CPSM M1~3

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mmp3基质金属蛋白酶3

mmp3基质金属蛋白酶3MMP3 (Matrix Metalloproteinase-3) 是一种基质金属蛋白酶，它被细胞用来消化细胞间凝胶以及整合细胞壁和其他结构。

它可以用于改变细胞外微环境和结构，主要作用是维持和调节细胞排列以及形成和释放特定结构抗原，例如血管内皮生长因子，成纤维的降解。

1. 作用MMP3的作用有：•改变细胞外微环境和结构，维持和调节细胞间排列；•分解细胞间凝胶来释放特定的结构抗原，如血管内皮生长因子；•参与细胞内蛋白质合成、组蛋白修饰和降解过程；•参与心血管系统和免疫系统的发育和组织修复；•参与肿瘤发生，如肿瘤血管生成和肿瘤转移等；•参与胎儿发育，如胚鳞发育和子宫承体发育等；•参与其他发育过程，如脊椎发育和肌肉的形成等。

2. 结构MMP3具有典型的蛋白酶结构。

它含有一条完整的C-N路径和一个中性催化活性中心，这使它能够切割凝胶态的细胞外域，使细胞间的无机锆酸核酸得以释放。

3. 调控MMP3受多种类型的调节因子和细胞信号通路控制，它的活性受到细胞因子，如糖和氧化应激状态，血小板衍生生长因子等的活性影响。

它们促进MMP3的表达和活性，已经被证实存在肿瘤以及神经发育中的调控作用。

4. 应用MMP3的多种作用为其在药物开发和治疗方面提供了重要的应用机会：•正向治疗应用：改善缺血性疾病、癫痫、阿尔茨海默病以及其他神经系统疾病；•负向治疗应用：抑制肿瘤生长、抗凝血、预防心血管疾病以及新生儿疾病等；•诊断检测： MMP3可作为早期诊断结肠癌和前列腺癌的生物标志物。

MMP3是一种重要的蛋白酶，它可以通过调节细胞外微环境中特定的抗原和细胞结构，参与细胞内和细胞间的许多信号通路，促进组织和系统的发育，维持细胞细胞的活性和可活性，以及抗击肿瘤等，对于研究和治疗领域都有重要的应用价值。

mllt3基因

mllt3基因
摘要：
1.mllt3 基因简介
2.mllt3 基因在生物体中的功能
3.mllt3 基因与疾病的关系
4.mllt3 基因研究的意义与前景
正文：
mllt3 基因，全称为“myeloid/lymphoid or mixed-lineage leukemia tumor suppressor 3”，中文名称为“髓系/淋巴系或混合系白血病肿瘤抑制蛋白3”。

它是一种具有抑制肿瘤发生作用的蛋白质编码基因，对于生物体的健康具有重要意义。

mllt3 基因在生物体中具有多种功能。

首先，它能够调控细胞周期，防止细胞过度增殖。

其次，mllt3 基因可以影响染色体的结构和功能，避免染色体异常，从而防止肿瘤的发生。

此外，mllt3 基因还能参与细胞凋亡的调控，使细胞在适当的时机死亡，防止细胞不死化导致肿瘤的发生。

mllt3 基因与多种疾病的关系日益受到科学家们的关注。

研究表明，mllt3 基因在许多类型的癌症中发挥着肿瘤抑制蛋白的作用，如髓系白血病、淋巴瘤等。

当mllt3 基因发生突变或表达异常时，可能导致癌症的发生。

因此，研究mllt3 基因在疾病中的作用机制，有助于我们更深入地了解这些疾病的发病机制，为癌症的诊断、治疗和预防提供新的思路和策略。

mllt3 基因研究的意义与前景十分广阔。

随着研究的深入，科学家们有望
发现更多mllt3 基因相关的生物学过程和作用机制，为癌症治疗提供新的靶点。

此外，研究mllt3 基因还有助于开发针对髓系/淋巴系或混合系白血病等疾病的检测方法和治疗手段。

世界卫生组织2016版acml的诊断标准

世界卫生组织（World Health Organization，简称WHO）是一个国际公共卫生组织，其使命是通过各种卫生倡议来提高全球人民的健康水平。

WHO于2016年发布了一份新的肿瘤诊断分类标准，被称为“WHO 2016年Acute Myeloid Leukemia（AML）诊断标准”。

这一标准为医生和病患提供了最新的诊断方法，以便更准确地识别和治疗AML患者。

下面将详细介绍关于WHO 2016年AML诊断标准的内容：1. 背景介绍WHO 2016年AML诊断标准是一份面向医生和病患的重要文件，旨在帮助医疗专业人员更准确地诊断和分析AML。

