User’s Guide for the LySatool version 2.01
RECSIT1.1中英文对照全文

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)新版实体瘤疗效评价标准:修订的RECIST指南(1.1版本)Abstract摘要Background背景介绍Assessment of the change in tumour burden is an important feature of the clinical evaluation of cancer therapeutics: both tumour shrinkage (objective response) and disease progression are useful endpoints in clinical trials. Since RECIST was published in 2000, many investigators, cooperative groups, industry and government authorities have adopted these criteria in the assessment of treatment outcomes. However, a number of questions and issues have arisen which have led to the development of a revised RECIST guideline (version 1.1). Evidence for changes, summarised in separate papers in this special issue, has come from assessment of a large data warehouse (>6500 patients), simulation studies and literature reviews.临床上评价肿瘤治疗效果最重要的一点就是对肿瘤负荷变化的评估:瘤体皱缩(目标疗效)和病情恶化在临床试验中都是有意义的判断终点。
ins指南对静脉治疗的目标要求

ins指南对静脉治疗的目标要求英文回答:The goal of intravenous therapy, as outlined in the INS guidelines, is to provide safe and effective administration of medications and fluids directly into the veins. This method of treatment allows for rapid absorption and immediate therapeutic effect. The following objectives are set forth in the guidelines to ensure the achievement of this goal:1. Patient Safety: The primary objective of intravenous therapy is to ensure patient safety throughout the entire process. This includes proper patient identification, verification of the correct medication and dosage, and adherence to aseptic technique during insertion and maintenance of the intravenous line. Regular assessment and monitoring of the patient's condition are also essential to identify any potential complications or adverse reactions.2. Optimal Medication Administration: Intravenous therapy aims to provide the most effective and efficient delivery of medications. This involves selecting the appropriate route of administration, such as a peripheral vein or a central venous access device, based on the medication's characteristics and the patient's condition. The guidelines emphasize the importance of proper medication preparation, dilution, and compatibility to ensure accurate dosing and minimize the risk of medication errors.3. Fluid and Electrolyte Balance: Intravenous therapy is commonly used to restore and maintain fluid and electrolyte balance in patients with dehydration, electrolyte imbalances, or other fluid-related disorders. The guidelines provide recommendations for the selection and administration of appropriate fluids, taking into consideration the patient's age, underlying condition, and specific fluid needs. Close monitoring of fluid intake, output, and electrolyte levels is necessary to prevent complications such as fluid overload or electrolyte disturbances.4. Infection Prevention: Invasive procedures associated with intravenous therapy pose a risk of infection. The guidelines emphasize the importance of strict adherence to infection prevention practices, including hand hygiene, proper disinfection of the insertion site, and the use of sterile techniques during line insertion and maintenance. Regular assessment and monitoring for signs of infection, such as redness, swelling, or discharge at the insertion site, are essential to detect and treat infections promptly.5. Patient Education and Collaboration: The successful implementation of intravenous therapy requires active involvement and collaboration between healthcare providers and patients. The guidelines highlight the importance of patient education regarding the purpose, benefits, and potential risks of intravenous therapy. Patients should be informed about the signs and symptoms of complications and instructed on how to care for the intravenous line at home, if applicable.中文回答:根据INS指南,静脉治疗的目标是为了提供安全有效的药物和液体直接注入静脉的治疗方法。
胰岛移植即刻经血液介导的炎症反应应对策略

第14卷 第3期2023年5月Vol. 14 No.3May 2023器官移植Organ Transplantation ·移植前沿·胰岛移植即刻经血液介导的炎症反应应对策略杨玉伟 张婷 李万里 陈继冰 高宏君【摘要】 胰岛移植作为治疗1型糖尿病和终末期2型糖尿病的有效手段,可以使患者获得较好的血糖控制能力。
即刻经血液介导的炎症反应(IBMIR )是胰岛移植早期出现的非特异性炎症反应,发生后可迅速出现凝血级联和补体系统激活、炎症细胞聚集等,造成大量移植胰岛丢失,严重影响胰岛移植的疗效。
如何减轻IBMIR 对胰岛造成损伤是目前胰岛移植的研究热点,临床推荐的治疗胰岛移植IBMIR 的药物有肝素和肿瘤坏死因子-α抑制剂依那西普。
新近研究表明多种方法和药物可以减轻IBMIR 对胰岛的损伤,本文就这些临床研究成果和临床前研究成果进行综述,以期为胰岛移植IBMIR 的应对提供参考。
【关键词】 胰岛移植;糖尿病;即刻经血液介导的炎症反应(IBMIR );炎症反应;胰岛丢失;胰岛保护;胰岛封装;凝血【中图分类号】 R617,R587 【文献标志码】A 【文章编号】 1674-7445(2023)03-0005-06【Abstract 】 As an effective procedure for type 1 diabetes mellitus and end-stage type 2 diabetes mellitus, islet transplantation could enable those patients to obtain proper control of blood glucose levels. Instant blood-mediated inflammatory reaction (IBMIR) is a nonspecific inflammation during early stage after islet transplantation. After IBMIR occurs, coagulation cascade, complement system activation and inflammatory cell aggregation may be immediately provoked, leading to loss of a large quantity of transplant islets, which severely affects clinical efficacy of islet transplantation. How to alleviate the islet damage caused by IBMIR is a hot topic in islet transplantation. Heparin and etanercept, an inhibitor of tumor necrosis factor-α, are recommended as drugs for treating IBMIR following islet transplantation. Recent studies have demonstrated that multiple approaches and drugs may be adopted to mitigate the damage caused by IBMIR to the islets. In this article, the findings in clinical and preclinical researches were reviewed, aiming to provide reference for the management of IBMIR after islet transplantation.【Key words 】 Islet transplantation; Diabetes mellitus; Instant blood-mediated inflammatory reaction (IBMIR); Inflammation; Islet loss; Islet protection; Islet encapsulation; CoagulationTherapeutic strategy for instant blood-mediated inflammatory reaction after islet transplantation Yang Yuwei *, Zhang Ting, Li Wanli, Chen Jibing, Gao Hongjun.*Graduate School of Guangxi University of Chinese Medicine, Nanning 530001, China Correspondingauthor:GaoHongjun,Email:***************DOI: 10.3969/j.issn.1674-7445.2023.03.005基金项目:广西科技基地和人才专项(桂科AD22035122);广西研究生教育创新计划项目(YCSW2022355、YCXJ2021091)作者单位:530001 南宁,广西中医药大学研究生院(杨玉伟、李万里);广西中医药大学附属瑞康医院(张婷、陈继冰、高宏君)作者简介:杨玉伟(ORCID :0009-0000-2017-8883),硕士研究生,住院医师,研究方向为器官移植,Email :*****************通信作者:高宏君(ORCID :0000-0003-1451-0725),博士,主任医师,研究方向器官移植与胰岛移植,Email :***************对于疗效欠佳的1型糖尿病和伴有胰岛功能衰竭的2型糖尿病,胰岛移植已成为理想的治疗方法。
2021年ins指南修改内容

2021年ins指南修改内容The updates to the 2021 INS guidelines have sparked a lot of discussion and controversy within the medical community. Many healthcare professionals have voiced their concerns and opinions regarding the changes made to the guidelines. 2021年INS指南的更新引发了医学界许多讨论和争议。
许多医护人员已经表达了他们对指南变更的担忧和看法。
One of the key changes in the 2021 INS guidelines is the emphasis on evidence-based practice and the importance of incorporating new research findings into clinical practice. This shift towards evidence-based care is crucial in ensuring that patients receive the most effective and up-to-date treatment options. 2021年INS指南的一个关键变化是强调基于证据的实践和将新的研究发现纳入临床实践的重要性。
这种向基于证据的护理的转变对确保患者接受到最有效和最新的治疗选择至关重要。
Another significant update in the 2021 INS guidelines is the focus on individualized care plans for patients receiving intravenous therapy. This personalized approach takes into account the patient's uniqueneeds, preferences, and circumstances to optimize treatment outcomes and overall patient experience. 2021年INS指南中另一个重要更新是专注于接受静脉治疗的患者的个性化护理计划。
病理技术员教程英文版

