A Kaizen Based Approach for Cellular Manufacturing System

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英文翻译

英文翻译

A Facial Aging Simulation Method Using flaccidity deformation criteriaAlexandre Cruz Berg Lutheran University of Brazil.Dept Computer ScienceRua Miguel Tostes, 101. 92420-280 Canoas, RS, Brazil berg@ulbra.tche.br Francisco José Perales LopezUniversitat les Illes Balears.Dept Mathmatics InformaticsCtra Valldemossa, km 7,5E-07071 Palma MallorcaSpainpaco.perales@uib.esManuel GonzálezUniversitat les Illes Balears.Dept Mathmatics InformaticsCtra Valldemossa, km 7,5E-07071 Palma MallorcaSpainmanuel.gonzales@uib.esAbstractDue to the fact that the aging human face encompasses skull bones, facial muscles, and tissues, we render it using the effects of flaccidity through the observation of family groups categorized by sex, race and age. Considering that patterns of aging are consistent, facial ptosis becomes manifest toward the end of the fourth decade. In order to simulate facial aging according to these patterns, we used surfaces with control points so that it was possible to represent the effect of aging through flaccidity. The main use of these surfaces is to simulate flaccidity and aging consequently.1.IntroductionThe synthesis of realistic virtual views remains one of the central research topics in computer graphics. The range of applications encompasses many fields, including: visual interfaces for communications, integrated environments of virtual reality, as well as visual effects commonly used in film production.The ultimate goal of the research on realistic rendering is to display a scene on a screen so that it appears as if the object exists behind the screen. This description, however, is somewhat ambiguous and doesn't provide a quality measure for synthesized images. Certain areas, such as plastic surgery, need this quality evaluation on synthesized faces to make sure how the patient look like and more often how the patient will look like in the future. Instead, in computer graphics and computer vision communities, considerable effort has been put forthto synthesize the virtual view of real or imaginary scenes so that they look like the real scenes.Much work that plastic surgeons put in this fieldis to retard aging process but aging is an inevitable process. Age changes cause major variations in the appearance of human faces [1]. Some aspects of aging are uncontrollable and are based on hereditary factors; others are somewhat controllable, resulting from many social factors including lifestyle, among others [2].1.1.Related WorkMany works about aging human faces have been done. We can list some related work in the simulation of facial skin deformation [3].One approach is based on geometric models, physically based models and biomechanical models using either a particle system or a continuous system.Many geometrical models have been developed, such as parametric model [4] and geometric operators [5]. The finite element method is also employed for more accurate calculation of skin deformation, especially for potential medical applications such as plastic surgery [6]. Overall, those works simulate wrinkles but none of them have used flaccidity as causing creases and aging consequently.In this work is presented this effort in aging virtual human faces, by addressing the synthesis of new facial images of subjects for a given target age.We present a scheme that uses aging function to perform this synthesis thru flaccidity. This scheme enforces perceptually realistic images by preserving the identity of the subject. The main difference between our model and the previous ones is that we simulate increase of fat and muscular mass diminish causing flaccidity as one responsible element for the sprouting of lines and aging human face.In the next section will plan to present the methodology. Also in section 3, we introduce the measurements procedure, defining structural alterations of the face. In section 4, we present a visual facial model. We describe age simulation thrua deformation approach in section 5. In the last section we conclude the main results and future work.2.MethodologyA methodology to model the aging of human face allows us to recover the face aging process. This methodology consists of: 1) defining the variations of certain face regions, where the aging process is perceptible; 2) measuring the variations of those regions for a period of time in a group of people and finally 3) making up a model through the measurements based on personal features.That could be used as a standard to a whole group in order to design aging curves to the facial regions defined.¦njjjpVM2.1Mathematical Background and AnalysisHuman society values beauty and youth. It is well known that the aging process is influenced by several parameters such: feeding, weight, stress level, race, religious factors, genetics, etc. Finding a standard set of characteristics that could possibly emulate and represent the aging process is a difficult proposition.This standard set was obtained through a mathematical analysis of some face measurements in a specific group of people, whose photographs in different ages were available [7]. To each person in the group, there were, at least, four digitized photographs. The oldest of them was taken as a standard to the most recent one. Hence, some face alterations were attained through the passing of time for the same person.The diversity of the generated data has led to the designing of a mathematical model, which enabled the acquiring of a behavior pattern to all persons of the same group, as the form of a curve defined over the domain [0,1] in general, in order to define over any interval [0,Į] for an individual face. The unknown points Įi are found using the blossoming principle [8] to form the control polygon of that face.The first step consisted in the selection of the group to be studied. Proposing the assessment of the face aging characteristics it will be necessary to have a photographic follow-up along time for a group of people, in which their face alterations were measurable.The database used in this work consisted of files of patients who were submitted to plastic surgery at Medical Center Praia do Guaíba, located in Porto Alegre, Brazil.3.MeasurementsAccording to anatomic principles [9] the vectors of aging can be described aswhich alter the position and appearance of key anatomic structures of the face as can be shown in figure 1 which compares a Caucasian mother age 66 (left side) with her Caucasian daughters, ages 37 (right above) and 33 (right below) respectively.Figure 1 - Observation of family groupsTherefore, basic anatomic and surgical principles must be applied when planning rejuvenative facial surgery and treating specific problems concomitantwith the aging process.4.Visual Facial ModelThe fact that human face has an especially irregular format and interior components (bones, muscles and fabrics) to possess a complex structure and deformations of different face characteristics of person to person, becomes the modeling of the face a difficult task. The modeling carried through in the present work was based on the model, where the mesh of polygons corresponds to an elastic mesh, simulating the dermis of the face. The deformations in this mesh, necessary to simulate the aging curves, are obtained through the displacement of the vertexes, considering x(t) as a planar curve, which is located within the (u,v ) unit square. So, we can cover the square with a regular grid of points b i,j =[i/m,j/n]T ; i=0,...,m; j=0,...,n. leading to every point (u,v ) asfrom the linear precision property of Bernstein polynomials. Using comparisons with parents we can distort the grid of b i,j into a grid b'i,j , the point (u,v )will be mapped to a point (u',v') asIn order to construct our 3D mesh we introduce the patch byAs the displacements of the vertexes conform to the certain measures gotten through curves of aging and no type of movement in the face is carried through, the parameters of this modeling had been based on the conformation parameter.4.1Textures mappingIn most cases the result gotten in the modeling of the face becomes a little artificial. Using textures mapping can solve this problem. This technique allows an extraordinary increase in the realism of the shaped images and consists of applying on the shaped object, existing textures of the real images of the object.In this case, to do the mapping of an extracted texture of a real image, it is necessary that the textureaccurately correspond to the model 3D of that is made use [9].The detected feature points are used for automatic texture mapping. The main idea of texture mapping is that we get an image by combining two orthogonal pictures in a proper way and then give correct texture coordinates of every point on a head.To give a proper coordinate on a combined image for every point on a head, we first project an individualized 3D head onto three planes, the front (x, y), the left (y, z) and the right (y, z) planes. With the information of feature lines, which are used for image merging, we decide on which plane a 3D-head point on is projected.The projected points on one of three planes arethen transferred to one of feature points spaces suchas the front and the side in 2D. Then they are transferred to the image space and finally to the combined image space.The result of the texture mapping (figure 2) is excellent when it is desired to simulate some alteration of the face that does not involve a type of expression, as neutral. The picture pose must be the same that the 3D scanned data.