诺唯赞r323说明书
LF315 LF320 - LF320A LF323 - LF323A LF350 使用手册说明书
Manuale di istruzione perlavastovigliepourd’utilisation pour NoticeNotice d’utilisationlave-vaissellefür Gebrauchsanweisung fürGebrauchsanweisungGeschirrspülerforInstructionmanual forInstruction manualdishwashers Manual de instrucciones paralavavajillasLF315LF320 - LF320ALF323 - LF323ALF350FOREWORD1. Read the instructions contained in the enclosed booklet carefully, because it contains important information on installation, operation and maintenance safety. Store this booklet carefully for any further consultation by other operators.2. Having removed the packing material, check that all the equipment is present.If there is any doubt, do not use it and contact qualified personnel.The packing elements (plastic bags, foam polystyrene, nails, etc.) should be kept away from children, because they are dangerous.3. Before switching the equipment on, make sure that the model plate data conforms to that of the electrical and water distribution network.4. Installation should be carried out by qualified personnel according to the manufacturer's instructions.5. This equipment should be destined to the use which it has been conceived for. Any other application should be considered improper and consequently dangerous.6. The equipment should only be used by personnel trained for its use.7. Operators must strictly follow all hygienic requirements in the handling of clean dishware and cutlery.8. Do not leave the machine in an environment at temperatures lower than 0°C.9. The protection of the machine is IP X4, therefore it should not be washed with high pressure directed water jets.10. Q ualified personnel only can access the control panel, after having disconnected the machine from the primary current supply.11. T he appliance is made according to EEC 89/336 regarding radio noise suppression and electromagnetic compatibility.12. A ccording to EEC directive nr.23 of 19/02/1973 and the law of actuation nr.791 of 18/10/1987, our appliances are built-up according to the good technique norms in force in Italy and abroad.13. N oise level of the machine, less than 63dB(A)INSTRUCTIONS FOR USEOPERATION AND USE1)Before washing make sure that:• the wall-mounted on/off switch is switched on;• the water tap is open;• water is present in the distribution network;• the pump protection filters are installed in their respective positions;• the overflow in inserted;• all rotating parts are free;• the rinse aid dispenser is full;• make sure that dishware is in good conditions as it may cause cleaning difficulty and haven bacteria.2)Set switch “A1” to position 1 to enable the automatic wash tank filling and the consequent triggering of the heating element. The lamp “B1” is on.3)As soon as visual indicator “B2” is ON, pour about 30 gr. of detergent directly into the tank, paying attention to distribute it uniformly on the filters, the quantity being according to supplier's instructions. Add 15 gr. every 7 cycles to achieve a concentration of 1,5 gr./lt. In order to respect our environment, use only the correct amount of detergent.When using chlorinated detergent, it is suggested to use an automatic dispenser; otherwise, brownish spots might appear on the surfaces due to chlorine reactions. Detergent should always be placed near the pump filter.4)Then, introduce the glasses or the cups to wash, after having removed the solid waste and having placed them into the proper racks. The cups and the glasses should be turned upside down, while the cutlery should be put vertically into the proper container, and the same applies to dishware.5)By means of switch “A1” select the wash cycle according to conditions of the dishware (except LF315 models):• with particularly dirty dishes or deep dishes select the long cycle (pos.2)• with normally dirty dishes select the short cycle (pos.1)6)Close the door and press the “A2” button to start cycle, the end of which will be indicated by the switching off of the “B3” lamp.N.B.: Machine in conformity with the existing hygienic standards, guaranteeing a final rinse at 82°C. Wash cycle automatically lengthened if final rinse temperature is not reached.7)Remove the rack and slightly incline it to permit a perfect drain; allow dishware to dry and after having washed one’s hands, handle the rack in order not to touch the dishware inside then place the rack on hygienically clean shelves.8)At the end of washing, switch “A1” in position "0"; empty out the tank by taking out the overflow tube, then close the door and put the switch “A1” in position "1" for a few minutes to wash the machine. Then again put the switch “A1” in position "0" and wait until the tank is completely empty. Machines with drain pump, with switch “A1” in position "1" and the door open, simply push the “A5” button for the drain cycle and wait until the button is off. At this point, the tank filter can be taken out, in order to be washed, then replace it with the overflow in its place. For any further information