MK-5172 sodium salt_1425038-27-2_DataSheet_MedChemExpress
HANKS' BALANCED SALTS [HBSS] 产品说明书
![HANKS' BALANCED SALTS [HBSS] 产品说明书](https://img.taocdn.com/s3/m/181984b63086bceb19e8b8f67c1cfad6185fe96d.png)
HANKS' BALANCED SALTS [HBSS]Without calcium chloride, magnesium sulfate and sodium bicarbonate Product Number H2387Product DescriptionAlthough there have been many modifications to the original formulas in efforts to produce fully defined media, salt solutions still play an important role in tissue culture. A salt solution's basic function, to maintain the pH and osmotic balance in the medium and to provide the cells with water and essentialinorganic ions, is as valuable today as when it was first developed a century ago.Componentsg/L Potassium Chloride0.4Potassium Phosphate Monobasic 0.06(anhydrous)Sodium Chloride8.0Sodium Phosphate Dibasic(anhydrous)0.04788D -Glucose1.0Phenol Red•Na0.011Precautions and Disclaimer REAGENTFor R&D use only. Not for drug, household or other uses.Preparation InstructionsPowdered salts are hygroscopic and should beprotected from moisture. The entire contents of each package should be used immediately after opening. Preparing a concentrated salt solution is notrecommended as precipitates may form. Supplements can be added prior to filtration or introduced aseptically to sterile salt solution.1.Measure out 90% of final required volume ofwater. Water temperature should be 15-20 ˚C.2.While gently stirring the water, add the powderedmedium. Stir until dissolved. Do NOT heat. 3.Rinse original package with a small amount ofwater to remove all traces of powder. Add to solution in step 2.4.To the solution in step 3, add 0.35 g sodiumbicarbonate or 4.7 ml of sodium bicarbonatesolution [7.5%w/v] for each liter of final volume of medium being prepared. Stir until dissolved.5.While stirring, adjust the pH of the medium to 0.1-0.3 pH units below the desired pH since it may rise during filtration. The use of 1N HCl or 1N NaOH is recommended.6.Add additional water to bring the solution to finalvolume.7.Sterilize immediately by filtration using amembrane with a porosity of 0.22 microns.8.Aseptically dispense medium into sterile container. Storage and StabilityStore the dry powdered salts at 2-8 °C under dry conditions and liquid medium at 2-8 °C in the dark. Deterioration of the powdered medium may be recognized by any or all of the following: [1] color change, [2] granulation/clumping, [3] insolubility.Deterioration of the liquid medium may be recognized by any or all of the following: [1] pH change, [2] precipitate or particulates, [3] cloudy appearance [4] color change. The nature of supplements added may affect storage conditions and shelf life of the medium. Product label bears expiration date.ProcedureMaterials Required but Not Provided:Water for tissue culture [W3500]Sodium Bicarbonate [S5761] orSodium Bicarbonate Solution, 7.5% [S8761]1N Hydrochloric Acid [H9892]1N Sodium Hydroxide [S2770]Medium additives as requiredReference1.Hanks, J. (1976) Hanks' Balanced SaltSolution and pH Control. Tissue Culture Association Manual. 3, 3.Revised: March 2007Sigma-Aldrich, I nc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see reverse side of the invoice or packing slip.。
硫酸钠结晶盐干燥优化
煤炭与化工Coal and Chemical Industry第44卷第4期2021年4月Vol 44 No.4Apr. 2021化工工艺与工程硫酸钠结晶盐干燥优化郭瑞亚（河北工大晟珂工程科技有限公司，河北 石家庄050000）摘要：某煤化工浓盐水资源化利用装置中硫酸钠结晶盐干燥单元在干燥过程中易出现产品盐质量不合格，工人工作量大，操作环境粉尘大，袋式除尘器进口管道易堵塞，频繁进行设 备清洗检修以及零部件的更换，部分检修空间环境差，装置无法长周期安全稳定运行。
针对 上述存在的问题进行了工艺流程及设备的优化改造。
改造后，取得了较好的环保效益和社会 效益，降低了整个浓盐水资源化利用装置的运行成本，提高了装置单元运行的回收率。
关键词：硫酸钠；干燥；双桨叶；脉冲除尘器；优化中图分类号：X781 文献标识码：B 文章编号：2095-5979 （ 2021） 04-0124-03Optimized drying of sodium sulfate crystalline saltGuo Ruiya(Hebei Gongda Shengke Engineering Technology Corporation Ltd.,Shijiazhuang 050000, China )Abstract : The sodium sulfate crystal salt drying unit in a coal chemical industry's concentrated brine resource utilizationdevice is prone to product salt failure during the drying process, the workload of workers is large, the surrounding working environment is dusty and the operating environment is poor, and the inlet pipe of the bag filter is easy to block , Equipmentcleaning and parts replacement are frequent, maintenance is frequent, part of the maintenance space environment is poor, and the device cannot operate safely and stably for a long period of time.In view of the above-mentioned problems, the process flow and equipment of the sodium sulfate crystal salt drying unit in the concentrated brine resource utilizationdevice were optimized and modified.After the renovation, good environmental and social benefits have been achieved. The operating cost of the entire concentrated brine resource utilization device is reduced, and the recovery rate of the device unit operation is improved.Key words : sodium sulfate; drying; Double blade; Pulse dust collector; optimization0引 言鉴于近年来国家能源局、环境保护部等相关部门相继出台一系列针对现代煤化工企业的环境管理政策，煤化工企业需要坚持走高效、节能、环保 和可持续发展的道路，企业才能得以生存发展。
磷钨酸负染色液(2%,pH7.0)
版本：A4 修改日期：2023.12.18 磷钨酸负染色液(2%,pH7.0)产品简介：负染色又称阴性染色，是由Hall 发现的相对于普通染色(即正染色)而言的染色技术，其原理在于利用重金属盐包绕低电子密度的样品，增强样本四周的电子密度，造成细微结构之间的＂质量－厚度”差异，增强散射吸收反差，使样品在黑暗的背景上呈现明亮的结构，负染色液有磷钨酸、钼酸铵、印度墨汁等，其中最常用的是1～3%磷钨酸。