¦¦¦ mi nj lk n j m i lk k j i w B v B u B b w v u 000,,)()()(')',','(¦¦ m i nj n jmij i v B u B b v u 00,)()(),(¦¦ m i nj n j m i j i v B u B b v u 00,)()(')','(¦¦¦ mi nj lk n j m i lk k j i w B v B u B b w v u 000,,)()()(')',','(Figure 2 - Image shaped with texturemapping5.Age SimulationThis method involves the deformation of a face starting with control segments that define the edges of the faces, as¦¦¦ mi nj lk n j m i lk k j i w B v B u B b w v u 000,,)()()(')',','(Those segments are defined in the original face and their positions are changed to a target face. From those new positions the new position of each vertex in the face is determined.The definition of edges in the face is a fundamental step, since in that phase the applied aging curves are selected. Hence, the face is divided in influencing regions according to their principal edges and characteristics.Considering the face morphology and the modeling of the face aging developed [10], the face was divided in six basic regions (figure 3).The frontal region (1) is limited by the eyelids and the forehead control lines. The distance between these limits enlarges with forward aging.The orbitary region (2) is one of the most important aging parameters because a great number of wrinkles appears and the palpebral pouch increases [11]. In nasal region (3) is observed an enlargement of its contour.The orolabial region (4) is defined by 2 horizontal control segments bounding the upper and lower lips and other 2 segments that define the nasogenian fold. Figure 3 - Regions considering the agingparametersThe lips become thinner and the nasogenian fold deeper and larger. The mental region (5) have 8 control segments that define the low limit of the face and descend with aging. In ear curve (6) is observed an enlargement of its size. The choice of feature lines was based in the characteristic age points in figure 6.The target face is obtained from the aging curves applied to the source face, i.e., with the new control segment position, each vertex of the new image has its position defined by the corresponding vertex in the target face. This final face corresponds to the face in the new age, which was obtained through the application of the numerical modeling of the frontal face aging.The definition of the straight-line segment will control the aging process, leading to a series of tests until the visual result was adequate to the results obtained from the aging curves. The extremes of the segments are interpolated according to the previously defined curves, obtained by piecewise bilinear interpolation [12].Horizontal and vertical orienting auxiliary lines were defined to characterize the extreme points of the control segments (figure 4). Some points, that delimit the control segments, are marked from the intersection of the auxiliary lines with the contour of the face, eyebrow, superior part of the head and the eyes. Others are directly defined without the use of auxiliary lines, such as: eyelid hollow, eyebrow edges, subnasion, mouth, nasolabial wrinkle andnose sides.Figure 4 - Points of the control segmentsOnce the control segments characterize the target image, the following step of the aging process can be undertaken, corresponding to the transformations of the original points to the new positions in the target image. The transformations applied to the segments are given by the aging curves, presented in section 4.In the present work the target segments are calculated by polynomial interpolations, based on parametric curves [12].5.1Deformation approachThe common goal of deformation models is to regulate deformations of a geometric model by providing smoothness constraints. In our age simulation approach, a mesh-independent deformation model is proposed. First, connected piece-wise 3D parametric volumes are generated automatically from a given face mesh according to facial feature points.These volumes cover most regions of a face that can be deformed. Then, by moving the control pointsof each volume, face mesh is deformed. By using non-parallel volumes [13], irregular 3D manifolds are formed. As a result, smaller number of deformvolumes are necessary and the number of freedom incontrol points are reduced. Moreover, based on facialfeature points, this model is mesh independent,which means that it can be easily adopted to deformany face model.After this mesh is constructed, for each vertex on the mesh, it needs to be determined which particularparametric volume it belongs to and what valueparameters are. Then, moving control points ofparametric volumes in 3D will cause smooth facialdeformations, generating facial aging throughflaccidity, automatically through the use of the agingparameters. This deformation is written in matricesas , where V is the nodal displacements offace mesh, B is the mapping matrix composed ofBernstein polynomials, and E is the displacementvector of parametric volume control nodes.BE V Given a quadrilateral mesh of points m i,j ,, we define acontinuous aged surface via a parametricinterpolation of the discretely sampled similaritiespoints. The aged position is defined via abicubic polynomial interpolation of the form with d m,n chosen to satisfy the known normal and continuity conditions at the sample points x i,j .>@>M N j i ,...,1,...,1),(u @@>@>1,,1,),,( j j v i i u v u x ¦3,,),(n m n m n m v u d v u x An interactive tool is programmed to manipulate control points E to achieve aged expressions making possible to simulate aging through age ranges. Basic aged expression units are orbicularis oculi, cheek, eyebrow, eyelid, region of chin, and neck [14]. In general, for each segment, there is an associated transformation, whose behavior can be observed by curves. The only segments that do not suffer any transformation are the contour of the eyes and the superior side of the head.5.2Deformation approachThe developed program also performs shape transformations according to the created aging curves, not including any quantification over the alterations made in texture and skin and hair color. Firstly, in the input model the subjects are required to perform different ages, as previouslymentioned, the first frame needs to be approximately frontal view and with no expression.Secondly, in the facial model initialization, from the first frame, facial features points are extracted manually. The 3D fitting algorithm [15] is then applied to warp the generic model for the person whose face is used. The warping process and from facial feature points and their norms, parametric volumes are automatically generated.Finally, aging field works to relieve the drifting problem in template matching algorithm, templates from the previous frame and templates from the initial frame are applied in order to combine the aging sequence. Our experiments show that this approach is very effective. Despite interest has been put in presenting a friendly user interface, we have to keep in mind that the software system is research oriented. In this kind of applications an important point is the flexibility to add and remove test facilities. 6.Results The presented results in the following figuresrefer to the emulations made on the frontalphotographs, principal focus of this paper, with theobjective to apply the developed program to otherpersons outside the analyzed group. The comparisonswith other photographs of the tested persons dependon their quality and on the position in which theywere taken. An assessment was made of the new positions, of the control segments. It consisted in: after aging a face, from the first age to the second one, through the use of polynomial interpolation of the control segments in the models in the young age, the new positions are then compared with the ones in the model of a relative of older age (figure 5). The processed faces were qualitatively compared with theperson’s photograph at the same age. Figure 5 - Synthetic young age model,region-marked model and aged modelAlso the eyelid hollow, very subtle falling of the eyebrow, thinning of the lips with the enlarging of the nasion and the superior part of the lip, enlargingof the front and changing in the nasolabial wrinkle.7.ConclusionsModelling biological phenomena is a great deal of work, especially when the biggest part of the information about the subject involves only qualitative data. Thus, this research developed had has a challenge in the designing of a model to represent the face aging from qualitative data.Due to its multi-disciplinary character, the developed methodology to model and emulate the face aging involved the study of several other related fields, such as medicine, computing, statistics and mathematics.The possibilities opened by the presented method and some further research on this field can lead to new proposals of enhancing the current techniques of plastic face surgery. It is possible to suggest the ideal age to perform face lifting. Once the most affected aging regions are known and how this process occurs over time. Also missing persons can be recognized based on old photographs using this technique. AcknowledgementsThe project TIN2004-07926 of Spanish Government have subsidized this work.8. References[1] Burt, D. M. et al., Perc. age in adult Caucasianmale faces, in Proc. R. Soc., 259, pp 137-143,1995.[2] Berg, A C. Aging of Orbicularis Muscle inVirtual Human Faces. IEEE 7th InternationalConference on Information Visualization, London, UK, 2003a.[3] Beier , T., S. Neely, Feature-based imagemetamorphosis, In Computer Graphics (Proc.SIGGRAPH), pp. 35-42, 1992.[4] Parke, F. I. P arametrized Models for FacialAnimation, IEEE Computer & Graphics Applications, Nov. 1982.[5] Waters, K.; A Muscle Model for Animating ThreeDimensional Facial Expression. Proc SIGGRAPH'87,Computer Graphics, Vol. 21, Nº4, United States, 1987. [6] Koch, R.M. et alia.. Simulation Facial SurgeryUsing Finite Element Models, Proceedings of SIGGRAPH'96, Computer Graphics, 1996.[7] Kurihara, Tsuneya; Kiyoshi Arai, ATransformation Method for Modeling and Animation of the Human Face from Photographs, Computer Animatio n, Springer-Verlag Tokyo, pp.45-58, 1991.[8] Kent, J., W. Carlson , R. Parent, ShapeTransformation for Polygon Objects, In Computer Graphics (Proc. SIGGRAPH), pp. 47-54, 1992. [9] Sorensen, P., Morphing Magic, in ComputerGraphics World, January 1992.[10]Pitanguy, I., Quintaes, G. de A., Cavalcanti, M.A., Leite, L. A. de S., Anatomia doEnvelhecimento da Face, in Revista Brasileira deCirurgia, Vol 67, 1977.[11]Pitanguy, I., F. R. Leta, D. Pamplona, H. I.Weber, Defining and measuring ageing parameters, in Applied Mathematics and Computation , 1996.[12]Fisher, J.; Lowther, J.; Ching-Kuang S. Curveand Surface Interpolation and Approximation: Knowledge Unit and Software Tool. ITiCSE’04,Leeds, UK June 28–30, 2004.[13]Lerios, A. et al., Feature-Based VolumeMetamorphosis, in SIGGRAPH 95 - Proceedings,pp 449-456, ACM Press, N.Y, 1995.[14]Berg, A C. Facial Aging in a VirtualEnvironment. Memória de Investigación, UIB, Spain, 2003b.[15]Hall, V., Morphing in 2-D and 3-D, in Dr.Dobb's Journal, July 1993.。

