Morphological identification of transformer magnetising inrush current
真核细胞翻译起始因子在头颈部肿瘤中的表达

真核细胞翻译起始因子在头颈部肿瘤中的表达韩敏;陈瑛【期刊名称】《中国耳鼻咽喉颅底外科杂志》【年(卷),期】2007(13)5【摘要】目的探讨真核细胞翻译起始因子(eIF4E)在头颈部肿瘤中的表达及其临床意义.方法采用免疫印迹方法(Western Blot)检测40例头颈部恶性肿瘤和10例头颈部良性病变中eIF4E抗原的表达.结果所有头颈部恶性肿瘤均有eIF4E蛋白表达,而良性病变组织中eIF4E蛋白表达较少,所有的特异性条带均位于25.0 KD的位置,二者差异有统计学意义(P<0.05).在头颈部恶性肿瘤中eIF4E表达与患者年龄、性别、病变部位及病理类型无关(P>0.05);eIF4E表达与TNM分期、病理分级相关(P<0.05).初诊病例与复发病例之间eIF4E表达有统计学意义(P<0.05).结论 eIF4E 在头颈部肿瘤的发生、发展及转移中可能起重要作用.【总页数】4页(P324-327)【作者】韩敏;陈瑛【作者单位】青岛大学医学院附属医院,耳鼻咽喉科,山东,青岛,266003;山东大学齐鲁医院,耳鼻咽喉科,山东,济南,250012【正文语种】中文【中图分类】R739.91【相关文献】1.宫颈癌组织中真核细胞翻译起始因子4E 和血管内皮生长因子的表达及意义 [J], 李龙2.真核细胞翻译起始因子4E 在皮肤基底细胞癌中的表达 [J], 邓越;刘海东;庄乐;马伟元3.真核细胞翻译起始因子4E蛋白在鼻咽癌中的表达及其临床意义 [J], 孙艳芹;徐秋燕;赵颖海;甘思远;尹金宝;李淑贤;胡新荣4.头颈部肿瘤组织中真核细胞翻译起始因子的表达及意义 [J], 韩敏;陈瑛5.溃疡性结肠炎中真核细胞翻译起始因子A1和血管内皮生长因子表达及意义 [J], 廖如奕;姚萍;张艳因版权原因,仅展示原文概要,查看原文内容请购买。
老年痴呆症的生物标志物研究

老年痴呆症的生物标志物研究老年痴呆症,又称为阿尔茨海默病(Alzheimer's disease,AD),是一种逐渐进展的神经退行性疾病,主要影响老年人的认知功能,包括记忆、思维、定向和理解能力等。
随着全球人口老龄化的加剧,老年痴呆症的发病率逐年上升,给患者、家庭和社会带来了沉重的负担。
因此,寻找有效的诊断方法和治疗策略显得尤为重要。
生物标志物作为一种客观、可测量的指标,能够反映疾病的发生、发展和治疗反应,对于老年痴呆症的早期诊断、病情监测和药物研发具有重要意义。
一、老年痴呆症的概述老年痴呆症是一种慢性、进行性的大脑疾病,其病理特征包括大脑中的β淀粉样蛋白(Aβ)沉积形成的老年斑、tau 蛋白过度磷酸化导致的神经纤维缠结、神经元丢失和神经炎症等。
这些病理变化会逐渐损害大脑的结构和功能,导致认知障碍和行为异常。
老年痴呆症的临床症状通常在疾病的中晚期才明显表现出来,此时大脑的损伤已经较为严重,治疗效果往往不佳。
因此,早期诊断和干预是延缓疾病进展、提高患者生活质量的关键。
二、生物标志物的定义和分类生物标志物是指可以客观测量和评估的生理、生化或分子指标,能够反映正常生理过程、病理过程或药物治疗反应。
在老年痴呆症的研究中,生物标志物主要分为以下几类:Aβ42:Aβ42 是Aβ 的一种亚型,在老年痴呆症患者的脑脊液中含量降低。
Tau 蛋白:包括总 Tau 蛋白(Ttau)和磷酸化 Tau 蛋白(Ptau),老年痴呆症患者脑脊液中 Tau 蛋白水平升高,尤其是 Ptau181 和Ptau217 等特定亚型。
2、血液生物标志物Aβ 相关蛋白:血液中的Aβ40、Aβ42 及其比值可以作为老年痴呆症的潜在生物标志物,但目前其诊断价值仍存在争议。
Tau 蛋白:与脑脊液中的 Tau 蛋白类似,血液中的 Tau 蛋白水平在老年痴呆症患者中也可能发生变化,但检测方法的准确性和可靠性需要进一步提高。
神经丝轻链(NfL):NfL 是神经元损伤的标志物,老年痴呆症患者血液中 NfL 水平升高。
语言学Morphology形态学课件