Leagene 磷钨酸负染色液(2%,pH7.0)适用于显示大分子、细菌、病毒、原生动物、噬菌体、细胞器、核酸大分子、蛋白质晶体及其他大分子材料等，染色后的样品图像呈现透明的亮光，而背景图像呈黑色。
该试剂仅用于科研领域，不适用于临床诊断或其他用途。
产品组成：自备材料：1、 离心机2、 载网3、 显微镜操作步骤(仅供参考)：(一)滴染法1、样品低速离心(2000g ，10min)或采用其他方法浓缩样品，制成悬浮液并且使其达到一定浓度和纯度。
2、将样品悬浮液直接滴于带有支持膜的载网上。
3、用滤纸条从液滴边缘吸去多余液体，稍干燥。
4、 滴加负染色液。
5、吸去多余染色液，自然干燥，进行显微镜观察。
(二)漂浮法1、样品低速离心(2000g ，10min)或采用其他方法浓缩样品，制成悬浮液并且使其达到一定浓度和纯度。
2、将带有支持膜的载网置于样品液滴上漂浮以沾取样品。
编号 名称 DZ0035 Storage 磷钨酸负染色液(2%,pH7.0) 100ml RT 避光 使用说明书 1份3、载网置于负染色液上漂浮1～2min。
4、吸去多余染色液，自然干燥，进行显微镜观察。
染色结果：样品透明的亮光背景黑色注意事项：1、目的样本尽量新鲜。
2、样品应为均匀的悬浮液，其纯度和浓度应适宜，否则无法与染色剂之间产生特异和清晰的结合反应。
3、为了您的安全和健康，请穿实验服并戴一次性手套操作。
4、试剂开封后请尽快使用，以防影响后续实验效果。
甲亚胺-甲亚胺H酸分子式结构式CAS编号
PJ-JYA检测硼含量指示剂分析纯甲亚胺 H-酸甲亚胺甲亚胺-H朋检科技选用了避光性更好的黑色瓶子，让产品存放起来更安全；同时外套食品级铝箔包装袋，与人接触无害，避免了无关人员直接接触化学试剂的担忧。
产品名称：甲亚胺-H(甲亚胺，H-酸甲亚胺)型号：PJ-JYA 品牌：朋检分子式：C17H12NNaO8S2性状：橙黄到橙红色粉末。
容重：0.15-0.2g/cm3。
用途：甲亚胺-H酸，已被广泛用作分析硼的显色剂，适用于土壤、肥料、植株、水体中硼（B）含量的测定。
检测原理：振荡提取后，取用EDTA掩蔽铁、铝、铜等干扰离子。
当PH为5时，试样溶液中的PENG酸根离子与甲亚胺—H酸生成黄色配合物，在波长415nm出测定其吸光度。
包装：每瓶10g包装，可定制5g小包装，1kg或2kg大包装等。
发货期：款到当天发货批发价：详谈我们所采用的H-酸甲亚胺的合成工艺先进，合成纯度高，可满足硼等微量元素的分析要求。
目前国内专业的甲亚胺销售批发商。
每瓶10g包装。
欢迎咨询选购，量大从优！别名：甲亚胺；甲亚胺-H；H-酸甲亚胺；甲亚胺-H水合物；偶氮甲碱H；水合偶氮次甲基—H；8-羟基-1-(亚水杨基氨基)萘-3,6-二磺酸单钠盐英文名：Azomethine-H；Azomethine-H hydrate；8-Hydroxy-1-(salicylideneamino)naphthalene-3,6-disulfonic Acid Mono sodium SaltCAS编号：32266-60-7分子式：C17H12NNaO8S2分子量：445.39结构式：纯度：不低于96.5%（以干品计）。
用途：与硼酸根离子络合形成稳定的黄色物质，颜色深浅与硼酸根浓度符合郎伯比尔定律。
用于土壤、食品、自来水、冶金等领域微量、痕量硼的测定。
线性：硼酸根标准系列显色的回归系数可达到99.9%以上。
含量标准：甲亚胺-H (Azomethine-H)铁(Fe)…………………≤0.03%分子式：………C17H12NNaO8S2硫酸盐(SO4)…………≤0.01%分子量：……………445.39金属属Pb)……………………≤0.003%干重失重：………………≤ 5%氰化物(CN)…………无反应性状：橙黄到橙红色粉末硼(HBO2)……………检不出。
水溶液臭味除妥氧化物灌洗用品安全数据表说明书
SAFETY DATA SHEET 1. IdentificationProduct identifier: Water Based Malodor Air Freshener & DeodorizerOther means of identificationSDS number: RE1000037011Recommended restrictionsProduct Use: Air FreshenerRestrictions on use:Not known.Manufacturer/Importer/Distributor InformationManufacturerCompany Name: CLAIRE MANUFACTURING COMPANYAddress: 1000 Integram DrPacific, MO 63069Telephone: 1-630-543-7600Fax:Emergency telephone number: 1-866-836-88552. Hazard(s) identificationHazard ClassificationPhysical HazardsFlammable aerosol Category 1Label ElementsHazard Symbol:Signal Word:DangerHazard Statement: Extremely flammable aerosol.PrecautionaryStatementssources. No smoking. Do not spray on an open flame or other ignitionsource. Do not pierce or burn, even after use.Storage: Protect from sunlight. Do not expose to temperatures exceeding50°C/122°F.Hazard(s) not otherwiseNone.classified (HNOC):3. Composition/information on ingredientsMixturesChemical Identity CAS number Content in percent (%)*2-Propanol67-63-0 1 - <5%Nitrogen7727-37-9 0 - <0.1%4. First-aid measuresIngestion:Rinse mouth thoroughly.Inhalation: Move to fresh air.Skin Contact:Remove contaminated clothing and wash the skin thoroughly with soap andwater after work.Eye contact:Rinse immediately with plenty of water.Most important symptoms/effects, acute and delayedSymptoms: No data available.Hazards: No data available.Indication of immediate medical attention and special treatment neededTreatment:No data available.5. Fire-fighting measuresGeneral Fire Hazards: Use water spray to keep fire-exposed containers cool. Fight fire from aprotected location. Move containers from fire area if you can do so withoutrisk.Suitable (and unsuitable) extinguishing mediaSuitable extinguishingmedia:Use fire-extinguishing media appropriate for surrounding materials.Unsuitable extinguishingmedia:Do not use water jet as an extinguisher, as this will spread the fire.Specific hazards arising from the chemical:Vapors may travel considerable distance to a source of ignition and flash back.Special protective equipment and precautions for firefighters Special fire fightingprocedures:No data available.Special protective equipment for fire-fighters: Firefighters must use standard protective equipment including flame retardant coat, helmet with face shield, gloves, rubber boots, and in enclosed spaces, SCBA.6. Accidental release measuresPersonal precautions,protective equipment and emergency procedures: Ventilate closed spaces before entering them. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Keep upwind.Methods and material for containment and cleaning up: Stop the flow of material, if this is without risk. Absorb with sand or other inert absorbent.Notification Procedures:ELIMINATE all ignition sources (no smoking, flares, sparks or flames inimmediate area). Stop leak if you can do so without risk.Environmental Precautions: Avoid release to the environment. Prevent further leakage or spillage if safeto do so. Do not contaminate water sources or sewer. Environmentalmanager must be informed of all major spillages.7. Handling and storagePrecautions for safe handling: Keep away from heat, hot surfaces, sparks, open flames and other ignitionsources. No smoking. Do not spray on an open flame or other ignitionsource. Do not pierce or burn, even after use. Do not handle until all