Approaches for Molecular Sensors Design

Approaches for Molecular Sensors Design

Approaches for Molecular SensorsDesignMolecular sensors are essential tools for detecting and quantifying select moleculesin various samples using biological and chemical events. The design of molecular sensors is a crucial step in ensuring their specificity, sensitivity, and accuracy. Effective sensor design requires an understanding of the biological and chemical interactions involved in signal transduction, as well as the design requirements and constraints for the sensor's application. In this article, we explore some of the approaches used for molecular sensor design.1. Rational DesignRational design is a strategy that focuses on exploiting known molecular interactions and structural features to design a sensor that can detect a specific target molecule, or class of targets. This design approach involves studying the structure and function of the target molecule, identifying the key features that allow it to bind selectively to the sensor, and creating a sensor that mimics these features. Rational design is particularly useful when the target molecule has a well-established structure, and when the chemical and biological properties of the target molecule are well-defined. Examples of rational design approaches include the design of aptamer-based sensors and the design of synthetic receptors.2. High-Throughput ScreeningHigh-throughput screening (HTS) is a strategy that uses combinatorial chemistry and high-throughput techniques to identify molecular structures that can interact with a specific target molecule. This is accomplished by screening a large number of potential sensor molecules in parallel, using high-throughput techniques such as microarrays or combinatorial libraries. HTS is particularly useful when the target molecule is not well-defined or when the chemical or biological properties of the target molecule are unknown.Examples of high-throughput screening approaches include phage display and chemical library screening.3. Directed EvolutionDirected evolution is a strategy that involves creating a large population of sensor molecules, then subjecting the population to selective pressure to screen for molecules that can interact with a specific target molecule. This approach is based on the principles of evolution, with sensor molecules that exhibit the desired interaction with the target molecule being selected and amplified while those that do not interact are eliminated. Directed evolution is an effective approach when the target molecule is complex or when the desired interaction is unknown. Examples of directed evolution approaches include selection-based methods, such as SELEX and surface display methods.4. Rational-Combinatorial DesignRational-combinatorial design is a hybrid approach that combines aspects of rational design and high-throughput screening. This approach involves designing a sensor molecule based on known interactions and structural features, then using high-throughput techniques to screen a combinatorial library of sensor molecules for the desired interaction. Rational-combinatorial design is effective when the target molecule has both well-defined structure and unknown chemical or biological properties. Examples of rational-combinatorial design approaches include the design of molecularly imprinted polymers and the design of DNA-encoded libraries.In summary, the design of molecular sensors requires the use of various approaches and strategies, based on the nature of the target molecule and the specific application of the sensor. Rational design, high-throughput screening, directed evolution, and rational-combinatorial design are all valuable design approaches for molecular sensors. By understanding these approaches, researchers can develop effective molecular sensors with high specificity, sensitivity, and accuracy.。

什么是lean精益生产

什么是lean精益生产

Teams learn to work together to rapidly implement solutions for these barriers
© 2003 Kaufman Global, LLC
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Value-Added vs. Non Value-Added
… from the the Customer’s Perspective
Lead time reduction is achieved by identifying and eliminating waste
Overproduction / Making To Much Ties up capital, diverts production from customer requirements, loss of inventories Transporting / Moving Things Unnecessarily increases production time, extra WIP
Agenda
What is Lean?
• Description
• Leadership • Implementation
• Benefits
© 2003 Kaufman Global, LLC
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Objectives of Presentation
• Establish Awareness Concerning “Lean” • Outline Lean Implementation Focus & Priorities • Discuss Critical Work streams to Implement Lean
New Lean Tools (e.g., 20 Keys)

cell design_ov

cell design_ov
• Cell Kaizen enables lean cell concepts for manufacturing by eliminating waste (muda), unevenness (mura), and overburden (muri).
05/99
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Cell Kaizen Steps
05/99
2
Demand Fluctuation
• Plant Management must resolve the conflict through:
– Lead Time Reduction – Cell Concepts
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3
Lead Time Reduction
• To adjust to market demand trends, manufacturing must reduce and control:
• The following summarizes how Toyota progressed over the years in their layout strategy to best utilize operator / machine / material in evolving to their final objective-lean multi-U-cells.
• Bird Cage Layouts
Lathe Drill
1 1
2
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Drill Lathe
2
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3
Lathe
Lathe Drill
05/99
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Process Sequence Operations (Solitary Island)

意大利 - 4 2021 化妆品 - 功效评估和支持声明的策略说明书

意大利 - 4 2021 化妆品 - 功效评估和支持声明的策略说明书

Italia – 4 2021MAKE-UP - Valutazioni di efficacia e strategie di supporto ai claimClaudia CartiglianiISPE srl | ItaliaREFERENZE1.Guidelines for the evaluation of the efficacy of cosmetic products – COLIPA Guidelines. May 2008.2. Fotofinder Dermoscope II: The leading system for video-dermoscopy and clinical documentationin dermatology. Manual, December 2006.3. ASTM Manual on Consumer Sensory Evaluation ASTM Special Technical Publication 682.American Society for Testing and Materials. 1986.4. Guidelines for the selection and training of sensory panel members. American Society for Testingand Materials 1981.5. Meilgaard M, Civille G V, Carr B T. Sensory evaluation techniques. 2nd edition. CRC Press, Inc. 19916. ASTM 1490 – 19: Standard guide for two Sensory Descriptive Analysis approaches for skin creamsand lotions.7. Piérard G E. EEMCO guidance for the assessment of skin colour. J. Eur. Acad. Dermatol. Venereol.Jan.1998: 10(1): 1-11.8. International Standard ISO 16217:2020. Cosmetics – Sun protection test methods – Waterimmersion procedure for determining water resistance.9. Burgo R, He Y, Lampe L, Mustafa E. Natural polymer for modern colour applications. Personal CareFebruary 2014: 63-68.10. Berardesca E, Loden M, Serup J, Masson P, Rodrigues L M. The revised EEMCO guidance for thein vivo measurement of water in the skin. Skin Research and Technology 2018: 24: 351-358.11. Jacobi U et al. In vivo determination of skin surface topography using an optical 3D device. Skinresearch and technology 2004: 10: 207-214.12. Jaspers S et al. Optical topometry with PRIMOS: a powerful tool to prove the efficacy of skin careproducts in in vivo studies. 21st IFSCC International Congress, Berlin, Proceedings 2000:430-434.13. Knox A, Loichle J W, Lockwood K P, Shaffer M J. An accurate, non-invasive new method forassessing volumizing, thickening and lengthening efficacy of mascara products.Italia – 4 202114. Katsuyuki T, Shotaro H, Masanori A. Functional Cosmetology – Substantiation of CosmeticsEfficacy: Recent Progress and Future Promise. Society of Cosmetic Chemists of Japan. Yakuji Nippo Ltd. 2003.15. Fagien S. Management of hypotrichosis of the eyelashes: Focus on bimatoprost. Clinical,Cosmetic and Investigational Dermatology. Dove Medical Press Ltd. 2010: 3: 39-48.。