concerning equipment cleaning, read chapter "USEFUL SUGGESTIONS".9)When the washing is finished, switch off the equipment by turning off the main supply through the general wall switch and close the water supply.INSTRUCTIONS DURING THE WASHING1)Do not plunge bare hands into the water containing the detergent. If this happens, wash them immediately and abundantly with fresh water.2)When the machine is operating, do not open the door too rapidly.3)Use only specific anti-foaming detergents.4)Disconnect the equipment in case the machine is out of order or it does not work properly. For the repairs consult a technical assistance centre authorised by the manufacturer and ask only for an original spare parts.5)Never modify the thermostat settings.6)Check that lamp “B2” is on.7)Wash tank water should be changed at least twice a day or according to daily wash requirements.8)Do not subject clean dishware to any further cleansing treatment such as brushes or drying towels.If these instructions are not followed, the safety of the equipment can be compromised.USEFUL SUGGESTIONS1) MAINTENANCEIMPORTANT: Before carrying out the cleaning and maintenance operations, disconnect the equipment from the electric supply.Frequently check and clean the nozzles. The frequency of this operation will depend on the quantity of residues, which may result in an unsatisfactory washing result.For the inside and outside cleaning of the machine, do not use corrosive products such as sodium hypochlorite (bleach) savelling water and hydrochloric acid, acids, steel wool or steel brushes.The presence of calcium and magnesium salt in the water can compromise machine performance, thus ask qualified personnel to remove the deposits periodically.In order to avoid some oxidation risks, or chemical reactions, generally the stainless steel surfaces have to be well cleaned.2) OPTIMAL RESULTS:A possible wash deficiency can be noticed when residue remains.Marks can be caused by an insufficient rinse: in this case checkthat the rinse nozzles are clean and that there is sufficient water supply pressure.In case of dishware residue check that:• the washing nozzles are clean• the water temperature is around 60°C• there is detergent• the pump suction filter is clean• the racks are suitable for the dishes and cutlery that are to be washed • the position of the cutlery and the dishes in the racks are correct3) TEMPORARY MACHINE NON-USEIn case the machine is stopped for some weeks, it is recommended before closing it to fill the tank and run the machine with clean water, then empty it out, in order to avoid the forming of bad odour and that any residue remains in the pump.If necessary repeat this operation until the water leaving the machine is clean. If the machine is stopped for many weeks, it is recommended to oil the stainless steel surfaces with paraffin oil and to discharge the water from the boiler and the electric pump.4)SANITIZING THE MACHINESanitizing the machine at least once a week is of the utmost importance in order to guarantee hygiene even when the machine is not in use.It is advisable to use a disinfecting product suggested by an authorised detergent dealer.The use of this product will satisfy hygienic requirements, even during machine non use.Before switching off the machine run the machine briefly with cleanwater.5)HARD WATER CONDITIONSIf a hard water supply is present, mineral deposits will form within the machine and also on dishware.In order to avoid the above conditions a periodic removal of these deposits is necessary.The frequency and method of this operation upon consultation by your detergent supplier.6)RESINS REGENERATION OF THE WATER SOFTENER (only for machines with built-in water softener)The resins regeneration of the water softener is completely automatic. The medium frequency of this operation is about every 40 baskets (referred to an initial hardness of 24° Clark). In any case, this value can change according to the water hardness; some opaque spots on the glasses will show that it is necessary to start the regeneration. This operation has to be carried out at the end of working day and with full tank.First of all, make sure that in the designated tank container “S” there is some coarse salt (1 Kg. is enough for about 5 regenerations). Set the switch “A1” to position "1", then push the button “A4” till the lamp “B4” is on.At this point the machine automatically performs all the necessary operations for about 20 minutes, during this operation the machine cannot be used. When the lamp is off, it means that the regeneration is finished. At this point, it is recommended to switch off the machine, to empty the tank and the equipment is ready to be used.CONTROL PANELSA1Main switch0Machine off1Short cycle2Long cycleA2Push button “CYCLE START”A4Push button “REGENERATION” (models LF320A and LF323A) A5Push button “DRAIN CYCLE” (if required)B1Pilot lamp “MACHINE ON"B2Pilot lamp “MACHINE READY"B3Pilot lamp “MACHINE WORKING"B4Pilot lamp “REGENERATION” (models