病理技术员教程英文版Pathology Technician TutorialIntroduction:Welcome to the pathology technician tutorial! In this tutorial, we will guide you through the basic skills and knowledge required to become a pathology technician. As a pathology technician, you will play a crucial role in the diagnosis and treatment of various diseases by performing laboratory tests on patient samples. This tutorial will provide you with the essential information you need to excel in this career.Chapter 1: Introduction to PathologyIn this chapter, we will introduce you to the field of pathology. You will learn about the different types of diseases and their pathological mechanisms. You will also understand the importance of pathology in the healthcare system and the role of pathology technicians in patient care.Chapter 2: Laboratory SafetyIn this chapter, we will cover the essential safety guidelines that pathology technicians need to follow in the laboratory. You will learn about proper personal protective equipment (PPE) usage, handling hazardous materials, and protocols for waste disposal. Safety is of utmost importance in the lab, and this chapter will ensure that you are well-prepared to work in a safe environment.Chapter 3: Specimen Collection and ProcessingIn this chapter, you will learn about the correct techniques for specimen collection and processing. We will cover various types of samples, including blood, urine, tissues, and body fluids. You will understand the importance of proper handling and storage of specimens to maintain their integrity for accurate testing.Chapter 4: Microscopic ExaminationIn this chapter, we will delve into the microscopic examination techniques used by pathology technicians. You will learn how to prepare slides, stain specimens, and operate microscopes. We will also cover different staining techniques and their applications in diagnosing diseases.Chapter 5: Laboratory InstrumentationIn this chapter, we will introduce you to the various laboratory instruments used in pathology. You will learn about automated analyzers, centrifuges, microtomes, and other equipment used in pathology laboratories. Understanding the functionality and maintenance of these instruments is essential for accurate and efficient testing.Chapter 6: Laboratory Testing and Quality ControlIn this chapter, we will discuss the different laboratory tests performed by pathology technicians. You will gain knowledge about common tests such as blood counts, urinalysis, cultures, andimmunoassays. We will also cover quality control measures and the importance of maintaining accuracy and precision in laboratory testing.Chapter 7: Data Analysis and ReportingIn this final chapter, we will focus on data analysis and reporting. You will learn how to interpret laboratory test results, correlate findings with patient history, and generate accurate reports for healthcare professionals. Effective communication and attention to detail are crucial skills required for this phase of the pathology technician's role.Conclusion:Congratulations on completing the pathology technician tutorial! You now have a solid understanding of the field of pathology and the essential skills required to excel as a pathology technician. Remember to continue learning and updating your knowledge as new technologies and advancements emerge in the field. Good luck on your path to becoming a successful pathology technician!。
摩托罗拉 accessories 编程软件说明书

Motorola Accessory Programming SoftwareTable of Contents1.Introduction2.What's New in this Release3.Requirements4.Installation and Removal5.Open Issues Summary6.Legal Notice7.Publicly Available Software Legal Notices1. IntroductionThe Accessory Programming Software provides organizations with the ability to upgrade and manage the accessory devices.The Accessory Programming Software application contains an upgrade tool that can be used to upgrade one or multiple accessory devices at a time and a retrieve log tool to retrieve the device logs.2. What's New in this ReleaseVersion Notes1.0Initial release allows a user to upgrade their Mission critical and Operations critical wirelessaccessory devices.2.0This release allows a user to upgrade their XE RSM accessory devices.2.8This release allows a user to upgrade their GPS RSM as well as wireless devices.APS R2.8must beused for firmware upgrade to Mission Critical Wireless R01.04.00and Operations Critical WirelessR01.03.01or later firmware.3.0This release allows a user to upgrade their WRSM accessory devices4.0This release allows a user to recognize the name for Long Range OCW Wireless RSM as OCWWRSM.4.1This release allows a user to upgrade and manage their XE500Model1and Model1.5accessorydevices4.2This release allows a user to set codeplug to enable channel knob position broadcast duringpower up for their accessory devices.4.3This release allows a user to set Volume Channel codeplug for their XE500accessory devices.4.4This release allows a user to set Kodiak Device Operation Mode for their OCW WRSM accessorydevices.4.5This release allows a user to set Kodiak Device Operation Mode for their OCW WPOD accessorydevices.4.6This release allows a user to set the Radio,Wave and Kodiak Device Operation Mode for theirWRSM accessory devices.4.7This release allows a user to set the Send Channel Control Powerup for XVE500,XVP850andVolume Control Feature codeplug for XVE500,XVE NO KNOB,XVP850/830,XVN500RSMaccessory devices for FDNY support.4.8This release allows a user to upgrade XV RSM(PMMN4123A and PMMN4145A)accessorydevices.4.9This release fixes the XE500Model1volume configuration missing in version4.8and allows auser to disable over temperature reporting status for XVN500RSM accessory devices.4.10This release allows a user to set Volume and Channel codeplug for their XVE DIV1accessorydevices.4.11This release allows a user to set Extra Loud Earpiece Compatible codeplug for their WM800accessory devices.3. RequirementsOperating Systems●Microsoft®Windows®7Home/Professional Edition●Microsoft®Windows®8.1Home/Professional Edition●Microsoft®Windows®10Home/Professional EditionNote●Please see the application help file for information on how to use the Accessory Programming Software4. Installation and RemovalInstallationAdministrative rights on the PC in which the software is to be installed are required.To download the Accessory Programming Software,please visit the Motorola Solutions MOL website.After downloading the software,please refer to the“APS User Guide.pdf”for instructions to install the software.If a previous version of Accessory Programming Software has already been installed,please remove the software first and install the new software.RemovalIn the Control Panel,select the"Programs and Features"option.Select the Accessory ProgrammingSoftware item from the list of programs and click the Uninstall button.5. Open Issues SummaryOn rare occasion,after completion of the firmware upgrade user may get the following WARNING:"The device has been upgraded successfully but fails to reset.Please disconnect and reconnect the USB cable to reset the device."User can IGNORE this warning since the device was upgraded successfully.6. Legal NoticeMotorola Solutions is a registered trademark of Motorola Solutions,IncMicrosoft®and Windows®are registered trademarks of Microsoft Inc.7. Publicly Available Software Legal NoticesThis media,or Motorola Solutions Product,may include Motorola Solutions Software,Commercial Third Party Software,and Publicly Available Software.The Motorola Solutions Software that may be included on this media,or included in the Motorola Solutions Product,is Copyright(c)by Motorola Solutions,Inc.,and its use is subject to the licenses,terms and conditions of the agreement in force between the purchaser of the Motorola Solutions Product and Motorola Solutions,Inc.The Commercial Third Party Software that may be included on this media,or included in the Motorola Solutions Product,is subject to the licenses,terms and conditions of the agreement in force between the purchaser of the Motorola Solutions Product and Motorola Solutions,Inc.,unless a separate Commercial Third Party Software License is included,in which case,your use of the Commercial Third Party Software will then be governed by the separate Commercial Third Party License.The Publicly Available Software that may be included on this media,or in the Motorola Solutions Product,is listed below.The use of the listed Publicly Available Software is subject to the licenses,terms and conditions of the agreement in force between the purchaser of the Motorola Solutions Product and Motorola Solutions,Inc.,as wellas,the terms and conditions of the license of each Publicly Available Software package.Copies of the licenses for the listed Publicly Available Software,as well as,all attributions,acknowledgements,and software information details,are included below.Motorola Solutions is required to reproduce the software licenses,acknowledgments and copyright notices as provided by the Authors and Owners,thus,all such information is provided in its native language form,without modification or translation.For instructions on how to obtain a copy of any source code being made publicly available by Motorola Solutions related to software used in this Motorola Solutions Product you may send your request in writing to:Motorola Solutions,INC.Government&Public Safety BusinessPublicly Available Software Management1301E.Algonquin RoadSchaumburg,IL60196USA.In your request,please include the Motorola Solutions Product Name and Version,along with the Publicly Available Software specifics,such as the Publicly Available Software Name and Version.Note,the source code for the Publicly Available Software may be resident on the Motorola Solutions Product Installation Media,or on supplemental Motorola Solutions Product Media.Please reference and review the entire Motorola Solutions Publicly Available Software Notifications/EULA for the details on location of the source code.Note,dependent on the license terms of the Publicly Available Software,source code may not be provided.Please reference and review the entire Motorola Solutions Publicly Available Software Notifications/EULA for identifying which Publicly Available Software Packages will have source code provided.To view additional information regarding licenses,acknowledgments and required copyright notices for Publicly Available Software used in this Motorola Solutions Product,please select Legal Notices display from the GUI(if applicable),or review the Notifications/EULA File/ReadMe,on the Motorola Solutions Install Media,or resident in the Motorola Solutions Product.Motorola Solutions and the Stylized M logo are registered in the US Patent and Trademark Office.All other trademarks,logos,and service marks("Marks")are the property of the respective third party owners.You are not permitted to use the Marks without the prior written consent of Motorola Solutions or such third party which may own the Marks.===========================================================================PUBLICLY AVAILABLE SOFTWARE LIST===========================================================================Name:Microsoft WPF ToolkitVersion: 3.5.40619.1Description:The WPF Toolkit is a collection of WPF features and components that are being made available outside of the Framework ship cycle.The WPF Toolkit not only allows users to get new functionality more quickly,but allows an efficient means for giving feedback to the product team. Many of the features will be released with full source code as well.SoftwareSite:/wpfSourceNo Source Distribution Obligations.Code:License:Microsoft Public License(Ms-PL)Microsoft Public License(Ms-PL)This license governs use of the accompanying software.If you use the software,you accept this license.If you do not accept the license,do not use the software.1.DefinitionsThe terms"reproduce,""reproduction,""derivative works,"and"distribution"have the same meaning here as under U.S.copyright law.A"contribution"is the original software or any additions or changes to the software.A"contributor"is any person that distributes its contribution under this license."Licensed patents"are a contributor's patent claims that read directly on its contribution.2.Grant of Rights(A)Copyright Grant-Subject to the terms of this license,including the license conditions and limitations in section 3,each contributor grants you a non-exclusive,worldwide,royalty-free copyright license to reproduce its contribution,prepare derivative works of its contribution,and distribute its contribution or any derivative works that you create.(B)Patent Grant-Subject to the terms of this license,including the license conditions and limitations in section3, each contributor grants you a non-exclusive,worldwide,royalty-free license under its licensed patents to make, have made,use,sell,offer for sale,import,and/or otherwise dispose of its contribution in the software or derivative works of the contribution in the software.3.Conditions and Limitations(A)No Trademark License-This license does not grant you rights to use any contributors'name,logo,or trademarks.(B)If you bring a patent claim against any contributor over patents that you claim are infringed by the software, your patent license from such contributor to the software ends automatically.(C)If you distribute any portion of the software,you must retain all copyright,patent,trademark,and attribution notices that are present in the software.(D)If you distribute any portion of the software in source code form,you may do so only under this license by including a complete copy of this license with your distribution.If you distribute any portion of the software in compiled or object code form,you may only do so under a license that complies with this license.(E)The software is licensed"as-is."You bear the risk of using it.The contributors give no express warranties, guarantees or conditions.You may have additional consumer rights under your local laws which this license cannotchange.To the extent permitted under your local laws,the contributors exclude the implied warranties of merchantability,fitness for a particular purpose and non-infringement.。
【超能陆战队】台词中英对照

【超能陆战队】台词中英对照Get up!Get up! 赢家诞生完胜对手 The winner!By total annihilation. 催命阎王 Yama! 谁是下一个谁还有胆量在赛场上一决雌雄Who’s next?Where’s the guts to stopGet up!Get up! 赢家诞生完胜对手The winner!By total annihilation. 催命阎王 Yama!谁是下一个谁还有胆量在赛场上一决雌雄Who’s next?Where’s the gut s to stop me in the ring? 挑战我的小阎王 With little Yama! 我能试试吗 Can I try?我有个机器人是我自己造的I have a robot.I built it myself. 算了吧小子这儿有规矩交钱才能入场 Beat it kid!House Rules:You gotta pay to play.这些够了吗Oh,Is this enough? 你叫什么小朋友What’s your name,little boy? 我叫小宏滨田宏 Hiro,Hiro Hamada. 准备好你的机器人小虫 Prepare your bot,Zero... 两方对垒决一死战Two bots enter...One might leaves. 准备好了吗Fighters ready? 开战 Fight!这是我第一次参赛能再试一次吗That was my first fight.Can I try again?没人喜欢输不起的人小朋友 No one likes a sore loser littleboy. 回家吧 Go home. 我还有钱I’ve got more money... 准备好了吗Fighters ready? 开战 Fight! 磁力神 Megabot! 灭了他 -再见了小阎王-什么 -Not more”Little Yama”.-But what? 这2怎么可能This is not possible! 我也没想到也许是新手运气好吧Hey,I’m as surprised as you are.Beginner’s luck. 你还想再来一次吗Do you wanna go again? 阎王 Yama? #NAME? -No one hustles Yama!-Wooh!Hey! 给他点颜色看看Teach him a lesson! 伙计们有话好好说Hey fellas.Let’s talk about this.-小宏快上车-阿正-Hiro,get on!-Tadashi! 来得真是时候 Ooh!Good timing. #NAME?-Are you okay?-Yeah. #NAME?-Are you hurt?-No! 那你在想什么笨蛋 Then,what are youthinking,knuckle head! 你十三岁从高中毕业就是为了干这个You graduated high school and you’re 13 and this iswhat you’re doing? 抓紧了 Hold on!机器人比赛是违法的你会被抓进监狱的Bot fighting is illegal.You’re gonna get yourself arrested.机器人比赛不违法参与赌博才...才违法Bot fighting is not illegal.Betting on bot 但没人会注意到的我势头可猛了老哥But,so who could heed.I’m on a roll,big brother. 谁也不能阻止我3And there is no stopping me! 哦不 Oh,no. 嗨卡斯阿姨Hi,Aunt Cass.你们还好吗快告诉我你们没事Are you guys okay?Tell me you’re okay... #NAME?-We’re fine.-We’re okay. 那就好 Oh good.那你们两个小笨蛋在想什么Then what were you two knuckle heads thinking?!过去的十年我含辛茹苦把你们拉扯大 For 10 years,I heed the best I could to raise you. 我十全十美吗不Have I been perfect?No! 我很会养小孩吗不Do I know anything about children?No!我该找本育儿手册来看吗也许吧Should I pick a book on parenting?Probably?我想说什么来着我本来想说...Where I was going with this?I had a point... #NAME?#NAME? 我也爱你I love you too!因为你们俩我不得不在节拍诗之夜早早收工I had to close up early because of you two fellons on beatpoetry night.因为你们我都暴饮暴食了过来糯米 Stress eating because of you!Come on,Moty! 真的好好吃啊4This is really good!你最好在卡斯阿姨吃光餐厅里的所有You’d better make this up to Aunt Cass,想办法补偿她before she eats everything in the cafe. 那是自然 For sure.我希望你能吸取教训小子And I hope you learn your lesson,bone head. 我会的Absolutely.你还要去参加机器人比赛是吗You’re going fight boting,aren’t you?小镇那边还有一场比赛There’s a fight across town. 如果我现在预约还能赶得上If I book now,I could still make it. 你什么时候做事前能用用你那聪明的大脑瓜啊When are you gonna start doing something with that bigbrain of yours?干吗像你一样去上大学What?Go to college like you? 好让别人教我我早就知道的东西 So people can tell me stuff I already know?你简直不可理喻 Unbelievable.老妈老爸会怎么说啊Ahh!What would Mom and Dad say? 我不知道他们已经5过世了I don’t know.They’re gone. 我三岁时他们就死了记得吗They died when I was 3,remember? #NAME?-I’ll take you.-Really?我阻止不了你但我不会让你自己去I can’t stop you from going,but I’m not gonna let you go on your own. 太棒了Sweet!我们来你的呆子学校做什么What are we doing at your nerd school?机器人比赛在那边我去拿点东西Gotta grab something. 要用很长时间吗Is this gonna take long? 淡定我的大宝贝拿完东西就走Relax,you big baby,we will be in and out. 你还没见过我的实验室呢Anyway,you’ve never seen my lab.太棒了终于见到你的呆子实验室了 Oh great!I get to see your Nerd Lab. #NAME?-Heads up!-Wooh! 电磁悬浮Electromag suspension? 你是谁Who are you?神行御姐这是我弟弟小宏 Gogo,this is my brother,Hiro.欢迎来到呆子实验室Welcome to the Nerd Lab. 是啊 Yeah...6我从未见过应用在自行车上的电磁悬浮呢I’ve never seen Electromag suspension on a bike before. 零阻力骑得更快Zero resistance,faster bike.但...还不够快But...Not fast enough. 还不够 Yet.别动站在线后面 Ohh!Woohh!Do not move!Behind the line please.芥末无疆这是我弟弟小宏 Hey,Wasabi.This is my brother,Hiro.你好啊小宏做好大吃一惊Hello,Hiro.Prepare to be amazed. 接好了 Catch! #NAME?-Laser induced Plasma?-Oh,yeah. 运用一点磁约束技术来达到...With a little magnetic confinement for ah.. 超精密程度Ultra precision.你怎么在这么多东西中找到自己要用的Wow,how did you find anything in this mess?我有个系统每样东西都放在各自的位置I have a system.There is a place for everything,andeverything in its place. #NAME?-I need this!-You can’t do that! 你把这弄乱了社会需要秩序!7This is anarchy!Society has rules! 不好意思借过一下Excuse me!Coming through! 阿正 Tadashi!我的天哪你一定是小宏Oh my gosh,you must be Hiro! 久仰大名啊I’ve heard so much about you! 来得正好Perfect timing!Perfect timing! 全是碳化钨That’s a whole lot of Tungsten Carbide. 足足四百磅400 pounds of it.过来你一定会喜欢这个的Come here!Come here!You’re gonna love this. 一点高氯酸A dash of per chloric acid. 一点钴一点过氧化氢A smidge of cobalt,a hint Hydrogen Peroxide...加热至五百开尔文然后...super heated to 500 Kelvin,and...快看 Tadah! 很不错吧It’s really great,huh? #NAME?-So pink.-Here’s the best part. 很神奇吧I know right!化学试剂对金属的脆化作用Chemical metal embrittlement! 不赖嘛哈妮柠檬Not bad,Honey Lemon. 哈妮柠檬神行御姐芥末无疆8Honey Lemon?Gogo?Wasabi?我把芥末洒在了衬衣上就洒了一次 I spilled wasabi on my shirt one time people.One time! 外号都是弗莱德取的 Fredis the one who comes up with the nicknames. 谁是弗莱德Ah...Who’s Fred? 鄙人在此This guy right here!莫惊慌卡通服而已我真人可不长这样Ah!Ah!Don’t be alarmed,it is just a suit.This is not my real face and body.我叫弗莱德The name is Fred.白天我是学校的吉祥物但到了晚上 School mascot by day but by night, 我还是学校的吉祥物I’m also a sc hool mascot. 话说你的专业是什么So,what’s your major?不我不是这的学生不过我可是专业级科学控No!No!I’m not a student but I am a major scienceenthusiast..我最近一直在怂恿哈妮去开发一个I’ve been turning to get honey to develop a formula...能把我变成喷火蜥蜴的化学公式That can turn me into a fire breathing lizard at will. 但她居然说这”不科学”9But she says that’s not”science”. 真心不科学It’s really not.才怪那我让芥末无疆做的缩小激光呢Yeah,and I guess the shrink ray I ask Wasabi 也不是科学吗for isn’t science,either? #NAME?-Is it?-Nope! #NAME?-Well then,what about invinsiblesandwich?-Hiro! 你想啊你吃着三明治 Imagine eating a sandwich but, 可周围的人都觉得你脑子有病everybody just thinks you’re crazy. 够了喂 Just stop. #NAME?-Laser Eye?-What? #NAME?-Tingly fingers?-Never gonna happen!那开个杂货店总可以了吧 Then what about grocery stores.-那你在研究什么-我展示给你看-So,what are you been working on?-I’lll show you. 胶带纸 Duct Tape?别怪我泼冷水老哥这个人家发明过了I hate to break it to you,Bro.Already been invented. 老哥痛痛痛Awww!Dude!Awww... 这就是我研究的项目10This is what I’ve been working on.你好我叫大白是你的私人健康助手Hello,I am Baymax.Your personal health care companion.我察觉到你需要医疗护理当你说 I was alerted to the need for medical attention when you said: 嗷的时候 Awww... 机器人护士?A robotic nurse?从一到十级你的疼痛指数是On a scale of 1 to 10,How would you rate your pain?你是说生理上的还是心理上的 Physical,or emotional? 正在扫描I will scan you now. 扫描完成Scan complete.你的小臂有轻微的上皮组织擦伤 You have a slight epidermal abrasion on your forearm我建议进行除菌喷雾处理I suggest an anti-bacterial spray. 等等这个喷雾的主要成分是什么Whoa,whoa...What’s in the spray specifically?喷雾的主要成分是”杆菌肽” The primary ingredient is:”Bacitracin.”真糟糕我不巧对那个东西过敏11That’s a bummer,I’m actually allergic to that. 你并不对杆菌肽过敏You’re not allergic to Bacitracin. 倒是对花生有轻微过敏You do have a mild allergy to:Peanuts. 真不赖 Not bad.你对这个机器人的编程还真不错嘞You’ve done some serious coding on this thing huh!啊哈他被编入超过一万种医疗护理程序Ahah!Programmed to over more than 10,000 medicalprocedures.大白之所以成为大白就是靠这个芯片 This chip!Is what makesBaymax,”Baymax.” 乙烯树脂 Vinyl?对为了做出无害又可爱的效果Yeah,going for a non-threatening huggable kind of thing.看上去像一个移动的棉花糖别见怪 Looks like a walking marshmallow.No offense.我是机器人我不会见怪I am a robot.I can not be offended. 超光谱镜头Hyperspectro Cameras? 没错 Yup. #NAME?-Titanium skeleton.-Carbon fiber. 对哦更轻便Right.Even lighter.好赞的驱动器你从哪儿弄到的12Killer actuators,where did you get those?就是在这里加工的在实验室里Machined them right here...In house.. #NAME? #NAME? #NAME? -He can lift a thousand pounds.-Shut up!你是个乖宝宝来跟棒棒糖You have been a good boy,have a lollipop. 真棒 Nice! 直到你说”我很满意你的照顾”I can not deactivate until you say: 我才会结束工作You are satisfied with your care. 那好吧我很满意你的照顾Well then,I’m satisfied with my care.他会帮助很多很多人的He’s gonna help a lot of people. #NAME?-Hey,what kind of battery does it use?-Lithium lon. 铝电解超级电容器充电速度更快You know,Super Capacitor would charge way faster. 开夜车呢滨田先生Burning the midnight oil,Mr.Hamada?教授你好其实我已经在收尾了Hey,Professor,I actually was finishing up.你一定是小宏机器人拳击手对吗You must be Hiro.Bot fighter,right?13在我女儿还小的时候她也一心想做这个When my daughter was younger,That’s all she wanted todo. 我能看看吗 May I? 当然 Sure! 嗯不错 Hmm!磁力伺服器Magnetic Bearing Servos. 超酷的吧想看看我怎么操纵它们吗 Pretty sick huh?Wanna see how I put them together?嘿天才这就是教授本人发明的Hey,genius!He invented them!你是罗伯特?卡拉汉 You are Robert Callaghan? 是那个机器人学卡拉汉定理的卡拉汉吗Like as in,Callaghan....Callaghan’s Laws of Robotics? 正是在下That’s right.想过来这做研究吗你的年龄不是问题 Ever think about applying here?Your age wouldn’t be an issue.他对他的机器人搏击事业可是很认真的I don’t know,he’s pretty serious about his career in bot fighting. #NAME?-Well,kind of serious.-I can see why.凭你的机器人打赢一定很容易With your bot winning must come easy. 差不多吧Yeah,I guess.如果你喜欢做简单的事情Well,if you like things easy, 那或许我们的项目不适合你14then my program isn’t for you. 在这里我们不断地探索机器人的极限 We push the boundaries of robotics here.我的学生们会创造未来My students go on to shape the future.很高兴认识你小宏祝你比赛顺利 Nice to meet you,Hiro.Good luck with the bot fights.想赶上那场比赛的话你最好快点You gotta hurry if you wanna catch that bot fight. 我必须到这里上学 I have to go here!如果我不来这所极客大学我会发狂的If I don’t go to this nerd school.I’m gonna lose my mind. 我怎么才能被录取How do I get in?学校每年一次会举办学生科技展Every year,the school has a student showcase.你如果能做出一个让卡拉汉眼前一亮的东西You come up with something that blows Callaghan away,你就稳了You’re in.不过你一定要做得漂亮But,it’s gotta be great. 相信我Trust me... 这将会是It will be...什么也没有完全没想法Nothing!No ideas. 空脑子笨脑子15Useless empty brain. 才十四岁就一败涂地了 washed up at 14. 太悲哀 So sad.什么都想不出来完了我永远也录取不上了I got nothing!I’m done!I’m never getting in!我还没对你放弃希望呢I’m not giving up on you. #NAME?-What are you doing?-Shake things up.用你的超大号大脑好好想一想Use that big brain of yours to think your way out. 换一个角度看问题Look for a new angle.好多酷炫的科技设备你感觉怎么样 Wow,a lot of sweet tech heretoday.How you feelin’? 我以前可是机器人拳击手You’re talking to an ex-bot fighter, 这阵势想吓到我还远远不够It takes a lot more than this to rattle me. 他紧张着呢Yup,he’s nervous. 小家伙没什么好担心的Oh!You have nothing to fear little fella. 他好紧张He’s so tense.-没我才不紧张-放松点小宏 -No!I’m not.-Relax,Hiro...你的设计棒极了快告诉他神行御姐 Your tech is amazing!Tell him,Gogo...16别叽歪了拿出点气概 Stop whining,woman up. 我好着呢I’m fine.你需要什么小家伙What you need,little man? 除臭剂薄荷糖还是新内裤Deodorant breath mint,fresh pair of under pants? 内裤你有病得治了Under pants?You need serious help. 我这是有备而来Hey,I come prepared. 我已经六个月没洗衣服了I haven’t done laundry in 6 months.一条内裤我能穿四天One pair last me four days.前穿穿后穿穿然后翻过来再来一遍I go front,I go back,I go inside out then I go front and back.#NAME? -Wow!That is both disgusting and awesome.-Don’t encourage him.这叫做”循环再利用”It’s called”recycling”. 下一位展示者滨田宏 Next Presenter:Hiro Hamada. #NAME?-Oh yeah!This is it!-I guess I’m up.照相照相大家一起说”小宏”Okay!Okay,photo!Photo!Everybody say:”Hiro!” 小宏 Hiro!17我们爱你小宏祝你好运 We love you,Hiro.Good luck! 别搞砸了Don’t mess it up. 祝展示成功小家伙Break a leg,little man! 科学万岁耶 Science,yeah!上吧弟弟展示的机会来了 Alright,Bro.This is it! 拜托别让我失望了Come on,don’t leave me hanging. 怎么了?What’s going on? 我真的很想去你们学校 I really wannago here. 你可以的You got this. 大家好 Hi...我的名字是滨... My name is Hiro... 抱歉 Sorry.我的名字是滨田宏My name is Hiro Hamada.我发明了一些自认为很神奇的东西And,I’ve been working o n something that I think is pretty cool. 希望你们能喜欢I hope you like it. 这是一个微型机器人 This,is a microbot.深呼吸 Breathe.看起来微不足道It doesn’t look like much.