《医学免疫学》白细胞分化抗原 ppt课件

髓样细胞 血小板
CD14、CD35（CR1）、CD64（FcγRⅠ） CD36、CD41CD42a−CD42d、CD51、CD61、CD62P（P 选择素）
NK 细胞 非谱系 黏附分子
CD16（FcγRⅢ）、CD56（NCAM-1）、CD94、CD158（KIR）、CD161（NKR-P1A）
CD30、CD32（FcγRⅡ）、CD45RA、CD45RO、CD46（MCP）、CD55（DAF）、CD59
3. Clinical application of CD and adhesion molecule as well as their monoclonal antቤተ መጻሕፍቲ ባይዱbody
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Cell Surface Molecules and HLDA
• Surface Molecules of Immune cells Receptors: TCR, BCR, PRR, CKR, CR MHC: MHCⅠⅡ Co-stimulatory Molecules: CD28 Adhesion Molecules: integrin,selectin
• HCDM（Human cell differentiation molecules）
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Rules for assigning a CD number
• at least one Workshop—characterised antibody and good molecular data
membrane with GPI conjunction
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Classification of LDA
• Immunoglobulin superfamily • Cytokine receptor family • Type C lectin superfamily • Integrin family • TNF superfamily • TNF receptor superfamily
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LDA
• Expressed on leukocyte, erythrocyte and megakaryocytes or thrombocytes
• Other non-hematopoietic cells • Trans-membrane protein or
glycoprotein • Some are anchored on plasma
红细胞
CD233−CD242
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一、CD molecules of T lymphocytes
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1，CD3(p98)
• Consists of 5 proteins that are designated as , , , and .
• Three dimers: , , ()
• The cytoplasmic domain contains ITAM (immunoreceptor tyrosine-based activation motif) YxxL/V
Chapter VII
Leukocyte differentiation antigen and
Adhesion molecule
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When T cell meets DC or B cell ………
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1. LDA，CD，CAM
2. Functional molecule and human leukocyte differentiation antigen on immunocyte surface
• the antibody is available.
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分组
T 细胞 B 细胞
CD分子（举例） CD2、CD3、CD4、CD5、CD8、CD28、CD152（CTLA−4）、CD154（CD40L） CD19、CD20、CD21、CD40、CD79a（Igα）、CD79b（Igβ）、CD80（B7-1）、CD86（B7-2）
CD11a−CD11c、CD15、CD15s（sLex）、CD18（整合素β2）、CD29（整合素β1）、CD49a−CD49f、 CD54（ICAM-1）、CD62E（E 选择素）、CD62L（L 选择素）
细胞因子/趋化 CD25（IL-2Rα）、CD95（Fas）、CD116−CDw137、CD178（FasL）、CD183 性细胞因子受体 （CXCR3）、CD184（CXCR4）、CD195（CCR5）
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Cell Surface Molecules
• Leukocyte differentiation antigen(LDA) :The cell surface markers which express or disappear on the different leukocytes in the different stage of differentiation and activation.
内皮细胞
CD105（TGF-βRⅢ）、CD106（VCAM-1）、CD140（PDGFR）、CD144（VE 钙黏素）
碳水化合物结构 CD15u、CD60a−CD60c、CD75
树突状细胞
CD83， CD80， CD86，CD85（ILT/LIR）
干细胞/祖细胞 CD133、CD243
造血干细胞
CD34，CD117
• the antigen is expressed on the surface of cells involved in immune reactions
• the antibodies react with primary cells (not just transfectants or recombinant protein)
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Cell Surface Molecules
• CD (cluster of differentiation) : Cell surface molecules of leucocytes that are distinguishable with monoclonal antibodies as an immunologic marker.