AML是一种白血病，其特征是骨髓和外周血中白细胞的异常增殖。

由于AML的临床表现复杂多变，因此需要依靠精确的诊断标准来确定患者的病情和治疗方案。

2. 诊断标准的制定目的WHO 2016年AML诊断标准的制定目的在于：提供一套权威的、普遍适用的诊断标准，帮助医疗专业人员更准确地识别和分类AML。

通过这一标准，医生可以更好地了解患者的病情，为其提供更有效的治疗方案。

WHO 2016年AML诊断标准主要包括以下几个方面的内容：（1）骨髓和外周血的形态学特征：包括原始细胞的形态特征、染色体和分子遗传学特征等。

（2）免疫表型和免疫表型：对AML细胞表面的抗原和细胞内的标记进行分析。

（3）分子遗传学特征：对AML患者的基因组进行分子生物学检测，以确定病情的分子遗传学特征。

（4）临床表现和诊断标准：对AML患者的临床表现进行详细描述，并根据相关的诊断标准进行综合判断。

4. 标准的应用范围WHO 2016年AML诊断标准适用于全球范围内的医疗机构和医生，以及所有患有AML的患者。

这一标准通过其权威性和准确性，为全球范围内的医疗机构提供了统一的诊断和治疗依据，有助于提高AML患者的生存率和生活质量。

WHO 2016年AML诊断标准的发布，对于全球范围内的AML患者和医疗机构具有重要的意义和影响。

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3.3
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M13 DNA载体的特点 1

M13噬菌体的特点感染Ecoli后，在宿主细胞内会形成双链的复制型DNA （ replication form DNA, RF DNA）。可以象质粒DNA那样在体外进行纯化和操作。无论是RF DNA或ss DNA都能转染E.coli的F+或F-细胞。噬菌体颗粒的大小是受其DNA的大小制约的，这一点正好与λ噬菌体相反，所以M13噬菌体并不存在包装限制的问题。
5、便于克隆：有质粒上的多种单一酶切位点。
6、不能体内包装，不裂解受体细胞，在细胞内不能形成噬菌体颗粒，因而不能形成噬菌斑。
利用质粒进行克隆
“柯斯克隆” 原理及步骤 1．分离外源DNA片段35～45kb
2．外源DNA与两个粘粒相连，且cos方向相同
M13 DNA载体的构建
M13mp 载体系列
插入一段lac DNA 片段，即带有-半乳糖苷酶基因(lacZ) 的调控序列及其N 端头146个aa编码信息，宿主F’因子携带缺失第1141位氨基酸的lacZ’
M13 DNA载体的特点
1、克隆的DNA片段以特定单链的形式输出受体细胞外，在DNA定向突变中非常有用. 2、M13重组体筛选简便可以利用菌落的蓝白斑筛选转染的转化子 3、制备的单链DNA、双链RF-DNA M13噬菌体，不经体外包装，可以转染大肠杆菌受体。
（二）柯斯质粒的特点
1、具有λ噬菌体的特性。具有cos位点，能像 λ-DNA一样体外包装，并高效导入受体细胞。 2、具有质粒载体的持性。可以在受体细胞内自由复制，以质粒DNA的形式存在于细胞内。 3、具有高容量的克隆能力。可以装载比质粒或 λ-DNA大得多的外源DNA片段，40kb。 4、便于筛选：携带质粒的选择标记。
大肠杆菌的M13单链噬菌体DNA