但是当它和其他小伙伴们团结起来的时候But when it links up with the rest of its pals... 就变得有趣18多了Things gonna get a little more interesting.它们由这个神经发射器控制The Microbots are controlled with this neurotransmitter.我想让它们做什么I think about what I want them to do...它们就照做 They do it.这项创造的应用是无止境的The applications for this tech are limitless. 建筑物Construction... 曾经需要大队人马What use to take teams of people 人工建造数月或数年working by hands for months or years.现在只要一个人就可以完成Can now be accomplished by one person.这仅仅是九牛一毛And that’s just the beginning... 可不可以用在 Howabout... 交通运输上? Transportation?微型机器人可以轻松移动任何物体至任何地方 Microbots can move anything,anywhere,with ease. 只有想不到If you can think it... 没有做不到microbots can do it.你的思维局限是它唯一的限制19The only limit is your imagination. 微型机器人 Microbots! 那是我外甥That’s my nephew! 是我家人我爱我家人My Family!I love my family! 棒呆了 Nailed it! #NAME?-You did it!-You did it bad. -做得好小宏-太让我震惊了老弟-Good job,Hiro.-It blows my mind,dude.观众爱死你了太神奇了They loved you.That was amazing! 是的 Yes.经过进一步开发你的技术将会是革命性的With some development,your tech could be revolutionary.你是阿拉斯泰尔?克雷 Alastair Krei. 我可以看看么? May I? 太棒了Extraordinary.我希望你能把你的机器人卖给克雷科技I want your microbots at Krei Tech. 不是吧 Shut up.克雷先生说得对 Mr.Krei is right.你的机器人将唤醒技术革新Your microbots are an inspired piece of tech. 你可以继续开发它们You can continue to develop them...也可以把它们卖给一个唯利是图的小人20Or you can sell them to a man whose only guided by hisown self interest. 罗伯特我知道你是怎么看我的Robert,I know how you feel about me 但是这不关你的事But it shouldn’t affect you...一切由你决定小宏 This is your decision,Hiro.但至少你要知道克雷先生为达目的 But you should know,Mr.Krei has cut corners喜欢走捷径忽视科学 and ignored sound science to getwhere he is. 不是那样的That’s just not true. 克雷科技才不会善用你的机器人I wouldn’t trust Krei Tech with your microbots 其他东西也是 or anything else 小宏 Hiro...我能给你提供超乎想象的酬劳I’m offering you more money than any fourteen year old could imagine. 多谢你的赏识克雷先生但我不会卖 I appreciate the offer,Mr.Krei.But they are not for sale. 我真是高估了你的智商I thought you were smarter than that. 罗伯特 Robert. 克雷先生 Mr.Krei...那是我弟弟的机器人That’s my brother’s. 哦对了Oh,that’s right.我期望能在课堂上见到你21I’m lo oking forward of seeing you in class... 哇耶难以置信Wohoo!Yeah!Unbelievable!天才们让我们去喂饱这些饥渴难耐的大脑吧Alright geniuses!Let’s feed those hungry brains. 回餐厅晚饭我请客Back to cafe,dinner is on me! 太棒了免费美食最棒了Yes,nothing is better than free food. #NAME?-Aunt Cass...-Unless it’s moldy. -我们会赶回去的好么-当然 -We’ll catch up,okay?-Sure. 我为你感到骄傲I’m so proud of you! #NAME?-Both of you!-Thanks,Aunt Cass. 我知道你要说什么I know what you gonna say. 我应该感到自豪I should be proud of myself 因为我的天赋终于能用于正途...because I’m finally using my gift for something important..不我只是想告诉你No!No,I was just gonna tell you, 整个展示中你的裤裆都是开的 your fly was down for the whole show.哈哈别搞笑Haha,Hilarious! 什么啊 What?Ahh!欢迎来到怪咖大学Welcome to Nerd School, 怪咖 Nerd! 我22Hey,I am...如果不是你我不会有今天所以I wouldn’t be here if it wasn’t for you,so... 你知道You know...谢谢你没有放弃我Thanks for not giving up on me. 你还好么Are you okay?我没事但是卡拉汉教授还在里面Yeah,I’m okay.But Professor Callaghan is still in there. 阿正不要 Tadashi,No! 教授还在里面Callaghan’s in there. 我得去救他Someone has to help. 阿正 Tadashi! 阿正 Tadashi! 嗨Hey... 嗨卡斯阿姨 Hey,Aunt Cass. 松田夫人来餐厅了Mrs.Matsuda’s in the cafe.穿的衣服一点都不适合她八十岁的年纪She’s wearing something super inappropriate for an 80year old. 每次都能让我捧腹大笑 It always cracks me up. 你应该下楼看看You should come down. 以后再说吧 Maybe later.对了学校又打电话来了 Oh,the university called again.开学已经有几周了It’s been a few weeks since classes started, 但他们说现在23去报道还不晚but they said its not too late to register. 知道了谢谢Okay,thanks. 我会考虑的I’ll think about it. 嗨小宏 Hi,Hiro!我们只是想看看你怎么样了 We just wanted to check in and see how you’re doing. 我们希望你能来学校老弟 Wewish you were here,buddy.小宏如果现在让我选一种超能力Hiro,if I could have only one super power right now...我希望我能穿过这个摄像头给你一个大大的拥抱 it wouldbe the ability to crawl through this camera and give you abig hug. 嗷Awww...你好我是大白你的私人健康助手Hello,I am Baymax,Your personal health care companion. 你好 Hey...大白我不知道你还能用Baymax,I didn’t know you were still active.我听到一声惨叫发生了什么事?I heard a sound of distress.What seems to be the trouble?我刚刚砸到了脚趾头我很好Oh,I just had my toe a little.I’m fine.24从一到十你的疼痛等级是多少?On a scale of 1 to 10,How would you rate your pain? 零? Zero?我很好真的多谢你可以缩回去了I’m okay,really.Thanks.You can shrink now. #NAME?-Does it hurt when I touch it?-That’s okay.No!No touching!嗷! Aw!你摔倒了You have fallen. 你说呢 You think? 从一...On a scale of one... 从...On a scale... 从...On a scale... 从一到十...On a scale of one to ten... 从一到十你的痛感是几级?On a scale of one to ten,How would you rate your pain? 零 Zero. #NAME?-It is alright to cry.-No!No... #NAME?-Crying is a natural response to pain.-I’m not crying.-让我为你扫描看是否受伤-别扫我 -I will scan you forinjury.-Don’t scan me.-扫描完毕-不可理喻!-Scan complete.-Unbelieveable! 你没有受到外伤You have sustained no injuries. 但是你的荷尔蒙水平和神25经递质 However,your hormone and neurotransmitter levels 都显示你有异常情绪波动indicate that you are experiencing mood swings.常见于青少年人群症状鉴定:Common on adolescenes.Diagnosis: 青春期躁动 Puberty.你说什么? Woah!What?好吧你该缩回去了Okay,time to shrink now. 这一时期身体会出现毛发的增长You should expect an increase in body hair.尤其在脸部胸部腋窝和... Especially on your face,chest,armpits,and... 谢谢你解释够多啦Thank you,that’s enough. 身体还会感到莫名强烈的冲动You may also experience strange and powerful new urges.好啦咱乖乖回箱子里去好不Okay,let’s go you back in your luggage.直到你说你满意我的照顾我才可以结束工作I can not deactivate until you say:You are satisfied withyour care.好吧我很满意你的...Fine,I’m satisfied with my... 我的微型机器人? Mymicrobot? 这是怎么回事?26This doesn’t make any sense.青春期的少年在成熟的过渡期常感到迷茫Puberty can often be a confusing time for young adolescentflowering into a manhood. 不! No!微型机器人之间是互相感应的但... The thing is attracted with other microbot,but...这不可能啊它们不是都烧毁了That’s impossible,theywere destroyed in a fire. 肯定有地方坏了Something’s broken. 你的微型机器人好像要去哪Your tiny robot is trying to go somewhere.噢是吗那你帮忙找出它想去的地方吧Oh,yeah?Why don’t you find out where he is trying to go?这样能缓解你青春期的情绪波动吗 Would that stabilize your pubescent mood swings? 当然Absolutely. 大白? Baymax? 大白? Baymax? 大白?Baymax? 不是吧 What? 小宏? Hiro?嗨卡斯阿姨 Hi,Aunt Cass. #NAME?-Wow,you’re up?-Yeah,I figured it was time. 你是要去登记入学吗Are you registering for school?是啊我考虑过你说的了确实让我振作不少Ah,yes.I’ve thought about what you said.Really inspired me. 亲爱的那27太棒了! Oh,honey.That’s so great!好嘞今晚加餐我会留些鸡翅...Okay,special dinner tonight.I leave up some chickenwings... 放些辣得脸发麻的辣酱 You know,with a hot sauce that makesus faces numb. 好啊听起来不错 Okay,sounds good. 那好!再抱一个 Great!Last hug. 大白! Baymax! 大白!Baymax! 大白! Baymax! 大白! Baymax!疯了么你这是要干嘛Are you crazy?What are you doing? 我找到你的微型机器人要去的地方了...I have found where your tiny robot wants to go..都跟你说了它坏了!它没有要去... I told you,its broken!It’s nottrying to go... 锁住了 Locked. 那有窗户There is a window. 请注意安全Please exercise caution.从这样的高度坠落可导致身体损伤 A fall from this height could lead to bodily harm. 糟了个糕 Oh,no.抱歉请允许我放走些空气Excuse me,while I let out some air. 好了吗Are you done? 好了 Yes.我需要点时间重新充满It will take me a moment to re-inflate.28好吧声音轻点就是了Fine,just keep it down. 我的微型机器人? My microbots? 有人在批量制造Someone’s making more. 小宏?Hiro?心脏病都快被你吓出来了You gave me a heart attack. 我的手掌内置电击器My hands are equipped with defibrillators. -预备!-停!住手! -Clear!-Stop!Stop! 我只是打个比方It’s just an expression! 糟了个糕 Oh,no. 快跑! Run! 噢快点! Oh,come on! 我跑不快I am not fast. 是啊我看到了! Yeah,no kidding! 快!快!速度! Go!Go!Come on! 把门踢倒! Kick it down! 出拳! Punch it! 快!快! Go!Go! 跟上快!快! Come on,go!go! 快走! Move it! 快点! Come on!快点!从窗户出去! Come on!The window! 挤过去! Suck in! 大白! Baymax! 小宏? Hiro?快点~咱们赶紧离开这!跑~速度! Come on!Let’s get out ofhere!Go!Hurry!好了听我整理一下思路Alright,let me get this straight. 一个头戴歌伎面具的男人 A man in a kabuki mask 带着一队会飞的小机器人袭击了29你attacked you with an army of miniature flying robot.是微型机器人! Microbots! 微型机器人 Microbots.嗯他通过戴在头部的发射器Yeah,he was controlling them以心电感应的方式控制那些机器人telepathically with a neurocranial transmitter.也就是说这位面具先生 So Mr.Kabuki was using 用超能力袭击了你和气球人ESP to attack you and balloon man.你那会飞的机器人被盗后你有报案吗? Did you file a report when your flying robots was stolen?没有我以为它们都被烧毁了No,I thought they were all destroyed.听起来是有点不可思议不过当时大白也在告诉他 Look,Iknow it sounds crazy but Baymax was there too.Tell him. 是的长官他说的是事...实 Yes,officer.He is telling the tru...th.怎么...你怎么了?What the...What’s wrong with you? 电量不足 Lowbattery.嘿嘿尽量坚持到家..Whoa!Whoa,try to keep it ho..me 我是您的私人健康助手30大白...I am a health care,your personal Baymax...孩子我们还是打电话让你家长来一趟吧Kid,How about we call your parents and get them downhere. 什么? What?在这张表上填上姓名电话然后我们再...Write your name and number down in this piece ofpaper,and we can... 