safetyprecautions have been read and understood. Obtain special instructionsbefore use. Use personal protective equipment as required.Conditions for safe storage, including anyincompatibilities: Pressurized container: protect from sunlight and do not expose to temperatures exceeding 50°C. Do not pierce or burn, even after use. Store locked up. Aerosol Level 18. Exposure controls/personal protectionOccupational Exposure LimitsChemical Identity Type Exposure Limit Values Source2-Propanol REL400 ppm980 mg/m3US. NIOSH: Pocket Guide to ChemicalHazards(2005)STEL400 ppm US. ACGIH Threshold Limit Values(2008)STEL500 ppm1,225 mg/m3US. OSHA Table Z-1-A (29 CFR 1910.1000)(1989)STEL500 ppm1,225 mg/m3US. Tennessee. OELs. Occupational ExposureLimits, Table Z1A(06 2008)TWA400 ppm980 mg/m3US. Tennessee. OELs. Occupational ExposureLimits, Table Z1A(06 2008)PEL400 ppm980 mg/m3US. OSHA Table Z-1 Limits for AirContaminants (29 CFR 1910.1000)(02 2006)TWA400 ppm980 mg/m3US. OSHA Table Z-1-A (29 CFR 1910.1000)(1989)STEL500 ppm1,225 mg/m3US. California Code of Regulations, Title 8,Section 5155. Airborne Contaminants(092006)AN ESL200 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)ST ESL2,000 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)STEL500 ppm1,225 mg/m3US. NIOSH: Pocket Guide to ChemicalHazards(2005)TWA200 ppm US. ACGIH Threshold Limit Values(2008)TWA PEL400 ppm980 mg/m3US. California Code of Regulations, Title 8,Section 5155. Airborne Contaminants(092006)AN ESL492 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)ST ESL4,920 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)1,2-Benzenedicarboxylic acid, 1,2-diethyl ester REL 5 mg/m3US. NIOSH: Pocket Guide to ChemicalHazards(2005)TWA 5 mg/m3US. ACGIH Threshold Limit Values(2008) TWA PEL 5 mg/m3US. California Code of Regulations, Title 8,Section 5155. Airborne Contaminants(092006)TWA 5 mg/m3US. OSHA Table Z-1-A (29 CFR 1910.1000)(1989)TWA 5 mg/m3US. Tennessee. OELs. Occupational ExposureLimits, Table Z1A(06 2008)ST ESL50 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL 5 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)Acetic acid, pentyl ester REL100 ppm525 mg/m3US. NIOSH: Pocket Guide to ChemicalHazards(2005)TWA50 ppm US. ACGIH Threshold Limit Values(2008)STEL100 ppm US. ACGIH Threshold Limit Values(2008)STEL100 ppm532 mg/m3US. California Code of Regulations, Title 8,Section 5155. Airborne Contaminants(092006)TWA PEL50 ppm266 mg/m3US. California Code of Regulations, Title 8,Section 5155. Airborne Contaminants(092006)TWA100 ppm525 mg/m3US. Tennessee. OELs. Occupational ExposureST ESL2,700 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)ST ESL500 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL50 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL270 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)PEL100 ppm525 mg/m3US. OSHA Table Z-1 Limits for AirContaminants (29 CFR 1910.1000)(02 2006)TWA100 ppm525 mg/m3US. OSHA Table Z-1-A (29 CFR 1910.1000)(1989)TWA20 ppm US. ACGIH Threshold Limit Values(2008) Bicyclo[3.1.1]hept-2-ene,2,6,6-trimethyl-ST ESL3,500 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)ST ESL630 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL63 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL350 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)TWA10 ppm US. ACGIH Threshold Limit Values(2008) Acetic acid, phenylmethylesterTWA PEL10 ppm61 mg/m3US. California Code of Regulations, Title 8,Section 5155. Airborne Contaminants(092006)ST ESL100 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL10 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)ST ESL610 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL61 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)STEL 2 ppm US. ACGIH Threshold Limit Values(03 2018) Benzene, 1,1'-oxybis- -Vapor.TWA 1 ppm US. ACGIH Threshold Limit Values(03 2018)PEL 1 ppm7 mg/m3US. OSHA Table Z-1 Limits for AirContaminants (29 CFR 1910.1000)(02 2006)TWA PEL 1 ppm7 mg/m3US. California Code of Regulations, Title 8,Section 5155. Airborne Contaminants(092006)REL 1 ppm7 mg/m3US. NIOSH: Pocket Guide to ChemicalHazards(2005)TWA 1 ppm7 mg/m3US. OSHA Table Z-1-A (29 CFR 1910.1000)(1989)Benzene, 1,1'-oxybis-ST ESL70 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL7 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)Benzene, 1,1'-oxybis- - TWA 1 ppm7 mg/m3US. Tennessee. OELs. Occupational ExposureBenzene, 1,1'-oxybis-ST ESL10 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL 1 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)TWA 5 ppm US. ACGIH Threshold Limit Values(01 2010) 2,6-Octadienal, 3,7-dimethyl-- Inhalable fraction andvapor.2,6-Octadienal, 3,7-dimethyl-ST ESL50 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)ST ESL310 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL31 µg/m3 US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)AN ESL 5 ppb US. Texas. Effects Screening Levels (TexasCommission on Environmental Quality)(112016)Biological Limit ValuesChemical Identity Exposure Limit Values Source40 mg/l (Urine)ACGIH BEL (03 