chairman﹡manchair
The chairman looked at the audience. The audience looked at the chairman. 2) Relative uninterruptibility: New elements cannot be inserted into a word even when there are several parts in a word. disappointment dis + appoint + ment Paul, (Jane) and Rebecca are my classmates.
语言学Morphology形态学
1. Word
Word: a unit of expression that has universal intuitive recognition by native-speakers, whether spoken or written
1.1 Three senses of “word”: 1) A physically definable unit:
members are not regularly added. Pronouns, prepositions, conjunctions, articles, etc. Open-class: A word whose membership is in principle infinite or unlimited. Nouns, verbs, adjectives, adverbs Note: The distinction is not quite as clear-cut as it seems. Prepositions: regarding, throughout, out of, according to, with regard to, in spite of, be means of ; Auxiliary verbs
形态学和句法学的联系和区别

1.语言形态学(Morphology)是一门研究人类语言构词形态及语法形态多样
性和规律性的语言学基础学科。
本专业方向,通过多语种语料对比分析、经典和前沿文献阅读、课堂和课后研讨等方式,为语言学专业学习者提供语言形态学研究的基础训练,使其了解人类语言形态的多样性和规律性,获得基本的语言形态分析能力,并理解语言形态学领域的主要理论及重要问题。
语言形态学涵盖屈折、派生、复合、组并、附着语素、格系统、变价操作、和谐与一致、中心或依附成分标识、心理词库、词频作用、及形态操作规则和理论模型等方面知识,还涉及语言形态学与其他语言学分支学科(如音系学、句法学等)的各种界面问题,是一门既传统又不断创新发展的语言学分支学科。
2.句法学(syntax)是一门研究语言词组和句子各组成成分之间结构关系及其
内在规律的语言学核心学科。
本专业方向,通过介绍句法学理论和分析方法,提供句法学研究的基础理论知识和分析训练,帮助语言学专业学习者掌握句法分析的主要技术性手段,并培养其实际应用的能力。
句法学研究涵盖词组和句子结构的生成、结构层次及其形式表征、结构的转换机制、结构对词组和句子语义的制约、跨语言的结构形式变化参数、生成语法理论在句法分析中的应用等方面的经验性和理论性问题,是半个多世纪以来国际语言学研究的最具活力的分支学科之一。
Chapter 3 Morphology 要点总结

Chapter 3 Morphology(形态学)1.What is morphology(形态学)?Morphology, as a branch of linguistics , is the study of the internal structure, forms and classes of words.eg. Unfriendly → un + friend + ly2.Morphemes(词素、语素)A morpheme is a minimal unit of meaning or grammatical function.eg. Maps→(2 units)→map + s3.Types of morphemes:free morphemes(自由语素) and bound morphemes(黏着语素)1>Free morphemes(自由语素)A.Some morphemes can stand alone as words, such morphemes are called freemorphemes.B.Rooot(词根) & Stem(词干)❶Root:a root is the based form of a word which cannot be further analyzed . It may be a free morpheme(as black in blackbird, blackboard, blacksmith) as well as a bound morpheme( -ceive in perceive认识,deceive欺骗,receive).❷Stem: a stem is any morpheme or combination of morpheme to which an inflectional affix can be added (friend in friends, friendship in friendships are both stem).C . Free Morphemes can be divided into two categories. They are:Closed Class & Opened Class(封闭词类和开放性词类)❶Closed Class(functional morphemes): a closed class is one whose membership is principle fixed or limited. (封闭类:连介代冠conjunctions, preposition, pronouns, articles)❷Open Class( lexical morphemes): an open class is one whose membership is principle indefinite or unlimited. (包括:名动形副数叹noun, verbs, adjectives)2>Bound Morphemes(黏着语素)A.Some morphemes cannot normally stand alone, but function only as parts of words.Such morphemes are called bound morphemes.Bound morphemes are actually affixes(词缀)—>prefix(前缀), suffix(后缀), infix(中缀).eg. dis- , un- , -ity, -al, -sB. Two Categories of Bound Morphemes:Derivational Morphemes(派生语素) & Inflectional Morphemes(屈折语素)❶Derivational Morphemes(派生语素): ~~ are used to make new words in the language and are often used to make words of a different grammatical category from the stem.eg. nouns→ verbs/ adj. verbs→ nouns/ adj.friend→ unfriend解除朋友关系( noun→ verb)❷Inflectional Morphemes(屈折语素):~~ are not used to produce new words, but rather to show aspects of the grammatical function of a word.①plurality(复数): - s, - es, - ies……②tense(时态): - s, - ing, - en, - ed……③possessive case(所有格): ’s④comparative/ superlative degree(比较级/最高级): -er, - esteg. dislikes → dis + +3> free morphemes(自由语素) & bound morphemes(黏着语素)❶All monomorphemic(单词素/单语素) words are free morphemes;❷These polymorphemic words are either compounds( combination of two or more free morphemes) or derivatives(words derived from free morphemes).4.Morphs(形素) and Allomorphs(语素变体)Morphs: the phonological and orthographic forms which realize morphemes are termed ― morphs‖.(语素的语音及对应拼写法的体现叫形素)Most morphemesSome morphemesAllomorphs: an allomorph is any of the different form of the same morpheme( 语素变体是同一个语素的不同形式).eg. plurality ―- s‖: map→ maps; dog→ dogs; class→ classed; mouse→ mice; sheep→ sheep Complementary distribution(互补分布):allomorph is a member of a set of morph;allomorph can’ t occur in the same environment .5> Types of Word Formation(构词法)❶Compounding(合成法)Words are formed by putting two words together, this way of building new words is called compounding.❷Derivation(派生法)Derivation is done by adding affixes to other words or morphemes.❸Conversion(转换法)Many words have more than one part of speech. A noun can become a verb easily and a verb can be used as a noun.❹Backformation(逆向构词法)As we have editor, we get edit by dropping – or . This process is called ~~❺Clipping(截短法)This process by cutting off part of word is called ~~❻Blending(混合法)A single new word can also be formed by combining two separate forms, this process iscalled ~~~❼Acronymization(缩略法)。
英语语言学概论Morphology形态学