LF320A and LF323A) B5Pilot lamp “DRAIN CYCLE” (if required)I Regulating screw for rinse aid injectorS Salt container (models LF320A and LF323A)S Plug (models LF320, LF323 and LF350)INSTALLATION AND MAINTENANCEINSTRUCTIONSThe following instructions are addressed to a qualified personnel the only one authorised to carry out checks and repairs, if any.The manufacturer declines any responsibility in the case of interventions made by a non qualified personnel or the use of spare parts other than those supplied by the Manufacture.INSTALLATIONDuring installation, carry out proper machine levelling, which is a prerequisite for a correct operation thereof (max. tolerance 2°).In order to prevent any damage caused by steam going out of the machine, make sure that the surrounding materials do not deteriorate in its presence. After machine installation check thermostat settings, booster 85°C, tank 60°C.1)ELECTRICAL CONNECTIONThe electrical safety of this equipment is only assured if it is connected as follows. It is necessary to connect the equipment to an effective earthing as specified by the electrical safety regulations in force. Check that this basic requirement is complied with, in case of any doubt ask for a careful check of the installation by a qualified personnel. In the case the earthing is not efficient there will be a dispersion due to the suppresser.The machine shall be included in a correctly dimensioned equipotential, whose effectiveness is to be very tight in accordance to the procedures set for in the applicable safety standards. The connection shall be performed through a screw marked by the plate near the rear side of the appliance.The manufacturer declines any responsibility for any damages caused by lack of an effective ground installation. For three phase 380/400V hook-up, have available a wall circuit breaker switch with multiple phase protection (20A for models LF315, LF320 and LF320A; 16A for models LF323, LF323A and LF350) with contact aperture distance, equal to or not exceeding 3mm and a supply cable no less than 2.5mm². For other supplies the cable cross section must be calculated according to voltage and length of cabling. If cabling too long adjust cable size to Amp rating; do not pull on supply cable or install it under tension. If cable needs to be replaced use type H07RN-F.2)WATER CONNECTIONInstall a 55°C water tap in a well accessible place, terminating in a 3/4" fitting, which the pipe strainer and inlet hose shall be connected to.Carefully comply with any national or regional regulations in force.The operating pressure should be neither less than 2 bars or greater that 4 bars (200/400 kPa). If water pressure is inferior then 2 bar, a pressure increase pump is necessary. If water pressure exceeds 4 bar, a pressure reducer is necessary.In order to obtain best results, it is suggested that the water supply have a hardness not greater that 8 Clarke.3)WATER DRAINArrange a water drain towards the floor with siphon and connect the machine with the flexible tube given with the machine, so that it leans towards the drain. Moreover, make sure that the hose does not have constrictions.Make sure that the building drain tubing withstands temperatures up to 70°C.4)RINSE AID DOSAGEMake sure that rinse aid suction hose is correctly installed in it’s proper container. The dosage is automatic with the adjusting of the screw "I", which after screwing to a full stop unscrew two turns. At this point the machine automatically takes the necessary liquid for every rinse: during the washing operations, check that the liquid of the container does not run short.For filling the dosing tube, start the machine without plugging the overflow in: at that point switch the machine on (pos.1) and off (pos.0). Repeat this operation several times at intervals of few seconds, until the rinse aid reaches the injector. Wait until the machine reaches the correct temperature (lamp “B2” on). Make some empty cycles, then try to wash: if the objects washed show some drops, this means that the rinse aid is insufficient. On the contrary, the presence of marks can mean that there is too much rinse aid or the water is too hard. The regulation can change according to the kind of rinse aid.5)DETERGENT DOSAGE (for machines with built-in detergent dispenser)With the screw on the side of the detergent pump, close completely the product intake, then slowly open the screw until the desired intake quantity has been reached. The correct quantity is indicated by the detergent supplier. Check that the intake of the pipe during the rinse cycle is as preset. (1cm = 1g approximately). Maximum intake or delivery distance: 2 meters.ENERGY CONSUMPTIONModel Wash tankcapacity(l)Rinse waterconsumpt.