高职《生物制药技术》课程与国家职业标准对接的“三个结合”

高职《生物制药技术》课程与国家职业标准对接的“三个结合”

第49卷第2期2021年1月广㊀州㊀化㊀工Guangzhou Chemical IndustryVol.49No.2Jan.2021高职‘生物制药技术“课程与国家职业标准对接的 三个结合 ∗谢承佳,陈秀清,郭双华(扬州工业职业技术学院,江苏㊀扬州㊀225127)摘㊀要:基于高职院校培养高素质技术技能型人才的定位和目标,高职教育人才培养有必要在学科体系内在逻辑的基础上达成课程标准与国家职业标准的融通㊂本文以药品生产技术专业核心课程‘生物制药技术“课程为例,在实践研究的基础上提出了高等职业教育课程与国家职业标准对接需做到三个结合:教学模块与职业功能结合㊁教学项目与岗位工作任务结合㊁教学考核与职业技能鉴定结合,以最大限度地实现学校人才培养与企业人才需求的无缝对接㊂关键词:职业标准;课程标准;技能鉴定㊀中图分类号:G710㊀文献标志码:A文章编号:1001-9677(2021)02-0123-03㊀㊀㊀㊀㊀㊀㊀㊀㊀㊀㊀㊀㊀∗基金项目:扬州工业职业技术学院2018年校级教改课题 基于 一城六区 制药产业发展的高职院校‘生物制药技术“课程标准与国家职业标准对接研究 (课题编号:2018XJJG19);扬州工业职业技术学院2016年校级教育教改课题 能力本位视阈下提升高职院校教师校本课程开发能力的研究 (课题编号:2016XJJG07)㊂第一作者:谢承佳(1982-),女,副教授,主要研究方向为教育信息化㊁教学设计等㊂Three Combinations of Biopharmaceutical Technology Course in Higher Vocational Education and National Vocational Standards ∗XIE Cheng -jia ,CHEN Xiu -qing ,GUO Shuang -hua(Yangzhou Polytechnic Institute,Jiangsu Yangzhou 225127,China)Abstract :Based on the positioning and goal of cultivating high -quality skilled talents in higher vocational colleges,it was necessary to achieve the integration of curriculum standards and national vocational standards based on the discipline system.Taking the course of Biopharmaceutical Technology as an example,on the basis of practical research,it proposed that in order to maximize the seamless connection between school personnel training and corporate talent needs,the integration of higher vocational education courses and national vocational standards needed to be combined in three ways:the combination of teaching modules and professional functions,the combination of teaching projects and job tasks,and the combination of teaching assessment and vocational skill appraisal.Key words :vocational standards;curriculum standards;skill identification‘国家中长期教育改革和发展规划纲要(2010-2020年)“中指出 加快建立健全政府主导㊁行业指导㊁企业参与的办学机制,推动职业教育适应经济发展方式转变和产业结构调整要求,培养大批现代化建设需要的高素质劳动者和技能型人才 [1]㊂高职院校培养的是高素质技术技能型人才,是以培养岗位技能为核心,但是,我国高等职业教育发展历史较短,职业教育培养的毕业生具备的职业素养与企业需求的职业素养有一定的差异㊂基于这样的现状,同时在长期的教学实践中,我们认识到有必要在学科体系内在逻辑的基础上达成课程标准与国家职业标准的融通㊂国家职业标准是劳动技能的衡量准则,是对从业人员在某一专业领域的职业素质最基本要求,课程标准与国家职业标准的融通,可以使更多的受教育者和培训对象的职业技能与就业岗位相适应,最大限度的实现学校人才培养与企业人才需求的对接㊂在这样的基础上,本文探讨了药品生产技术专业‘生物制药技术“课程内容与职业标准对接的问题研究,希望能指导一线教学,提高人才培养质量㊂1㊀课程概况1.1㊀专业概况在全国范围内,江苏省是医药大省㊂截至2019年底,省内正规的制药企业有超过500家[2]㊂在这样的区域经济发展背景下,我院化学工程学院在2006首次开办了化学制药技术专业,目前已经过十多年的发展㊂2016年,根据国家的相关文件,专业名称变更为药品生产技术专业㊂在本专业开办之初,秉承 市场为导向,以就业为目的,以能力为本位 的人才培养观,对制药产业及企业进行了充分调研,确定主要岗位群㊂目前,根据调研结果,药品生产技术专业主要有六大主要岗位群,包括化学药品生产岗位㊁生物药物生产岗位㊁药物制剂生产岗位㊁化工生产岗位㊁药品经营与124㊀广㊀州㊀化㊀工2021年1月管理岗位㊁药品质量控制岗位㊂对不同的岗位分析对应的工作任务,从而提炼职业能力要求㊂例如,生物药物生产岗位对应的素质能力要求主要包括 掌握生物药物生产工艺流程及环境划分㊁设备操作及质量控制等相关知识,具备生物制药的基本理论知识和岗位操作技能;具有药物制剂制备与设备维护保养能力 ,而药物制剂生产岗位则需要员工能够 掌握典型剂型的生产工艺流程,具备典型制剂制备及质量控制的操作技能;熟悉常用制剂设备的基本操作,具有常用制剂设备使用与维护能力;懂得常用仪器的使用方法;有解决药物制剂制备过程中一般性技术问题的能力 [3]㊂根据各个岗位提炼的职业能力要求,确定了学习领域,设计了 基于工作过程系统化导向 的课程体系,主要由文化课㊁专业课和拓展课三大课程模块构成㊂其中,专业课又包括专业平台课,专业模块课和综合实践课,分别对应职业通用能力㊁专项能力和综合能力㊂‘生物制药技术“课程就属于专业模块课程,旨在提高学生的职业专项能力,主要对应岗位为生物药物生产岗位㊂1.2㊀‘生物制药技术“课程概况作为药品生产技术的专业核心课程,‘生物制药技术“课程教学的主要任务是使学生熟悉生物技术的发展与基本概念㊁掌握生物制药技术的操作与相关应用㊂其前导课程为‘微生物技术及应用“‘制药过程及设备选择与操作“㊂后续课程为‘药物制剂操控“‘药物分离与纯化“㊂在‘生物制药技术“课程教授的十多年时间中,随着区域经济发展,授课团队越发感觉到课程应注重学生职业的可持续发展性,因此,有必要在国家职业标准导向下基于区域经济对高职‘生物制药技术“课程的课程标准进行改革㊂一方面,随着经济转型和产业升级,企业㊁单位用人对从业人员的职业能力要求也在不断变化㊂职业标准体现的是社会对人才的需求,而课程标准则是规定高职院校的课程如何更有效地培养出社会所需要的人才㊂因此,职业标准与课程标准以社会需要的人才为平台,前者提供社会对人才的要求,后者将人才的要求反馈到高职课程中㊂另一方面,高职院校人才培养规格也影响经济发展及产业结构㊂高校需要供给能够适应高新技术产业迅速发展和产业结构转型升级所需要的高素质㊁高技能人才,才能为区域产业结构转型升级提供保障㊂因此,高职院校人才培养规格描述的课程标准,应该具备可持续发展性㊂2㊀高职‘生物制药技术“课程与国家标准对接的 三个结合2.1㊀教学模块与职业功能结合具体职业岗位(群)的职业能力需求有其内在的层次结构,课程教学目标和课程教学内容应该根据这种 层级层次 