中枢神经系统淋巴瘤(英文版)及病例分享

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淋巴瘤病历模板范文

淋巴瘤病历模板范文英文回答：Lymphoma Medical Record Template Sample.Patient Information:Name: John Smith.Age: 45。

Gender: Male.Date of Admission: 15th March 2022。

Chief Complaint:The patient presented with persistent fatigue, unexplained weight loss, and enlarged lymph nodes in the neck and groin region.Medical History:The patient has no significant past medical history. He is a non-smoker and has no known allergies. There is no family history of lymphoma or any other malignancies.Physical Examination:Upon physical examination, the patient appeared pale and fatigued. Multiple enlarged lymph nodes were palpablein the neck, axilla, and groin regions. The largest lymph node measured approximately 3 cm in diameter. No hepatosplenomegaly or other abnormal findings were noted.Diagnostic Tests:1. Complete Blood Count (CBC): The CBC revealed mild anemia with a hemoglobin level of 10.5 g/dL. The white blood cell count was within the normal range, but the lymphocyte count was slightly elevated.2. Biopsy of Lymph Node: A lymph node biopsy was performed, and histopathological examination revealed a diffuse large B-cell lymphoma.3. Imaging Studies: CT scans of the chest, abdomen, and pelvis were conducted to determine the extent of the disease. The scans showed multiple enlarged lymph nodes in various regions, including the mediastinum and retroperitoneum.Diagnosis:Based on the clinical presentation, physical examination findings, and biopsy results, the patient was diagnosed with diffuse large B-cell lymphoma, stage II.Treatment Plan:The patient was referred to the hematology-oncology department for further management. The treatment plan includes a combination of chemotherapy and immunotherapy. The specific regimen will be determined by the oncologistbased on the patient's overall health and disease stage. Regular follow-up visits and imaging studies will be scheduled to monitor treatment response and disease progression.Prognosis:The prognosis for diffuse large B-cell lymphoma varies depending on the stage of the disease, overall health of the patient, and response to treatment. With appropriate treatment, the five-year survival rate for stage II lymphoma is approximately 70%.中文回答：淋巴瘤病历模板范文。

原发性中枢神经系统淋巴瘤8例临床分析

近年来收治的８例ＰＮＬ患营的临甄示，ＣＳ床资料。以探讨ＰＮＬ的临床特点及ＣＳ治疗措施。报告如下。
１资料与方法
疗早期采用ＣＰ方案．后改用替尼ＨＯ
１１一般资料收集１９．９８年１川至
浙江宁波３５２１００
作者简介：王新东（９０１７一
）男，江．浙图３头颅ＭＲＩ图４头颅ＭＲＩ
省慈溪市人．瘤科副主仔医师，表论文肿发
６篇。
Ｔ像示肿瘤呈低信号。
Ｔ像示肿瘤呈高信号。
率较低．１１为／０万，所有原发颅内行颅脑Ｃ在Ｔ检有，行颅脑ＭＲ检查６分型均为Ｂ细胞型淋巴瘤。根据肿瘤１
肿瘤巾仅占ｌｆ２％。ｊ０世纪８代以例。ＣＯ年Ｔ检查示肿瘤为等或高密度影，部位均采用手术治疗．术后辅以放走小稳２例；肢体活动不便１例。８例患者均为
发肿瘤，病灶位于幕上６例，幕下２例１实验室检查８例ＰＮＬ患者．２ＣＳ叶．外周血白细胞分类巾淋巴细１１例
维普资讯
・
９０・５
Ｍ０ｅｎＰａｔａｄｃｅｅｅｅｏ，Ｖｏ１，Ｎ．２ｄｒｒｃｉｌＭｅｉｎ，ＤｃｍｂｒＯ７ｃｉ２１９ｏ１．
原发性中枢神经系统淋巴瘤８例临床分析

中枢神经系统淋巴瘤概述及影像学特点、诊治流程(最新)

弥漫浸润性淋巴瘤主要应与病毒性脑炎区别鉴别要点包括:
①病毒性脑炎呈弥漫性分布时，常有灰质受累较严重或以脑回侵犯为主的表现，T1WI呈弥漫性脑回样高信号是其特征，而淋巴瘤不会表现为脑回样高信号；
②淋巴瘤在CT平扫时多呈等密度或稍高密度，而病毒性脑炎呈低密度； ③淋巴瘤增强扫描时显著均质强化，而病毒性脑炎一般不强化，或病灶周围.仅有轻度
线状强状。
累及胼胝体而侵犯双侧半球的原发淋巴瘤需要与胶质母细胞瘤区别鉴别要点包括:
①原发淋巴瘤CT密度和MR信号较均匀，而胶质母细胞瘤CT密度和MR信号不均匀； ②原发淋巴瘤通常呈均质显著强化，而胶质母细胞瘤通常呈不均质、不规则环形强化； ③氢质子波谱检查，肿瘤实质部分出现明显的Lip波提示可能为淋巴瘤； ④胶质母细胞瘤在磁敏感加权成像时可见明显的磁敏信号，而淋巴瘤无。
临床表现与其他颅内肿瘤类似，头痛、恶心、呕吐、颅压增等，无特征性。病程较短，如不治疗，多在症状发生后3-5个月内死亡。由于恶性淋巴瘤对放、化疗敏感，及时放射治疗能明显改善病人的预后。但手术治疗不能改善该病预后，故早期正确诊断有重要意义，也因此影像诊断非常重要。
影像学特点
中枢神经系统淋巴瘤多起自血管周围间隙内的单核吞噬细胞系统，因为脑内靠近脑表面及脑室旁血管周围间隙较明显，故肿瘤常发生在近中线深部脑组织，其一侧常与脑室室管膜相连，或肿瘤靠近脑表面，也容易累及胼胝体而侵犯对侧半球。肿瘤内一般无钙化。
均质强化的脑原发淋巴瘤，有时需要与结核瘤鉴别氢质子波谱对两者的鉴别有重要意义。结核瘤和淋巴瘤均可在0.9-1.6ppm处出现明
显的Lip波，但结核瘤脑正常代谢物质明显降低或缺乏，包括NAA波、Cr波、Cho波和 MI波，而淋巴瘤表现为Cho波升高。

中枢神经系统英文汇总

中枢神经系统英文汇总English: The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord. It is responsible for integrating and coordinating sensory information as well as controlling and regulating bodily functions. The brain, which is the control center of the CNS, receives and processes information from the body's senses, initiates responses, and stores memories. The spinal cord connects the brain to the rest of the body and serves as a pathway for transmitting nerve signals between the brain and the peripheral nervous system. The CNS plays a crucial role in motor function, cognition, emotion, and behavior, and any damage or dysfunction in this system can have significant impacts on an individual's physical and mental health.中文翻译: 中枢神经系统(CNS)是由脑和脊髓组成的神经系统的一部分。

淋巴瘤病历书写范文

淋巴瘤病历书写范文英文回答：Patient Name: [Patient's Name]Gender: [Patient's Gender]Age: [Patient's Age]Date of Admission: [Admission Date]Chief Complaint:The patient presented with complaints of persistent fatigue, unexplained weight loss, and night sweats for the past few months.History of Present Illness:The patient initially noticed fatigue and weight loss,which was accompanied by night sweats. The symptoms gradually worsened over time, prompting the patient to seek medical attention. There was no history of fever, cough, or any other respiratory symptoms. The patient denied any recent travel or exposure to sick contacts.Past Medical History:The patient had no significant past medical history. There were no known allergies or adverse reactions to medications.Family History:There was no significant family history of lymphoma or any other malignancies.Social History:The patient is a non-smoker and does not consume alcohol. There is no history of any occupational exposure to toxins or chemicals.Physical Examination:On physical examination, the patient appeared pale and fatigued. There were no significant abnormalities noted in the cardiovascular, respiratory, or gastrointestinal systems. Lymph nodes in the neck, axilla, and groin were palpable and enlarged. The spleen was also palpable below the left costal margin.Laboratory Investigations:Complete blood count revealed a decreased hemoglobin level and thrombocytopenia. Peripheral blood smear showed the presence of atypical lymphocytes. Liver and renal function tests were within normal limits. Serological tests for viral infections, including HIV, were negative.Imaging Studies:Computed tomography (CT) scan of the chest, abdomen, and pelvis showed multiple enlarged lymph nodes in variousregions. There were no significant abnormalities noted in other organs.Biopsy Results:A lymph node biopsy was performed, and histopathological examination revealed the presence of malignant lymphoid cells. Immunohistochemistry confirmed the diagnosis of lymphoma.Diagnosis:Based on the clinical presentation, laboratory investigations, imaging studies, and biopsy results, the patient was diagnosed with lymphoma.Treatment:The patient was referred to the hematology department for further management. The treatment plan included chemotherapy and radiation therapy.Prognosis:The prognosis of lymphoma depends on various factors, including the type and stage of the disease. The patient will be closely monitored and receive regular follow-up visits to assess the response to treatment and overall prognosis.中文回答：患者姓名，[患者姓名]性别，[患者性别]年龄，[患者年龄]入院日期，[入院日期]主诉：患者主诉为持续性疲劳、体重下降和夜间盗汗等症状，已持续数月。

mskcc中枢神经系统淋巴瘤评分标准

mskcc中枢神经系统淋巴瘤评分标准在撰写这篇关于MSKCC中枢神经系统淋巴瘤评分标准的文章之前，我们首先需要了解什么是中枢神经系统淋巴瘤（CNSL）以及MSKCC 评分标准的基本概念。

中枢神经系统淋巴瘤是一种罕见但具有挑战性的类型的淋巴瘤，它发生在大脑、脑膜、脊髓和眶区，有时也涉及视神经和听神经。

而MSKCC评分标准是由美国纽约斯隆·凯特琳癌症中心（MSKCC）制定的一套评分标准，用于评估CNSL患者的预后和治疗方案。

我们需要从什么是CNSL开始，然后逐步深入解释MSKCC评分标准的内容和意义，同时要注意在文章中多次提及“MSKCC中枢神经系统淋巴瘤评分标准”，以便读者能够清晰地理解我们所要讨论的主题内容。

接下来，我们将逐一介绍MSKCC评分标准的各项内容和标准，比如患者的芳龄、疾病的严重程度、临床症状、病理学特征、治疗反应等方面的评分指标，以及其对CNSL患者预后和治疗方案的指导作用。

在文章的中部部分，我们将对MSKCC评分标准进行综合分析，结合具体的临床案例或研究数据，以体现该评分标准的临床应用和意义。

我们可以分享一些关于CNSL淋巴瘤和MSKCC评分标准的个人观点和理解，以便让读者更加贴近主题的内涵。

在文章的结尾部分，我们将对整篇文章进行总结回顾，强调MSKCC评分标准在CNSL领域的重要性和价值，并展望该评分标准在未来的发展和应用前景。

这篇文章将以严谨、全面、深入的方式，展现关于MSKCC中枢神经系统淋巴瘤评分标准的内容和意义，帮助读者更好地理解和应用该评分标准。

文章的总字数将超过3000字，全面展现对该主题的深度和广度的探讨。

CNSL（中枢神经系统淋巴瘤）是一种罕见的淋巴瘤类型，通常起源于B细胞。

它可以发生在大脑、脑膜、脊髓等部位，严重影响患者的生活质量和生存率。

目前，针对CNSL的治疗较为困难，因此对其准确评估和预后的判断非常重要。

MSKCC评分标准作为一套科学、可靠的评分工具，对CNSL患者的治疗和预后具有重要指导意义。

原发中枢神经系统弥漫大B细胞淋巴瘤临床分析

原发中枢神经系统弥漫大B细胞淋巴瘤临床分析摘要：目的提高对原发中枢神经系统弥漫大Ｂ细胞淋巴瘤的认识。

方法回顾性分析2007年1月至2016年7月期间收治的11例原发中枢神经系统弥漫大Ｂ细胞淋巴瘤患者的临床资料。

结果临床表现主要为颅内压增高、中枢神经功能缺损症状；7例患者为单发部位病变，4例患者为多发部位病变；7例患者免疫组化：CD20+、CD79a+、LCA+、Ki-67+、CD10- 表达均为100%；Ki-67+：增殖指数60%-80%：11例患者脑脊液均未见肿瘤细胞，行骨髓检查均未见骨髓浸润；10例患者起始化疗采用以大剂量甲氨蝶呤联合利妥昔单克隆抗体为基础的系统化疗联合鞘内局部注射加或不加全颅脑放疗，总缓解率90%；11例患者总生存率为81.81%，2年OS率为50%，与单纯化疗的病人相比，化疗联合放疗或自体造血干细胞移植两组病人总生存率无统计学差异。

结论大剂量甲氨蝶呤联合利妥昔单克隆抗体为基础的系统化疗联合鞘内局部注射的治疗方案仍是原发中枢神经系统弥漫大Ｂ细胞淋巴瘤首选治疗方案，化疗联合放疗或自体造血干细胞移植并不能带来病人生存获益。

关键词：弥漫大Ｂ细胞淋巴瘤；中枢神经系统；甲氨蝶呤；利妥昔单克隆抗体原发中枢神经系统弥漫大Ｂ细胞淋巴瘤（Primary central nervous system diffuse large B-cell lymphpma，PCNS-DLBCL）为少见的结外型NHL，约占所有NHL的1％-2％[1]。

PCNS-DLBCL早期诊断较为困难，由于其影像表现较复杂，临床症状不典型，常误诊为胶质瘤、转移瘤、炎症等。

本研究通过对PCNS-DLBCL的临床症状、影像学、免疫组化、治疗方法、预后等特点进行观察和分析，旨在探讨PCNS-DLBCL的临床特征，以提高对其发病特点、诊断及预后的再认识。

1.资料和方法1.1 研究对象2007年1月至2016年7月在苏州大学附属第一医院血液科确诊为PCNS-DLBCL资料完整的初治患者共11例，男6例，女5例，年龄38-73岁，中位年龄53岁。

原发性中枢神经系统淋巴瘤(PCNSL)诊治进展

原发性中枢神经系统淋巴瘤(PCNSL)是指原发于脑、脊髓、眼或软脑膜的淋巴瘤，病理特征与弥漫大B细胞淋巴瘤(DLBCL)相似，PCNSL大多数为B细胞起源;临床PCNSL病灶以脑室附近较多见，好发于50——70岁者，PCNSL占脑肿瘤的3%， 95%以上为DLBCL，T细胞起源的及其他类型的PCNSL发生率极低仅见个案报道;WHO(2008)肿瘤分类已经将原发于中枢神经系统的DLBCL归类为一个特殊实体瘤。

PCNSL患者主要表现为精神状态的改变、颅内压增{如头痛、恶心呕吐及视乳头水肿以及局部压迫症状，包括癫痫、记忆力减退、行走不稳、视野障碍、言语模糊以及轻度偏瘫。

除了脑部受累，还有10%——20%患者有眼部受累，表现为视物模糊或者诉有“漂浮物”。

一、PCNSL诊断1、颅脑影像学检查颅脑影像学检查对于PCNSL临床诊断与鉴别诊断具有重要作用。

PCNSL的MRI特征是在T1WI呈等或稍低信号，T2WI呈稍低、等或{信号，单个或多个同质病变，较局限，边缘不规则，90%病变周围伴有不同程度的水肿，增强后肿瘤明显均匀一致增强是本病的特点。

60%——70%的患者肿瘤为单发病灶，80%——90%的病灶位于小脑幕上。

在免疫缺陷患者，可见多发病灶呈环状强化。

免疫缺陷患者的临床表现与免疫功能正常患者有所不同，前者为多发病灶且几乎均伴有多系统损害。

PCNSL为乏血管肿瘤，故灌注加权成像(PWI)特征性的表现为肿瘤对比增强明显而血流灌注量不明显增加，但通透性明显增加;DWI呈{信号影，ADC 为等信号或低信号。

PCNSL的影像学检查具有一定特点，但影像学检查有其局限性，尤其不典型病例难以与其他颅内肿瘤及疾病相鉴别，对于影像学提示PCNSL患者，尚需立体定向活检等检查进行确诊。

2、立体定向活检立体定向活检是明确诊断最有效的方法，有报道活检的敏感性在90%以上，该方法是确诊PCNSL的主要手段，但活检时可导致出血甚至更严重并发症，尤其是脑干周围病灶更应特别注意。

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The MRI feature of PCNSL

Feature 1: cusp-angle sign

Feature 2: navel sign
The MRI feature of PCNSL

T1WI equal or short signal T2WI equal or long signal +c greatly enhanced

Therapy of PCNSL

Radiothrapy 1.WBRT is first choise.(40Gy/2Gy/4w) 2.SRT is second chiose, the target area is 2cm around the lesion.
Therapy of PCNSL
Question

What dou you think about the diagnosis?

Is this lesion a kind of glioma?
Pathology:
lymphomas
PCNSL

(Primary Central Nervous System Lymphomas)
GFAP is negative
Ki-67 is usually higher than 60%.
The feature of PCNSL

Location: deep in the white matter, around the
ventrical ,basilar ganglion ,corpus callosum

Watanaba classicified PCNSL into 4 types: 1.single or multiple solid type 2.diffused memberan-incised type 3.venticial-middleline-incised type 4.ependeding ,necrosis and cyst are hardly
seen (because the lack of vessel )
The feature of PCNSL

Feature 2: grow around vessels tubelike Feature 3: edema is quite severe than meningioma Feature 4: ependyma and dura are usually incised (mice-tail sign)
Therapy of PCNSL
Hormonal therapy: 1.PCNSL is sensitive to cortisone. After this therapy, the complaints can be greatly improved. 2.Biopsy is strongly recommended before hormonal therapy.
Pathology classification

Diffused huge B cell(18/21) Diffused samll B cell(1/21) Distypical peripheral T cell(2/21)
CD20,CD79a are positively expressed

Chemical Therapy (2 weeks after radiotherapy ) BCNU+VM-26 HD-MTX
The Diagnosis and Therapy of PCNSL
(Primary Central Nervous System Lymphomas)
The Diagnosis and Therapy of PCNSL
(Primary Central Nervous System Lymphomas)
Department of Neurosurgery
Case 1
Male,60y,accepted with the complaints of epilpsy and aphasia for 1 month.
MRI is very important !

1. Location: deep in the white matter, around
the ventrical ,basilar ganglion ,corpus callosum 2. edema is quite severe than meningioma

PCNSL is a special type of lymphomas which only raising intracranial, without lesion of same type in other part in the body. It’s a rare lesion intracranial, about 1%6%. It’s rarely diagnosised before operation.

3. ependyma and dura are usually incised (mice-tail sign) 4. cusp-angle sign and navel sign 5.MRS: Peak “Leap” ,Cr↓,Cho↑,NAA missing.
Type of PCNSL