英语语言学概论Morphology形态学
• Bound morphemes(粘着词素): those that can not occur alone as separate words.-ful, -less, re- de, tele-vis-ion, un-happy
• blackboard=black+board • disagree=dis +agree • 2 meaningful: can not be further
divided without destroying its meaning • cap+tain, man+age==manage
英语语言学概论Morphology形态学
Chapter 5 Morphology(形态学, 词法学)
Internal structures of words and rules of word formation
英语语言学概论Morphology形态学
careful wonderful successful beautiful widen deepen shorten fasten sharpen Impossible, incorrect, improper, illegal, report, import export transport support porter respect inspect expect suspect prospect boys girls toys books tables bottles working, thinking speaking, cutting, hitting the, to,for,bird, leg, air, captain. suffixes,prefixes,roots,inflectional suffixes,free root
英语语言学概论 Chapter 5 Morphology(形态学)

"basketball" (combination of "basket" and "ball")
"mother-in-law" (combination of "mother" and "in-law")
"blackboard" (combination of "black" and "board")
• Inflectional Variation: Morphology also deals with the inflectional variation of words, which refers to the changes in word form that indicate grammatical function or category. Understanding inflectional morphology is crucial for proper sentence structure and grammar.
Grammar
目录
• The Relationship between Morphology and Vocabulary
01
Morphological Overview
Definition and Purpose
Definition: Morphology is the study of the structure and forms of words in a language. It focuses on the internal composition of words, including the derivation of new words from existing words (derivational morphology) and the modification of words through the addition or deletion of affixes (inflectional morphology).
Morphology

Morpheme(8-4) Free and bound morphemes
unfriendly, carefulness, international unfriendly, carefulness, international Free morphemes(自由词素): those morphemes that can occur alone or can constitute words, e.g. chair, man. Bound morphemes(粘连词素): those morphemes that cannot occur alone but with another morpheme, e.g. un, ly, ful, ness, al.
Morpheme(8-5) Root and stem
wonderfully, unhappiness, unreasonable Root(词根): the base form of a word that cannot further be analyzed without total loss of identity, e.g. reason in unreasonable. Stem(词干): any morpheme or combination of morphemes to which other morphemes can be added, e.g. reason and reasonable in unreasonable. A root is a stem. But a stem is not necessarily a ee morpheme, bound morpheme, root, stem, affix, prefix, surfix, infix, inflectional affix, derivational affix, allomorph
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0.8
J
0 IEE 2002 Electronics Letters Online No: 20020223 DOI: 10.1049/el:20020223
E-mail: jaelee@ajou.ac.kr References
26 November 2001
Jae-Chon Lee (Department o Systems Engineering, Ajou Universig, f 5 Won-Chon-Dong, Pal-Dal-Gu. Su- Won-Si, 442-749, Korea)
‘An adaptive RAM-DFE for storage channels’, IEEE Truns. Commun., 1991,39, pp. 1559-1568 2 WIDROW, B., MCCOOL, J., and BALL, M.: ‘The complex LMS algorithm’, Proc. IEEE, 1975,63, pp. 719-720 3 CHERUBINI, G.: ’Nonlinear self-training adaptive equalization for partialresponse systems’,IEEE Trans. Commun., 1994, 42, pp. 367-376 4 COWAN, C.F.N., SMITH, S.G., and ELLIOT, J.H.: ‘A digital adaptive filter Using a memory-accumulator architecture: theory and realisation’, IEEE Trans. Acoust.. Speech Signal Process., 1983, 31, pp. 541-549
f=Z+I,
f’=-I+I,
Introduction: In the design of a protection relay for large power transformers, the second harmonic of the current signal has been frequently utilised as the characteristic component of the asymmetrical magnetisation peculiar to the inrush to block the trip signal triggered by magnetising inrush conditions [ 11. However, for modern power transformers the second-harmonic contents of inrush currents may drop below 7% whereas the fault current may be more than 15%, and certain difficulties arise when protecting such transformers by using harmonic analysis-based algorithms. In this Letter we introduce a mathematical morphology-based algorithm [2] to identify transformer magnetising inrush current in the time domain. Identification method: To morphologically decompose a signal f as f; with a set of components {h,= 1, 2, . . . }, a constructive i transform can be applied to obtain a family of residues of $ If the residue of two transforms, 4 and $, is defined as R { 4 , i t ( f ) 4(f) $(f ), with an antiextensive and positively = defined transform y , the general representation scheme [3, 41 can be defined as: the family of residues offwith respect to y is {ri, i= 1, 2, . . . }, where r l =f and r;+, =R{7,,y(r,)) y(rJ is a null signal; the until set Cr;}, f ; = y(rJ is the residual representation off with respect to constructive transform y . The reconstructionf* offcan be obtained as f*= J;. The partial j-components reconstruction is given by
A novel method based on morphological signal decomposition, to
identify the power transformermagnetising inrush current waveform is
presented.
To perform the decomposition, the input current waveform is firstly transformed to obtain two signals f and f ’ , defined as
for a large N compared to that of N M for the direct form. As an altemative, the N-table realisation was also presented with reduction in multiplication counts. However, the single table structure benefits from N locations update at a time, resulting in a lot faster convergence. Exploiting some symmetry in the signal constellation and the segment-reassemble concept used in the work on distributed arithmetic [3, 41, an extension of this work to the case of general input quantised with eight bits or more would be a subject of further study.
L
1
I
I
I
I
I
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1005
1010
t[SI, s
1015
1020
1025
1 FISHER, K.D., CIOFFI, J.M., ABBOTT, WL., BEDNARZ, PS., and MELAS,
C.M.:
Fig. 1 Typical inrush current waveform Consider a typical cycle of the inrush current as shown in Fig. 1, where the 50 Hz current signal I is normalised as I/In. The asymmetries of the waveform exhibit in both amplitude and duration of the positive and negative segments. If the signal is decomposed to obtain amplitudes of peak A,,, and valley A,,,, from a flat support of given length L, then the asymmetries of the amplitude and interval S between them can be quantified and compared with those in the internal fault current and normal power system operation conditions. The morphological system for identifying the magnetising inrush current is shown in Fig. 2.
Morphological identification of transformer magnetising inrush current
Fig. 2 Block diagram of proposed method
P. Sun, J.F. Zhang, D.J. Zhang, Q.H. Wu and S. Potts
,f=
xi
where Io is a predetermined constant. lo is necessary since the morphological decomposition requires that the input signal f satisfies If0 kg](t)> 0. The value of Io is not important as long as it results in bothfandf‘ being positive. Since the current signal contains both peaks and valleys, due to the erosion operation in the decomposition procedure being able to only extract peaks of a signal, the inverted input signalf’ is decomposed separately and then inverted again to obtain the valleys of the signal. The structuring function g involved for decomposition is a simple zero-valued flat line with 0.002 s length, with its origin at the centre. However, the maximum number of iterations of decomposition does not have to be as large as to obtain a full reconstruction of the original signal, as long as it can extract the peaks of the waveform for measurement. In our study, we choose 0.008 s as the final structuring function. Therefore, there are three iterations of morphological transform, with structuring function length at 0.002, 0.004, 0.006, 0.008, respectively, and accordingly the output signal in either positive or negative segment is the sum of r 2 , r 3 , r4 and r 5 . Simple criteria can be employed to quantify the asymmetry in a signal, as follows: