(±)-Bay K 8644_L型Ca2+通道激活剂_71145-03-4_Apexbio
AP20187_二聚体药,具有细胞通透性。_195514-80-8_Apexbio
AP20187 是一种小分子二聚体药物。 为了解决移植物对宿主的抵抗作用，需要对移植细胞的体内行为进行控制。在 conditional
system 中，AP20187 可作为二聚化（CID）的化学诱导剂。在基因治疗中，CIDs 具有很大的 优势，它可以在没有毒性作用的条件下获得选择性。体内研究表明，AP20187 可以显著增加 转导红细胞、血小板以及较小程度上粒细胞的数量。 据报道，AP20187 也被用于 AP20187–LFv2IRE 系统。在该系统中，AP20187 可引起 LFv2IRE 的激活，从而导致肝脏糖原含量和肌肉葡萄糖摄取的增加。
动物实验: 动物模型 剂量 溶解方法
CD1 小鼠
10 mg/kg，腹腔注射。
为了评估 LFv2IRE 的表达和酪氨酸磷酸化，在注射 AP20187 之前 的 4 周，CD1 小鼠经尾静脉注射 AAV2/8-TBG-LFv2IRE 或 AAV2/1-MCK-LFv2IRE 载体。在 AP20187 给药后 2 小时，AP20187 依赖性的 LFv2IRE 酪氨酸磷酸化被检测到，在 6 小时之后达到峰 值，24 小时后回到基础水平。在接受 AAV2/8-TBG-LFv2IRE 而没有
多粘菌素B硫酸盐
北京希凯创新科技有限公司春季产品大促销产品名称产地货号规格价格SDS（颗粒状）（原装） SERV A 30765 5kg 2800.00SDS（颗粒状）（分装）SERV A 20765 100g 65.00SDS（颗粒状）（分装） SERV A 20765 250g 160.00X-gluc （原装） SERV A 15248.05 1g 1800.00X-gluc （分装） SERV A 15248.03 100mg 260.00DTT （原装）SERV A 20710 1kg 11000.00DTT （分装） SERV A 20710 100g 1300.00DTT （分装） SERV A 20710 10g 150.00胶原酶NB4 SERV A17454.011g1650.00 胶原酶NB4 (分装) SERV A 17454.01 100mg 210.00胶原酶NB6 SERV A17458.031g8200.00 聚乙二醇20000 SERV A33138.025kg1250.00聚乙二醇6000 SERV A33137.025kg1250.00聚乙二醇6000（分装） SERV A 33137.02 500g 150.005-溴-2’-脱氧脲苷 SERV A 15240.01250mg390.005-溴-2’-脱氧脲苷 SERV A 15240.021g 1088.00考马斯亮兰G250 SERV A 17524.0125g330.00考马斯亮兰R250 SERV A 17525.0125g330.00二甲基甲酰胺 SERV A20270.03250ml170.00二甲基甲酰胺 SERV A20270.041L450.00蛋白酶抑制剂 SERV A51867.0210mg580.00预染蛋白marker SERV A 39216 250ul2520.00过硫酸铵 SERV A13375.031Kg420.00过硫酸铵（分装） SERV A 13375 50g 35.00200.00甘氨酸（分装） SERV A 23390 500gMTT SERV A20395.021g360.00甲酰胺 SERV A21710.01100ml180.00四甲基乙二胺 TEMED SERV A 35925.01 100ml 220.00甲苯胺蓝 SERV A36693.0225g550.00 氯三苯四唑（TTC） SERV A 37130.03 10g 480.00Test Mixture For Pi- Determination Ph 3-10 SERV A 39211.01 10mg535.00北京希凯创新科技有限公司电话：************传真：************多粘菌素B硫酸盐 SERV A 47975.0125ml 330.0010g盐酸四环素 SERV A35866.01259.00抑肽酶 SERV A10mg13718.01578.005mg52682.02抑肽素 SERV A260.00硫代乙酰胆碱（碘化） SERV A 10570.01 1g230.005mg10710.01放线菌素D SERV A346.001g ATP.Na2 SERV A10920.01173.00EDTA (2Na 盐） SERV A 11280.01100g180.0014421.031STK吉姆萨染液 SERV A800.00500mg15060.02生物素 SERV A389.00SERV A 15090.01 100mg 590.00 bisbenzimide h 33258research grade100g15220.03丙酮酸钠 SERV A590.0035230 100gD-山梨醇（分） SERV A48.00SERV A 22168 250g 550.00 Phytagel™Plant cell culturetested powder 植物凝胶硫酸庆大霉素（分） SERV A 22185 1g 150.00尿素 SERV A500g24524110.00250g35724消泡剂 SERV A210.002g阿利新兰8GX SERV A12021160.00 Gamborg's B 5 植物干粉培SERV A 47306.04 10L 500.00养基10×10mL 600.00SC24019Cruz弗氏不完全佐剂 Santa10×10mL 1200.00弗氏不完全佐剂 Sigma F5506弗氏完全佐剂 Sigma、 F5881 10×10mL 1389.00蛋白酶K （PCR级别） Roche 3508838103 100mg 245.00抗人白介素10 抗体R&D AF-217-NA 100μg 2500.00EGF细胞因子美国进口原装 CRP0819 100μg 450.00安琪酵母粉FA18 5kg 600.00酵母粉安琪 FA18 500g85.00酵母粉英国 L21 500g160.00胰蛋白胨英国 L42 500g320.00Promega Z5481 15×0.6mL 730.00 Streptavidin MagneSphere®Paramagnetic Particles100mgC9891胶原酶 SIGMA675.001kg盐酸胍 FLUKA50950400.00盐酸胍（分）FLUKA50950100g 55.00 北京希凯创新科技有限公司电话：************传真：************010-******** 010-******** 010-******** 010-*******低分子量Marker 17-0446-01575ug/支 210.00100g(分) 480.00405720001DEAE-52 纤维素 whatman230.0025g脱氧但酸钠 SIGMAD6750Digoxin-BSA bovine SIGMA D0565 25mg 7480.00110.005gH9627苏木精（分） SIGMAmouse anti-goat IgG-FITC SANTA CRUZ SC2356 200ul/0.5ml 550.00mouse anti-goat IgG-TR SANTA CRUZ SC3916 200ug/0.5ml 550.00297.00100ml福林酚 MERCK109001010080.001VLH0262HAT SIGMA1VL60.00H0137HT SIGMA聚乙二醇20000（分） FLUKA 81300 100g 65.00聚乙二醇 6000(分） FLUKA 81260 100g 55.00HEPES （分装）15506 100G 90.00DOW ANGUSHEPES （分装）15506 500G 400.00DOW ANGUS55.00 HEPES SPECTRUM25GHE155800.005kg1162245000氯化钠 MERCK485.001kg1065791000磷酸氢二钠 MERCK75.00100G81210PEG1500 FLUKA享受实验的乐趣！享受我们的服务！！！Enjoy Your Research！Enjoy Our Service！！！北京希凯创新科技有限公司电话：************传真：************010-******** 010-******** 010-******** 010-********。
乙酰胆碱
Revised: 01 October 2004Product InformationAmplex® Red Acetylcholine/Acetylcholinesterase Assay Kit (A12217)IntroductionThe Amplex ® Red Acetylcholine/Acetylcholinesterase Assay Kit provides an ultrasensitive method for continuously monitor-ing acetylcholinesterase (AChE) activity or for detecting acetyl-choline (ACh) in a fluorescence microplate reader or fluorometer.Potential uses for this kit include screening for AChE inhibitors and measuring the release of ACh from synaptosomes. In the assay, AChE activity is monitored indirectly using 10-acetyl-3,7-dihydroxyphenoxazine (Amplex Red reagent), a sensitivefluorogenic probe for H 2O 2.1 First, AChE converts the acetylcho-line substrate to choline. Choline is in turn oxidized by choline oxidase to betaine and H 2O 2, the latter of which, in the presence of horseradish peroxidase, reacts with Amplex Red reagent in a 1:1 stoichiometry to generate the highly fluorescent product resorufin.1,2 Because resorufin has absorption and fluorescence emission maxima of approximately 571 nm and 585 nm, respec-tively (Figure 1), there is little interference from autofluorescence in most biological samples.Experiments with purified AChE from electric eel indicate that the Amplex Red Acetylcholine/Acetylcholinesterase AssayKit can detect AChE levels as low as 0.002 U/mL using a reac-tion time of one hour (Figure 2). By providing an excess of AChE in the assay, the kit can also be used to detect acetylcho-line levels as low as 0.3 µM, with a range of detection from 0.3 µM to 100 µM acetylcholine (Figure 3).MaterialsKit Contents$Amplex Red reagent (MW = 257, Component A), five vials,each containing 1 mg$Dimethylsulfoxide (DMSO), anhydrous (Component B),1.3 mL$Horseradish peroxidase (Component C), 200 U, where 1 unit is defined as the amount of enzyme that will form 1.0 mg purpurogallin from pyrogallol in 20 seconds at pH 6.0 at 20°C$Hydrogen peroxide (H 2O 2) (Component D), 500 µL of a sta-bilized ~3% solution; the actual concentration is indicated on the component label$5X Reaction Buffer (Component E), 28 mL of 250 mM Tris-HCl, pH 8.0$Choline oxidase from Alcaligenes sp. (Component F), 12 U,where 1 unit is defined as the amount of choline oxidase that will form 1.0 µmole of H 2O 2 due to oxidation of 1 µmole of choline to betaine aldehyde per minute at pH 8.0 at 37°CFigure 1. Normalized absorption and fluorescence