得赶紧带你回家充电 I gotta get you home to your charging station. 还能走吗? Can you walk?我将对你进行扫描扫描完毕I will scan you now.Scan complete. 健康Health care. 听好... Okay...要是阿姨问起来 If my aunt asked,你就说我们一整天都待在学校知道吗 we are at school all day,got it? 我们从窗户跳下来We jump out of window. 不是声音轻点!嘘!No,But be quiet!Shhh! 我们从窗户跳下来We jump out of window. 你可不能这么回卡斯阿姨But you can’t say things like that on our Aunt Cass. 小宏?Hiro?你回来了亲爱的? You home,sweetie? 是的!That’s right! 就知道我没听错嗨!31I thought I heard you.Hi! 嘿卡斯阿姨 Hey,Aunt Cass. 看看我的小大学生啊Oh,look at my little college man.我迫不及待地想听你在学校的一切Ah!I can’t wait to hear all about it. 马上就好咯Oh!It means its almost ready. 你能安静会儿吗 You bequiet? 好了来大吃一顿吧Alright,get ready to have your face melted.明天就会感觉到这酸爽了你知道我在说什么吧We are gonna feel this things tomorrow.You know whatI’m saying? 好吧坐下来都告诉我Okay,sit down,tell me everything. 情况是这样的因为我注册得太晚了 The thing is,since I registered so late.我有很多功课要赶上I’ve got a lot of school stuff to catch up on. 什么声音What was that? 是糯米团 Mochi. 该死的猫Oh!That darn cat. 就当饯行吃一盘好吗Oh!Just take a plate for the road,okay? #NAME?-Don’t work too hard.-Thanks for understanding. 毛茸茸的宝贝 Hairy baby. 毛茸茸的宝贝 Hairy baby. 好了起来吧Alright,come on.32我会坚持下去我是你的私人助手I’ll carry on,I’m your personal Baymax.一只脚前一只后One foot in front of the other. 没道理啊This doesn’t mak e any sense. 阿正 Tadashi. 什么 What? 阿正 Tadashi. 阿正走了Tadashi’s gone. 他什么时候回来When will he return? 他死了大白He is dead,Baymax. 阿正身体十分健康Tadashi was in excellent health.饮食健康坚持锻炼他应该会长寿With a proper diet and exercise,He should have lived along life. 是他应该会Yeah,He should have. 但发生了一场火灾... But there is a fire... 现在他去了Now he’s gone. 阿正就在这里 Tadashi is here.不虽然大家都说只要有人记得他No,people keep saying he is not really gone. 他就不是真的消失了As long as who remember him.但还是很痛... Still hurts.. 我没有检测出伤口I seen no evidence of physical injury. 那是另外一种伤痛33It’s a different kind of hurt.你是我的病人我想帮助你 You are my patient.I would like to help. 这个你治不了You can’t fix this one buddy. 你在做什么Ah..What are you doing? 我在下载伤心病治疗的数据库I am downloading a database on personal lost. 数据库下载完成Database downloaded. 治疗方法包括接触朋友爱人Treatments include:Contact with friends,and loved ones.。
难治性抑郁症的管理临床实践指南英文

难治性抑郁症的管理临床实践指南英文全文共3篇示例,供读者参考篇1Clinical Practice Guideline for the Management of Treatment-Resistant DepressionIntroductionTreatment-resistant depression (TRD) is a common and challenging condition that affects a significant number of individuals worldwide. Despite the availability of multiple pharmacological and non-pharmacological treatment options, a subset of patients with depression fails to respond adequately to standard interventions. In recent years, significant progress has been made in understanding the pathophysiology of TRD and developing novel treatment strategies. This clinical practice guideline aims to provide evidence-based recommendations for the management of TRD in clinical practice.Diagnosis and AssessmentThe diagnosis of TRD should be made after a careful evaluation of the patient's symptoms, treatment history, and response to previous interventions. Assessment tools such as theHamilton Depression Rating Scale (HDRS) and the Montgomery-Åsberg Depression Rating Scale (MADRS) can be used to evaluate the severity of depressive symptoms. In addition, a comprehensive psychiatric evaluation should be conducted to rule out other psychiatric disorders that may mimic depression or contribute to treatment resistance.Pharmacological InterventionsFor patients with TRD, pharmacological interventions remain the mainstay of treatment. Antidepressant medications such as selective serotonin reuptake inhibitors (SSRIs),serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs) are commonly used in the management of TRD. In cases where patients do not respond to first-line antidepressants, switching to another class of antidepressants or augmenting with other medications such as atypical antipsychotics, lithium, or thyroid hormones may be considered.PsychotherapyIn addition to pharmacological interventions, psychotherapy can also play an important role in the management of TRD. Cognitive-behavioral therapy (CBT), interpersonal therapy (IPT), and mindfulness-based interventions have been shown to beeffective in treating depression and improving treatment outcomes in patients with TRD. Psychotherapy can be used as a standalone treatment or in combination with pharmacotherapy to enhance the effectiveness of treatment.Electroconvulsive Therapy (ECT)Electroconvulsive therapy (ECT) is a highly effective treatment option for patients with severe TRD who have not responded to pharmacological or psychotherapeutic interventions. ECT is typically reserved for patients with severe depressive symptoms, psychotic features, and suicidal ideation. ECT has been shown to produce rapid and sustained improvements in mood and is considered safe andwell-tolerated in the majority of patients.Ketamine and Other Novel Treatment ApproachesKetamine, a glutamatergic modulator, has emerged as a promising treatment for TRD. Intravenous ketamine administration has been shown to produce rapid antidepressant effects in patients with TRD, with improvements observed within hours of treatment. Other novel treatment approaches such as transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS), and deep brain stimulation (DBS) are also being investigated as potential options for patients with TRD.ConclusionIn conclusion, the management of TRD requires a comprehensive and individualized approach that takes into account the patient's symptoms, treatment history, and preferences. This clinical practice guideline providesevidence-based recommendations for the management of TRD and highlights the importance of a multidisciplinary approach involving psychiatrists, psychologists, and other healthcare professionals. By implementing these recommendations in clinical practice, healthcare providers can improve treatment outcomes and quality of life for patients with TRD.篇2Clinical Practice Guidelines for the Management of Treatment-Resistant DepressionIntroductionTreatment-resistant depression (TRD) is a challenging condition characterized by a lack of response to standard antidepressant therapy. It is estimated that up to 30% of patients with depression do not adequately respond to initial treatment, and a proportion of these individuals may go on to develop TRD. Management of TRD requires a comprehensive approach thatincludes a combination of pharmacological andnon-pharmacological interventions. This document provides evidence-based recommendations for the management of TRD in clinical practice.Diagnostic EvaluationThe first step in managing TRD is to ensure an accurate diagnosis. This involves a thorough assessment of the patient's history, symptoms, and response to previous treatments. It is important to rule out other psychiatric or medical conditions that may be contributing to the treatment resistance. A comprehensive evaluation should also include a review of the patient's medication history, substance use, and psychosocial stressors.Pharmacological InterventionsWhen managing TRD, it is important to consider switching to a different antidepressant medication or augmenting with an additional agent. Some common strategies include:- Switching to a different class of antidepressant- Augmenting with a second-generation antipsychotic- Augmenting with a mood stabilizer- Adding a stimulant medication- Considering off-label use of ketamine or esketamineNon-Pharmacological InterventionsIn addition to pharmacotherapy, non-pharmacological interventions can play a valuable role in the management of TRD. These may include:- Cognitive-behavioral therapy (CBT)- Interpersonal therapy (IPT)- Mindfulness-based therapies- Electroconvulsive therapy (ECT)- Transcranial magnetic stimulation (TMS)- Vagus nerve stimulation (VNS)Treatment SettingPatients with TRD may benefit from treatment in a specialized mental health setting, such as a mood disorders clinic or an inpatient psychiatric unit. These settings provide access to a multidisciplinary team of mental health professionals who can collaborate on the patient's care. In severe cases, hospitalizationmay be necessary to ensure the safety and stability of the patient.Monitoring and Follow-UpRegular monitoring of symptoms and treatment response is essential in the management of TRD. Clinicians should closely monitor the patient's mood, energy level, appetite, and sleep patterns. It is important to assess for potential side effects of medications and to address any concerns or barriers to treatment compliance. Follow-up appointments should be scheduled at regular intervals to assess the effectiveness of the treatment plan and make adjustments as needed.ConclusionManaging TRD requires a comprehensive and individualized approach that addresses both pharmacological andnon-pharmacological interventions. By followingevidence-based guidelines and collaborating with a multidisciplinary team of mental health professionals, clinicians can help patients with TRD achieve remission and improve their quality of life.篇3Management Clinical Practice Guidelines forTreatment-Resistant DepressionIntroductionTreatment-resistant depression (TRD) is a challenging condition that affects a significant number of individuals worldwide. It is characterized by persistent symptoms of depression despite multiple treatment attempts with various antidepressant medications. Managing TRD requires a comprehensive approach that goes beyond traditional pharmacotherapy and includes psychotherapy, lifestyle modifications, and other interventions. This clinical practice guideline aims to provide healthcare professionals with evidence-based recommendations for the management of TRD.Assessment and DiagnosisThe first step in managing TRD is an accurate assessment and diagnosis. This includes a thorough evaluation of the patient's history, symptoms, and potential contributing factors. It is essential to rule out other medical conditions that may be causing or exacerbating the symptoms of depression. In addition, a comprehensive mental health assessment, including a psychiatric evaluation, should be conducted to determine theseverity of the depression and identify any comorbid psychiatric disorders.Treatment OptionsOnce a diagnosis of TRD has been established, treatment options should be tailored to the individual patient's needs. Pharmacotherapy remains a cornerstone of TRD treatment, with options including switching to a different antidepressant medication, adding a second medication, or trying a combination of medications. It is essential to monitor the patient closely for side effects and treatment effectiveness.In addition to pharmacotherapy, psychotherapy is an essential component of TRD management. Cognitive-behavioral therapy (CBT) has been shown to be effective in treating TRD by helping patients identify and change negative thought patterns and behaviors. Other types of therapy, such as interpersonal therapy (IPT) and psychodynamic therapy, may also be beneficial for some patients.Lifestyle modifications, such as exercise, diet, and sleep hygiene, can also play a significant role in managing TRD. Regular physical activity has been shown to improve mood and reduce symptoms of depression, while a healthy diet and adequate sleep can support overall mental health.Other treatment options for TRD include neuromodulation techniques, such as transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT). These treatments are typically reserved for patients who have not responded to other interventions and may be effective in severe cases of TRD.Follow-Up and MonitoringRegular follow-up and monitoring are essential for patients with TRD to ensure treatment effectiveness and detect any potential side effects. Healthcare professionals should schedule regular appointments with patients to assess their symptoms, medication compliance, and overall well-being. It is crucial to involve the patient in treatment decision-making and encourage open communication about treatment outcomes.ConclusionManaging TRD requires a multidisciplinary approach that addresses the complex nature of the condition. This clinical practice guideline provides evidence-based recommendations for healthcare professionals to effectively manage TRD and improve patient outcomes. By utilizing a combination of pharmacotherapy, psychotherapy, lifestyle modifications, and other interventions, healthcare professionals can help patients with TRD achieve remission and regain their quality of life.。
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User’s Guide for the LySatool version2.01Mikael BuchholtzApril18,20051.IntroductionThe LySatool[4]implements a security analysis for the process calculus LySa.This calculus comprises language primitives for modelling of network communication that achieves security by applying cryptographic techniques.The analysis is an over-approxi-mating program analysis that can guarantee confidentiality and authentication properties for LySa processes—even when these are under attack from arbitrary network attackers. This user’s guide explains how to operate the LySatool.However,it does not explain how the analysis works nor does it give the necessary insight to interpret the analysis result.The user is referred to other published material on these matters.For example, LySa and the analysis are described in[1].The main novelty of version2of the LySatool is an addition of an analysable meta-level,which is described in[3].Further details on the correctness of the various features implemented in LySatool version2may be found in[2].2.Operating the LySatoolThe LySatool is implemented in Standard ML of New Jersey[5](SML/NJ)and uses the Succinct Solver[6]as a solving back end.The LySatool takes as input a LySa process and returns an analysis result.The LySatool can be invoked by running an SML/NJ script as detailed below.Alternatively,the LySatool can be invoked through calls to an SML/NJ API,which contains a rich set of function for interacting with the tool.The API is surveyed in Appendix A.2.1.A Sample SessionThe LySatool can be invoked through the script run.sml,which can be loaded into an SML/NJ promt by>use("run.sml");1The input to the LySatool is afile containing a LySa process.The script contains a function run to invoke the tool on such afile.For example,the LySatool may be invoked on thefile examples/publickey.lysa by calling>run("examples/publickey.lysa");The result of running the LySatool is an HTMLfile examples/publickey.html,which contains the input LySa process along with the analysis result.Both are presented in HTML format.The resultingfile has the same name as the inputfile except that its suffix is replaced by.html.The LySatool can be invoked with various parameters.This can by done by calling the function runp,which takes parameters as its second argument.For example, >runp("examples/publickey.lysa",Analysis2.version1parameters);runs the LySatool with parameters that correspond to the behaviour of version1of the LySatool.The syntax for LySa processes is detailed in Section3while the parameters are discussed in Section43.ASCII Grammar of LySaThe LySatool takes as input a LySa process,which may contain destination and origin authentication annotations.The LySa process is given in ASCII format following the grammar in Figure1.Here the set identifier contains strings that begin with a letter followed by zero,one,or more letters or digits.The set number contains strings with decimal representation of non-negative numbers.The following list of strings are con-sidered to be keywords that cannot be used for other purposed than described by the grammar:as,at,CPDY,dest,decrypt,in,let,orig,NATURAL1,NATURAL2,NATURAL3,NATURAL01,NATURAL02,NATURAL03,new,subset,ZEROAny string between an opening/*until thefirst closing*/are comments and disregarded when parsing.In the grammar a non-terminal post-fixed with+denotes non-empty comma-separated list of that non-terminal while a non-terminal post-fixed with∗denotes a(possibly empty)comma-separated list of that non-terminal.Anεin the body of a rule denotes the empty string.The prefix operators on processes(input,output,decryption,and restriction)binds tighter than the!at replication,which again binds tighter than parallel composition. Parallel composition is left associative.Finally,indexed parallel has lowest precedence meaning that the scope of indexed parallel reaches as far as possible!Alternative prece-dence may be forced by adding parentheses around processes and terms.2proc::=(proc)|<term∗>.proc|(term∗;var∗).proc|decrypt term as{term∗;var∗}:term orig in proc|decrypt term as{|term∗;var∗|}:term orig in proc|(new name)proc|(new+-name)proc|!proc|proc|proc|0|let identifier subset iset in proc||_{assign}proc|(new_{assign+}name)proc|(new_{assign+}+-name)proc term::=(term)|{term∗}:term dest|{|term∗|}:term dest| name|namep|namem|varname::=identifier subscriptnamep::=identifier+subscriptnamem::=identifier-subscriptvar::=identifier subscriptsubscript::=_{index∗}|εindex::=identifier|numberiset::={index∗}|iset union iset|NATURAL1|NATURAL2|NATURAL3|NATURAL01|NATURAL02|NATURAL03|ZEROassign::=index in numberdest::=[at cryptopoint dest{cryptopoint∗}]|[at cryptopoint]|εorig::=[at cryptopoint orig{cryptopoint∗}]|[at cryptopoint]|εcryptopoint::=identifier subscript|CPDYFigure1:ASCII grammar for LySa.Names and variables are parsed according the same syntax and conflicts are resolved by ensuring that any occurrence of a variable that is in scope(of an input or a decryption) will indeed be interpreted as a variable.At all other places elements will be interpreted as names.Thus,processes will never contain free variables though they may contain free names.Annotations of origin and destination information are added in square brackets.The annotations give both a crypto-point denoting the place of decryption/encryption as well as a set of crypto-points for expected origin/destination.The latter information may be left out and this will be interpreted as the semantic equivalent of having no requirement of origin/destination.If an annotation is altogether empty the decryption/encryption will further more be interpreted as if it takes place at an unspecified crypto-point.34.LySatool ParametersThe LySatool takes the following parameters in an SML record(where default values are given in parenthesis):withAttacker:bool(true)input process is analysed together with all arbitrary at-tackers when withAttacker is set to true.With to false,the analysis is run without an attackerattackerIndex:string("")It is sometimes desirable to model that legitimate prin-cipals communicate with the attacker(i.e.with illegitimate principals).If the legitimate principals are described by an indexed parallel composition it may be convenient to let a particular index(e.g.index0)denote interaction with the at-tacker.However,with this kind of modelling,interaction with the attacker may cause auxiliary error messages inψbecause the attacker uses CPDY as its crypto-point but CPDY is usually not an intended origin or destination specified by the annotations.By assigning the parameter attackerIndex the value"0"each set of crypto-points in an annotation of the0th unfolding of an index parallel composition will have CPDY added.Thus,interaction with the attacker,which occurs in0th unfolding, will no longer cause auxiliary error messages.mergeExpressionLabels:bool(true)Labels are automatically attached to all LySa expressions and these labels are used as non-terminals in the tree grammars in the analysis result.When mergeExpressionLabels is set set to true,identical expressions may be assigned the same label.This,in turn,may reduce the size of the tree grammars that are computed,thereby,reducing the time it takes to compute the analysis result.When set to false labels are unique. mergeInputVariables:bool(true)When the attacker is present,all the values known to the attacker may become bound to any variables in an input.When the pa-rameter mergeInputVariables is set to true all these input variables are merged into a single variable,x•,in the analysis result.This may reduce the size of the analysis result,thereby,reducing the time it takes to compute the result.It only makes sense to set this parameter to true when the attacker is present! References[1]C.Bodei,M.Buchholtz,P.Degano, F.Nielson,and H.Riis Niel-son.Static validation of security protocols.Journal of Computer Security, 2004.To appear.Preliminary version available at http://www.imm.dtu.dk/ pubdb/views/edoc download.php/3199/pdf/imm3199.pdf.4[2]M.Buchholtz.Automated analysis of security in networking systems.Ph.D.thesisproposal.Available from http://www.imm.dtu.dk/∼mib/thesis/,December2004. [3]M.Buchholtz.Automated analysis of infinite scenarios.In Proceedings of TrustworthyGlobal Computing(TGC2005),Lecture Notes in Computer Science.Springer Verlag, 2005.To appear.[4]LySatool.http://www.imm.dtu.dk/cs LySa/lysatool,2005.Webpage hosted by In-formatics and Mathematical Modelling,Technical University of Denmark.[5]Standard ML of New Jersey./,2004.Webpage hosted by theSML/NJ Fellowship.[6]Succinct Solver.http://www.imm.dtu.dk/cs SuccinctSolver/,2004.Webpage hostedby Informatics and Mathematical Modelling,Technical University of Denmark. A.APIThe LySatool distribution contains the following groups offiles:run.sml script to run the LySatool directly on afile and produce HTML output. mllysa.sml data structure MLLysa,which represents LySa processes,and auxiliary functions on processes.analysis2.sml data structure Analysis2for the constraint generation function of the meta-level analysis(see Figure2).io/directory for input/output functionally from/to ASCII(see Figure3), to HTML(see Figure4),to L A T E X(see Figure5).io/lysa.sty L A T E X package for typesetting LySa processes.io/lysa-mode.el simple Emacs mode for syntax high-lighting of LySa processes. examples/directory for examples.sources.cm sourcefile for SML/NJ Compilation Manager.COPYRIGHT copyright for the LySatool.A.1.Analysis2The constraint generation function is embedded in the structure Analysis2shown in Figure2.The constraint generation is performed by the function generate,which takes a LySa process and parameters as input and produces a ALFP constraint as output. The parameters are detailed in Section4and may be default,version1parameters, or user specified parameters.The function analyse is provided for backwards portability with version1of the LySatool.The string version specifies the current version of the LySatool.5structure Analysis2:sigval generate:{attackerIndex:string,mergeExpressionLabels:bool,mergeInputVariables:bool,withAttacker:bool}->MLLysa.Proc->stringval default:{attackerIndex:string,mergeExpressionLabels:bool,mergeInputVariables:bool,withAttacker:bool}val version1parameters:{attackerIndex:string,mergeExpressionLabels:bool,mergeInputVariables:bool,withAttacker:bool} val analyse:MLLysa.Proc->stringval version:stringendFigure2:Structure for constraint generation in thefile analysis2.sml. structure LysaASCIIIO:sigexception parseError of stringval parseFile:string->MLLysa.Procval parseStream:TextIO.instream->MLLysa.Procval parseString:string->MLLysa.Procval toFile:string->MLLysa.Proc->unitval toString:MLLysa.Proc->stringendFigure3:Structure for ASCII input and output in thefile io/lysaasciiio.sml.A.2.LysaASCIIIOThe structure LysaASCIIIO shown in Figure3can be used to parse LySa processes from afile,stream,or a string according to the grammar given in Section3.The structure also contains functions toString and toFile to print a LySa process in ASCII format into a string and afile,respectively.A.3.LysaHTMLIOThe structure LysaHTMLIO shown in Figure4contains a function toHTML,which takes afile name(without suffix),a LySa process,the analysis parameters,and the analysis result.It produces a browsable HTML document(suffixed.html)containing the LySa process and the analysis result.A.4.LysaLatexIOThe structure LysaLatexIO shown in Figure5contains functions to print LySa processes into L A T E X format.This L A T E X output uses macros from the L A T E X package in thefile6structure LysaHTMLIO:sigval toHTML:string->MLLysa.Proc->{attackerIndex:string,mergeExpressionLabels:bool,mergeInputVariables:bool,withAttacker:bool}->’a*(string*string list list)list->unitendio/lysahtmlio.sml.structure LysaLatexIO:sigval toFile:string->MLLysa.Proc->unitval toString:MLLysa.Proc->stringendFigure5:Structure for L A T E X output of processes in thefile io/lysalatexio.sml. io/lysa.sty.7。