(l)Tankheater(W)Rinseheater(W)Washpump(W)Totalelectric load(W)Output inracks perhour with55°C inletwaterOutput inracks perhour with12°C inletwaterLF31518 3.520003000400350024--LF32018 3.520003000400350030/2010LF320A18 3.520003000400350030/2010LF32318 3.520004200450440036/2412LF323A18 3.520004200450440036/2412LF35018 4.020006000750675040/3017In the event of low water supply temperature, the will be a subsequent machine output drop.WIRING DIAGRAMA1Main switchA2Start switchA4Regeneration switch (mod.LF320A and LF323A only)A5Drain pump switch (if required)B1Pilot lamp power onB2Pilot lamp machine readyB3Pilot lamp machine workingB4Pilot lamp regeneration (mod.LF320A and LF323A only)B5Pilot lamp drain pump (if required)C2Booster heater contactorC2bis Safety contactor of booster heaterD1Wash timerD2Wash timerD4Regeneration timer (mod.LF320A and LF323A only)D5Drain pump timer (if required)E1Hot rinse solenoid valveE4Regeneration solenoid valve (mod.LF320A and LF323A only)F1Door switchG1CondensatorG2Anti noise filterH1JunctionM1Wash pumpM2Drain pump (if required)M3Detergent dispenser (if required)M6Rinse booster pump (if required)P1Pressure switchR2Booster heaterR3Tank heaterT2Booster thermostatT2A2nd contact of booster thermostatT2bis Booster safety thermostatT3Tank thermostatThe manufacturer declines any responsibility for any printing errors contained in this booklet. The manufacturer also reserves the right to make any modifications to its products that do not affect the basic characteristics thereof.REFER TO ELECTRICAL DRAWING。
胰岛素诺和锐30r的使用说明书（Insulinaspart30Rmanual）
胰岛素诺和锐30r的使用说明书（Insulin aspart 30R manual）Novorapid 30 flexpen - only to find the "charge", deal with itDrug name: novorapid 30 flexpenInsulin Aspart 30 InjectionNovorapid 30 FlexPen Description: novorapid 30 flexpen (for the treatment of diabetes mellitus) can better simulate the physiological insulin secretion, improve postprandial glucose control, less severe and nocturnal hypoglycemia, and the meal immediately before injection, greatly increase the treatment compliance of patients.Novorapid 30 flexpen:Category: Imported Drugs[name of drug]Commodity name: novorapid 30 flexpenDrug name (medium): Insulin Aspart 30 InjectionChinese Pinyin: Mendongyidaosu 30 ZhusheyeEnglish Name: Insulin Aspart 30 InjectionDosage form: injection[main ingredient] insulin aspart (using biotechnology toreplace the proline of human insulin amino acid chain B28).[character] this product is clear and colorless aqueous solution of insulin aspart.[pharmacological toxicity] hypoglycemic effects of insulin aspart insulin aspart is through a combination of molecular and muscle and adipose cells on insulin receptor, promote glucose uptake, while inhibiting glycogen release to achieve. Human insulin aspart core amino acid chain B28 in the proline was replaced by aspartic acid, so human soluble insulin in the tendency to form six dimer is reduced in insulin aspart in. Thus, subcutaneous absorption is faster than soluble human insulin.[pharmacokinetics] human soluble insulin aspart lead is rapid onset, lower the blood glucose concentration decreased. The duration of the injection was short after subcutaneous injection. The average time for insulin to reach the highest blood concentration was 50% of soluble human insulin. The peak time of type 1 diabetic patients is about 40 minutes after subcutaneous injection. About 4-5 hours after injection, the concentration returned to base. This product absorbs very quickly. But there are differences between groups the highest blood concentration, stressed the importance of novorapid refill individualized treatment.[indications] used in the treatment of diabetes mellitus[usage] this product is faster than the soluble human insulin, and has a shorter duration of action. It is usually due to rapid onset, so it is generally necessary to be injected immediatelybefore meals. Take the medicine immediately after meals, if necessary. The dosage should be individualized and decided by the doctor according to the patient's condition. But it should be used in combination with medium or long-acting insulin, at least once a day. The insulin requirement is usually 0.5-1.0U per kilogram body weight. Among them, 2/3 dosage is prandial insulin, another 1/3 dosage is base insulin. The improvement of metabolic control in diabetic patients can effectively delay the occurrence and progression of late complications. Therefore, improvements in metabolic control, including glucose testing, are recommended. After subcutaneous injection, the abdominal wall, thigh, deltoid region and gluteal region can be selected, or continuous infusion in the abdominal wall. The injection position shall be rotated in the same area. After subcutaneous injection, it takes effect within 10-20 minutes, so it is necessary to eat carbohydrate containing foods within 10 minutes after injection. The maximal effect time was 1-3 hours after injection, and the hypoglycemic effect lasted for 3-5 hours. Do not use this medicine if the solution is no longer transparent or colorless. To prevent cross infection, this product is for personal use only. Before use, please check the integrity of the product (for example: no cracks), if the cartridge has been damaged, or rubber