emission spectra ofresorufin, the product of the Amplex Red reagent.Figure 2. Detection of electric eel acetylcholinesterase activity using the Amplex Red reagent–based assay. Each reaction contained 50 µM acetylcholine, 200 µM Amplex Red reagent, 1 U/mL HRP , 0.1 U/mL choline oxidase and the indicated amount of acetylcholinesterase in 1X Reaction Buffer. Reactions were incubated at room temperature.After 15 and 60 minutes, fluorescence was measured in a fluorescence microplate reader using excitation at 560 ± 10 nm and fluorescence detection at 590 ± 10 nm.•Acetylcholine chloride (MW = 181.7, Component G),~100 mg•Acetylcholinesterase from electric eel (Component H),60 U, where one unit is defined as the amount of enzyme that will hydrolyze 1.0 µmole of acetylcholine to choline and acetate per minute at pH 8.0 at 37°C Each kit provides sufficient reagents for approximately 500 assays using a fluorescence microplate reader and reaction volumes of 200 µL per assay.Storage and HandlingUpon receipt, the kit should be stored frozen at -20°C, pro-tected from light. Stored properly, the kit components should remain stable for at least six months. Allow reagents to warm to room temperature before opening vials. The Amplex Red reagent is somewhat air sensitive. Once a vial of Amplex Red reagent is opened, the reagent should be used promptly. PRO-TECT THE AMPLEX RED REAGENT FROM LIGHT.Experimental ProtocolThe following procedure is designed for use with a fluores-cence multiwell plate scanner. For use with a standard fluoro-meter, volumes must be increased accordingly. Please note that the product of the Amplex Red reaction is unstable in the pres-ence of thiols such as dithiothreitol (DTT) or 2-mercaptoethanol.For this reason, the final DTT or 2-mercaptoethanol concentra-tion in the reaction should be less than 10 µM.The absorption and fluorescence of resorufin are pH-depen-dent. Below the pK a (~6.0), the absorption maximum shifts to ~480 nm and the fluorescence quantum yield is markedly lower.In addition, the Amplex Red reagent is unstable at high pH (>8.5). For these reasons, the reaction should be performed at pH 7–8, for example by using the provided reaction buffer (pH 8).Stock Solution Preparation1.1 Prepare an ~20 mM stock solution of the Amplex Red re-agent: Allow one vial of the Amplex Red reagent (Component A) and DMSO (Component B) to warm to room temperature.Just prior to use, dissolve the contents of the vial of Amplex Red reagent (1 mg) in 200 µL DMSO. Each vial of Amplex Red re-agent is sufficient for approximately 100 assays of 200 µL each.This stock solution should be stored frozen at -20°C, protected from light.1.2 Prepare a 1X working solution of Reaction Buffer by adding 5 mL of 5X Reaction Buffer stock solution (Component E) to 20 mL of deionized water (dH 2O). This 25 mL volume of 1X Reaction Buffer is sufficient for approximately 100 assays of 200 µL each, with a 5 mL excess for making stock solutions and dilutions.1.3 Prepare a 200 U/mL stock solution of horseradish peroxidase (HRP) by dissolving the contents of the vial of HRP (Component C) in 1.0 mL of 1X Reaction Buffer. After use, the remaining solution should be divided into small aliquots and stored frozen at -20°C.1.4 Prepare a 20 mM H 2O 2 working solution by diluting the ~3% H 2O 2 stock solution (Component D) into the appropriate volume of dH 2O. The actual H 2O 2 concentration is indicated on the component label. For instance, a 20 mM H 2O 2 working solution can be prepared from a 3.0% H 2O 2 stock solution by diluting 23 µL of 3.0% H 2O 2 into 977 µL of dH 2O. Please note that although the ~3% H 2O 2 stock solution has been stabilized to slow degradation, the 20 mM H 2O 2 working solution will be less stable and should be used promptly.1.5 Prepare a 20 U/mL stock solution of choline oxidase bydissolving the contents of the vial of choline oxidase (Component F) in 600 µL of 1X Reaction Buffer. After use, the remaining solution should be divided into small aliquots and stored frozen at -20°C.1.6 Prepare a 100 mM solution of acetylcholine in dH 2O. For example, dissolve 5 mg of acetylcholine chloride (Component G)in 275 µL of dH 2O. This solution should be made fresh before each set of experiments. Because acetylcholine hydrochloride is hygroscopic, the remaining solid should be stored desiccated at -20°C. Please note that the concentration of acetylcholine in the stock solution should be considered approximate, since the ace-tylcholine hydrochloride may have varying amounts of water in the solid.1.7 Prepare a 100 U/mL stock solution of acetylcholinesterase by dissolving the contents of the vial of acetylcholinesterase (Com-ponent H) in 600 µL of 1X Reaction Buffer. After use, the re-maining solution should be divided into small aliquots and stored frozen at -20°C.Acetylcholine AssayThe following protocol describes the assay of acetylcholine in a total volume of 200 µL per microplate well. The volumes rec-ommended here are sufficient for ~100 assays.Figure 3. Detection of acetylcholine using the Amplex Red reagent–based assay. Each reaction contained 200 µM Amplex Red reagent,1 U/mL HRP , 0.1 U/mL choline oxidase, 0.5 U/mL acetylcholinesterase and the indicated amount of acetylcholine in 1X Reaction Buffer. Reac-tions were incubated at room temperature. After 15 and 60 minutes,fluorescence was measured with a fluorescence microplate reader usingexcitation at 560 ± 10 nm and fluorescence detection at 590 ± 10 nm.2.1 Prepare an acetylcholine standard curve: Dilute the appro-priate amount of 100 mM acetylcholine stock solution (prepared in step 1.6) into 1X Reaction Buffer to produce acetylcholine concentrations of 0 to 100 µM. Use 1X Reaction Buffer without acetylcholine as a negative control. A volume of 100 µL will be used for each reaction. Please note that the acetylcholine concen-trations will be twofold lower in the final reaction volume.2.2 Dilute the acetylcholine-containing samples in 1X Reaction Buffer. A volume of 100 µL will be used for each reaction.2.3 Prepare a positive control by diluting the 20 mM H2O2work-ing solution to 10 µM in 1X Reaction Buffer.2.4 Pipet 100 µL of the diluted samples and controls into sepa-rate wells of a microplate.2.5 Prepare a working solution of 400 µM Amplex Red reagent containing 2 U/mL HRP, 0.2 U/mL choline oxidase and 1 U/mL acetylcholinesterase by adding 200 µL of Amplex Red reagent stock solution (prepared in step 1.1), 100 µL of the HRP stock solution (prepared in step 1.3), 100 µL of the choline oxidase stock solution (prepared in step 1.5) and 100 µL of the acetylcho-linesterase stock solution (prepared in step 1.7) to 9.5 mL of 1X Reaction Buffer. This 10 mL volume is sufficient for ~100 as-says. Note that final concentrations of each component will be twofold lower in the final reaction volume.2.6 Begin the reactions by adding 100 µL of the Amplex Red reagent/HRP/choline oxidase/acetylcholinesterase working solu-tion to each microplate well containing the samples and controls.2.7 Incubate the reactions for 30 minutes or longer at room temperature, protected from light. Because the assay is continu-ous (not terminated), fluorescence may be measured at multiple time points to follow the kinetics of the reactions.2.8 Measure the fluorescence in a fluorescence microplate reader using excitation in the range of 530–560 nm and emission detec-tion at ~590 nm (see Figure 1).2.9 For each point, correct for background fluorescence by sub-tracting the values derived from the no-acetylcholine control. Acetylcholinesterase AssayThe following protocol provides a guideline for using the Amplex Red Acetylcholine/Acetylcholinesterase Assay Kit to measure acetylcholinesterase activity. The volumes recom-mended here are sufficient for ~100 assays, each containing a volume of 200 µL.3.1 Dilute the acetylcholinesterase-containing samples in 1X Reaction Buffer. A volume of 100 µL will be used for each reaction.3.2 Prepare a positive control by diluting the 100 U/mL acetyl-cholinesterase stock solution (prepared in step 1.7) into 1X Reac-tion Buffer to produce a 0.2 U/mL acetylcholinesterase solution. Use 1X Reaction Buffer without acetylcholinesterase as a nega-tive control. A volume of 100 µL will be used for each reaction.3.3 Prepare a second positive control by diluting the 20 mMH2O2working solution to 10 µM in 1X Reaction Buffer.3.4 Pipet 100 µL of the diluted samples and controls into sepa-rate wells of a microplate.3.5 Prepare a working solution of 400 µM Amplex Red reagent containing 2 U/mL HRP, 0.2 U/mL choline oxidase and 100 µM acetylcholine by adding 200 µL of Amplex Red reagent stock solution (prepared in step 1.1), 100 µL of the HRP stock solution (prepared in step 1.3), 100 µL of choline oxidase stock solution (prepared in step 1.5) and 10 µL of acetylcholine stock solution (prepared in step 1.6) to 9.59 mL of 1X Reaction Buffer. This 10 mL volume is sufficient for ~100 assays. Note that final con-centrations of each component will be twofold lower in the final reaction volume.3.6 Begin the reactions by adding 100 µL of the Amplex Red reagent/HRP/choline oxidase/acetylcholine working solution to each microplate well containing the samples and controls.3.7 Incubate the reactions for 30 minutes or longer at room tem-perature, protected from light. Because the assay is continuous (not terminated), fluorescence may be measured at multiple time points to follow the kinetics of the reactions.3.8 Measure the fluorescence in a fluorescence microplate reader using excitation in the range of 530–560 nm and emission detec-tion at ~590 nm (see Figure 1).3.9 For each point, correct for background fluorescence by sub-tracting the values derived from the no-acetylcholinesterase control.References1. Anal Biochem 253, 162 (1997);2. J Immunol Methods 202, 133 (1997).Product List Current prices may be obtained from our Web site or from our Customer Service Department.Cat #Product Name Unit Size A12217Amplex® Red Acetylcholine/Acetylcholinesterase Assay Kit *500 assays*............................................................................. 1 kit A12222Amplex® Red reagent (10-acetyl-3, 7-dihydroxyphenoxazine).................................................................................................. 5 mg A22177Amplex® Red reagent *packaged for high-throughput screening*............................................................................................10 x 10 mg A36006Amplex® UltraRed reagent....................................................................................................................................................... 5 x 1 mgContact InformationFurther information on Molecular Probes products, including product bibliographies, is available from your local distributor or directly from Molecular Probes. Customers in Europe, Africa and the Middle East should contact our office in Paisley, United Kingdom. All others should contact our Technical Assis-tance Department in Eugene, Oregon.Please visit our Web site for the most up-to-date informationMolecular Probes, Inc.29851 Willow Creek Road, Eugene, OR 97402Phone: (541) 465-8300 Fax: (541) 335-0504Customer Service: 6:00 am to 4:30 pm (Pacific Time) Phone: (541) 335-0338 Fax: (541) 335-0305 order@ Toll-Free Ordering for USA and Canada:Order Phone: (800) 438-2209 Order Fax: (800) 438-0228 Technical Assistance: 8:00 am to 4:00 pm (Pacific Time) Phone: (541) 335-0353 Toll-Free: (800) 438-2209Fax:(541) 335-0238 tech@ Invitrogen European HeadquartersInvitrogen, Ltd.3 Fountain DriveInchinnan Business ParkPaisley PA4 9RF, UKPhone: +44(0) 141 814 6100 Fax: +44(0) 141 814 6260 Email: euroinfo@Technical Services: eurotech@Molecular Probes products are high-quality reagents and materials intended for research purposes only. These products must be used by, or directly under the supervision of, a technically qualified individual experienced in handling potentially hazardous chemicals. Please read the Material Safety Data Sheet provided for each product; other regulatory considerations may apply.Several Molecular Probes products and product applications are covered by U.S. and foreign patents and patents pending. Our products are not available for resale or other commercial uses without a specific agreement from Molecular Probes, Inc. We welcome inquiries about licensing the use of our dyes, trademarks or technologies. Please submit inquiries by e-mail to busdev@. All names containing the designation ® are registered with the U.S. Patent and Trademark Office.Copyright 2004, Molecular Probes, Inc. All rights reserved. This information is subject to change without notice.。
Rink Amide-MBHA Resin_0_431041-83-7_Apexbio
//struct//
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Rink Amide-MBHA resin: 4-(2',4'-Dimethoxypheyl-Fmoc-aminomethyl-phenoxy-acetamidonorleucyl-MBHA resin；取代：0.4 - 0.8 mmole/g 树脂；bead 尺寸 100-200 目（聚苯乙烯-1％ DVB）。
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Other Resin and Derivatives
信号通路:
结构：应用：使用 Rink Amide MBHA resin 和 Fomc 策略得到 C-末端酰胺形式的肽。可用于固 相肽合成的取代的二苯甲基胺和苄胺联动剂，鉴定了他们在三氟乙酸中的相对不稳定性。通 过 N α-9-fluorenylmethyloxycarbonyl 保护基策略合成的两个不同的肽酰胺比较了两个最具 反应活性的连接试剂[2]。 参考文献: [1] Boussard C, Doyle VE, Mahmood N, Klimkait T, Pritchard M, Gilbert IH. Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure. Eur J Med Chem. 2002;37(11):883-90. [2] Michael S. Bernatowicz, Scott B. Daniels, Hubert Kster. A comparison of acid labile linkage agents for the synthesis of peptide C-terminal amides. Tetrahedron Letters Volume 30, Issue 35, 1989, Pages 4645–4648
Radezolid_新型的恶唑烷酮类抗生素_869884-78-6_Apexbio
细胞和内皮细胞，从而发挥其抗菌作用。 体外：一项研究发现，Radezolid 在所有类型的细胞（人角质形成细胞、内皮细胞、支气管 上皮细胞、成骨细胞、巨噬细胞以及大鼠胚胎成纤维细胞）中具有相似的积累量（~10 倍）。 在所有这些模型中，不论细菌种类、耐药表型或感染的细胞类型，在相等质量浓度下， Radezolid 的抗菌作用均比 Linezolid 高 10 倍。上述数据表明，Radezolid 的胞内积累量在治疗 细胞复发性或持续性感染中起着决定性作用[2]。 体内：接种 24 小时后，50 mg/kg 的 Radezolid 和 Linezolid 表现出相当的细菌负荷减少。组 织药物浓度的曲线下面积（AUC）分析表明，相对于未受感染的大腿组织，Radezolid 在受感 染大腿中的积累量为 2.4 倍。Linezolid 没有积聚于受感染的大腿[3]。 临床试验：Radezolid（INN，RX-1741）由 Rib-X 制药有限公司研发，用于治疗严重的多重耐 药菌感染。Radezolid 已完成了两项 II 期临床试验。上述两项临床试验分别验证了 Radezolid 对无并发症皮肤及皮肤结构感染（uSSSI）和社区获得性肺炎（CAP）的疗效 （/wiki/Radezolid）。
引用文献
1.Michalska K, Gruba E, et al. "Application of spectroscopic methods (FT-IR, Raman, ECD and NMR) in studies of identification and optical purity of radezolid." Spectrochim Acta A Mol Biomol Spectrosc. 2017 Apr 20;183:116-122. PMID:28456082 2.Michalska K, Gruba E, et al. "Enantioselective recognition of radezolid by cyclodextrin modified capillary electrokinetic chromatography and electronic circular dichroism." J Pharm Biomed Anal. 2017 May 30;139:98-108. PMID:28279932
BNP-(1-32)--human-脑利钠肽-114471-18-0-Apexbio
信号通路:
BNP (1-32), human
产品描述:
脑利钠肽（BNP），也被称为 B 型利钠肽或 GC-B，是由心脏的心室响应心肌细胞过度拉伸而 分泌的一种含有 32 个氨基酸的多肽。BNP 的释放是由钙离子调节的（1）。BNP 的命名是由
于最初它是在猪脑提取物中被确定，但是在人类中它主要产于心室。BNP 的生理学作用与 ANP 类似，包括降低全身血管阻力和中心静脉压以及增加尿钠排泄。因此，BNP 和 ANP 的 净效应是降低血液量，从而降低全身血压和后负荷，最终导致心输出量增加，部分归因于较
高的射血分数。BNP 或 NT-BNP 的主要临床应用是在紧急设置中排除急性心脏衰竭（2）。重 组 BNP 即奈西立肽（Nesiritide），被用于治疗心脏衰竭（3）。
实验操作
细胞实验: 细胞系 溶解方法
反应时间 应用
动物实验: 动物模型 剂量 注意事项
正常成年犬心室成纤维细胞 BNP (1-32)在无菌水中的溶解度大于 10mM。分装保存在-80℃， 可保存数月。 1 μM, 5 min
产品说明书
化学性质
产品名: BNP (1-32), human 修订日期: 6/30/2016
产品名: Cas No.: 分子量: 分子式: 别名:
化学名: SMILES: 溶解性: 储存条件: 一般建议:
运输条件:
BNP (1-32), human 114471-18-0 3464.04 C143H244N50O42S4 H2N-Ser-Pro-Lys-Met-Val-GlnGly-Ser-Gly-Cys-Phe-Gly-Arg-Ly s-Met-Asp-Arg-Ile-Ser-Ser-SerSer-Gly-Leu-Gly-Cys-Lys-Val-Le u-Arg-Arg-His-OH
南京建成 产品目录及价格表 17-3-22
抗坏血酸过氧化物酶（APX）测试盒（紫外 比色法） 抗坏血酸氧化酶（AAO）活性测试盒（比色 抗坏血酸（AsA）含量测试盒（紫外比色 γ-谷氨酰半胱氨酸连接酶（GCL）测试盒 （比色法） 硫氧还蛋白氧化还原酶（TrxR）测试盒（比 色法） 硫氧还蛋白过氧化物酶（TPX）测试盒（紫 外比色法） NAD激酶（NADK）测试盒（比色法） NADH氧化酶（NOX）测试盒（比色法） 辅酶ⅡNADP（H）含量测试盒（比色法） 辅酶ⅠNAD（H）含量测试盒（比色法） 腺苷脱氨酶（ADA）测试盒（酶比色法） （微板法） 游离脂肪酸（NEFA）测试盒（酶法，双试 剂）（微板法） 5’－核苷酸酶（5’-NT）测试盒（酶比色法） （微板法） 糖化血清蛋白（GSP）试剂盒（NBT法） （微板法） 胆碱酯酶（CHE）测试盒（速率法）(微板 白蛋白（ALB）测定试剂盒（带标准：溴甲 酚绿法） 柠檬酸合成酶（CS）测定试剂盒（微板法） 柠檬酸合成酶（CS）测定试剂盒（微板法） 植物提取液 蔗糖测定试剂盒（国标法） 蔗糖测定试剂盒（紫外比色法） γ-谷氨酰半胱氨酸合成酶（γ-GCS）测定试剂 盒（速率法） 糜蛋白酶测定试剂盒 谷氨酸测定试剂盒（紫外比色法） 超微量ATP酶测试盒（Na+K+、Ca2+Mg2+、 T－ATP酶） 超微量ATP酶测试盒（Na+K+、Ca2+Mg2+、 T－ATP酶） 超微量ATP酶测试盒（Na+K+、Ca2+Mg2+、 T－ATP酶） 超微量ATP酶测试盒（Na+K+、Ca2+Mg2+、 T－ATP酶） 超微量ATP酶测试盒（Na+K+、Ca2+Mg2+－ ATP酶） 超微量ATP酶测试盒（Na+K+、Ca2+Mg2+－ ATP酶）
AdvanceBio SEC 130A
AdvanceBio SEC 130Å Protein Standard, Part Number 5190-9416*************(24小时)化学品安全技术说明书GHS product identifier 应急咨询电话（带值班时间）::供应商/ 制造商:安捷伦科技贸易（上海）有限公司中国（上海）外高桥自由贸易试验区英伦路412号（邮编:200131)电话号码： 800-820-3278传真号码: 0086 (21) 5048 2818AdvanceBio SEC 130Å Protein Standard, Part Number 5190-9416化学品的推荐用途和限制用途5190-9416部件号:安全技术说明书根据 GB/ T 16483-2008 和 GB/ T 17519-2013GHS化学品标识:AdvanceBio SEC 130Å 蛋白标样，部件号 5190-9416推荐用途3.5 mg, 冻干:有关环境保护措施，请参阅第 12 节。
物质或混合物的分类根据 GB13690-2009 和 GB30000-2013紧急情况概述固体。
[冻干]无资料。
无资料。
H320 - 造成眼刺激。
H334 - 吸入可能导致过敏或哮喘症状或呼吸困难。
物理状态:颜色:气味:GHS危险性类别警示词:危险危险性说明:H320 - 造成眼刺激。
H334 - 吸入可能导致过敏或哮喘症状或呼吸困难。
:防范说明标签要素混合物中由对水生环境毒性未知的组分组成的比率： 87.3%象形图皮肤腐蚀/刺激 - 类别 3严重眼损伤/眼刺激 - 类别 2B H334呼吸道致敏物 - 类别 1H317皮肤致敏物 - 类别 1P261 - 避免吸入粉尘。
P264 - 作业后彻底清洗。
P272 - 受沾染的工作服不得带出工作场地。
事故响应:P342 + P311 - 如有呼吸系统病症： 呼叫解毒中心或医生。
A-770041_选择性Lck抑制剂_869748-10-7_Apexbio
生物活性
靶点 :
Tyrosine Kinase
信号通路:
Src
产品描述:
Src 家族酪氨酸激酶包含 8 个高度同源的蛋白，主要表达于造血组织，其中 lck 和 fyn 在 T 细 胞中表达。Lck 在 T 细胞受体信号转导的起始阶段起关键作用，导致下游信号通路级联。 A-770041 是一种口服可用的吡唑并[3,4-d]嘧啶，与之前报道的化合物相比，A-770041 对 Lck
有选择性。 体外：A-770041 是一种 147 nM 的 Lck 抑制剂(1 mM 的 ATP)，对 Fyn 的选择性为其他相关 Src 家族激酶的 300 倍。研究发现，A-770041 可抑制全血中伴刀豆球蛋白 A 刺激的 IL-2 的产生， EC50 值约为 80 nM[1]。 体内：A-770041 具有口服生物利用度(每公斤体重用药 10 mg 的情况下 F = 34.1 ± 7.2%)， 反应半衰期时间（t1/2）为 4.1 ± 0.1 小时。口服 A-770041 可抑制体内伴刀豆球蛋白 A 诱 发的 IL-2 的产生(体内 EC50 值为 78 ± 28 nM)。每日每公斤体重用药 10 mg 或以上剂量的 A-770041 可跨越主要组织相容性障碍，至少在 65 天内防止 Brown Norway 大鼠向 Lewis 大鼠 进行心脏异位移植的排斥反应。此外，每日每公斤体重给药 20 mg 的 A-770041 或 10 mg 的 环孢菌素 A 的动物体内的移植物发生最小微血管改变或多灶性单核细胞浸润。相反， A-770041 给药的动物体内的移植物中的肌细胞矿化作用比环孢菌素 A 给药的动物体内的移 植物中的肌细胞矿化作用弱。 临床试验：目前 A-770041 处在临床前发展阶段，还没有临床数据。
MMAD_微管蛋白抑制剂_203849-91-6_Apexbio
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Cell Cycle/Checkpoint
信号通路:
Microtubule/Tubulin
O=C([C@@H]([C@@H](OC)[C@]1([H])CCCN1C(C[C@@H](OC)[C@@ H](N(C)C([C@@H](NC([C@H](C(C)C)N([H])C)=O)C(C)C)=O)[C@@H]( C)CC)=O)C)N[C@H](C2=NC=CS2)CC3=CC=CC=C3 Soluble in DMSO
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
特别声明
产品仅用于研究，
不针对患者销售，望谅解。
每个产品具体的储存和使用信息显示在产品说明书中。ApexBio 产品在推荐的条件下是稳定 的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长 期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照 产品说明书上的要求名: MMAD 修订日期: 6/30/2016
产品名: Cas No.: 分子量: 分子式: 别名: