and behaviour in response to changes in the internal and external environment. To permit adaptive responses, nervous systems recreate proper-ties of the internal or external world in activity pat-terns that are referred to as neural representations. Representations can be thought of as dynamic clus-ters of cells, the activity patterns of which correlate with features of the outside world. By recreating the environment in a language that is suitable for brain computation, representations are thought to medi-ate the selection of appropriate action in response to stimulus configurations in the animal’s environment. Given the importance of internal representations in guiding behaviour, understanding their mechanisms has become one of the central goals of contemporary neuroscience.Representations have been studied at multiple lev-els, from the earliest stages of sensory systems, where sensory maps reproduce the spatial organization of the sensory receptors, to the highest levels of associa-tion cortices, where representations bear little resem-blance to activation patterns in the receptor population (BOX 1). The mechanisms underlying the formation of representations at the bottom of the representational hierarchy (near the sensory receptor populations) have been explored extensively, particularly in the visual system. Much less is known about how representations form at higher levels, where representations depend more strongly on intrinsic cortical computations. The aim of this Review is to discuss mechanisms of neuralrepresentation in the medial entorhinal cortex (MEC), which is near the apex of the cortical hierarchy 1, using well-studied representations in the primary visual cortex (V1) as a reference.Place cells and grid cellsThe MEC and the hippocampus are a part of the brain’s neural map of external space 2–4 (BOX 2). Multiple func-tional cell types contribute to this representation. The first spatial cell type to be discovered was the place cell 5,6. Place cells are hippocampal cells that fire selec-tively when animals are at certain locations in the envi-ronment. The description of place cells in the 1970s was followed, more than 30 years later, by the discovery of grid cells , one synapse upstream of place cells, in the MEC 7–9. Grid cells are place-selective cells that fire at multiple discrete and regularly spaced locations 7. These firing locations form a hexagonal pattern that tiles the entire space that is available to the animal 8 (FIG. 1a). Whereas ensembles of place cells change unpredictably from one environment to the next 10,11, the positional relationship between grid cells is maintained, reflecting the structure of space independently of the contextual details of individual environments 12. The rigid struc-ture of the grid map, along with its spatial periodicity, points to grid cells as a part of the brain’s metric for local space 4,12.Place cells and grid cells were discovered in rats, but similar cells have subsequently been reported in mice 13–15, bats 16,17, monkeys 18–21 and humans 22,23, although the bulk of research on entorhinal–hippocampal spa-tial representation is still carried out using rodents. The strong correspondence in each species between entorhinal–hippocampal firing patterns and a measur-able property of the external world — the location of1Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and T echnology, 7491 T rondheim, Norway.2Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403-1254, USA. 3Max Planck Institute of Neurobiology, AmKlopferspitz 18, 82152 Planegg-Martinsried, Germany.Correspondence to E.I.M. e-mail: edvard.moser@ ntnu.nodoi:10.1038/nrn3766 Published online 11 June 2014Entorhinal cortexAn interface between the three-layered hippocampal cortex and six-layeredneocortex. It provides the main cortical input to the dentate gyrus.Place cellA type of hippocampal neuron that typically has a singleenvironmentally specific spatial receptive field. There is no discernible relationship between firing patterns in different environments.Grid cells and cortical representationEdvard I. Moser 1, Yasser Roudi 1, Menno P . Witter 1, Clifford Kentros 1,2, T obias Bonhoeffer 1,3 and May-Britt Moser 1Abstract | One of the grand challenges in neuroscience is to comprehend neural computation in the association cortices, the parts of the cortex that have shown the largest expansion and differentiation during mammalian evolution and that are thought to contribute profoundly to the emergence of advanced cognition in humans. In this Review, we use grid cells in the medial entorhinal cortex as a gateway to understandnetwork computation at a stage of cortical processing in which firing patterns are shaped not primarily by incoming sensory signals but to a large extent by the intrinsic properties of the local circuit.Neuroscience VS 1VI OI H OS 23DaLateral Rostral30 °LStimulus orientationCb Db Grid cellsParahippocampal neurons that have regularly repeatinghexagonally spaced receptive fields. Co-activity patternsremain largely the same across different environments.the animal — makes the spatial representation circuit a powerful experimental model system for understanding neural computation at the highest levels of the association cortices, many synapses away from sensory receptors and motor outputs.Grid cells and sensory inputsThe defining feature of grid cells is their hexagonal fir-ing structure 8. However, grid cells differ in grid spacing (the distance between grid fields), grid orientation (the rotation of grid axes) and grid phase (the x –y locations. The visual stimulus used in thisCA1 SubiculumMEC Layer VI Layer V Layer III Layer IIHippocampalof firing vertices)8,24(FIG. 1b). Grid cells exhibit vari-able degrees of asymmetry24,25, and periodicity may beexpressed more strongly along one axis of the triangu-lar grid than the two others26. Collectively, the variety ofgrid cells defines a map of the animal’s relative position inthe environment7,12. Because grid cells differ in spacing, each place in the local environment is associated with a unique combination of active cells, enabling neurons with access to this combined activity to faithfully read out the animal’s location.The map of grid cells is dynamic, in the sense that acti-vation is driven by the animal’s movement in the envi-ronment3,8. For grid activity to be updated in accordance with ongoing movement, grid cells must have access to sensory signals that correspond to the animal’s change in location. Only a few types of sensory input are suf-ficiently continuous to enable smooth translation of the grid representation. Such inputs include proprioceptive and kinaesthetic feedback as well as vestibular signals and optic flow. Consistent with a primary role for self-motion inputs and a secondary role for inputs from stationary cues, grid cells retain their hexagonal firing pattern after removal of visual or olfactory landmarks8,12. Pairs of grid cells tend to maintain spatial firing relationships across environments, independently of landmark identities12, as expected if the algorithm were based on self-motion.A strong dependence on motion cues might imply a role for grid cells in representations based on path integration, a process whereby animals keep track of their position by integrating linear and angular run-ning speed over time to yield spatial displacement rela-tive to a reference position (for example, the starting position of a path)27–29. Both place cells and grid cells express outcomes of path integration, in the sense that firing fields can often be related to distance of movement from a reference position rather than to inputs from stationary visual cues30–34. Recent work has identified a dedicated cell population for linear representation of running speed within the MEC35. By integrating speed over time, these speed cells may provide grid cells with information about changes in position. A role for speed cells and grid cells in path integration is consistent with the observation that rats with MEC lesions fail to navigate back to a refuge under conditions in which only self-motion cues are informative36,37. However, mechanisms for path inte-gration may exist in multiple brain circuits, as sug-gested by the fact that, in humans, unlike rats, simple self-motion-based navigation is spared by lesions that include the entorhinal cortex37,38.Path integration can only be used to calculate dis-placement from fixed reference positions. Stationary cues are required to associate path-integration coordi-nates with absolute position. The fact that grid phase and grid orientation remain stable across test sessions8, and that grid fields rotate along with external reference points in cylindrical environments8, suggests that grid coordinates are anchored to the external environment. Experiments in compartmentalized mazes suggest that grid maps anchor at many locations and often near sali-ent environmental features32. Frequent anchoring may prevent drift owing to accumulation of path-integration error39. However, the frequency at which grid maps are updated is not known. Grid maps may be re-anchored at regular intervals — for example, on individual cycles of the local theta rhythm — or resetting may occur in response to specific cues in the environment.| Neuroscienceb aGrid scaleGrid orientation Grid phaseG r i d s p a c i n g (c m )Dorsoventral location (rank-ordered)01020Rat: 15708Dorsoventral location (rank-ordered)1020TT9G r i d s p a c i n g (c m )1201003001020TT10Rat: 15314cP r o b a b i l i t ydTT5TT3Theta rhythmOscillatory activity in the range of 6–10 Hz in the local field potential of the hippocampus. It is produced by large and widespread ensembles of hippocampal neurons that oscillate in synchrony.Salt-and-pepper-like organizationCortical architecture in which single cells are tuned for the orientation of a stimulus but show no particular order in their arrangement. This arrangement is seen in the rodent visual cortex.Architecture of the grid mapAlthough grid fields are modulated by sensory inputs, such inputs are not sufficient to explain how the grid pattern itself is formed. The hexagonal grid pattern is not reflected in any of the polysynaptic sensory inputs to the grid cells, suggesting that it arises intrinsically in the MEC or the wider parahippocampal circuit of which the MEC is a part. This possibility justifies a closer look at the functional architecture of the grid cell network.The organization of grid cells is partly topographic and partly non-topographic 8. Grid scale shows topographic organization in the sense that grid cells with small fields and small interfield distances predominate in the dorsal part of the MEC. At more ventral levels, cells with larger grid scales predominate 7,24,40. By contrast, the phase of the grid pat-tern exhibits no discernible large-scale topography 8. Local ensembles of grid cells apparently cover the entire range of grid phases at all MEC locations. The distribution of grid phases is similar to the interspersed or salt-and-pepper-like organization of response properties in several sensory corti-ces, such as odour representations in the piriform cortex 41,42 or orientation maps in the visual cortex of rodents 43–45. However, fine-scale topography of grid phase has not been ruled out. Samples of simultaneously recorded cells are generally small, and the resolution of tetrode recordings does not enable anatomical mapping at a scale of less than 50–100 micrometres 46. Thus, approaches with better ana-tomical resolution need to be developed before estimates of the functional microarchitecture can be made 47,48.The lack of grid-phase topography does not rule out the presence of discrete cell assemblies with unique func-tions. Recent recordings from up to almost 200 grid cells per animal have suggested, in agreement with a small sample of data from an earlier study 25, that grid cells cluster into modules of cells with similar grid scale, grid orientation and grid asymmetry but different grid phase 24 (FIG. 1c). Modules with short grid wavelengths (spacing) predominate at the dorsal end of the MEC. Larger-scale modules are added successively towards the ventral MEC without discarding the shorter wavelengths. The increase in grid scale is discontinuous. If grid modules are sorted by wavelength, from short to long, the average wavelength increases from one module to the next by a factor of 1.4, as in a geometric progression (FIG. 1d). At the same time, the number of cells per module decreases.Figure 1 | Basic properties of grid cells. a | Spatial firing pattern of a grid cell from layer II of the rat medial entorhinal cortex (MEC). The grey trace shows the trajectory of a foraging rat in a 2.2 m wide square enclosure. The locations at which the grid cell spikes are superimposed on the trajectory are shown in black. Each black dot corresponds to one spike. Note the periodic hexagonal pattern of the firing fields of the grid cell. b | Cartoons of firing patterns of pairs of grid cells (shown in blue and green), illustrating the differences between grid scale, grid orientation and grid phase. Lines in left and middle panels indicate two axes of the grid pattern (which define grid orientation); crosses in the panel on the right indicate grid phase (x –y location of grid fields). c | Modular organization of the grid scale. Grid spacing is shown as a function of position along the recording track in the MEC, with cells (represented by grey circles) rank-ordered from dorsal to ventral and one panel per tetrode (TT). On each tetrode, grid spacing increases in discrete steps. d | A schematic showing that the increase in grid scale across modules follows a geometric progression rule. From one module to the next, average grid scale increases by a constant factor (1.4 in this case). Part a is reprinted from Moser, E. I. & Moser, M. B. Grid cells and neural coding in high-end cortices. Neuron 80, 765–774 (2013)229. Copyright (2013), with permission from Elsevier. Part c from REF . 24, Nature Publishing Group.Head direction cells Neurons found throughout parahippocampal areas and in other brain regions (for example, the anterior thalamus) for which the primary feature of the receptive field is the direction in which the animal’s head is pointing.Attractor networkA network with one or more stable firing-rate pattern that is stored in the structure of the synaptic connectivity.Theoretical analyses suggest that such an organizationmay be optimal for obtaining maximal spatial resolutionfrom a minimal number of grid cells49,50. The emergenceof an architecture that maximizes information from alimited pool of neurons is reminiscent of the balancebetween the number of on and off cells in the retina,which has been shown to match the statistical structureof common visual scenes51.The functional coherence of grid cells within mod-ules and their separation from grid cells in other mod-ules raise the possibility that grid networks consist ofanatomically overlapping subnetworks that exhibitstrong intrinsic coupling but weaker coupling to othersubnetworks.Key questions for the future will be todetermine which cells wire together in such networks,at which developmental stage this wiring takes placeand how cells of the same network find each other.For functional maps in the visual cortex, there is moreinformation on these questions: it is now reasonablywell established that activity-dependent mechanismsare involved in forming the map or, in the special caseof rodents, connecting cells with particular responseproperties52–54. The basic organization of connectionsin the visual pathway is established before visual expe-rience as a result of spontaneous correlated activity(retinal and cortical waves)55–58 or by means of gap-junction coupling of clonally related neurons at prenataldevelopmental stages59,60. It remains unknown whetherthe developmental processes underlying the modu-lar architecture of grid cell ensembles rely on similarmechanisms.The entangled nature of grid modules differs from theorganization of representations for continuous variablesin some other cortical systems. For example, in the visualcortex of cats and monkeys, orientation-selective cells areorganized into continuous pinwheel-like structures thatmap orientations successively through the 180-degreeorientation cycle61. Orientation maps in these species aresmooth except at the very centre of the pinwheel62,63 and atthe border between direction-sensitive domains43. Becauseorientation is circular, a pinwheel-like arrangement maybe required for optimal continuity. Other parameters suchas ocular dominance, disparity, spatial frequency and, ofcourse, position in space are mapped continuously acrossthe entire cortical surface64–70. A notable exception is thesalt-and-pepper-like organization of orientation tuningin the rodent visual cortex43–45. Plausible explanations forthis exception lie in the relative scale of the cortical area,the magnification factor and the receptive field scatter,which make an interspersed organization a necessityif all stimulus para m eters are to be represented in eachregion of visual space. If a mouse had functional columnsthe size of those in cats, and not a salt-and-pepper-likeorganization, it would only see one stimulus feature — forexample, one orientation — in any portion of the visualfield. We can only speculate whether a similar explana-tion may hold true for the salt-and-pepper-like repre-sentation of grid phase in the MEC, whether grid phasewould be represented topographically in mammals withlarger MECs and whether topographic representationmatters for the way animals perceive space.Finally, MEC networks do not only consist of gridcells. Grid cells intermingle with head direction cells— cells that fire only if the rat’s head is pointing in acertain direction relative to external cues. These cellswere first found in the adjacent presubiculum71,72 butwere subsequently also recorded in the MEC9. Gridcells and head direction cells further intermingle withborder cells — cells that fire exclusively when the ratis close to a salient border of the environment, such asthe wall of a recording enclosure or the edge of a plat-form73,74 — as well as the aforementioned speed cells,the firing rates of which increase monotonically withrunning speed, independently of the rat’s location orhead direction35. Cells with border-determined firingproperties also exist in the subiculum75,76. Grid cells,head direction cells, border cells and speed cells arefunctionally discrete populations but coexist with cellswith conjunctive properties9,35,74. The mixture of func-tional cell types in the MEC has an interesting analogyin the visual system in visual area V2 — and to a lesserextent V1 — where, at least in primates, cells coding forcolour, disparity, orientation, motion, spatial frequencyand other properties coexist, albeit to a certain extentin certain compartments77. In the visual cortex, as inthe MEC, functional properties are distributed ontodiscrete but intermingled cell types.Attractor networks and mechanismsSeveral properties of grid cells point to local circuitcomputation as the source of the grid pattern. Withinmodules of grid cells, cell assemblies respond withcoherent changes in grid phase, grid orientation andgrid scale when the animal is brought to a differentenvironment12,24 or following interventions that changethe scale of the grid, such as exposure to an unfamil-iar environment25,78,79 or compression of the recordingenclosure24,25. In each case, the relationship between fir-ing fields of cell pairs is conserved despite major changesin the properties of individual cells and without anyobvious relationship to sensory inputs78. These observa-tions are consistent with the idea that grid cells operateas ensembles of interconnected neurons whose activitypatterns move across continua of attractor states (BOX 3;FIG. 2). Attractor models provide powerful workinghypotheses for grid cells, although alternative mecha-nisms, such as interference between theta-frequencymembrane potential oscillations80–82, have also beenexplored4,83. Oscillatory interference models of grid cellshave guided some of the most important experimentalstudies on grid cells, but there is mounting experimentalevidence against simple versions of these models (BOX 4).The focus of this article is therefore on attractor network-based mechanisms.The idea of an attractor network is one of the mostinfluential concepts in theoretical systems neurosci-ence84–87. Attractor networks can be traced back toDonald Hebb88 who argued that co-firing neuronsshould be more strongly connected to each other than tothe rest of the network, thus forming so-called Hebbiancell assemblies. Activating a subset of the neurons insuch an assembly will lead to activation of the rest. TheContinuous attractorAn attractor network in which the collection of attracting points form not a discrete set but a continuum (a ring or a sheet).Mexican hat connectivity The connectivity of networks in which neurons are arranged on a ring or sheet such that the excitatory connections of each neuron decrease progressively with distance, whereas inhibitory connections increase in strength.Stellate cells Morphologically defined as cells with a round soma and dendrites radiating from it in all directions. In the medial entorhinal cortex, stellate cells are the main origin of the projection to the dentate gyrus and CA3.activation may self-sustain by reverberation of activitythrough the strong connections that link neurons withinthe Hebbian assembly.In a seminal theoretical study that paved the way forthe continuous attractor concept, Amari89 showed thatstable localized activity patterns can be maintained innetworks in which neurons are arranged on a ring, suchthat the excitatory connections of each neuron decreaseprogressively with distance on the ring, whereas inhibi-tory connections increase (Mexican hat connectivity).Since this study, continuous attractors have been used tomodel various sensory and non-sensory processes, rang-ing from motor-cortex representations of movement tra-jectories90, orientation selectivity in V1 (REFS 91,92), eyeposition93, directional tuning of head direction cells94,95and the position of an animal in space, as represented bythe firing of hippocampal place cells87,96–99.The fact that grid cells maintain their activity patternafter removal of light or other sensory stimuli points to aself-sustaining mechanism8. Not surprisingly then, soonafter the discovery of grid cells, several continuous attrac-tor models were introduced to explain the formation ofspatially periodic firing3,100,101(FIG. 2). All of these mod-els have two stages. First, cells are arranged on a matrixaccording to grid phase. Localized activity (a ‘bump’) isformed when the network has Mexican hat connectiv-ity; that is, cells with similar grid phases are connectedthrough excitatory connections, or they receive less inhi-bition than those with larger phase differences, whichalways inhibit each other (FIG. 2a,b). Bumps can be formedat multiple network locations, with competitive inter-actions leading to the formation of a hexagonal bumppattern on the network array100,101, or the bump can begenerated at a single location, with periodic firing emerg-ing when the activity bump returns to the same locationin a toroidal matrix3,102. In either case, once local activityis generated, the bump is moved by path integration inresponse to asymmetrical speed and direction inputs tothe grid cells, mirroring a mechanism that was originallyproposed for head direction cells95. When the bump fol-lows the animal’s movement, activity is expressed as agrid pattern in each individual cell.Continuous attractor models with Mexican hat con-nectivity were able to produce grid patterns, but it wassoon found that these models relied on connectivitymatrices that were different from those of key circuits ofthe MEC. The prime challenge is the almost complete lackof excitatory connections between layer II stellate cells, thecell type containing the largest number of grid cells andthe most regular grid patterns9,26,103–105. Paired recordingshave shown that excitatory connections are nearly absentamong stellate cells in adult animals and that stellate cellsare instead strongly connected through fast-spiking inhib-itory interneurons106–108. The inhibition between pairs ofstellate cells seems to be consistent in magnitude — thatis, all-or-none107.In response to the lack of excitatory connectionsbetween stellate cells, it was shown that attractor modelscan function with only inhibitory interconnections107–109(FIG. 2c–f). In the presence of external excitatory drive,neural activity in an inhibitory network self-organizedinto a stable hexagonal pattern. Competitive inhibitoryinteractions drove activity to maximally spaced posi-tions. As in the earlier excitatory models, a path-inte-gration mechanism could be used to move the activitybumps across the neuronal lattice in accordance withthe animal’s movement. The emergence of grid patternsin purely inhibitory networks has also been shown in aprevious study of Mexican hat connectivity in whichinhibition decreased progressively as grid phasesbecame more similar101. The dependence on tonic exter-nal excitatory drive predicted by these models has beenverified in a study in which hippocampal projectionsto the MEC were silenced by infusion of a GABAergicagonist in the hippocampus109. Infusions led to substan-tial drops in the firing rates of grid cells, accompaniedby a progressive loss of grid structure and the appear-ance of directional tuning, as expected when residualexternal inputs take over as determinants of grid cellfiring. Similar disruptions of grid cell firing have beenobserved under other conditions that reduce excitatoryinput to grid cells110,111.The relationship between external excitatory inputand grid structure verifies one prediction of the inhibi-tory models but far from proves any of them. Thesemodels demonstrate that inhibitory connections, suchas those that connect layer II stellate cells, are sufficientfor activity to self-organize into a hexagonal pattern.However, whether this actually is the mechanism of gridcell formation remains to be determined. Per today, in|Neuroscience 0 ms 20 ms40 ms60 ms 100 ms 500 msW 0 = –0.01W 0 = –0.02W 0 = –0.04R = 10R = 15R = 20Strong excitatory inputWeak excitatory inputcdefbPhase differencePhase differencePhase differencethe absence of further theoretical development and new experimental data, the high demands that attrac-tor models put on network connectivity disallow them to be adopted as straightforward explanations of grid cells (BOX 3).Assumptions about recurrent connectivityAttractor models of grid cells require neurons to be connected to each other, directly or indirectly, by way of synaptic weights that depend on the phase differ-ence between neurons 3,100,101,107. Whether developmen-tal processes allow for the complexity of such a wiring scheme is an open question. The salt-and-pepper-like organization of the grid network 8 implies that prefer-ential coupling between phase-matched cells cannot be obtained merely by letting cells connect to their nearest neighbours.One possibility is that grid cells overcome the lack of topography by connecting, directly or indirectly, to cells with similar grid phases irrespective of distance. There is some precedence for connectional specificitybetween distributed but functionally similar neurons in V1 of the visual cortex, where cells that code for spe-cific orientations are frequently connected, whereas cells with different orientation preferences are con-nected more rarely 112–115. If cells with similar grid prop-erties wire together similarly in the MEC, how could they find each other? A study by Li et al.59 used in utero electroporation to label cells from one developmental clone in V1. At adult age, sister neurons from this clone were not only more strongly connected but also more similarly tuned for orientation and direction than ran-domly selected neighbouring neuron pairs. These neu-rons were initially connected by gap junctions, which later gave way to chemical synapses. We do not know whether connectional topography between phase-matched cells within modules in the MEC has a similar developmental origin.The development of lateral connectivity becomes simpler if the connectivity problem is reduced from two dimensions to one. This has been suggested in a two-step model by Grossberg and colleagues 116,117. In theFigure 2 | Excitatory and inhibitory attractor models for grid cells. a –c | A variety of connectivity patterns have beenused in attractor models of grid cells to generate hexagonal firing patterns. These include the Mexican hat connectivity used by Fuhs and Touretzky 100 (part a ), the Mexican hat-like connectivity of Burak and Fiete 101 (part b ) and the step-like inhibitory connectivity used by Couey et al.107 (part c ). The connectivity patterns differ in the complexity of the phase dependence of the synaptic weights. In models with Mexican hat connectivity, cells have progressively decreasing excitatory connections combined with increasing inhibitory connections, whereas the Mexican hat-like connectivitymodel and the step-like connectivity model use purely inhibitory connections, although the inhibitory fields have different shapes. All three connectivity patterns produce a hexagonal grid pattern. d | The step-like connectivity model leads to the spontaneous formation of a hexagonal grid pattern. Successive sheets illustrate the network at different developmental stages (0 to 500 ms), with individual pixels corresponding to individual neurons and neurons arranged according to grid phase in each sheet. Activity of neurons is colour-coded, as indicated by the scale bar. Connection radii R of two example neurons are shown as white and green circles (diameter 2R ). e | Single-neuron activity (red dots) in a circular arena from the simulation in part d . W 0 is the strength of the inhibitory connectivity. It can be seen that W 0 and R control the size of the grid fields and their spacing. f | External excitatory drive is necessary for grid formation. Spike distribution plots (on the left, as in part e ) and directional tuning curves (firing rate as a function of direction, on the right) with strong excitatory output and weak excitatory output. When the external input drops below a critical amount, the activity on the neuronal sheet is vulnerable to distortions, and the hexagonal structure is not detectable in time-averaged plots. At the same time, head direction input becomes the dominant source of input and cells become directional. Parts d and e from REF . 107, Nature Publishing Group. Part f from REF . 109, Nature Publishing Group.。

EM30718 Datasheet 2014Oct

EM30718 DatasheetI2C Interface Digital Proximity and Ambient Light SensorVersion 1.012014-10-08CONTENTS Description (6)Features (6)Functional Block Diagram (7)PIN Configuration (8)Parameters (8)PS Spectral Response Range (10)I2C State Machine (11)Timing (11)Registers Operation (12)Function Description (12)Software Initialization Description (15)Registers Definition (18)Sample Application (25)PCB Design (26)Package Outline Dimensions (27)Recommended Structure Design (29)Packing (29)Recommended Reflow Profile (31)NOTICE: (32)FIGURE LISTFig. 1 EM30718 Functional Block Diagram (7)Fig. 2 PS Spectral Response Range (10)Fig. 3 Slave State Machine (11)Fig. 4 Data Structure (11)Fig. 5 Write waveform (11)Fig. 6 Read waveform (12)Fig. 7 Register random write operation (12)Fig. 8 Register page write operation (12)Fig. 9 Register random read operation (12)Fig. 10 Sensor Operation State Machine (13)Fig. 11 Transient Interrupt Mode Operation (14)Fig. 12 Recommended Interrupt Procedure Flowchart (17)Fig. 13 ALS value vs. ambient light lux (22)Fig. 14 PS count vs. distance (cm) in different reflecting surface (The grey card is GC1890S with 18% grey) (22)Fig. 16 Operation current vs. supply voltage (23)Fig. 17 Normalized ALS Response vs. Angle (23)Fig. 18 Normalized PS response vs. Angle (24)Fig. 19 Typical Application Circuit of EM30718 (25)Fig. 20 Typical Application Circuit of EM30718 in cases of LEDA connect to VBAT directly (26)Fig. 21 PCB layout design guide (all linear dimensions are in mm) (27)Fig. 22 Side view of package (27)Fig. 23 Package Outline Dimensions (28)Fig. 24 Recommended in case of Air gap <= 1.0mm, without rubber (29)Fig. 25 Recommended in case of Air gap > 1.0mm, with rubber added (29)Fig. 26 Tape & Reel Information (30)Fig. 27 Recommended Reflow Profile for SMT (31)TABLE LISTTable. 1 Pin Configuration (8)Table. 2 I2C bus timing characteristics (8)Table. 3 Electrical Characteristics (9)Table. 4 Optical Characteristics (9)Table. 5 Absolute Maximum Ratings (10)Table. 6 Registers and Register bits (18)Table. 7 REGISTER 0x00 (RESERVED) (18)Table. 8 REGISTER 0x01 (CONFIGURE) - PROX/ALS CONFIGURATION (18)Table. 9 REGISTER 0x02 (INTERRUPT) - PROX/ALS INTERRUPT CONTROL (19)Table. 10 REGISTER 0x03 (PROX_LT) - INTERRUPT LOW THRESHOLD FOR PROXIMITY SENSOR (19)Table. 11 REGISTER 0x04 (PROX_HT) - INTERRUPT HIGH THRESHOLD FOR PROXIMITY SENSOR (19)Table. 12 REGISTER 0x05 (ALSIR_TH1)-INTERRUPT LOW THRESHOLD FOR ALS/IR (19)Table. 13 REGISTER 0x06 (ALSIR_TH2) INTERRUPT LOW/HIGH THRESHOLDS FOR ALS/IR (19)Table. 14 REGISTER 0x07 (ALSIR_TH3) - INTERRUPT HIGH THRESHOLD FOR ALS/IR (20)Table. 15 REGISTER 0x08 (PROX_DATA) - PROXIMITY SENSOR DATA (20)Table. 16 Register 0x09 (ALSIR_DT1) - ALS/IR sensor data (Lower 8 bits) (20)Table. 17 Register 0x0A(ALSIR_DT2) - ALS/IR sensor data(upper 4 bits) (20)Table. 18 Register 0x0E (RESET) - Soft Reset (20)Table. 19 Register 0x0F (OFFSET) - Offset Control of PS (21)Table. 20 I2C Device address (21)Table. 21 Plating Thickness (26)DescriptionEM30718 is an I 2C interface sensor includes Ambient Light Sensor (ALS), Proximity Sensor (PS), and built-in LED driver. It is designed especially for smart phones and tablets with capacitive touch panel. With its ultra-low-power design, it is also useful for proximity wake-up application.Features● Proximity Sensor, Ambient Light Sensor, LED driver and IR LED integrated in a single Optical Module ● Wide Spectrum Response of Ambient Light Sensor (ALS)● 50Hz/60Hz Flicker Noise Rejection● Temperature Compensation● Higher Sensitivity of Proximity Sensing with better SNR design ● Programmable Interrupt for PS and ALS ● Proximity Sensor (PS) Ambient Light Rejection'● Built-In LED constant current driver high voltage tolerance up to 5.5V ● PS offset adjust for crosstalk calibration ● Enhanced PS dark surface detect flexibility ● Programmable LED driver current● Average Current (Operation Current 95μA in low-power mode, Sleep Mode Current 0.5μA ) ● Output Type: I 2C Bus (ALS/PS) up to 400K Hz ● Operation Voltage 2.5V ~ 3.6V● Logic Interface Voltage VBUS = 1.8V or VBUS = VDDGND LDR LEDAINT VDD 8LEDK 7SCL 1SDA 23456Top ViewBottom ViewFunctional Block DiagramFig. 1 EM30718 Functional Block DiagramPIN ConfigurationI 2C State MachineTimingFig. 5 Write waveformEM30718 ALS and PS can work at the same time. ALS detects ambient light in every 100ms, and the detection value is the average of the ambient light during the period of 100 ms; PS can be set one detection in every 100 ms or 800 ms, and its LED driver current is programmable in order to meet requirements of different applications.SCL SDADA TARADATA!APFig. 10 Sensor Operation State MachineWhen both the ALS and PS are enabled, it is recommended that the software is operating in ALS Polling (Polling)/PS Interrupt (Interrupt) mode, ie. ALS register is read in every 200 ms, and main controller will adjust the backlight pulse width according to the count of ALS.After the PS upper and lower threshold initialization is completed, PS count move from lower than lowFig. 11 Transient Interrupt Mode OperationSoftware Initialization DescriptionEM30718 software on initialization process is recommended as follows: WriteRegData(1, 0); //Disable and Power downWriteRegData(2, 0); //Clear all Interrupt FlagWriteRegData(0x0e, 0); //Initialize Reset Registeruint8 PSLT, PSHT;PSLT = 0x40; //64 – PS Low Threshold ValuePSHT = 0x48; //72 – PS High Threshold ValueWriteRegData (3, PSLT);WriteRegData (4, PSHT);WriteRegData(0xf, 0x00); //Initialize PS offset//Disable ALS InterruptWriteRegData (5, 0x00);WriteRegData (6, 0xf0);WriteRegData (7, 0xff);if(val == 0x03) //Enable both PS & ALS{int PSLT=0x40;int PSHT=0x48;i2c_smbus_write_byte_data(this_client, 0x02, 0);i2c_smbus_write_byte_data(this_client, 0x03, PSLT);i2c_smbus_write_byte_data(this_client, 0x04, PSHT);i2c_smbus_write_byte_data(this_client, 0x0F, 0x00;i2c_smbus_write_byte_data(this_client, 0x05, 0x00);i2c_smbus_write_byte_data(this_client, 0x06, 0xF0);i2c_smbus_write_byte_data(this_client, 0x07, 0xFF);i2c_smbus_write_byte_data(this_client, 0x01, 0xBE);}else if(val& EM30718_PROXIMITY) //Enable PS only{int PSLT =0x40;int PSHT=0x48;i2c_smbus_write_byte_data(this_client, 0x03, PSLT);i2c_smbus_write_byte_data(this_client, 0x04, PSHT);i2c_smbus_write_byte_data(this_client, 0x0F, 0x00);i2c_smbus_write_byte_data(this_client, 0x01, 0xB8);}else if(val& EM30718_ALS) //Enable ALS only{i2c_smbus_write_byte_data(this_client, 0x05, 0x00);i2c_smbus_write_byte_data(this_client, 0x06, 0xF0);i2c_smbus_write_byte_data(this_client, 0x07, 0xFF);i2c_smbus_write_byte_data(this_client, 0x01, 0x06); }Fig. 12 Recommended Interrupt Procedure FlowchartRegisters DefinitionFig. 13 ALS value vs. ambient light luxFig. 14 PS count vs. distance (cm) in different reflecting surface (The grey card is GC1890S with 18% grey)Sample ApplicationSuggested PCB pad layout guidelines for the Dual Flat No-Lead surface mount package are shownbelow.Fig. 20 PCB layout design guide (all linear dimensions are in mm)Package Outline DimensionsFig. 21 Side view of packageFig. 22 Package Outline DimensionsRecommended Structure DesignFig. 23 Recommended in case of Air gap <= 1.0mm, without rubberFig. 24 Recommended in case of Air gap > 1.0mm, with rubber addedPackingTape and reel dimensions is compliant to JEDEC MSL 3Fig. 25 Tape & Reel InformationTemperature gradient in cooling Max-5°C/secFig. 26 Recommended Reflow Profile for SMTThe product require to control strictly to prevent moisture absorption into unit. The recommend control is as following. Rebaking of the reel will be required if the devices is unpack from the MBB bag more than 24 hours. If rebaking is required, it should be done at 50℃ for 12 hours.NOTICE:1. The information here contained could be changed without notice owing to product and/or technicalimprovements. Please make sure before using the product that the information you are referring to is up-to-date.2. No responsibilities are assumed by us for any consequence resulting from any wrong or improper operation,etc. of the product.。

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Attention:
1> The net motion is a simple harmonic motion.