构建不同的教学模块㊂课程教学项目模块设定的思路为:首先,根据国家职业标准中的职业功能确定项目模块范围;再结合江苏省制药产业现状和发展趋势对项目模块进行调整;之后,对职业功能中的工作内容列表分析,并基于学生的认知规律,将不同职业功能中的共同工作任务部分整合,将不同工作任务根据职业功能划分成单独模块㊂根据国家职业标准,生物制药技术方向对应的职业工种包括五大类,具体为:生化药品制造工㊁发酵工程制药工㊁疫苗制品工㊁血液制品工和基因工程产品工[4]㊂在此基础上,我们对江苏省的制药产业进行了综合考察,通过资料查阅及调查研究发现,江苏省制药产业结构分布的实际情况是:在500多家正规制药企业中,只有不超过10家为疫苗专营或兼营企业㊂结合制药技术概念界定,将疫苗制品工对应的职业要求归并至 细胞工程 教学模块;此外,考虑到产业现状与升级需求,增加 酶工程 教学模块㊂综上所述,本着区域经济发展服务的需求,根据职业功能确定教学模块为血液制品与生化分离技术㊁天然生物材料与天然药物㊁发酵工程技术与发酵药物㊁细胞工程技术与免疫技术药物㊁基因工程技术与基因药物㊁酶工程技术与生化反应制药㊂具体见图1㊂图1㊀职业功能与教学模块对应表Fig.1㊀Correspondence of professional functions andteaching modules在每一教学模块中,基于各个岗位的工作内容描述,同时充分考虑与前导课程可能存在的重复性及与后续课程存在的衔接性,制定各个模块的教学目标,并确定教学内容㊂例如,发酵工程制药工的职业描述中主要包括10个方面[3],其中,诸如 使用消毒锅或消毒柜等,对培养基㊁压缩空气或其他材料㊁设备㊁器皿等进行消毒㊁灭菌 ㊁ 采用微生物方法培养㊁制备各级生产菌种,复壮㊁选育优质高产生产菌株 等方面主要属于前导课程‘微生物技术及应用“教学范畴㊂而诸如 使用固液分离设备进行发酵液或浸提液的固液分离 ㊁ 使用溶剂或交换树脂等进行有效药用成分的提取和纯化 等职业能力要求也是后续课程‘药物分离与纯化“的教学目标㊂因此,综合考虑后将发酵工程技术与发酵药物这一个模块的教学目标确定为:了解发酵工程技术的概念,掌握发酵工程制药的一般工艺流程及技术特点,熟悉主要的发酵技术药物及生产工艺㊂并以典型发酵工程产品,包括抗生素㊁维生素㊁氨基酸等为教学载体,通过这些药品生产工艺的讲解达到职业标准中 操作发酵设备和控制仪器㊁仪表,根据发酵代谢指标适当调节发酵工艺条件,完成发酵 加入工具酶和中间体,控制工艺条件,完成抗生素的酶解㊁转化工序 等职业能力要求㊂2.2㊀教学项目与岗位工作任务结合将真实工作任务融入教学体系已成为高职院校课程开发和改革的共识[5-6]㊂考虑到与地区医药产业发展相适应的问题,需要确定合适的工作任务以便实现情境与岗位对接㊂而实施基于正式工作工程的项目,其目标是引导学生处于一个自己想要去了解的境地,让学生能以相对积极的态度去做原本可能并不喜欢做的东西,在完成相关项目的过程中重新构建知识㊂通过一门课程所呈现的多个教学项目的实施和训练,实现学生从 学生 到 企业员工 身份的转变,发展职业能力㊂以 青霉素的发酵生产 这一教学项目为例㊂青霉素高效㊁低毒㊁临床应用广泛,是人类历史上发现的第一种抗生素,也是学生在生活中经常能接触到的一类药品㊂通过微生物发酵是生产青霉素的主要途径之一,其工艺控制难度较大,但对于其他抗生素类药品发酵工艺的学习具有示范性㊂通过与企第49卷第2期谢承佳,等:高职‘生物制药技术“课程与国家职业标准对接的 三个结合 125㊀业沟通确定职业能力需求,结合参考‘药品生产质量管理规范“及发酵制药工职业标准,确定教学重点及教学目标(见表1)㊂同时,结合企业生产示例设定教学情境:东方梦想科技园生物工程有限公司是完全按照GMP要求建造的现代化生物工程公司,拥有设施先进的研发中心,发酵车间,生物分离车间,三废处理车间,动力车间,大型仓库等,公司具有8个200顿的发酵罐,青霉素年产量为2100吨㊂学生是东方梦想科技园生物有限公司的一线生产操作人员,日常工作内容为青霉素的发酵生产㊂在教学实施环节,遵循正常工作流程,并考虑技能级次,确定教学顺序为 发酵环境要求 ㊁ 发酵流程认知 ㊁ 发酵参数控制 ㊁ 发酵生产对接 ㊂在实践环节,利用智慧教室及仿真软件打造虚实融合的教学环境,通过丰富的活动设计,并配合各种激励性措施和反思性活动,使真实工作任务支持学习的功能得以充分有效发挥㊂例如,在学生操作仿真软件的过程中,设定两人为一小组,模拟真实生产过程,一人扮演中控室人员,主要负责DCS操作,一人扮演工艺员,主要负责监督管理㊂通过这样的分工合作互助互提,激发团队潜能,培养学生的职业观㊂表1㊀青霉素的发酵生产教学要求Table1㊀Teaching requirements for fermentationproduction of penicillin青霉素的发酵生产教学情境学生是东方梦想科技园生物有限公司的一线操作人员,该公司青霉素年产量为2100吨教学目标知识目标:能理解青霉素发酵工艺流程,会分析各个参数之间的影响及联系;技能目标:能根据监测参数判断发酵趋势并进行正确的操作处理;素养目标:能按照岗位职责要求,遵守生产纪律,完成各项生产任务教学重点青霉素发酵的工艺操作教学难点青霉素发酵工艺参数的控制在教学项目实施过程中,结合工作情境设计教学方法㊂即:考虑在实际工作情境中知识和技能的传递情境,并充分考虑教学规律及其他客观因素,设计教学方法㊂例如,对于在实际工作岗位中以语言传递为主要方式的学习过程,可采用讲授法等;以实际感知为主的知识形成过程,在授课中可采用演示法㊁参观法㊁角色扮演法等;以实际训练为主的技能培养过程,可采用理实一体化教学㊁仿真教学等㊂此外,创新精神是企业的核心竞争力,而企业的创新来自员工的积极参与意识㊁勇气和能力㊂因此,在教学中,我们也鼓励教师多用㊁用好诸如探究法㊁讨论法等以引导探究为主的方法㊂2.3㊀教学考核与职业技能鉴定结合职业技能鉴定是国家职业资格证书制度的重要组成部分,是对劳动者从事某种职业所应掌握的技术理论知识和实际操作能力做出客观的测量和评价㊂将职业技能鉴定的相关内容融入教学考核,有助于强调学生将所学知识和技能在实践中加以应用,积极引导学生自主学习,强化学生动手能力㊁职业素养和工程意识[7]㊂首先,在理论教学方面,将教学内容的知识点与职业标准中的考点对接㊂例如,发酵制药工的职业描述之一是 采用微生物方法培养㊁制备各级生产菌种,复壮㊁选育优质高产生产菌株 ,其中涉及到的知识点包括:微生物的生长㊁接种技术㊁菌种的扩大培养㊁菌种保存㊁菌种的复壮㊁菌种的选育等,在平时的教学中,我们就将这些内容与教学案例相结合或作为单独知识点进行讲解,既避免了职业技能鉴定时再花费大量时间再进行系统培训,从而避免了教育资源的重复和浪费;又提高了学生通过职业鉴定的合格率㊂在实训基地建设方面,建设工学结合的实训基地,从而保障职业技能鉴定与高职教学活动的结合㊂我们采用 自主开发㊁校企共建 的建设模式,按照 生产型㊁职场化 的理念建成了一批集技能训练㊁项目化教学实施㊁技术开发与服务㊁社会培训与技能鉴定㊁技能竞赛㊁职业素质养成等功能于一体的完整的制药实训室体系,具体包括有机合成㊁生物发酵㊁化学制药㊁药物制剂㊁分析测试等涵盖药品生产技术的上㊁中㊁下游,其中包含两个江苏省的省级研发和测试中心㊂同时,在校外实训基地建设方面,我们也与包括江苏扬农集团有限公司㊁扬州联博药业有限公司㊁扬子江药业集团有限公司在内的紧密合作企业分地区㊁分层次建成了工学交替㊁顶岗实习㊁产学研结合的10余个校外实训实习基地㊂校内和校外实训基地的建成为有效保障了工学结合背景下职业技能鉴定与教学活动的结合㊂同时,通过良好的职业氛围,培养学生爱岗敬业㊁团结互助的职业素养㊂3㊀结㊀语综上所述,高等职业教育课程与国家职业标准的对接研究,需依据职业标准,以区域经济的实际需求为落脚点和出发点㊂在高职‘生物制药技术“课程的改革中,我们遵循此原则,做到了教学模块与职业功能结合㊁教学项目与岗位工作任务结合㊁教学考核与职业技能鉴定结合,切实提高药品生产技术专业学生的职业核心素养,为学生今后的职业发展奠定坚实的基础㊂参考文献[1]㊀国家中长期教育改革和发展规划纲要(2010-2020年)[OL]./publicfiles/business/htmlfiles/moe/info_list/ 201407/xxgk_171904.html?authkey=gwbux.[2]㊀国家药品监督管理局[OL]./datasearchcnda/face3/dir.html.[3]㊀国家职业技能标准编制技术规程(2018年版)[M].北京,2018.[4]㊀江苏省职业技能鉴定网[OL]./jdfww_bak/zcfg/zsglyjdsf/.[5]㊀关艳阁.现代国家职业标准导向下的高职课程改革研究[D].广州:广东技术师范学院,2015.[6]㊀戴有华,于泓,刘旭.高职机制专业课程教学内容与国家职业标准对接研究[J].职业教育研究,2013,(9):11-13.[7]㊀李慧丽.我国高职院校课程内容与职业标准对接的研究[D].上海:华东理工大学,2016.。

JIT(经典讲义)

JIT(经典讲义)
21
Single-Card Kanban System
Receiving post
Kanban card for product 1
Kanban card for product 2
Storage area
O2
Fabrication
cell
O1
O3
O2
Empty containers
Full containers
15
A Sample Kanban
及時化生產系統
16
The Origin of Kanban
a) Two-bin inventory system Bin 1
Reorder card
Q-R
Bin 2 R
b) Kanban inventory system Kanban
R
Q = order quantity R = reorder point - demand during lead time
✓ Triangular kanban used to signal production at the previous workstation
✓ Material Kanban
✓ Used to order material in advance of a process
✓ Supplier Kanbans
及時化生產系統
17
Types of Kanbans —
Dual kanbans
及時化生產系統
18
Single-Card Kanban System
Receiving post
Kanban card for product 1
Kanban card for product 2

拇指血流灌注指数试验与改良Allen试验的比较

拇指血流灌注指数试验与改良Allen试验的比较

硕士学位论文论 文 题 目: 拇指血流灌注指数试验与改良Allen试验的比较Evaluation of the patency of the hand collateralarteries with thumb Perfusion Index test:Comparison with the modified Allen’s test研 究 生 姓 名: 吴阳指导教师: 刘松学科专业: 麻醉学研究方向: 麻醉学临床技能训练与研究论文工作时间: 2015年6月至2016年12月目录中文摘要 (1)英文摘要 (2)正 文 (3)前 言 (3)资料与方法 (7)结 果 (10)讨 论 (15)结 论 (22)参考文献 (23)致 谢 (33)附录A (34)附录B (44)拇指血流灌注指数试验与改良Allen试验的比较中文摘要目的:探讨拇指血流灌注指数(Perfusion Index,PI)试验替代改良Allen试验(modified Allen's test,MAT)评价掌部组织侧支循环血流灌注的可行性。

方法:选择1108例拟行择期手术并需要经桡动脉入路进行有创动脉压力监测的患者,在桡动脉穿刺前先后用MAT和拇指PI值试验分别评价患者试验侧掌部组织侧支循环血流灌注的情况,并将两种试验方法结果进行统计学比较和分析。

结果:在1108例患者中MAT阴性患者1035例(93.41%),阳性患者73例(6.59%);拇指PI值试验阴性患者1090例(98.38%),其中包括57例MAT阳性患者,阳性患者18例(1.62%)。

拇指PI值试验阴性患者行经该侧桡动脉入路进行有创动脉压力监测,两种试验方法结果进行卡方检验,差异有统计学意义(x2=51.27, P<0.05)。

两种试验方法影响因素进行logistic回归分析发现两种试验方法结果阳性率均与年龄和性别有相关性(P<0.05)。

结论:在本研究中用拇指PI值试验筛选出1.62%的患者不宜行经桡动脉入路进行有创动脉压力监测。

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The Journal of Technology Studies19Organizations are currently encounteringa necessity to respond to rapidly changingconsumer needs, desires, and tastes. Tocompete in this continuously changingenvironment, these organizations must seekout new methods allowing them to remaincompetitive and flexible simultaneously,enabling their companies to respond rapidlyto new demands. The contemporary industrialworld is in a new era termed the “thirdindustrial revolution” (Black, 1991). The effectof this new era is dramatic to most businessesbecause they have been forced into the globaleconomy by emerging global competition. Inorder for companies to remain competitive,retain their market share in this globaleconomy, and satisfy both external and internalcustomers, continuous improvement ofmanufacturing system processes has becomenecessary (Kokuo, 1992; Shingeo, 1988;Yaruhiro, 1993). The method used to design aflexible, unique, controllable, and efficientcellular manufacturing system has become atopic that modern industrial operations areeager to learn and implement. The Kaizentechnique has been proven as an effective toolfor process improvement (Yung, 1996), processreengineering (Lyu, 1996), and even fororganizational designs (Berger, 1997). Kaizennow is further implemented in industries fordesigning cellular manufacturing system toreduce cost and working space.As an example of the successfulimplementation of Kaizen, take the case of aU.S. wood window company in the state ofIowa. This company has been using Kaizensince 1991 to redesign their shop floor,replacing expensive, nonflexible automationwith low cost, highly flexible cellularapplications. This company uses Kaizen torespond rapidly to consumer needs and toresolve problems in their manufacturingprocesses. Kaizen is used extensively in Product,Process, and Production (PPP) development.The major strategy of this development is todesign a new product while considering thefunctions of products, the production processesused, and efficient production practices on theshop floor. This approach is similar toconcurrent engineering; however, the distinction between concurrent engineering and Kaizen is that the latter calls for the creation of a team that includes cross-functional employees, such as engineers, shop managers, and operators, working together on targeted areas. With a set of goals and a series of brainstorming processes, this team is expected to obtain a solution for resolving the problem within a week’s time. During this week, the team concentrates on nothing but the project at-hand. This wood window company has successfully undertaken hundreds of projects over the past eight years. Achieving success in this way, the company has become a model for many local industries.The Kaizen process is successful because it employs the lean thinking approach of designing a flexible, controllable, efficient, and unique manufacturing process (Womack &Jones, 1996). This article describes an example of Kaizen’s success in a pull cellular manufacturing system and addresses this success in terms of cost, space, and improved worker satisfaction.What Is Kaizen?Kaizen is a Japanese word that has become common in many Western companies; the word indicates a process of continuous,incremental improvement of the “standard”way of work. This kind of creative improvement is something that every employee is capable of contributing to. The front-line employee is, in fact, most familiar with the actual work; there may be no one person to ask for improvement ideas.Kaizen thrives by being adopted into the organizational culture. Successful implementation results in a cooperative atmosphere where everyone is aware of the key goals and measures of success. In this type of environment, implementation of new concepts is readily achieved with a high degree of success.Kaizen can be applied to any area in need of improvement. Kaizen is more than just a means of improvement because it represents the daily struggles occurring in the workplace and the manner in which those struggles are overcome (Kaizen Teian 1, 1992; Kaizen T eian 2, 1992). The flexibility inherent in this A Kaizen Based Approach for Cellular Manufacturing System Design: A Case StudyJoseph C. Chen, John Dugger, and Bob HammerT heJournalofTechnology Studies20approach makes it applicable to myriad corporate situations with only a few basic requirements necessary before full implementation can be realized.The Kaizen approach requires that all employees participate; therefore, everyone in the company is encouraged to play a role in Kaizen activities. Kaizen has three major components:1.Perceptiveness: All Kaizen projects are based on identified problems. If no problem has been identified, there is no use for Kaizen. 2.Idea development: This stage requires more than one person to provide better innovative ideas; therefore, forming a Kaizen focus team for the identified problem is very important. In this team-assembly process, one key is putting employees who work in the problem area together in order to interact in this innovative team.3.Decision, implementation, and effect:Kaizen is only valuable if and when it is implemented. In the decision-makingprocess, the team identifies what appearsThe Journal of Technology Studies21to be the best solution to the problem being dealt with, and then begins the implementation process. Following implementation, the team is also responsible for evaluating the effect of the Kaizen process once it has been imple-mented in the shop flow of a factory.Transferring these three stages into a systematic approach, Figure 1 shows the flow chart of the Kaizen process employed in this case study. The following section of this article introduces, step-by-step, how a Kaizen approach has been used to implement a pull cell design. The steps of this approach are summarized as follows:1.Identify a problem.2.Form a team.3.Gather information from internal and external customers, and determine goals for the project.4.Review the current situation or process.5.Brainstorm and consider seven possible alternatives.6.Decide the three best alternatives of the seven.7.Simulate and evaluate these alternatives before implementation.8.Present the idea and suggestions to managers.9.Physically implement the Kaizen results and take account of the effects.The following case study demonstrates the Kaizen practice.Case StudyThe focus of this project is the virtual manufacture of meat tenderizers. The full de sign of a meat tenderizer is shown in Figure 2. The problem identified in this virtual situation is that the product is currently too expensive to produce.After the cellular manufacturing system was introduced, a Kaizen team was formed to design a cellular manufacturing system to reduce production costs and improve the quality of every product. In order to address this system design problem, a design engineer, a manufacturing engineer, a quality engineer, and two machining operators were invited to be team members in this Kaizen project.[JCD1]After identifying the problem, forming theteam, and discussing the problem with allthe employees in that production area, theteam met to discuss the goal of this project. A brainstorming process was used to explore theteam’s goals. For this particular project, therewere three goals: (a) reduce 25% of the unitcost, (b) design a cellular manufacturingsystem, and (c) reduce floor space by 15%.With setting these goals, the team could beginto review the current process of the product.Review of Current Situation/ProcessMeat tenderizer production consists ofmachining four basic components followed bya final assembly process (Figure 2). The facility is organized as a job shop with a separateassembly line. Flow of material follows a push Figure 2. A Final Assembly Drawing for the Meat Tenderizer.T heJournalofTechnology Studies22model: the up-stream operation pushes the work-in-progress (WIP) to the down-stream operation and requests information from the down-stream operator. The current process needs to be determined and developed into a Process at a Glance (Figure 3), displaying the current method in a step-by-step flow.The sequence of the manufacturing process begins with the cutting of raw stock.The operator is given a cut sheet and a cut quantity for each part. Some setup time is necessary between the production of each part and is considered as internal setup time.Referring to Figure 2, the first cutting operation produces the aluminum handle, the second produces the aluminum dowel, the third produces the plastic grip, and the fourth produces the aluminum head. After a specified quantity of aluminum is cut for the handle, it is delivered to the lathe operator, where the drilling and reaming operation is performed,allowing the handle to accept the dowel insert.Then, the relief cut, diameter reduction, and threading operations are performed. The proper length for the handle is established at this time. This process is repeated until the batch quantity delivered from the cutting operation is completed. The operator then performs the necessary setup required for the next operation.The next part of the meat tenderizer to arrive at the lathe is the dowel. Both ends are faced, with one end center-drilled to facilitate a milling operation later in the manufacturing process. Straight knurling is also applied at this time.[j2] Once the batch quantity is completed, the setup for production of the plastic grip is done. At the lathe, the plastic grip is faced on one end, drilled, and reamed[j3]. The grip is also rotated to the opposite end to prepare it for a later machining operation. This operation is repeated until the required batch size is produced. At this time,the operator returns to the first operation for turning the aluminum handle.Once the lathe operations on the aluminum handle and the dowel have been completed, the parts go to a press operation in the assembly area. At the press, the aluminum dowel is inserted into the handle to a specified depth of 2.375 inches. This operation is repeated until the predetermined batch size has been produced. From this point, the handle and dowel move to the milling operation,where the nine flutes are applied. When the complete batch is finished, the parts are moved to a polishing center where the handles receive a final finish. These finished parts are then inventoried until delivered to the assembly area.The next component to move through the Figure 3. The Process at a Glance of Production of the Meat Tenderizer.The Journal of Technology Studies23process is the plastic grip (Figure 2). After being prepared by the lathe operation, the grip is delivered to a milling process where 10 flutes are machined. Once this process has been done on the batch quantity, the plastic grips are taken back to the lathe to go through the final ball end-milling operation. From this point, the grips are cleaned and de-burred. Once this de-burring procedure is complete, the parts are passed to an inventory location, awaiting final assembly.The meat tenderizer head (Figure 2) is produced concurrently with other parts of the product. Once the cutting operation is complete, the batch quantity is delivered to themilling operation where the block is faced on all sides and a pattern is cut on each end. Once the milling operation has been performed, the head is transferred to the drilling and tapping process, where the hole is drilled and tapped.After this operation is finished, the meat tenderizer head is delivered to a de-burring and polishing station, and then to inventory to await final assembly.The assembly process operates around an assembly station consisting of four work-stations for each of the meat tenderizer’s four components (aluminum handles, dowels,plastic grips, and the tenderizer head) with one worker at each station. First, the aluminum handle is threaded into a fixture to protect the threads and align the part. The dowel is then pressed into the handle and the assembly is removed from the fixture. This process is repeated until the lot size is complete. Next,the assembly is delivered to the milling operation where the nine flutes are milled onto the handle. After the handle is milled and polished, it is returned to the assembly area for final assembly. The aluminum handle is threaded into the fixture as before, in order to protect the threads. To ensure proper alignment, the plastic grip is pressed onto the handle. The assembly is then removed from the fixture and the tenderizer head is threadedonto the handle assembly. The completed product is cleaned, packaged, and prepared for shipment to a retail outlet.Brainstorming and Consideration of Possible AlternativesOnce everyone on the team understands the current method, a brainstorming phase begins in order to accumulate ideas determining seven new processes to be evaluated. No ideas are too bizarre, ranging from doing nothing at all to viewing various ways to completely redesign the process. Thenumber of new processes changes depending on the project, but seven is the number typically used because it creates a high degree of stimulation during the limited time allotted for the brainstorming phase.The seven proposed methods should be displayed in a chart that allows everyone to view them quickly and easily. The information provided also needs to be clear and concise,including a process sketch, a brief explanationT heJournalofTechnology Studies24of the operation, a measuring gauge, a list of necessary tools, and required fixtures. The seven methods for this project are summarized in Figure 4. Once these methods are developed,an evaluation of these proposed processes must be undertaken.Evaluation and Selection of Process A group approach was implemented based on the three goals of this project to develop evaluation criteria. The decision was made to evaluate this project based on the following criteria: (a) flexibility: with two subcriteria: simplicity and ease of repetition;(b) cost: with five subcriteria: capital investment, labor costs, tooling costs, known technology, and required maintenance costs;and (c) safety: with seven subcriteria: safe,clean, ergonomic, of desired quality, required skills, defects per shift, and meets customer specifications. The first column in Table 1shows the criteria for evaluating the seven alternatives. In addition, the weight of each criterion and the value of the subcriteria are also determined and shown in the second and third columns of Table 1.The evaluation sheet determines how the seven proposed methods will be assessed.This sheet should consist of categories that are appropriate for the project. Once the evaluation sheet is prepared, each member of the team independently rates the seven proposed methods on a scale from 1 to 5,with 1 indicating strongly disagree and 5indicating strongly agree. A value of X can be entered if the team member feels that one of the proposed methods is not an acceptable solution. After each member has voted, the results are tallied and entered into a chart as shown in the last seven columns of Table 1.From this chart, the three best methods can be selected for simulation. The top threemethods selected in this study were Methods 5, 4, and 1. At this point, one method was chosen for simulation to determine how effective it might be when implemented.Prototype and SimulationAlternative number 5 shown in Figure 4was chosen for prototyping and simulation because it had the highest score in the decision matrix (Table 2). The design of the cell was developed and carefully laid out using measurements from actual machines involved.Tables, chairs, cardboard boxes, or any other readily available material can be used tosimulate the cell design. Members of the team used stop watches to simulate the cycle time of each station in the cell. The workers in thecell could not move to the next assignment in Table 1. The Evaluation Criteria, Weights, Values, and Overall Scores for the Seven Alternatives.The Journal of Technology Studies25the process until signaled by the timekeeper.By following this example, the cycle time of the cell was predicted very accurately relative to real-time values.Another important key to success under the Kaizen methodology is to generate a written description of worker responsibilities.This key must be provided in order for everyone involved to be acutely aware of what is going on in the process. A pictorial representation of the cell design can be seen in Figure 5. Before worker responsibilities can be addressed, a few explanations of the cell are necessary.Cell DesignThe cell is a U-shaped pull design with a one-piece flow. A de-coupler is used betweenthe workers to break the dependency of the process and relax the need for precise line balancing (Black, 1991). It holds one part with a specific input and output, and is not a storage area or buffer. Every part of the cell, in each machine and in each de-coupler, is ready to be advanced. Work begins at the last process, and no part can advance through the cell until the part is removed from the de-coupler. This signals the other worker to begin. In other words, the work is “pulled” through the cell.The assignment of the work is as follows.Worker ResponsibilitiesWORKER 1Starts at Station 4, and pulls the cleaned part from the de-coupler, signaling Worker2 to begin the process at Station 3. Worker 1 places the clean part in Station 4 and packages it, then walks to Station 1 and waits until the de-coupler is empty to begin work. When Worker 2 pulls the part from the de-coupler, Worker 1 places the finished part that was in Station 1 into the de-coupler and begins this process. When the operation at Station 1 has been completed,the worker walks back to Station 4 and pullsthe cleaned part from the de-coupler. Theprocess is then repeated.WORKER 2Begins at Station 3 when Worker 1 pulls the part from the de-coupler. Worker 2 will move the already cleaned part to the de-coupler and will then move the part from Station 2 to Station 3 and clean it. After it is cleaned, Worker 2 will move to Station 2 and pull the part from the de-coupler,signaling Worker 1 to begin work at Station 1. Worker 2 will perform the process at Station 2 and then move back to Station 3. When the de-coupler isemptied, Worker 2 repeats this procedure.Figure 5. The Proposed Two-Worker Cell Layout.T heJournalofTechnology Studies26After physical simulation with this cell implementation, a cycle time of 27 to 29seconds was obtained through measurement.These results exceeded the goal of the team,allowing them to plan for the presentation of this new alternative to upper management for approval before this approach could be fully adopted on the shop floor.Presentation and Implementation Presentation to upper management is crucial for Kaizen to succeed because it allows upper management to observe the impactKaizen is having on the success of theorganization while keeping them in theinformation loop. Additionally, it provides anexcellent method to train the entireorganization on Kaizen implementation. Thepresentation can also be used to providefeedback to improve the implementation of theKaizen methodology, resulting in thecontinuous improvement the name Kaizenimplies. This increase in visibility betweenupper management and the workforceestablishes a high level of communication,creating trust and understanding, eventuallyresulting in improved employee relations andmorale.ResultsThe existing cycle time per assembly was62 seconds. The new cycle time was about28 seconds, which constitutes anapproximate 44% reduction in cycle time.The existing assembly area consisting ofworkstations occupied 192 square feet. Theproposed assembly area requires two cells,which use a space of 160 square feet. Thenew plan reduces the workspace by 37%.Quality to the consumer is 100% becausethe “make one check one pass one on”method provides 100% inspection, ensuringthat no inferior-quality products are passedon to the consumer. Scrap and re-work areminimized because quality problems becomevisible immediately and can be addressedbefore additional defects may be produced.Employee morale is improved because thecellular design makes it possible for workersto fill multiple jobs. With Kaizen, workersrotate the tasks they undertake, raisingsatisfaction and morale. Higher workersatisfaction and morale decrease boredom,resulting in increased productivity andhigher quality workmanship.Conclusion The Kaizen process acknowledges the information at all levels of an organization through the incorporation of a special type of intense teamwork. In addition, process steps that require seven alternatives force teams to think “outside the box,” which often results in major innovations. Finally, the general guidelines are fundamentally sound manu-facturing practices, such as “one piece flow”and the elimination of non-value added practices.When implementing the Kaizen approach,much of the responsibility lies with upper management. Pitfalls include the tendency of upper management to micromanage the teams and a lack of initial training in teamwork effectiveness.The ability of an organization to respond to the rapidly changing global marketplace will eventually determine the ultimate success of that organization. The implementation of Kaizen addresses many of the needs that modern organizations face.While Kaizen brings continuous improvement, it also develops a communications network throughout the organization that intrinsically supports a method of checks and balances within daily operations. The daily trials and tribulations that upper management once confronted on their own are now solved by the workforce,increasing morale and allowing upper management to concentrate efforts on strategic planning.Dr. Joseph Chen is an Associate Professor in the Department of Industrial Education and T echnology at Iowa State University (ISU). He is a member of Alpha Xi Chapter of Epsilon Pi T au.Dr. John C. Dugger is Dean of the College of T echnology at Eastern Michigan University. He is a member of Alpha Xi Chapter and received a Laureate Citation in 1997.Mr. Rob Hammer is a T echnical and Resource Manager at Control Installation, Inc. in Des Moines, Iowa. He is a member of Alpha Xi Chapter.The Journal of Technology Studies 27ReferencesBerger, A. (1997). Continuous improvement and Kaizen: Standardization and organizational designs. Journal of Integrated Manufacturing Systems, 8(2), 110-117.Black, J .T . (1991). The design of the factory with a future. New York: McGraw-Hill.Kaizen Teian 1. (1992). Developing systems for continuous improvement through employee suggestions. Portland,OR: Productivity Press.Kaizen Teian 2. (1992). Guiding continuous improvement through employee suggestions. Portland, OR:Productivity Press.Kokuo, S. (1992). Eliminating minor stoppages on automated lines. Cambridge, MA: Productivity Press.Lyu, J. J. (1996). Applying Kaizen and automation to process engineering. Journal of Manufacturing Systems,15(2), 125-132.Shingeo, S. (1988). Non-stock production: The Shingo system for continuous improvements. Cambridge, MA:Productivity Press.Yaruhiro, M. (1993). Toyota production system (2nd ed.). Norcross, GA: Industrial Engineering and Management Press, Institute of Industrial Engineers.Yung, W. K. C. (1996). An integrated model for manufacturing process improvement. Journal of Materials Processing Technology, 61(1), 39-43.Womack, J. P ., & Jones, D. T. (1996). Lean thinking. New York: Simon & Schuster.。

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