piston issued a white bar code band, please do not use. Dial the needle after each injection. If the needle is not removed after injection, the change of temperature will cause the liquid to leak out of the needle. Don't refill the product. To determine the concentration of insulin before injection and type the correct, and in accordance with the guidelines for the use of insulin injection system of Novo Nordisk, careful operation. This product is used for subcutaneous injection. If insulin isinjected from the abdominal wall, it works faster. The injection site can be the abdomen, thighs, upper arms, or hips. The injection site should be rotated in the same area. Treatment of this product and other insulin refill as when two novo insulin syringes were used, each for different types of insulin injection syringe.[adverse reactions] hypoglycemia is the most frequent adverse event in insulin treatment. Symptoms of hypoglycemia often occur suddenly. Treatment with insulin may lead to edema and abnormal visual function, but these symptoms are transient. Local anaphylaxis may also occur during the course of insulin treatment (redness, edema, and itching) at the injection site. But usually for a short while, continuing treatment can disappear. Systemic anaphylaxis rarely occurs, but can be life-threatening. If the injection site is not rotated, it is possible to develop fat malnutrition at the injection site.[hypoglycemia] hypoglycemia, allergic to insulin aspart or other components of the preparation.[note] inadequate dosage or treatment interruption may lead to hyperglycemia and ketoacidosis, especially in type 1 diabetes mellitus (insulin-dependent diabetes mellitus). The first symptoms of hyperglycemia usually occur over hours or days. It includes nausea, vomiting, lethargy, flushing of the skin, dryness, dry lips, increased frequency of urination, thirst, loss of appetite, and breath with acetone. Untreated hyperglycemia events are likely to lead to death. Injection time novorapid should be closely linked with the meal time, which is close to the pre meal. It works quickly, so it isnecessary to consider whether the patient's comorbidities and the combination of drugs delay the absorption of food. A combination of diseases, especially infections, often increases the amount of insulin used. Liver or kidney damage can reduce the amount of insulin used in patients. When patients switch to other types or brands of insulin, strict medical monitoring should be maintained. Changes in insulin concentration, brand, type, species (animal, insulin, human insulin, human insulin analog) and / or manufacturing processes will lead to changes in dosage. Patients from the other application of insulin aspart after use may increase the number of daily injections or change the dose. If this adjustment is necessary, it will take place during the first or first few weeks or months. After the patient's glycemic control has been improved, for example, the initial symptoms of hypoglycemia can change after intensive insulin therapy, and attention should be given to the patient. Only in children compared with soluble insulin aspart using rapid onset under more favorable circumstances. For example, when the injection time is related to the meal time. If hypoglycemia occurs, the rapid onset of pharmacodynamics of the insulin analog results in hypoglycemia occurring earlier after insulin aspart injection than in soluble human insulin. If a large amount of exercise meal or not included in the plan of physical exercise may lead to hypoglycemia. Hypoglycemia may damage the patient's attention and responsiveness. As a result, there may be danger in the patient's particularly important activities (such as driving a car or operating machinery). Patients should be advised to guard against hypoglycemia during driving, especially in patients with reduced or decreased signs of hypoglycemia and frequent hypoglycemia. In this case, the patient should beallowed to continue driving.[pregnant and lactating women] there is no systematic study of pregnant women. It is recommended that women with diabetes, pregnancy, and pregnancy should be monitored throughout pregnancy until the end of pregnancy. In early pregnancy, the amount of insulin usually decreases and increases gradually after middle and late stages. No restrictions on the use of this product in lactating women. Breastfeeding mothers should be insulin does not cause harm to infants. But the dosage of insulin aspart may need to be adjusted.[children] use this product only when compared with soluble insulin, which is more rapidly effective.[elderly patients] good[drug interaction][drug overdose] would be hypoglycemia symptoms, including cold sweat, pale, fatigue, nervousness or anxiety, tremor, abnormal fatigue or weakness, mental disorders, difficulty concentrating, abnormal sleepiness, hunger, visual changes, headache, nausea and palpitation. Severe hypoglycemia can cause coma and / or convulsions, temporary or permanent brain damage or even death. Mild hypoglycemia can be treated with oral glucose or sugar. Therefore recommends that diabetics carry sugar or sugary foods such as biscuits. The patient was unconscious when severe hypoglycemia occurred,Glucagon can be administered by intramuscular or subcutaneousinjection of trained persons or by intravenous administration of glucose by medical personnel. If the patient does not respond to glucagon within 10-15 minutes, glucose should also be given intravenously.[specifications] 100 units per milliliter, 3 ml per bottle (special charge).[storage] unused products should be refrigerated at 2-8 degrees Celsius (not too close to cold ice chamber), not frozen.[validity] 24 months[import drug registration number] S2*******[approval number of imported drugs separately] J20050018[manufacturer] Denmark, Novo NordiskNovorapid 30 flexpen price: RMB 108Objectives: adherence to 4567 (fasting 4~5, 2 h after meal, 6~7), control 5678 (fasting <5.6, 2 hours after meal, <7.8).。
不同葡萄品种灰霉病抗性鉴定及褪黑素抗病机理初探
核农学报2024，38（4）：0674~0684Journal of Nuclear Agricultural Sciences不同葡萄品种灰霉病抗性鉴定及褪黑素抗病机理初探王宪璞代瑛姿郭宏扬杨志峰许丽丽 *（石河子大学农学院，特色果蔬栽培生理与种质资源利用兵团重点实验室，新疆石河子832003）摘要：灰霉病是严重危害葡萄生长和果实品质的主要病害之一。
为探究外源褪黑素（MT）缓解葡萄灰霉病发生的抗性机理，本研究以10个新疆主栽葡萄品种为试材，结合叶片、果实基本性状与病情严重度相关性分析，对不同葡萄品种灰霉病抗性进行综合评价；以成熟离体果实为试材，测定了MT对关键抗性指标的影响。
结果表明，部分参试葡萄品种灰霉病抗性水平差异显著，接种灰霉病病原菌（Botrytis cinerea）10 d后，阳光玫瑰和克瑞森葡萄叶片和果实表现感病，蓝宝石葡萄叶片表现感病，其余品种均表现不同程度的抗性，其中巨峰葡萄隶属函数综合得分最高、抗性最强。
B. cinerea侵染葡萄叶片后，不同抗性品种的叶片相对电导率、超氧阴离子、丙二醛及游离脯氨酸水平均呈上升趋势，其中阳光玫瑰和克瑞森葡萄叶片侵染前后各指标差异显著或极显著，巨峰葡萄叶片除游离脯氨酸水平在侵染前后差异显著外，其余指标均不显著。
外源100 μmol·L-1 MT提高了葡萄果实总酚含量、总抗氧化水平和苯丙氨酸淀粉酶、多酚氧化酶活性，缓解了B. cinerea对果实的危害，此外，MT显著上调了VvCu/Zn-SOD1a等活性氧清除相关基因的表达（以巨峰葡萄最为明显）。
综上所述，MT通过促进葡萄果实酚类物质代谢与维持活性氧平衡提高对灰霉病的抗性。
研究结果不仅为揭示褪黑素提高葡萄对灰霉病菌抗性的生理基础提供了理论依据，也为褪黑素提高葡萄灰霉病抗性的田间应用和优质抗病种质发掘利用提供了数据支撑。
关键词：葡萄；灰霉病；褪黑素；抗氧化性DOI：10.11869/j.issn.1000‑8551.2024.04.0674葡萄（Vitis Vinifera L.）是世界四大水果之一，也是重要的经济作物，栽培面积和产量逐年递增，截至2022年，我国葡萄栽培面积位居世界第三［1］。
诺适得说明书
核准日期：2011年12月31日修改日期：2014年02月18日2014年10月31日2016年01月12日2017年01月16日2018年04月28日2018年11月08日2018年11月21日2020年04月07日2020年06月24日2021年XX月XX日雷珠单抗注射液说明书请仔细阅读说明书并在医师指导下使用。
【药品名称】通用名称：雷珠单抗注射液商品名称：诺适得®/Lucentis®英文名称：Ranibizumab Injections汉语拼音：Leizhu Dankang Zhusheye【成份】活性成份：雷珠单抗化学名称：G1，抗-（人血管内皮生长因子）Fab片断（人-鼠单克隆rhuFabV2γ1-链），二硫键结合人-鼠单克隆rhuFabV2κ-链分子量：48KD处方组成：1mL含10mg雷珠单抗。
本品所含辅料为：α,α-海藻糖二水合物；组氨酸；盐酸组氨酸一水合物；聚山梨醇酯20。
【性状】透明至微乳白色液体。
【适应症】雷珠单抗注射液适用于成人:∙用于治疗湿性（新生血管性）年龄相关性黄斑变性（AMD）。
∙用于治疗糖尿病性黄斑水肿（DME）引起的视力损害。
∙用于治疗糖尿病视网膜病变（DR）[增殖性糖尿病视网膜病变（PDR）和中重度至重度非增殖性糖尿病视网膜病变（NPDR）]。
∙用于治疗继发于视网膜静脉阻塞（RVO）（视网膜分支静脉阻塞（BRVO）或视网膜中央静脉阻塞（CRVO））的黄斑水肿引起的视力损害。
∙用于治疗脉络膜新生血管（CNV，即继发于病理性近视（PM）和其它原因的CNV）导致的视力损害。
雷珠单抗注射液适用于早产儿:∙用于治疗I区（1+、2+、3或3+期）、II区（3+期）早产儿视网膜病变（ROP）和AP-ROP（急进性后极部ROP）。
【规格】10mg/mL，每瓶装量0.20mL。
【用法用量】本品应在有资质的医院和眼科医生中使用。
医院应具备疾病诊断和治疗所需的相关仪器设备和条件，眼科医生应具备确诊湿性年龄相关性黄斑变性，糖尿病性黄斑水肿，糖尿病视网膜病变（DR）[增殖性糖尿病视网膜病变（PDR）和中重度至重度非增殖性糖尿病视网膜病变（NPDR）],继发于视网膜静脉阻塞（RVO）的黄斑水肿，脉络膜新生血管疾病以及早产儿视网膜病变的能力和丰富的玻璃体内注射经验。
基于PI3K
申彤，刘佳佳，陈嘉，等. 基于PI3K/AKT1通路探讨山西老陈醋对高脂饮食诱导大鼠抗氧化作用机制[J]. 食品工业科技，2023，44（20）：398−406. doi: 10.13386/j.issn1002-0306.2022110310SHEN Tong, LIU Jiajia, CHEN Jia, et al. Explore the Mechanism of Shanxi Aged Vinegar on High-fat Diet-Induced Antioxidant in Rats Based on PI3K/AKT1 Pathway[J]. Science and Technology of Food Industry, 2023, 44(20): 398−406. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022110310· 营养与保健 ·基于PI3K/AKT1通路探讨山西老陈醋对高脂饮食诱导大鼠抗氧化作用机制申 彤1，刘佳佳1，陈 嘉2, *，庞全海1,*（1.山西农业大学动物医学学院，山西晋中 030801；2.山西农业大学食品科学与工程学院（农产品贮藏保鲜研究所），山西太原 030031）摘 要：目的：基于PI3K/AKT1通路探究山西老陈醋对高脂饮食诱导大鼠抗氧化作用机制。
方法：30只SPF 级雄性Wistar 大鼠随机分为5组：正常组（C ，常规饲料）、高脂模型组（M ，高脂乳剂）、低（LV ）、中（MV ）、高（HV ）剂量山西老陈醋干预组（1.35、2.7、5.4 g/（kg·bw ））。
造模（5周）同时给予陈醋干预后，山西老陈醋继续干预5周。
检测血清血脂含量、肝损伤指标及抗氧化酶活性；HE 染色观察肝组织病理学状态；qRT-PCR 和Western blotting 检测大鼠肝脏中PIK3CA 、AKT1 mRNA 及蛋白水平表达，免疫组织化学技术进行定位分析。
罗维X3 A3商品说明书
1S O L U T I O N S22TABLE OF CONTENTSROVI X3/A3 Base Vitals3Power Positioning System Overview 3Non Powered System Overview 3ROVI X3/A3 Base Overview 4/5Ultra Low Maxx Power Positioning 6/7407 Maxx Power Positioning 8/9MPS Maxx Power Positioning 10/11UPfront Maxx Power Positioning 12/13Lateral Tilt Maxx Power Positioning 14/15Single Post Back Power Positioning 14/15Mini Maxx Power Positioning 16/17System Personalization18/1923Choice is yoursBASE SPECIFICATIONSBASE VITALSROVI A3 ROVI X3HCPCS Codes K0856, K0861 K0856, K0861Suspension System Active Ride Control (ARC) Active Ride Control (ARC)Base Width 25.5" 23.25"Base Length 36.5" 36.5"Drive Wheel Size14" 14"Caster Wheel Size (front/rear) 6" 6"Base only Turning Radius 20.5" 19.5"Drivetrain 4-pole EAD Motors 4-pole EAD Motors Batteries2 x M34 2x M343 x M34* 3 x M34* 2 x M34 and 1 x M50*(*Option for Vent application) (*option for Vent application)Battery Charger8A, Off Board 8A, Off Board Batteries Weight (each) 38.5 lbs (M34) 38.5 lbs (M34)Range (1)17.7 miles 17.7 miles Weight Capacity300 lbs 300 lbs Base Weight (w/o batteries) 159 lbs 157 lbs Ground Clearance 3" 3"Maximum Speed6.2 mph 6.2 mph(1)Actual driving range and speed may vary due to factors