药学申报资料m1模块

药学申报资料m1模块药学申报资料中的M1模块是指药物质量控制和药物分析模块。

这个模块主要涵盖了药物质量控制的各个方面，包括药物分析方法、药物质量标准、药物稳定性研究等内容。

下面我将从多个角度对M1模块进行详细解释。

首先，药物分析方法是M1模块的重要内容之一。

药物分析方法是指用于检测和确定药物中活性成分、杂质和其他相关物质的方法。

这些方法可以包括物理、化学、生物学等多种技术手段，如高效液相色谱法、气相色谱法、质谱法、紫外可见光谱法等。

药物分析方法的选择和开发对于确保药物质量的一致性非常重要。

其次，药物质量标准也是M1模块的重要内容。

药物质量标准是指对药物质量进行评价和控制的指标和要求。

药物质量标准通常包括物理性质、化学性质、生物学性质、药效学性质等方面的指标。

这些指标可以根据药物的特性和用途进行制定，并且应符合相关法规和标准的要求。

此外，药物稳定性研究也是M1模块的重要内容之一。

药物稳定性研究是指对药物在不同条件下的稳定性进行评价和研究。

这包括药物在不同温度、湿度、光照等条件下的物理和化学变化情况的研究。

药物稳定性研究的结果可以用于确定药物的保存条件和有效期限，并为药物质量控制提供科学依据。

除了上述内容，M1模块还可能涉及其他方面的内容，如药物质量控制的原理和方法、药物分析设备和仪器的选择和验证、药物质量控制的质量管理体系等。

这些内容都是为了确保药物的质量和安全性而进行的研究和控制。

综上所述，药学申报资料中的M1模块涵盖了药物质量控制和药物分析的多个方面，包括药物分析方法、药物质量标准、药物稳定性研究等内容。

这些内容对于确保药物的质量和安全性具有重要意义。

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最新CPSM exam 1 23 全真题CPSM1 Demo下载