2013)2-Propanol (acetone:Sampling time: End of shift atend of work week.)Appropriate EngineeringNo data available.ControlsIndividual protection measures, such as personal protective equipmentGeneral information:Use personal protective equipment as required. Personal protectionequipment should be chosen according to the CEN standards and indiscussion with the supplier of the personal protective equipment.Eye/face protection: Wear goggles/face shield.Skin ProtectionHand Protection:No data available.Other: No data available.Respiratory Protection:In case of inadequate ventilation use suitable respirator. Seek advice fromlocal supervisor.Hygiene measures:When using do not smoke. Observe good industrial hygiene practices. Donot handle until all safety precautions have been read and understood.Obtain special instructions before use.9. Physical and chemical propertiesAppearancePhysical state:liquidForm: Spray AerosolOdor: No data available.Odor threshold: No data available.pH: No data available.Melting point/freezing point: No data available.Initial boiling point and boiling range: Estimated 100 °CFlash Point: Estimated 12.2 °CEvaporation rate: No data available.Flammability (solid, gas): No data available.Upper/lower limit on flammability or explosive limitsFlammability limit - upper (%): No data available.Flammability limit - lower (%):No data available.Explosive limit - upper (%):No data available.Explosive limit - lower (%):No data available.Vapor pressure:7,584.233 - 8,963.1845 hPa (20 °C)Vapor density:No data available.Density: No data available.Relative density:No data available.Solubility(ies)Solubility in water:No data available.Solubility (other):No data available.Partition coefficient (n-octanol/water):No data available.Auto-ignition temperature:No data available.Decomposition temperature:No data available.Viscosity:No data available.10. Stability and reactivityReactivity: No data available.Chemical Stability: Material is stable under normal conditions. Possibility of hazardousNo data available.reactions:Conditions to avoid: Avoid heat or contamination.Incompatible Materials: No data available.Hazardous DecompositionNo data available.Products:11. Toxicological informationInformation on likely routes of exposureSkin Contact: No data available.Eye contact: No data available.Ingestion: No data available.Symptoms related to the physical, chemical and toxicological characteristics Inhalation: No data available.Skin Contact: No data available.Eye contact: No data available.Ingestion: No data available.Information on toxicological effectsAcute toxicity (list all possible routes of exposure)OralProduct: Not classified for acute toxicity based on available data.Specified substance(s):2-Propanol LD 50 (Rat):5.84 g/kgDermalProduct: Not classified for acute toxicity based on available data.Specified substance(s):2-Propanol LD 50:> 2,000 mg/kgInhalationProduct: Not classified for acute toxicity based on available data.Specified substance(s):2-Propanol LC 50:> 5 mg/lLC 50:> 20 mg/lRepeated dose toxicityProduct: No data available.Specified substance(s):2-Propanol NOAEL (Rat, Inhalation, >= 104 Weeks): 5,000 ppm(m) InhalationExperimental result, Key studySkin Corrosion/IrritationProduct: No data available.Specified substance(s):2-Propanol in vivo (Rabbit): Not Classified Experimental result, Key study Serious Eye Damage/Eye IrritationProduct: No data available.Specified substance(s):2-Propanol Rabbit, 1 d: Irritating.Respiratory or Skin SensitizationProduct: No data available.Specified substance(s):2-Propanol Skin sensitization:, in vivo (Guinea pig): Non sensitising CarcinogenicityProduct: No data available.IARC Monographs on the Evaluation of Carcinogenic Risks to Humans:No carcinogenic components identifiedUS. National Toxicology Program (NTP) Report on Carcinogens:No carcinogenic components identifiedUS. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050):No carcinogenic components identifiedGerm Cell MutagenicityIn vitroProduct: No data available.In vivoProduct: No data available.Reproductive toxicityProduct: No data available.Specific Target Organ Toxicity - Single ExposureProduct: No data available.Specific Target Organ Toxicity - Repeated ExposureProduct: No data available.Aspiration HazardProduct: No data available.Other effects: No data available.12. Ecological informationEcotoxicity:Acute hazards to the aquatic environment:FishProduct: No data available.Specified substance(s):2-Propanol LC 50 (Pimephales promelas, 96 h): 9,640 mg/l Experimental result, KeystudyAquatic InvertebratesProduct: No data available.Specified substance(s):2-Propanol LC 50 (Daphnia magna, 24 h): > 10,000 mg/l Experimental result, Key study Chronic hazards to the aquatic environment:FishProduct: No data available.Aquatic InvertebratesProduct: No data available.Toxicity to Aquatic PlantsProduct: No data available.Persistence and DegradabilityBiodegradationProduct: No data available.Specified substance(s):2-Propanol53 % (5 d) Detected in water. Experimental result, Key study BOD/COD RatioProduct: No data available.Bioaccumulative potentialBioconcentration Factor (BCF)Product: No data available.Partition Coefficient n-octanol / water (log Kow)Product: No data available.Mobility in soil: No data available.Known or predicted distribution to environmental compartments2-Propanol No data available.Nitrogen No data available.Other adverse effects: No data available.13. Disposal considerationsDisposal instructions: Discharge, treatment, or disposal may be subject to national, state, or locallaws.Contaminated Packaging: No data available.14. Transport informationDOTUN Number: UN 1950UN Proper Shipping Name: Aerosols, flammableTransport Hazard Class(es)Class: 2.1Label(s): –Packing Group: IIMarine Pollutant: NoEnvironmental Hazards: NoMarine Pollutant NoSpecial precautions for user: Not regulated.IMDGUN Number: UN 1950UN Proper Shipping Name: Aerosols, flammableTransport Hazard Class(es)Class: 2Label(s): –EmS No.:Packing Group: –Environmental Hazards: NoMarine Pollutant NoSpecial precautions for user: Not regulated.IATAUN Number: UN 1950Proper Shipping Name: Aerosols, flammableTransport Hazard Class(es):Class: 2.1Label(s): –Packing Group: –Environmental Hazards: NoMarine Pollutant NoSpecial precautions for user: Not regulated.15. Regulatory informationUS Federal RegulationsTSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D)US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050) None present or none present in regulated quantities.CERCLA Hazardous Substance List (40 CFR 302.4):Chemical Identity Reportable quantity2-Propanol lbs. 100lbs. 10001,2-Benzenedicarboxylicacid, 1,2-diethyl esterAcetic acid, pentyl ester lbs. 5000lbs. 100Bicyclo[3.1.1]hept-2-ene,2,6,6-trimethyl-Superfund Amendments and Reauthorization Act of 1986 (SARA) Hazard categoriesFire HazardFlammable aerosolSARA 302 Extremely Hazardous SubstanceNone present or none present in regulated quantities.SARA 304 Emergency Release NotificationChemical Identity Reportable quantity2-Propanol lbs. 100lbs. 10001,2-Benzenedicarboxylicacid, 1,2-diethyl esterAcetic acid, pentyl ester lbs. 5000lbs. 100Bicyclo[3.1.1]hept-2-ene,2,6,6-trimethyl-SARA 311/312 Hazardous ChemicalChemical Identity Threshold Planning Quantity 2-Propanol10000lbs1,2-Benzenedicarboxylicacid, 1,2-diethyl ester10000lbsAcetic acid, pentyl ester10000lbsBicyclo[3.1.1]hept-2-ene,2,6,6-trimethyl-10000lbsAcetic acid, phenylmethylester10000lbsBenzene, 1,1'-oxybis-10000lbs2,6-Octadienal, 3,7-dimethyl-10000lbsNitrogen10000lbsSARA 313 (TRI Reporting)Chemical Identity Reportingthreshold forother usersReporting threshold formanufacturing andprocessing2-Propanol lbs lbs.Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130):Clean Water Act Section 311 Hazardous Substances (40 CFR 117.3)US State RegulationsUS. California Proposition 65This product contains chemical(s) known to the State of California to cause cancer and/or to cause birth defects or other reproductive harm.Methanone, diphenyl-Carcinogenic. 07 2012US. New Jersey Worker and Community Right-to-Know ActChemical Identity2-PropanolUS. Massachusetts RTK - Substance ListNo ingredient regulated by MA Right-to-Know Law present.US. Pennsylvania RTK - Hazardous SubstancesChemical Identity2-PropanolUS. Rhode Island RTKNo ingredient regulated by RI Right-to-Know Law present.International regulationsMontreal protocolNot applicableStockholm conventionNot applicableRotterdam conventionNot applicableKyoto protocolNot applicableInventory Status:Australia AICS: Not in compliance with the inventory.EINECS, ELINCS or NLP: Not in compliance with the inventory.Japan (ENCS) List: Not in compliance with the inventory.China Inv. Existing Chemical Substances: Not in compliance with the inventory.Korea Existing Chemicals Inv. (KECI): Not in compliance with the inventory.Canada NDSL Inventory: Not in compliance with the inventory.Philippines PICCS: Not in compliance with the inventory.New Zealand Inventory of Chemicals: Not in compliance with the inventory.Japan ISHL Listing: Not in compliance with the inventory.Japan Pharmacopoeia Listing: Not in compliance with the inventory.Mexico INSQ: Not in compliance with the inventory.Ontario Inventory: Not in compliance with the inventory.Taiwan Chemical Substance Inventory: Not in compliance with the inventory.Canada DSL Inventory List: On or in compliance with the inventory US TSCA Inventory: On or in compliance with the inventory 16.Other information, including date of preparation or last revisionIssue Date: 07/31/2019Revision Information:No data available.Version #: 1.0Further Information: No data available.Disclaimer: This information is provided without warranty. The information is believed tobe correct. This information should be used to make an independentdetermination of the methods to safeguard workers and the environment.。
凯氏定氮用的氢氧化钠标准溶液
凯氏定氮用的氢氧化钠标准溶液下载温馨提示：该文档是我店铺精心编制而成，希望大家下载以后，能够帮助大家解决实际的问题。
文档下载后可定制随意修改，请根据实际需要进行相应的调整和使用，谢谢!并且，本店铺为大家提供各种各样类型的实用资料，如教育随笔、日记赏析、句子摘抄、古诗大全、经典美文、话题作文、工作总结、词语解析、文案摘录、其他资料等等，如想了解不同资料格式和写法，敬请关注!Download tips: This document is carefully compiled by the editor. I hope that after you download them, they can help you solve practical problems. The document can be customized and modified after downloading, please adjust and use it according to actual needs, thank you!In addition, our shop provides you with various types of practical materials, such as educational essays, diary appreciation, sentence excerpts, ancient poems, classic articles, topic composition, work summary, word parsing, copy excerpts, other materials and so on, want to know different data formats and writing methods, please pay attention!凯氏定氮用的氢氧化钠标准溶液---引言在化学分析中，凯氏定氮法是一种常用的测定样品中氮含量的方法。
钼酸钠安全技术说明书
钼酸钠安全技术说明书中文名:钼酸钠英文名:Sodium molybdat分子式:NaMoO?2HO 分子量:241.95 242结构式:CAS号:7631-95-0 RTECS号:QA5085000 HS编码:28417090 UN编码: 危险货物编号: IMDG规则页码: 外观与性状:白色或略有色泽的结晶性粉末。
主要用途:用于制造生物碱、油墨、化肥、钼红颜料和耐晒颜料的沉淀剂、催化剂、钼盐，也可用于制造阻燃剂和无公害型冷水系统的金属抑制剂，还用作镀锌、磨光剂及化学试剂。
熔点:687 沸点: 相对密度:3(28饱和蒸汽压(Kpa): 溶解性:溶于水临界温度(?): 临界压力(1lpa): 燃烧热(kj,t001):避免接触的条件:燃烧性: 监规火险分级: 闪电(?): 自燃温度(?): 爆炸下限(v,): 爆炸上限(V%): 危险特征:燃烧(分解)产物: 稳定性:稳定禁忌物: 聚合危害: 灭火方法:不燃。
火场周围可用灭火介质。
危险性类别: 危险货品包装标志: 包装类别:储运注意事项:储存于阴凉、通风仓间内。
保持容器密封。
防止受潮和雨淋。
专人保管。
应与氧化剂、酸类、食用化工原料分开存放。
不能与粮食、食物、种子、饲料、各种日用品混装、混运。
操作现场不得吸烟、饮水、进食。
搬运时要装轻卸，防止包装及容器损坏。
分装和搬运作业要注意个人防护。
接触限值:中国MAC:4mg/m3前苏联MAC:4mg/m3美国TLV-TWA:5mg(mo)/m3美国TLV-STEL:未制定标准侵入途径:吸入食入毒性LD50(mg,kg):大鼠经口290健康危害:钼酸盐毒性较低皮肤接触:用肥皂水或清水彻底冲洗。
眼睛接触:拉开眼睑，用流动清水冲洗15分钟。
吸入:饮适量温水，催吐。
就医。
食入:误服者，饮适量温水，催吐。
就医。
工程控制:提供充分的局部排风。
呼吸系统防护:作业工人佩戴规定的口罩。
眼睛防护:防护服:穿相应的工作服手防护:戴皮手套其他:工作现场禁止吸烟，进食和饮水。
Sodium Azide说明书
Section 1- Product InformationProduct Name Sodium AzideSection 2-Composition / information on ingredientsSubstance/Preparation: SubstanceIngredient Name Sodium AzideCAS No. 26628-22-8EC Number RC0520EU Symbol T+,NR-Phrases R28,R32Note: See section 8 for occupational exposure limits and section 11 for LC50/LD50 informationSection 3- Hazards IdentificationPrimary hazards and critical effects Danger!May be fatal if absorbed through skin or if swallowed.May cause damage to the following organs: liver, brain, digestive system, centralnervous system, head.May be harmful to environment if released in large amounts.Do not get in eyes, on skin or on clothing. Do not ingest. Wash thoroughly afterhandling.Avoid contact of spilled material and runoff with soil and surface waterways. Physical/chemical hazards Not applicable.Human health hazards Very toxic if swallowed.Contact with acids liberates very toxic gas.Environmental hazards Very toxic to aquatic organisms. May cause long-term adverse effects in the aquaticenvironment.Section 4- First Aid MeasuresInhalation Ingestion If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention immediately.Skin Contact In case of contact, immediately flush skin with plenty of water.Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughlyclean shoes before reuse. Get medical attention.Eye Contact In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention.Notes to Medical Doctor Not available.Section 5- Fire Fighting MeasuresExtinguishing Media Use foam or all purpose dry chemicals to extinguish. This material is very toxic toaquatic organisms.Fire water contaminated with this material must be contained and prevented frombeing discharged to any waterway, sewer or drain.Fire-Fighting Procedures Fire fighters should wear positive pressure self-contained breathing apparatus(SCBA) and full turnout gear.Fire/Explosion Hazards Not applicableHazardous Decomposition Products These products are nitrogen oxides (NO, NO2...). Some metallic oxides.Section 6- Accidental Release MeasuresPersonal precautions Immediately contact emergency personnel. Keep unnecessary personnel away. Usesuitable protective equipment (Section 8).Follow all fire fighting procedures (Section 5).Environmental Precautions and Clean-up Methods If emergency personnel are unavailable vacuum or carefully scoop up spilled materials and place in an appropriate container for disposal.Avoid creating dusty conditions and prevent wind dispersal. Minimize contact of spilled material with soils to prevent runoff to surface waterways.Material Safety Data SheetDate Created 06/10/2010Date Updated 12/18/2012Email ******************Section 7- Handling and StorageHandlingDo not get in eyes, on skin or on clothing. Do not ingest. Wash thoroughly after handling. Avoid contact of spilled material and runoff with soil and surface waterways. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Packaging materials Use original container.Section 8- Exposure Controls/Personal Protection EquipmentOccupational Exposure Limits Not available Engineering controlsOpen handling is not permitted. All handling must be performed in a glove box or other totally enclosed system. Personal protective equipmentRespiratory SystemUse an approved, properly fitted, HEPA filter cartridge respirator, or a respirator of greater protection if there is the potential to exceed the exposure limit(s). Skin and bodyDisposable outer garments, or impervious garments of equal or greater protection. Hands Use chemical resistant, impervious gloves.Additional body garments should be used based upon the task being performed(e.g., sleevelets, apron, gauntlets, disposable suits) to avoid exposed skin surfaces.Appropriate techniques should be used to remove potentially contaminated clothing.EyesSafety glasses. Goggles, face shield, or other full-face protection if potential existsfor direct exposure to dust.Protective Clothing (Pictograms)Section 9- Physical and Chemical PropertiesFlash point Not availableSection 10- Stability and ReactivityStability The product is stable. Conditions and Materials to avoidReactive with metals, acids. Hazardous Decomposition Products Not availableSection 11- Toxicological InformationToxicity DataTest LD50 LD50 LD50 LD50 LDLo LDLo LDLo Result 27 mg/kg 27 mg/kg 23.7 mg/kg 20 mg/kg 129 mg/kg 143 mg/kg 29 mg/kg Route Oral Oral Oral Dermal Oral Oral Oral SpeciesRatMouseBirdsRabbitsHumanHumanHumanRoutes of Entry Absorbed through skin. Dermal contact. Eye contact. Inhalation.Ingestion.Acute toxicity Ingestion Very toxic if swallowed.Skin Contact Very toxic in contact with skin.Chronic toxicityAdverse Effects Adverse symptoms may include: nausea/vomiting headache blood pressure lowered nerve damagecentral nervous system depression liver abnormalities cerebral (brain) pathology.Target Organs May cause damage to the following organs: liver, brain, digestive system, central nervous system(CNS), head.Carcinogenic Effects Not availableMutagenic Effects Not availableDevelopmental and Teratogenic EffectsNot availableReproductive Effects Not availableOther Information Repeated exposure to a highly toxic material may produce general deterioration of health by anaccumulation in one or many human organs.Section 12- Ecological InformationEcotoxicity Data Species Not availableavailablePeriod NotavailableResult NotSection 13- Disposal ConsiderationsWaste Handling and Disposal Waste must be disposed of in accordance with federal, state and localenvironmental control regulations.Section 14- Transport InformationAirProper shipping name Not applicableUN/ID Number Not applicableIATA-DGR Class Not controlled under IATA.Packing Group Not applicableSection 15- Regulatory InformationEU RegulationsHazard Symbol(s) C; N; TRisk Phrases R28- Very toxic if swallowed. R32- Contact with acids liberates very toxic gas.R36/37/38- Irritating to eyes, respiratory system and skin. R50/53- Very toxic toaquatic organisms, may cause long-term adverse effects in the aquatic environment. Safety Phrases S26- In case of contact with eyes, rinse immediately with plenty of water and seekmedical advice. S28.1- After contact with skin, wash immediately with plenty ofwater. S36- Wear suitable protective clothing. S45- In case of accident or if you feelunwell, seek medical advice immediately (show the label where possible). S60- Thismaterial and its container must be disposed of as hazardous waste. S61- Avoidrelease to the environment.Refer to special instructions/Safety data sheets.U.S. Federal RegulationsHaz-Com Standard CLASS: Highly toxic.CLASS: Target organ effects.EPA TSCA 8(b) inventory: Sodium AzideTSCA 8(d) H and S data reporting: Sodium AzideSARA 313 toxic chemical notification and release reporting:Sodium Azide 50%available.State NotCanadian RegulationsWHMIS CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). CEPA No products were found.Provincial No products were found.Section 16- Other InformationGenScript corporation MSDS is believed to be correct but only used as a guide for experienced personnel, GenScript shall not be held liable for any damage resulting from the handling or from contact with the above product.。
物质安全技术说明书(MSDS)
一、化学物品与厂商资料中文名：重金属捕捉剂 英文名：分子式：R-NCSSNa相对分子量：10-15万CAS号：无供应商名称：广州市纳森化工有限公司地址/邮码：广州增城市荔城镇罗岗开发区红新路9号，511300。
应急联络电话：************二、主要组成及性状主要成分：接枝型二硫代氨基甲酸盐产品外观及性状：褐色粘稠液体。
主要用途：用于重金属废水处理。
三、危险性概述危险性类别：碱性，微弱腐蚀性侵入途径：吸入、食入。
健康危害：对皮肤和眼睛有微弱腐蚀作用。
燃爆危险：不燃。
四、急救措施皮肤接触：立即脱去被污染的衣着，用大量流动清水冲洗，至少15分钟。
就医。
眼睛接触：立即提起眼睑，用大量流动清水或生理盐水彻底冲洗至少15分钟。
就医。
吸入：迅速脱离现场至空气新鲜处。
保持呼吸道通畅。
如呼吸困难，给输氧。
如呼吸停止，立即进行人工呼吸。
就医。
食入：误服者用水漱口，给饮牛奶或蛋清。
就医。
五、消防措施危险特性：遇酸放出气体。
有害燃烧产物：硫化氢，氧化硫。
灭火方法及灭火剂：水、雾状水、砂土。
六、泄漏应急处理应急处理：隔离污染区，限制出入。
应急人员防护：建议应急人员戴自给式呼吸器，穿防酸碱工作服。
清除方法：小量泄露：收集于干燥、洁净、有盖的容器中。
或用大量水冲洗，洗水稀释后放入废水系统。
大量泄露：收集回收或运到废物处理场所处置。
七、操作处置与储存操作注意事项：分装和搬运作业要注意个人防护。
搬运时要轻装轻卸，防止碰撞、防止包装及容器损坏。
储存注意事项：储存于干燥清洁的仓库内。
远离火种、热源。
避免光照。
包装必须密封，切勿受潮。
应与氧化剂、酸类分开存放。
不宜久存，以免变质。
八、接触控制/个体防护工程控制：提供安全淋浴和洗眼设备。
呼吸系统防护：佩戴自吸过滤式口罩。
必要时，戴空气呼吸器。
眼睛防护：戴化学安全防护眼镜。
身体防护：穿橡胶耐酸碱服。
手防护：戴橡胶耐酸碱手套。
其他注意事项：工作现场禁止吸烟、进食和饮水。
工作毕，淋浴、更衣。
透明质酸 MSDS
Name:Sodium HyaluronateSynonym:Hyaluronic acid, sodium saltCAS:9067-32-7Section 1 - Chemical ProductMSDS Name: Sodium HyaluronateSynonym: Hyaluronic acid, sodium saltSection 2 - COMPOSITION, INFORMATION ON INGREDIENTSHazard Symbols: None Listed.Risk Phrases: None Listed.Section 3 - HAZARDS IDENTIFICATIONEMERGENCY OVERVIEWThe toxicological properties of this material have not been fully investigated. Potential Health EffectsEye:No information regarding eye irritation and other potential effects was found. Skin:No information regarding skin irritation and other potential effects was found. Ingestion:The toxicological properties of this substance have not been fully investigated.Inhalation:The toxicological properties of this substance have not been fully investigated. Inhalation of dust may cause respiratory tract irritation.Chronic:No information found.Section 4 - FIRST AID MEASURESEyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.Skin:Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.Ingestion:If victim is conscious and alert, give 2-4 cupfuls of milk or water.Never give anything by mouth to an unconscious person. Get medical aid immediately.Inhalation:Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.Notes to Physician:Section 5 - FIRE FIGHTING MEASURESGeneral Information:As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.Extinguishing Media:Use agent most appropriate to extinguish fire.Section 6 - ACCIDENTAL RELEASE MEASURESGeneral Information: Use proper personal protective equipment as indicated in Section 8.Spills/Leaks:Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGEHandling:Wash thoroughly after handling. Use only in a well-ventilated area.Avoid contact with skin and eyes. Avoid ingestion and inhalation.Storage:Store in a cool, dry place. Store in a tightly closed container.Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTIONEngineering Controls:Use adequate ventilation to keep airborne concentrations low.Exposure Limits CAS# 9067-32-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.Skin:Wear appropriate protective gloves to prevent skin exposure.Clothing:Wear appropriate protective clothing to prevent skin exposure.Respirators:Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if i rritation or other symptoms are experienced.Section 9 - PHYSICAL AND CHEMICAL PROPERTIESPhysical State: SolidColor: whiteOdor: Not available.pH: Not available.Vapor Pressure: Not available.Viscosity: Not available.Boiling Point: Not available.Freezing/Melting Point: Not available.Autoignition Temperature: Not available.Flash Point: Not available.Explosion Limits, lower: Not available.Explosion Limits, upper: Not available.Decomposition Temperature:Solubility in water: soluble in waterSpecific Gravity/Density:Molecular Formula:Molecular Weight:Section 10 - STABILITY AND REACTIVITYChemical Stability:Stable.Conditions to Avoid:Not available.Incompatibilities with Other Materials:Not available.Hazardous Decomposition Products:Carbon monoxide, carbon dioxide, sodium oxide.Hazardous Polymerization: Has not been reported.Section 11 - TOXICOLOGICAL INFORMATIONRTECS#:CAS# 9067-32-7: MT7250000 LD50/LC50:CAS# 9067-32-7: Oral, mouse: LD50 = >2400 mg/kg; Oral, rabbit: LD50 = >1 gm/kg; Oral, rat: LD50 = >800 mg/kg.Carcinogenicity:Sodium Hyaluronate - Not listed by ACGIH, IARC, or NTP.Other:See actual entry in RTECS for complete information.Section 12 - ECOLOGICAL INFORMATIONSection 13 - DISPOSAL CONSIDERATIONSDispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATIONIATANot regulated as a hazardous material.IMONot regulated as a hazardous material.RID/ADRNot regulated as a hazardous material.Section 15 - REGULATORY INFORMATIONEuropean/International RegulationsEuropean Labeling in Accordance with EC DirectivesHazard Symbols: Not available.Risk Phrases:Safety Phrases:S 24/25 Avoid contact with skin and eyes.WGK (Water Danger/Protection)CAS# 9067-32-7: No information available.CanadaCAS# 9067-32-7 is listed on Canada's DSL List.CAS# 9067-32-7 is not listed on Canada's Ingredient Disclosure List. US FEDERALTSCACAS# 9067-32-7 is not listed on the TSCA inventory.It is for research and development use only.SECTION 16-OTHERRevision Date: Apr 30,2009Previous Date: Apr 30,2005。
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
Product Name:
MK-5172 sodium salt CAS No.:
1425038-27-2Cat. No.:
HY-15298C
Product Data Sheet
MWt:
789.89Formula:
C38H50N6NaO9S+Purity :>98%
Solubility:
DMSO
Mechanisms:Biological Activity:
MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in
Pathways:Anti-infection; Target:HCV
Pathways:Metabolism/Protease; Target:HCV NS3/4A Protease q y p y
clinical development. IC50 Value: 7.4 nM and 7 nM for genotype 1b and 1a respectively, in replicon system [1]
Target: HCV NS3/4a protease in vitro: In biochemical assays, MK-5172 was effective against a panel of major genotypes and
variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar
EC50s against genotypes 1a, 1b, and 2a [2].in vivo: In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr.Wh d d t 5/k th l f MK 5172d ith AUC f 07M h References:
[1]. Steven Harper , John A. McCauley , Michael T. Discovery of MK-5172, a Macrocyclic Hepatitis
C Virus NS3/4a Protease Inhibitor. ACS Med. Chem. Lett., 2012, 3 (4), pp 332-336[2]Summa V Ludmerer SW McCauley JA MK-5172a selective inhibitor of hepatitis C virus When dosed p.o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 uM.hr.The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p.o. ...
[2]. Summa V, Ludmerer SW, McCauley JA, MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents
Chemother. 2012 Aug;56(8):4161-7.Caution: Not fully tested. For research purposes only
Medchemexpress LLC
18W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A
E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。