such as user weight, type andgrade of terrain, battery condition & charge level; type and condition of the drive wheels, and variations in the drive and control systems.MAXX POWER POSITIONING OPTIONSUltra Low●●407 (Single Pivot Tilt)● CALL FOR DETAILS MPS (Standing)●N/AUPfront (Forward Access)●●Lateral Tilt (Side-to-Side )● N/AMini (Pediatric)N/A●NON-POWER POSITIONING OPTIONSRehab Seat ●●Solid Seat Pan ●●Captains Seat●●SEATING OPTIONSAll Systems are available with the full range of Invacare ® Matrx ® Seating ProductsBLIZZARD WHITEMATTE BLACKSOLAR YELLOWMOTION GREENORIGINAL ORANGEBRIGHT BLUERED DELICIOUSPARTY PINKPURPLE REIGN3B A T T E R Y 2B A T T E R Y 1Make an educated decisionULTIMATE PERFORMANCEActive Ride Control (ARC) independent suspension system and powerful 4-pole motors work together to provide superior climbing ability and uncompromising stability with asmooth, powerful rideUNIQUEIN-LINE BATTERY CONFIGURATION ON X3Offers unmatched stabilityand performanceOnTraxxThe OnT raxx Enhanced Driving Module decreases the number of user driver control commands to maintain the wheelchair on its intended course when going over unevenor sloping terrain45BALANCEThe ROVI’s X3 base is the narrowest Group 3 style base. Its unique frame con fi guration optimizes weight distribution by concentrating the mass through the mid-line of the power base. This revolutionary con fi guration provides clients with the industry’s narrowest power base without sacri fi cing stability or performance.CONTROLROVI Bases utilize renowned PG Drives Technology. This electronics platform delivers both non-expandable and expandable control options with numerous innovative features. This industry-leading platform was chosen for its performance, reliability and ease of programming. The ROVI’s standard 4-pole motors have been precision matched for peak performance with PG Drives.The innovative On T raxx Enhanced Driving Module decreases the number of user driver control commands to maintain the wheelchair on its intended course when navigating uneven or sloping terrain.EXPERIENCE• Mid Wheel Drive base delivers compact footprint,ultimate stability, performance & maneuverability in tight spaces• Precise Driving Experience• Expertly Handles Uneven Terrain• Improved Experience via Gyro Technology• Ideal for clients that utilize a non-proportional inputdevice for drive control, such as a head array or a proximity switch tray • Faster Acceleration• Effortlessly climbs curb heights up to 2.5"• ROVI X3 offers a 1.875" Narrower Footprint • High Speed Motors: 5.8 mph & 6.2 mph • Complimentary ROVI USB ChargerSERVICE• Easily Accessible Drive Control Module(all electrical connections accessible in rear)• Motion Concepts Attendant Power PositioningProgrammers & Controllers • Unique Battery Con fi guration with easy Front & Rearaccess (while client remains in the chair)• Totally Accessible Fore-and-aft AdjustmentAssess your needs SPECIFICATIONS:ROVI A3 ROVI X3CONFIGURATIONSADD-ON MODULESSPECIFICATIONS:ROVI A3 ROVI X3NON-POWERED SYSTEMS67MATRX ® SEATINGFull line of award-winning Seating &Positioning Solutions from Pediatric to Heavy-DutyMAXX STYLE ULTRA RAILSlotted design for mounting ofpositioning accessoriesMAXX STYLE ULTRA TRACKIntegrated t-nut track for easy mounting of lateral thoracic supports and other positioningaccessories. . . little thingsmake a big differenceMake your heart happy SPECIFICATIONSROVI A3 ROVI X3CONFIGURATIONSADD-ON MODULES8LNX POWER CENTER MOUNT WITH EASY-TRANSFER FOOTPLATE-footplate extends and is flush with the floor when chair is in Anterior Tilt position7° OFANTERIOR TILT-Allows for repositioningand safe forwardtransfer capability-Assists withfunctional activitiesUNIQUE DESIGN-Single Pivot Tilt coupled withRecline module allows up to 185°of combined travel-Ideal for pressure management10Stand up for yourselfREMOVABLE KNEE BLOCK- Designed to safely secure theuser while standing-Angle, height & depth adjustable -Offers 3" of depth, 2"of independent width & 1.5" height adjustmentsSPECIFICATIONSROVI A3CONFIGURATIONSADD-ON MODULESOnTraxx ENHANCED DRIVING MODULE-Standard feature on MPS Maxx system -Decreases the number of user/drivercontrol commands-Maintains the wheelchair on its intendedcourse when going over unevenor sloping terrainPrior to evaluation and use, all consumers MUST consult with a qualified Physician and receive medical clearance and approval to use an assisted standing device. An experienced Occupational Therapist or Physical Therapist should be present during the evaluation and prescription process.PELVIC BELT-Center-pull, push button and adjustable 2-Pointpadded lap Belt -provides anterior positioning supportCHEST STRAP-Center-pull, push button and adjustable 2-Point padded Chest strap -height adjustable for anterior and posteriorsupportREMOVABLE CHEST BAR-Height & Angle adjustable -Designed to safely secure theuser while standing -Angle adjustability to accommodate asymmetriesFORWARD-LOCKING SUSPENSION SYSTEM-Offers additional stability and safety by locking front suspension arms as the Standing function isengagedSTORAGE BRACKET-Allows the Knee Block to be removed & stowed when standingfeature is not being usedRETRACTABLE KNEE BLOCK MOUNT11Be upfront with yourself SPECIFICATIONSX3ROVI A3 ROVICONFIGURATIONS++ADD-ON MODULES+ UPfront Module comes with up to 45° Anterior Tilt, 7" Seat Elevation & Synchronized Leg Mechanism totuck when in UPfront position12UPFRONT POSITION -Allows the system to shift forward up to 5.5" while elevating up to 7" with legs securely tucked underFORWARD-LOCKING SUSPENSION SYSTEMsafety by locking front suspension arms as the UPfront and Anterior Tilt functions are engaged-Reduced drive speed inUPfront positionPERFORMANCE-When system is not in UPfrontposition the ROVI A3’s ARCsuspension is fully functioning formaximum performanceand climbing capabilitySPEED-Reduced drive speed inUPfront positionSYNCHRONIZED LEGMECHANISM-Standard feature allowsthe leg to securely tuck underin UPfront positionANTERIOR TILT-Standard feature that offers upto 45° of Anterior Tiltand assists in forward transfersand field orientation13Make a latera l mo veSPECIFICATIONSROVI A3CONFIGURATIONS14LATCH MECHANISM-An attendant operated, manual latch mechanism provides back angle adjustments from 73° to 115° in 6° lockable incrementsBACK OPTIONS-Offered with our standard steel Rehab Back, Contour Back or with an Interface Plate for use with any ofour Matrx backrestsTRANSPORT FRIENDLY-Back will fold forward for easy transportation in low ceiling vehicles and many small commuter airplanesBUILT-IN SENSOR-Allows the seating system to automatically stop when seat is parallel to the base (0° home) positionLATERAL TILT-Offers up to 30° of Posterior Tiltand 170° of Recline whileLaterally tilted16Let kids be kidsSPECIFICATIONSROVIX3 CONFIGURATIONSADD-ON MODULES17Make it your ownDIPPEDFENDERS & BATTERY DOORS CAPTAINS SEAT OPTION -Available in Black or GreyLeatherette trim1819AIRBRUSH DESIGNSMake it your own . . . customize your fenders and/or battery doors withpersonalized airbrush or pinstripe design by Bob Rice. (Airbrush a, b & e)DIPPED DESIGNSMake it your own . . . personalize yourfenders, battery doors, shroud covers, and/or back shell surfaces with hydro dipped personalized theme. Wide variety of hydro dipping patterns to choose from.(Dipped c, d, f, g & h)abeghcdf20Motion Concepts USA 700 Ensminger Rd., Suite 112Tonawanda, New York 14150888.433.6818Motion Concepts CANADA 84 Citation Dr., Unit 1Concord, ON L4K 1C3866.748.7943 ***********************© 2019 Motion Concepts. All rights reserved. Trademarks are identi fi ed by the symbols ™ and ®. All trademarks are owned by or licensed to Motion Concepts unless otherwise noted. Speci fi cations are subject to change without noti fi cation.TRD0539 Rev A。
单价轮状说明书
单价轮状说明书【药品名称】通用名：口服轮状病毒活疫苗英文名：live Eotavirus Vaccine，Oral汉语拼音：Kou Fu Lun Zhuang Bing Du Huo Yi Miao【组成和性状】口服轮状病毒活疫苗系采用轮状病毒减毒株感染新生小牛肾细胞，经培育、收获病毒液后加入时宜的甜味保护剂制成，为橙红或粉红色澄清液体。
【规格】本品规格为每瓶1人份，每瓶剂量3.0ml。
每1ml疫苗所含活病毒量应不低于5.51gPFU/ml或1gCCID50。
每次人用口服剂量为3.0ml。
【质量标准】本疫苗依据2000年版《中国生物制品规程》2002年增补标准生产和检定，符合质量要求。
【作用和用途】本疫苗口服免疫后，可刺激机体产生对A群轮状病毒的免疫力，用于预防婴幼儿A群轮状病毒引起的腹泻。
【接种对象】本疫苗主要用于2个月至3岁婴幼儿。
【用法与用量】启开瓶盖，用吸管吸取本疫苗，直接喂于婴幼儿。
用量为每人一次口服3ml。
每年应服一次。
【禁忌】1.身体不适，发热，腋温超过37.5℃以上者。
2.急性传染病或者其它严重疾病患者。
3.免疫缺陷和接受免疫抑制治疗者。
【副反应及处理】口服后一般无不良反应；偶有低热、呕吐、腹泻等轻微反应，多为一过性，一般无需特殊处理。
必要时给予对症治疗。
【注意事项】1.开启小瓶时，切勿使消毒剂接触疫苗。
2.小瓶有裂纹、标签不清或液体浑浊者均不可使用。
3.小瓶开启后，疫苗应在1小时内用完。
4.使用本疫苗前、后须与使用其他疫苗或免疫球蛋白间隔2周以上。
5.请勿用热开水送服，以免影响免疫效果。
汉防己甲素通过抑制Mincle
汉防己甲素通过抑制Mincle/Syk 信号介导的巨噬细胞炎性活化减轻小鼠缺血再灌注诱导的急性肾损伤*彭泽1，2， 王洪连2， 粟宏伟3， 王丽2△（1成都市双流区九江社区卫生服务中心，四川 成都 610000；2西南医科大学附属中医医院中西医结合研究中心，四川 泸州 646000；3西南医科大学附属中医医院泌尿外科，四川 泸州 646000）［摘要］ 目的：探讨汉防己甲素（Tet ）对小鼠缺血再灌注诱导的急性肾损伤（IRI -AKI ）的作用及其机制。
方法：8周龄雄性C57BL/6小鼠随机分为假手术组、IRI -AKI 组、低剂量（20 mg/kg ）Tet 组、高剂量（40 mg/kg ）Tet 组和槲皮素（50 mg/kg ）阳性对照组，每组6只。
采用双侧肾动静脉夹闭45 min 后恢复血供的方法建立IRI -AKI 模型，Tet 和槲皮素组的IRI -AKI 小鼠于术前1 h 及术后连续3 d 给予相应剂量药物腹腔注射，假手术和IRI -AKI 组小鼠给予同等体积溶剂注射。
实验终点处死动物，收集血清及肾脏组织样本，进行肾功能、病理、mRNA 及蛋白等指标检测。
在体外，采用脂多糖（LPS ； 300 μg/L ）刺激的原代小鼠骨髓来源巨噬细胞（BMDM ）进行Tet （1、2和4 mg/L ）的抗炎活性研究。
结果：（1）与IRI -AKI 组相比，低和高剂量Tet 干预均能显著降低血清肌酐和血尿素氮水平（P <0.05），并减轻肾小管病理损伤（P <0.05）。
（2）Tet 干预可以显著抑制IRI -AKI 小鼠肾组织中白细胞介素1β（IL -1β）和IL -6的mRNA 和蛋白表达及NF -κB 信号的活化，减少肾组织巨噬细胞浸润（P <0.05）。
（3）在LPS 刺激的BMDM 中，Tet 同样抑制IL -1β和IL -6的mRNA 和蛋白表达及NF -κB 信号的活化（P <0.05）。
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诺唯赞r323说明书
1.简便快捷的操作
HiScriptRll RT SuperMix for qPCR (+gDNA wiper) (Vazyme #R323)包含基因组清除模块，可彻底去除RNA模板中残留的基因组DNA;同时Vazyme #R323包含逆转录反应所需的所有组分，只需加入模板RNA，20 min 内即可完成逆转录反应，操作简便快捷。
2.广泛的模板兼容性
分别以HeLa 细胞、小鼠肝脏、拟南芥叶片的完整RNA与降解RNA 为模板，使用HiScriptRIll RT SuperMix for qPCR (+gDNA wiper)(Vazyme#R323)以及市售常见品牌逆转录试剂(Supplier T)进行逆转录。
将得到的cDNA进行多个基因的qPCR定量分析，以不同基因为横坐标，扩增CT值为纵坐标绘图，比较不同产品的逆转录效率。
以HeLa细胞、小鼠肝脏、拟南芥叶片完整RNA以及降解RNA为模板进行逆转录定量，Vazyme #R323的扩增C┐值小于或等于T公司相关产品，说明Vazyme#R323逆转不同物种RNA、完整度较差的RNA模板皆具有卓越的逆转录效率。
3.超强的杂质耐受度
在RNA的提取过程中常常因操作或样本的特殊性导致RNA中混有有机试剂或杂质，这些物质的残留会严重影响逆转录效率。
乙醇、异丙醇、水平衡酚、异硫qing酸胍、腐殖酸是RNA提取过程中较为常见的杂质，测试其对逆转录效率的影响。