1.题目：The following is an example of a multiple choice question with a single answer. You are allowed only one answer. If you select letter A and then select letter C, your first answer is removed. The last selection you make is your recorded answer.Make a selection now and move on to the next question.What is the most densely populated country on the American continents?A.MexicoB.BelizeC.GuyanaD.El Salvador2题目：Select the best answer to this question. Practice using the mouse and the keyboard to select your answer.What is the world's saltiest body of water?A.Great Salt LakeB.Lake AssalC.Mediterranean SeaD.Dead Sea3题目：A supplier wishes to respond to a major RFQ provided by Company ABC. The supplier calls ABC's supply manager to question an instruction in the document. On checking her records, the supply manager finds that a clarification is required to answer the supplier's question. Which of the following should the supply manager do?A.Send a written addendum to all suppliers who received the original RFQB.Tell the supplier that she cannot answer the question and that the supplier should respond to the original request as writtenC.Answer only the specific question of the supplier who calledD.Send a written addendum to the supplier who called4题目：XYZ company of New York contracts with KOR company of Seoul, Korea for the delivery of 200,000 pounds of steel. Since the firms have not done business with each other before, KOR asks XYZ to obtain a letter of credit. Which of the following types of letters would MOST likely be preferred by XYZ's bank?A.Confirmed and revolvingB.Irrevocable and confirmedC.Irrevocable and revolvingD.Unconfirmed and nonrevolving5题目：EFG Company's supply manager is conducting a reverse auction for widgets. EFG is currently paying $10 each for a ten million unit annual commitment. Many potential suppliers have expressed interest in becoming a preferred supplier for the widgets. The supply manager invites twenty firms to participate in the auction, and sets an opening bid of $8.50. The online auction lasts six hours, but there are no bidders. Which of the following is the MOST likely cause for the lack of participation?A.The suppliers object to reverse auctions.B.The reserve price is too low.C.The specifications are unclear.D.The rules of the auction are confusing.6题目：The supply manager for a large oil company knows that responses to a routine high-value RFQ for steel supports are due in two days. One of the suppliers, a small, disadvantaged, minority-owned company, calls and states that they will need five more days to complete their quotation due to the illness of a key person in their estimating department. Which of the following is the MOST reasonable course of action for the supply manager to take?A.Tell the late supplier that if the quotation is not delivered by the requested date, it will not be consideredB.Extend the RFQ due date and notify all suppliers of the extensionC.Accept other quotations as scheduled and set aside a portion of the award for the late supplierD.Throw out all quotations and issue a new RFQ7题目：Generally, competitive proposals are used in the public sector whenA.sealed bidding is impracticable or impossibleB.the organization is buying services or high technology itemsC.specifications are inadequateD.the purchaser determines it is preferable8题目：Which of the following is the MOST important factor in determining the outcome of a negotiation?A.The state of mind of both partiesB.The forces of supply and demandC.The total value of the contractD.The amount of foreign competition9题目：When a performance bond is a contract requirement for obtaining an award, a buyer should do which of the following before authorizing a supplier to proceed?A.Insist that the amount specified in the performance bond cover the cost of the contractB.Ascertain that there are security rights with the bonding agencyC.Have an original of the performance bondD.Request the bond directly from the bonding agency10题目：CoffTech, Inc. is developing a new coffee maker, and its supply manager needs to obtain a computer chip that the company had never sourced before. The item is needed as soon as possible. The supply manager uses the services of a third-party auction site, which has already registered many chip manufacturers. The supply manager selects the three lowest bidders and estimates the total cost of ownership for each before selecting Supplier DEF. It immediately becomes evident, however, that DEF's chips do not perform as desired in the final product. From a sourcing perspective, which of the following is LEAST likely to be the cause of the chip failure?Using a reverse auction as the sourcing toolB.Having inadequate chip specificationsC.Failing to adequately plan prior to the auctionD.Allowing unqualified bidders to participate11.题目：The PRIMARY objective of documenting negotiations is toA.give the buyer a complete overview of the negotiationB.describe the type of contract that was preparedC.cover the details about what is being boughtD.allow others to understand the nature of the agreements12.题目：A buyer is responsible for costs that are higher than estimated under all of the following contracting methods EXCEPTA.Time and materialB.Cost plus fixed feeC.Fixed price with escalationD.Not to exceed13.题目：A supply manager is involved in negotiations for the sale of power-generating equipment, to be used on a large construction project. Reliability is critical, since equipment failure would result in severe financial loss to the supply manager's organization.In this situation, the supply manager is likely to insist on the inclusion in the contract of which of the following?A.A limited liability clauseB.A liquidated damages provisionC.A payback analysisA present value formula14.题目：When a product is sold on the basis of a supplier's sample or model, this will create which of the following types of warranty between the buyer and the seller?A.ImpliedB.ExpressC.MerchantabilityD.Liability15.题目：In a cost-plus fixed profit contract, the profit amount is altered only ifA.direct costs are increased due to availabilityB.the specifications and scope of the original job are changedC.overhead costs are lower than originally expectedD.administrative costs are higher than originally expected16.题目：Which of the following are important factors in influencing a purchasing and supply manager's selection of a contract type?I. Lack of competition among suppliersII. Inclusion of R & D requirementsIII. Availability, accuracy, and reliability of pricing dataIV. The magnitude of business involvedA.I and II onlyB.II and III onlyC.III and IV onlyD.I, II, III, and IVD题目：Major Steel Manufacturing, Inc. signed a contract in October with the Hard Coal & Coke Company for its annual supply of coal for three years commencing the following June, at a price to be determined by taking the average monthly retail price per ton, less a $.10 per ton quantity discount. In March, Major discovered that it had made a bad bargain and that it could readily fulfill its requirements elsewhere at a much greater discount. Major is seeking to avoid its obligation. Which of the following is TRUE?A.The pricing term is too indefinite and uncertain; hence, there is no contract.B.Since the amount of coal required is unknown at the time of the making of the contract, the contract is too indefinite and uncertain to be valid.C.Major is obligated to take its normal annual coal requirements from Hard or respond in damages.D.There is no contract since Major could conceivably require no coal during the years in question.18.题目：A supply manager is contracting for the development of a critical software application which requires frequent updates. Estimated development costs for the application are substantial, and the supply manager anticipates using the software over a long period of time to achieve an acceptable return on investment. While completing the supplier's profile, the supply manager learns that the developer has a history of failing to deliver updates to the software in a timely manner.Which of the following included in the license agreement will BEST protect the supply manager's organization?A.Events of defaultB.Software maintenanceC.Software upgradeD.Liquidated damages19.题目：A supply manager for BPA, Inc. learns that the company training manager plans to hold a series of classes for production associates and engineers regarding the use of new chemicals in a manufacturing process for a new product. Production will begin two weeks after training is completed. Typically, classes of this type are taught in-house, but due to a lack of availability, OSHA requirements, and a tight production schedule, the training manager has arranged for an outside services company to run the classes. The training company has not been used by BPA before, but the training manager says the company is highly recommended, and has trainers available immediately to teach the courses.Given this situation, which of the following is the BEST course of action for the supply manager to take?A.Insist that the BPA training manager cancel the classesB.Determine how much the training company charges for the classesC.Negotiate a master service agreement and SOW with the training companyD.Determine if the training company has already received confidential information20.题目：Oral contracts that involve more than the U.C.C.-specified dollar limit may be binding in all of the following cases EXCEPT when the contract period exceeds 60 daysA.the contract period exceeds 60 daysB.both parties behave as if a contract existsC.the goods are made specifically for the buyer's order and are not readily salable to othersD.the parties have always done business on an oral basis21.题目：A supply manager is supporting the information technology team in final negotiations and contract considerations for a software purchase. The software is to be used across the organization to support three impending mergers with small firms. To minimize risk to the organization, which of the following considerations, from a due diligence perspective, should the supply manager suggest for inclusion into the contract terms?A.Measurable performance factors and remediesB.Price protection and warrantiesC.Product specifications and pricingD.Supplier support and service levels22.题目：A midsized domestic manufacturer has been enjoying double-digit growth for the past three years. The CFO is facing challenges in providing the working capital to meet obligations and projected sales forecasts. Inventory turns are high compared to industry standards, and strategic relationships have reduced lead times considerably. Pricing is comparable to benchmarks in similar industries, as are other key supply metrics.In this situation, which of the following would provide the BEST opportunity to provide immediate cash for growth?A.Optimize the financial supply chainB.Buy hand-to-mouthC.Contract for short-term requirementsD.Extend payment terms23.题目：A U.S. steel pipe production company successfully negotiates a contract to buy steel from a major producer in Japan. The cost of the contract is negotiated to 9,000,000 Yen. On the date that the contract is signed, the spot exchange rate is 112.50 Yen Per U.S. Dollar. The supply manager fails to guarantee the rate by a contractual hedge.Delivery is made four (4) weeks after the order is placed. The supply manager checks the exchange rates at time of delivery and learns that the current spot exchange rate is 116.50 Yen Per U.S. Dollar. When the invoice is received, the exchange rate is 90.00 Yen Per Dollar. How much is the firm expected to pay?A.$80,000 USDB.$84,507 USDC.$90,000 USDD.$100,000 USD24.题目：A large U.S.-based manufacturing firm has a two-year contract with a supplier in France. The contract is for 2,000,000 Euro, with payment made in Euros. The exchange rate at the time the contract is made is 1 Euro = $1.25 USD. Over the past six months, the rate has been 1 Euro = $1.50 USD. The contract is up for renewal for another two years for 2,000,000 Euro.Given this situation, which of the following should be the FIRST course of action for the manufacturer regarding the payment terms?A.Renew the contract with the payment terms unchangedB.Provide advance payments to the supplier before the work is startedC.Determine which pricing currency offers the best alternativeD.Negotiate with the supplier to assume the currency risk25.题目：Lead division buying in a multisite decentralized supply management organization can BEST be employed under which of the following circumstances?A.When quantities purchased are large and have regular use patternsB.When buying requirements are unique to one divisionC.When engineering involvement in buying decisions is criticalD.When incoming purchases are coordinated with production schedules26.题目：Which of the following would be the LEAST appropriate reason for an organization to engage in cooperative purchasing?A.A desire to standardize productsB.A need for greater net savingsC.A desire to pool resources to create volumeD.A need for a shorter cycle time27.题目：A supply manager is assessing various international markets for the outsourcing of transaction processing in order to identify prospective bidders. One of the criteria being used for supplier selection is the ability of the successful bidder to build a workforce that matches the culture of the supply manager's organization and is able to meet service requirements. Which of the following is the LEAST important factor for the supply manager to consider in this assessment?A.Local labor force skill setB.Availability of employees fluent in required languagesC.Protected classes of employeesD.Minimum wage requirementsD28.题目：A university approaches an overseas company about a possible joint venture to invest in an expensive cyclotron for one of the university's labs. Soon after this initial contact is made, the balance of trade and balance of payments of the university's country improves. From an economic standpoint, what effect, if any, will the improvement have on the overseas company's desire to enter the joint venture?A.It is likely to increase.B.It is likely to decrease.C.It is likely to remain the same.D.Not enough information is provided to determine the outcome.29.题目：A supply manager is evaluating several possible suppliers for the offshoring of manufacturing operations. Some of the suppliers are in countries where frequent instances of unsafe work practices are known to occur.Given these circumstances, which of the following is the BEST course of action the supply manager can take?A.Request copies of the respondents' social responsibility policiesB.Contract with a third party to conduct audits of potential supplier's facilitiesC.Hire additional employees to perform supplier facility auditsD.Negotiate termination rights for safe working condition violations30.题目：A supply manager is considering an overseas supplier as a source of a critical component used in its manufacturing process. The supplier is located in a country that has significant cultural differences from the United States. In considering the cultural differences between the two companies, all of the following are true EXCEPT:A.The supply manager should consider using an overseas affiliate as a way of reducing the impact of business cultural differences.B.Although many countries have adopted English as the lingua franca, language may still be a problem.C.Cultural differences permeate everything, including the value placed on time.D.The use of an overseas affiliate will reduce the number of transactions from two to one, thusstreamlining business transactions.。