2> The x direction and frequency of the net motion do not change.
3> in phase and out of phase (同相和反相)
(2) = : straight-line equation
A2
y
x y A1 A2
(3) = /2 : elliptic equation
A1
A2
A1
x
x2 y 2 2 1 2 A1 A2
(4) general condition: elliptic equation
s x2 y2
2 A12 A2 cos( t )
A1
A2
A1
x
Net oscillation: simple harmonic oscillation, same frequency, net amplitude A12 A22
x A1 cos(t 1 ) y A2 cos(t 2 )

f
: the angular frequency (rad /s)
: the frequency (Hz) is determined by the system. is called natural frequency. : the phase indicates the state of motion.
Lissajous figure: If the ratio of the periods of two simple harmonic motions is the ratio of simple integer, the path of the particle is stable and closed, called Lissajous figure.
x1
2
x2 4 t
O
A
2
A
1
X A1-A2
(0= -/2)
Example 3: the x-t curves of two simple harmonic motions. The phase of the oscillation x1 is leading in comparison with the oscillation x2.
1. The simple harmonic motion:
Fs kx 2 d x 2x 0 2 dt
x(t ) A cos t
A particle attached to a spring
k m
The simple pendulum
The physical pendulum
2 2 A A1 A2 2 A1 A2 cos( 2 1 )
(1) in phase
2 1= 2k
(k=0, 1, 2,…)
so A A 1 A 2 , the net amplitude is maximum. (2) out of phase 2 1= (2k+1) (k=0, 1, 2,…)
A A A 2 A1 A2 cos( 20 10 )
A1 sin 10 A2 sin 20 Phase constant: tg A1 cos 10 A2 cos 20
Angular frequency:
x x1 x2 A cos(t )
(-3/4) (-/2) (-/4)
4. The superposition of two simple harmonic motions with the different frequency, and the directions of the motion are mutually perpendicular. The general path is complicated and unstable.
Chapter 12 Oscபைடு நூலகம்llatory Motion
§1. Simple harmonic motion (P404-413, 417-420) §2. Energy consideration in Simple harmonic motion (P413-416)
§3. The superposition of Simple harmonic motion (P486-488)
1
(A1=0.05m) (A2=0.06m)
( 0 ) 2
=10 (s-1)
Example 2: the x-t curves of two simple harmonic motions. Find the phase constant of the net motion.
x
A
0 -A/2
y A 1
-A2
0
A2
x
Ny Nx
fx 3 Tx fy 2
Ty
- A1
x A cos( m t )
0 0

4m
y A cos(n t 0 )
3 4m

2m

m
n:m
1:1
1:2 1:3
5 4m
3 2m
7 4m
2 m

4m
2:3
3:4
Decomposition of motion: A circular and elliptic motion can be decomposed into two simple harmonic motion whose directions of the oscillation are perpendicular. This can be used in the polarization of light.
2
t cos
1 2
2
t
1 2
, and both are very big.
x A(t ) cos t
A(t ) 2 A0 cos
1 2
2
t
x1
f1
t
beat frequency (拍频): the number of beats per second.
x2
f2
t
1 f 2 2
§4. Damped oscillations One common type of resistive force is proportional to the velocity and acts in the direction opposite the velocity. b is a constant. R bv

g L
m gd I
2. Mathematical representation of simple harmonic motion.
x(t ) A cos t
A : the amplitude 1 2 indicates the energy of the system. E K U kA 2 is determined by the initial conditions. T : the period
x A cos(t 0 )
◆ phase: = the angle between positive direction of x axis at the time t ◆ displacement: x(t) = the projection of
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