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模块一供应管理基础1、某供应商想回复ABC公司的一个重要的询价（RFQ）该供应商打电话给ABC公司的供应经理，询问询价单中的一个说明。

供应经理查看她自己的记录时，发现在回答这位供应商的问题之前必须先澄清一件事。

以下哪项是供应经理应该做的？(A) 给收到原始RFQ的所有供应商发送一份书面补充说明(B) 告诉供应商她不能回答这个问题，供应商应根据原始询价单的要求进行回复(C) 只回答打来电话的供应商提出的具体问题(D) 给打来电话的供应商发送一份书面补充说明2、纽约的XYZ公司与韩国首尔的KOR公司签订了200,000磅的钢材供应合同。

由于双方之前没有生意往来，KOR公司要求XYZ公司提供一份信用证。

XYZ公司的开户行最有可能选择以下哪种信用证？(A) 保兑和循环信用证(B) 不可撤销和保兑信用证(C) 不可撤销和循环信用证(D) 不保兑和非循环信用证3、EFG公司的供应经理正在举办一些小器具的逆向拍卖。

EFG目前为每件小器具支付的单价是10美元，全年总定量为1000万件。

许多候选供应商都表示有意成为这些小器具的首选供应商。

供应经理邀请了20家公司参加拍卖会，拍卖起价为8.5美元。

网上拍卖持续了6小时，但没人出价。

以下哪项最有可能是无人参与的原因？(A) 供应商反对逆向拍卖(B) 保留价太低baseline(C) 规格说明不清楚(D) 拍卖规则混乱4、某大型石油公司的供应经理知道，对某个常规的高价值钢材供应RFQ的回复期限只剩两天了。

公司的一家供应商（一家弱势的、少数民族拥有的小型企业）打来电话称，由于其估价部门的主要工作人员生病，他们需要再过五天才能完成报价。

以下哪项是供应经理应采取的最合理的做法？(A) 告诉供应商，如果不能按要求的日期提供报价，公司将不予考虑(B) 延长RFQ的截止期限并通知所有供应商(C) 按规定时间接收其他报价，为迟到的供应商留出一部分订单(D) 将所有报价作废，重发一份RFQ5、CoffTech公司正在开发一种新型咖啡机，公司的供应经理需要采购该公司以前从未购买过的一种计算机芯片。

公司急需该芯片。

供应经理利用一个第三方拍卖网站提供的服务进行采购，该网站已经有许多芯片制造商注册。

供应经理挑选了三家出价最低的供应商，并对每家的总体拥有成本进行了评估，最后决定选择供应商DEF。

不过，不久事实就证明，DEF的芯片在最终产品中的效果并不理想。

从采购的角度看，以下哪项最不可能是芯片失败的原因？(A) 采用了逆向拍卖作为采购工具(B) 没有足够的芯片规格说明(C) 拍卖前未充分进行规划(D) 允许不合格的投标人参与6、某公司的供应经理正在为谈判做准备。

供应经理对形势进行了分析，发现供应商在一年内可能会有新的竞争对手，谈判的产品没有替代品，供应经理所在的公司是该供应商在该产品方面最大的五家消费者之一，供应商希望锁住主要客户以应对将来出现的竞争。

供应经理有充分的信息(A) 进行SWOT分析(B) 进行波特（Porter’S）分析(C) 确定自己的谈判底限(D) 确定供应商的谈判底限7、一家破产后组建的机构的供应经理与该机构以前的供应商谈判，这是一种主要原材料的供应商。

该供应商在业内的总体表现堪称典范，供应经理希望从该供应商处购买全部此种原材料。

供应经理清楚地知道，如果目标价格能谈成，该机构将能在市场上站稳脚跟。

以下哪一项是供应经理在谈判中最薄弱的环节？(A) 订货量和交货时间无法确定(B) 该机构的财务历史有不良记录(C) 该供应商与该机构的竞争对手有生意往来(D) 供应经理希望签订长期合同8、10月份，Major steel Manufacturing公司于Hard Coal & Coke 公司签订了一份为期三年的煤炭年度供货合同，合同期限从随后的6月份开始，价格为每吨煤的月平均零售价格减去每吨煤的大批量折扣0.1美元。

3月份，Major 公司发现这笔交易并不合算，他们可以轻松地从其他地方找到能满足要求的货源，而且折扣大的多。

Major 公司正在试图逃避其义务。

以下哪项是正确的？（A）定价条款太不明确、太含糊。

因此合同不存在。

（B）由于签订合同时所需煤的数量未知，合同太不明确、太含糊，因此无效。

（C）Major 公司有义务从Hard 公司购买每年正常需要的煤，否则应对造成的损失负责。

（D）由于Major 公司在那几年所需煤的数量可以零，这是可以理解的，因此合同并不存在。

9、以下哪种预算类型包括计划内每月在工资和福利、设施、信息系统、旅行、和水电方面的支出？（A）资本预算（B）现金流预算（C）支出预算（D）项目预算10、AirReP是一家大型的飞机维修厂。

AirReP的主要经营理念是成本节约、成本规避、修理件的持久性以及符合政府监管要求。

由于公司正从行业萧条的低谷开始复苏，AirReP面临进一步降低成本的压力。

以下哪项是实现这些目标的最佳选项？（A）向部件制造商提供预测并直接向他们购买（B）少量多次的下订单（C）利用军用规范的同等件号，购买更多的通用部件（D）减少供应商数量11、某公司80%的采购订单订购的都是标准的商业化产品，订单金额都低于1，000美元。

在这种情况下，以下哪种降低成本的方法最不恰当？（A）合并采购（B）合并供应商（C）实施公司标准化项目（D）实施价值分析项目12、如果某工厂在其涂料车间推出一个降低成本的计划，供应经理为此所做的贡献不包括以下哪项？（A）采购符合规格要求、成本最低的涂料（B）确定刷涂料所需的工时（C）提出新的涂料规格（D）确定涂料质量对抛光工序的影响13、以下关于间接成本的说法哪项是正确的？（A）间接成本作为成品/服务输出的函数而增加。

（B）间接成本作为日常开支摊分的基础而变化。

（C）单位间接成本随产出的增加而减少（D）以上都不是14、某公司税前有10%的利润率，其销售额的50%用于购买材料。

公司的材料成本要减少多少个百分点才能与销售量增加5%相等？（A）1% （B）5% （C）7.5% （D）10%15、一月份，供应经理确定开关的标准成本每个1.15美元。

7月份，由于市场缺货，市面上的开关价格为1.35美元，供应经理的采购成本是每个1.25美元。

供应经理的这种做法产生的最终结果是什么？(A) 此次采购是良性采购，因为供应经理能买到紧缺材料。

(B) 材料的采购单位价格不理想，有10美分的不利价差。

(D) 由于材料供应短缺，此次采购对材料的价差无影响。

16、参考某产品的下列数据：直接材料成本：$10.00/单位直接劳务成本：$3.00/单位一般及行政开支：$5.00/单位水电费：$1.00/单位日常开支：$2.00/单位每个单位的可变总成本是多少？(A) $13.00(B) $15.00(C) $20.00(D) $21.0017、供应经理从中国进口了一种部件,用于某种成品的生产.该部件到达并存储在纽约城,然再运送到位于新泽西的制造厂,这种部件的相关成本是:单位成本=$.25 关税=$.01/单位仓储费=$.05/单位从中国至纽约的费用=$.06/单位海关手续费=$.02/单位从纽约至新泽西的运费=$.01/单位新泽西工厂的仓储费=$.02/单位该部件的到岸成本是多少?(A)$.35 ( B)$.39 (C)$.40 ( D)$.4218、一家美国钢管制造公司通过成功的谈判与一家日本的主要生产商签订了购买钢材的合同.合同的总价为9,000,000 日元.合同签订当天的即期汇率为1美元兑换112.5日元,供应经理没有利用套期保值合同对汇率进行担保.交货日期为下订单之后(4)星期.交货时供应经理查看了汇率并了解到当时的即期汇率是1美元兑换116.5日元,收到发票时的汇率是1美元兑换90日元.公司应该支付多少货款? (A)$80,000 美元(B)$84,507美元(C)90,000美元(D)100,000美元19、一家总部在美国的大型制造公司与法国的供应商签订了为期两年的合同,合同总价为2,000.000欧元,付款货币为欧元.合同签订时的汇率为1欧元=$1.25美元.在过去6个月内,汇率一直为1欧元=$1.50美元.合同即将到期,需续签两年总价为2,000.000欧元合同在这种情况下,以下有关支付条款的做法中哪项是制造商的第一步行动?(A) 续签合同,支付条款保持不变(B) 工作开始之前,向供应商支付预付款(C) 确定用哪种货币定价是最佳选择(D）就货币风险的承担问题与供应商进行协商20、公司要求供应经理在限期内尽快取得有关公司现有办公楼扩建的报价.供应经理向五家主要的建筑公司分发了建筑图纸,并要求他们在十个工作日内完成报价并提交报价.对报价进行评估时,供应经理发现最高报价和最低报价相差将近$200,000.供应经理应采取什么措施预防发生这一问题,Ⅰ、召开由所有供应商参加的投标前会议Ⅱ、审查图纸,看是否有差异Ⅲ、为供应商提供一份绩效工作说明书Ⅳ、将设计工作说明书分发给供应商A、Ⅰ和ⅢB、Ⅰ和ⅣC、Ⅱ和ⅢD、Ⅱ和Ⅳ21、以下哪项不属于供应商财务绩效详细报告的来源？（Ａ）邓白氏（Dun and Bradstreet ）报告（B）穆迪（Moody,s ）行业报告（Ｃ）美国证券交易委员会的ＩＯＫ报告（D）联邦贸易委员会报告22、由于部件故障，导致客户的成品退货率达到无法接受的水平。

与分包商一起解决问题的努力也失败了。

因此，供应经理组建了一个团队，研究从其他供应商处采购关键部件的问题。

预计需要6个月才能建立一个新的供货源。

以下哪项最不适合用于防止这种情形的出现？（A）将违约罚款纳入合同内容（B）采用更好的质量控制和验收标准（C）在签订合同时制定退出策略（D）为预制零部件建立寄售库存23、供应经理正在为一份业务流程（“应付款”）外包协议制定退出策略。

起草退出计划时可以不考虑以下哪项？（A）过渡至新的服务供应商，必须采取哪些措施（B）由谁负责保证措施的执行和完成（C）有谁支付过渡至新的服务供应商所需采取的费用（D）谁对不成功的关系负责模块二高绩效的供应管理1、一般情况下，供应商绩效评分表不包括以下哪项？A 评分的时间段B 接收和退回的供应商产品的数量C供应商财务评分D供应商名称2、某供应经理正与一个跨部门的团队一起，为新产品系列的情况进行策划，供应商管理部门最不可能参与以下哪项活动？A 最初的促销活动和长期影响的销量预测B 将部件从一个地方运到另一个地方的应急计划C 供应商技术革新、送货和成本分析D提前为供应商工装设备的变化做好计划3、一家制造商从许多供应商处购买一种商品，以供生产品牌产品之用，最可能带来的结果是A 引起技术小组和制造小组的不满B 促进供应商之间的竞争C 促进和支持未来的标准化计划D 提供质量一致性4、考虑以下标准化流程中的步骤I 组建委员会II 制定标准程序III 确定需标准化的领域IV 收集经常项目的数据V 监控并汇报结果以下哪项最恰当地描述了这些步骤的正确顺序（从第一部到最后一步）？A I II III IV VB III II IV I VC I IV III V IID III I IV II V5、某公司收到不合格的材料，制造副总裁要求提供解决这个问题的可选方案，并只接受不会导致公司成本增加的解决方案，在这种情况下，以下哪项是最不适当的补救措施？A 对材料退给供应商进行更换B 对材料进行返工，费用由供应商承担C 将这批不合格材料照原样投入使用D 对这批材料重新商讨一个折扣价6、某供应经理与供应商A签订了购买10000个螺铨的合同，价格0.08/个，到货时发现样品有缺陷，按《美国统一商法典》，以下哪项是供应经理可以做的？A 仅使用检验合格的螺铨并让供应商A更换退回的螺铨B 退回该批货物，以0.10/个的价格向供应商B购买10000个螺铨并向供应商A收取差价C A或BD 不是A也不是B7、以下哪项说明货物可在供应商指定的地点供货，而所有的运输、成本和风险均由买方负责？A CIPB DEQC EXWD FAS8、与国外货运代理人和承运人签订合同时，海关-商贸反恐怖联盟（CTPAT）建议美国进口商采取的最佳做法不包括以下哪项？A 货运代理人应要求所有新的发货人提供业务推荐人B 承运人应拒绝到不知名的地方取货C 货运代理人应与所有新客户会面并对他们实际所处位置进行核实D 承运人只应接受所有新客户的保付支票付款9、由于当地举行庆祝活动，XYZ公司烟花的销售量上升，XYZ公司需要很快地把存放在约1000英里（1600公里）以外仓库的库存转移过来以满足需求，在这种情况下，以下哪种是最恰当的运输方式？A 空运B 铁路运输C 卡车运输D 水运10、在为各个商品设立货运类别时，以下哪项是最不重要的考虑因素？A 物品的密度B 出发点到目的地之间的距离C 发货频率D 在集装箱里面的可堆装性11、某公司计划将物流部门职能交由供应管理部门负责，然而，计划遇到一些阻碍，反对意见认为，由于大多数运输费率已经公布，原本改进的空间很小，供应经理应作出以下哪项声明以支持通过使用供应管理技能可创造价值的观点？A 运输费率是可变的，但服务水平是不变的B 运输费率包括固定费率和可变费率C 供应商绩效指标能确保最佳运输费率D 承运人成本审计将会降低运输的总成本12、某供应经理供职于一家小公司繁忙的物流部门。