January Paper_Answers(1)
小学五年级上册J卷英语第2单元期测验题(答案和解释)

小学五年级上册英语第2单元期测验题(答案和解释)英语试题一、综合题(本题有50小题,每小题2分,共100分.每小题不选、错误,均不给分)1.Which word is used to say goodbye?A. HelloB. GoodbyeC. Good morningD. Please2.What do you use to write on a board?A. PenB. ChalkC. PencilD. Eraser3.Which animal can swim?A. DogB. BirdC. FishD. Cat4.Which of these is used for cutting?A. ForkB. SpoonC. KnifeD. Plate5.On Sundays, my family __________ (visit) my grandparents. We __________ (have) lunch together, and after that, we __________ (go) for a walk in the park. My brother__________ (love) playing with the dogs in the park, and I __________ (enjoy) reading under a tree.6.Which one is a pet?A. DogB. TigerC. LionD. Elephant7.My school is very big. It has many classrooms, a library, and a __. We have __ there every week. The school also has a __ where we can play sports like __ and __. I really enjoy my time at school with my friends and teachers.8.Which of these is a part of the body?A. HandB. TableC. TreeD. Chair9.Which of these is a wild animal?A. DogB. LionC. CowD. Horse10.The students ______ (study) for their exams all week. They ______ (take) a break on Friday afternoon and ______ (play) soccer together. Some of them ______ (feel) nervous, but most ______ (be) confident. They ______ (work) very hard, so I believe they ______ (do) well in the exams.11.Which season comes after winter?A. SummerB. AutumnC. SpringD. Fall12.Every morning, I ______ (wake) up at 7 o’clock. After I ______ (get) out of bed, I ______ (brush) my teeth and ______ (eat) breakfast. Then, I ______ (put) on my school uniform and ______ (leave) for school. I ______ (arrive) at school at 8 o’clock.13.You are going to the store with your parents. You need to buy some milk, bread, and eggs. What are you going to buy?A. ClothesB. GroceriesC. ToysD. Books14.Which of these animals has feathers?A. FishB. DogC. BirdD. Cow15.Which of these is used to cut paper?A. ScissorsB. KnifeC. PlateD. Fork16.Sarah and her friends are having a picnic in the park. They lay a big __________ on the grass. Sarah brought some __________, and her friend Lucy brought some__________. After eating, they play some games, like tag and __________. Everyone is enjoying the sunny day.17.It is a __________ day today, so we are going to the __________. I will bring my __________ to play with my friends. My mom will bring a __________ so we can have a picnic. I like to eat __________ and drink __________ at the beach. After playing, we will take a __________ in the sun.18.This afternoon, we __________ (1) a picnic in the park. My father __________ (2) sandwiches, and my mother __________ (3) juice. We __________ (4) a great time playing games and __________ (5) food. I __________ (6) some photos with my camera. It __________ (7) a beautiful day.19.I ______ (go) to the library every weekend. Last Saturday, I ______ (borrow) a book about dinosaurs. I ______ (read) it for two hours. The book ______ (be) very interesting. I ______ (learn) a lot of new things. After reading, I ______ (return) the book and ______ (borrow) another one about space.20.Which animal can swim?A. ElephantB. BirdC. FishD. Tiger21.Which of these is a season?A. WinterB. FridayC. JanuaryD. Tuesday22.How do you say "谢谢" in English?A. PleaseB. SorryC. Thank youD. Goodbye23.Which one is a fruit?A. DogB. AppleC. ChairD. Table24.Every day, I ______ (walk) to school. I ______ (leave) my house at 7:30 a.m. and ______ (arrive) at school at 8:00 a.m. Yesterday, I ______ (leave) a bit late and ______ (miss) the bus. I ______ (run) to school and ______ (arrive) just in time.25.Which one is a color?A. JumpB. GreenC. RunD. Sing26.Lily and her friends are preparing for a field trip to the __________. They are going to see __________ and learn about their habitat. Lily is excited because she loves animals and wants to become a __________ when she grows up. Her friend Tim is going to bring a __________ to take notes during the trip. They will also take __________ to capture the memories. After the field trip, they are going to have a picnic in the __________ and enjoy their lunch.27.I __________ (1) to the library every Saturday. I __________ (2) books about animals and __________ (3) them at home. My little brother __________ (4) to read stories about dinosaurs, and I __________ (5) to read about sea creatures.28.Which of these animals has a long neck?A. GiraffeB. LionC. ElephantD. Tiger29.Which of these is a day of the week?A. WednesdayB. SpoonC. ChairD. Plate30.Which one is a beverage?A. AppleB. WaterC. BreadD. Carrot31.Which of these is a color?A. GreenB. SpoonC. HatD. Shirt32.Which of these is a holiday?A. ChristmasB. MondayC. SeptemberD. Winter33.Every Saturday, my family goes to the __. We buy vegetables and fruits like __, __, and __. My dad always picks the __ because they are fresh and sweet. After shopping, we go to a café to drink __ and eat some __. We love spending time together as a family.34.What is the color of a banana?A. GreenB. YellowC. RedD. Purple35.Which of the following is a vegetable?A. AppleB. CarrotC. OrangeD. Grape36.Jack and his family are going to the beach for a day of fun. They pack a__________ (bag) with towels, sunscreen, and their __________ (swimsuits) for swimming. Jack loves playing beach volleyball, so he also brings a __________ (ball) to the beach. In the afternoon, they enjoy a __________ (snack) while watching the sunset.37.Tom is practicing his piano at home. He starts by playing the __________ to warm up his fingers. After that, he practices a __________ he learned in his music class. Tom is working hard to become a better __________ because he wants to perform at the school talent show.38.Which one is a tool?A. HammerB. CarC. DogD. Plate39.What do we call the sound a cat makes?A. BarkB. MeowC. RoarD. Moost holiday, I __________ (1) to the mountains with my friends. We __________ (2) hiking and __________ (3) many beautiful photos. We __________ (4) a great time there.41.Which one is a body part?A. TableB. ChairC. ArmD. Pen42.Which of these is a means of transportation?A. BicycleB. PlateC. ChairD. Spoonst Saturday, I _______ (visit) my grandparents. We _______ (spend) the whole day together. In the morning, we _______ (go) to the market, and in the afternoon, we_______ (play) cards. I _______ (help) Grandma with cooking dinner, and we _______ (eat) a big meal together.44.Which one is a color?A. BlueB. ChairC. TableD. Dog45.What do you use to cut paper?A. KnifeB. ForkC. ScissorsD. Plate46.Which of these is a type of flower?A. PineB. TulipC. OakD. Maple47.What is the opposite of "fast"?A. SlowB. TallC. ShortD. Big48.Jack is at school today. He has a lot of homework. First, he needs to finish his__________ homework. The teacher asked them to read a chapter from the __________. Jack writes down the answers to the questions and checks his __________. He also needs to study for his __________ test tomorrow. After finishing, Jack feels tired but proud of his work.49.What do we use to write on paper?A. KnifeB. EraserC. PenD. Plate50.Which of these animals has scales?A. FishB. DogC. CatD. Bird(答案及解释)。
九年级上册第一次月考英语质量检测试题(人教版,含答案)

一、情景反应(每小题1分,满分5分)本题共5个小题,每小题你将听到一组对话。
请你从每小题所给的A、B、C 三幅图片中,选1.A. B. C.2.A.B.C.3.A. B. C.4.A.B.C.5.A. B. C.二、对话理解(每小题1分,满分5分)本题共5个小题,每小题你将听到一组对话和一个问题。
请你从每小题所给的A、B、C 三个选项中,选出一个最佳选项,并在答题卡上将该项涂黑。
1.A.In Canada. B.In Australia. C.In America.2.A.The Spring Festival.B.The Lantern Festival.C.The Mid-Autumn Festival.3.A.They drank some beer. B.They sang traditional songs.C.They watched the fireworks.4.A.Mid-Autumn Day.B.Independence Day. bour Day.5.A.It’s on May 1st.B.It’s on October 1st.C.It’s on the first Monday in September.三、语篇理解(每小题1分,满分5分)本题你将听到一段对话。
请你根据对话内容和所提出的5个问题,从每小题所给的A、B、C三个选项中,选出一个最佳选项,并在答题卡上将该项涂黑。
1.When will Lisa take part in the English Contest?A.In July. B.In June. C.In January.2.Whenwill they listen to the VOA radio?A.Every morning. B.Every afternoon. C.Every evening.3.Wherewill they do exercises in the afternoon?A.Outside the classroom. B.At home. C.In the library.4.What will they do after they study in the library?A.Practice listening. B.Practice speaking. C.Practice writing.5.Why does the girl want the boy to help her on weekends as well?A.Because she is goodat English grammar.B.Because she doesn’t do well in English grammar.C.Because she wantsto practice her speaking on weekends.四、听力填空(每小题1分,满分5分)本题你将听到一篇短文。
欧盟GMP指南中文版

QbR Frequently Asked QuestionsDisclaimer: These are general answers and may not be applicable to every product. Each ANDA is reviewed individually. This document represents the Office of Generic Drugs’s (OGD’s) current thinking on these topics.Format and SubmissionHow should QbR ANDAs be submitted?OGD’s QbR was designed with the expectation that ANDA applications would beorganized according to the Common Technical Document (CTD) format, a submissionformat adopted by multiple regulatory bodies including FDA. Generic firms are strongly recommended to submit their ANDAs in the CTD format (either eCTD or paper) tofacilitate implementation of the QbR. The ANDA Checklist for completeness andacceptability of an application for filing can be found on the OGD web page:/cder/ogd/anda_checklist.pdf .What is a QOS?The Quality Overall Summary (QOS) is the part of the CTD format that provides asummary of the CMC aspects of the application. It is an important tool to make the QbR review process more efficient.How long should a QOS be?OGD believes the CTD guidance1 recommendation of 40 pages to be an appropriatecompromise between level of detail and concision. The CTD guidance recommendation does not include tables and figures.The same information should not be included in multiple locations in the QOS. Instead of repeating information, refer to the first location of the original information in the QOS by CTD section number.Should the QOS be submitted electronically?All applications should include an electronic QOS. For paper submissions, it isrecommended that both an electronic QOS and a paper QOS be included.What file format should be used for the QOS?All applications, both eCTD and paper submissions, should have an electronic QOS. The electronic QOS should be contained in one document. Do not provide separate files foreach section or question.The electronic QOS should be provided as both a pdf and a Microsoft Word file. Microsoft Word files should be readable by Word 2003.1 Guidance for Industry M4Q: The CTD – Quality (August 2001) /cder/guidance/4539Q.htmWhat fonts should be used in the QOS?Because of FDA’s internal data management systems, please use only use these TrueType fonts: Times New Roman, Arial, Courier New. Times New Roman is recommended as the main text font.Should the applicable QbR question be presented within the body of Module 2 of the relevant section, followed by sponsor's answer?Yes, include all the QbR questions without deletion in the QOS.Can the granularity of module 3 be used in module 2?Yes, the granularity can be used for section and subsection headings. However, the QOS should always be submitted as a single file.Can color be used in the QOS?Yes, but sponsors should ensure that the QOS is legible when printed in black and white.Colored text should not be used.Is the QOS format available on OGD webpage and questions therein mandatory to be followed?For an efficient review process, OGD desires all applications to be in a consistent format.See the OGD QbR questions and example QOS:/cder/ogd/QbR-Quality_Overall_Summary_Outline.doc/cder/ogd/OGD_Model_Quality_Overall_ Summary.pdf/cder/ogd/OGD_Model_QOS_IR_Product.pdfFor amendments to applications, should the documentation consist of a revision of the QOS? Would new PD reports be required?The QOS should not be updated after submission of the original ANDA. Any additional data (including any new PD reports) should be provided as a stand alone amendment.Responses to deficiencies should be provided in electronic format as both a pdf andMicrosoft Word file.After January 2007, what will happen to an application that does not have a QOS or contains an incomplete QOS?OGD will contact the sponsor and ask them to provide a QOS. If the sponsor provides the QOS before the application comes up for review, OGD will use the sponsor’s QOS.OGD’s QbR questions represent the current thinking about what information is essential to evaluate an ANDA. Reviewers will use deficiency letters to ask ANDA sponsors thequestions that are not answered in the sponsor’s QOS.In February 2007, 75% of ANDAs submitted contained a QOS.If a question is not applicable to a specific formulation or dosage form, should the question be deleted or unanswered?Sponsors should never delete a QbR question, but instead answer as not applicable, with a brief justification. Please answer all parts of multi-part questions.For sterile injectables, to what extent should sterility assurance be covered in QOS?The current QbR was not intended to cover data recommendations for Sterility Assurance information. In the future, other summaries will cover other disciplines.MAPP 5040.1, effective date 5/24/04, specifies location of the microbiology information in the CTD format.Where in the CTD should an applicant provide comparative dissolution data between the generic and RLD?The comparison between the final ANDA formulation and the RLD should be provided in5.3.1, this comparison should be summarized in the QOS. Comparisons with otherformulations conducted during development should be included in 3.P.2.Is it possible to submit an amendment in CTD format for a product that was already submitted in the old ANDA format?No, all amendments to an application under review should use the same format as theoriginal submission.How is a paper CTD to be paginated?“Page numbering in the CTD format should be at the document level and not at the volume or module level. (The entire submission should never be numbered consecutively by page.) In general, all documents should have page numbers. Since the page numbering is at the document level, there should only be one set of page numbers for each document.”2. For paper submission, tabs locating sections and subsections are useful.For the ANDA submitted as in paper CTD format, can we submit the bioequivalence study report electronically? Or does the Agency require paper copy only?The bioequivalence summary tables should always be provided in electronic format.Will QbR lead to longer review times?Many of the current long review times result from applications that do not completelyaddress all of the review issues and OGD must request additional information through the deficiency process. This iterative process will be reduced with the use of the QbR template.Sponsors that provide a QOS that clearly and completely addresses all the questions in the QbR should find a reduction in the overall review time.Will DMFs for the drug substance be required to be in CTD if the ANDA is in CTD format?No. CTD format DMFs are recommended.What should be included in 3.2.R.1.P.2, Information on Components?COA’s for drug substance, excipients and packaging components used to produce theexhibit batch.2 Submitting Marketing Applications According to the ICH/CTD Format: General Considerations/cder/guidance/4707dft.pdfHow should an ANDA sponsor respond to deficiencies?OGD requests that sponsors provide a copy of the response to deficiencies in electronic format as both a pdf file and a Microsoft Word file.QUALITY OVERALL SUMMARY CONTENT QUESTIONS2.3 Introduction to the Quality Overall SummaryWhat information should be provided in the introduction?Proprietary Name of Drug Product:Non-Proprietary Name of Drug Product:Non-Proprietary Name of Drug Substance:Company Name:Dosage Form:Strength(s):Route of Administration:Proposed Indication(s):Maximum Daily Dose:2.3.S DRUG SUBSTANCEWhat if an ANDA contains two or more active ingredients?Prepare separate 2.3.S sections of the QOS for each API. Label them 2.3.S [API 1] and2.3.S [API 2].What if an ANDA contains two or more suppliers of the same active ingredient?Provide one 2.3.S section. Information that is common between suppliers should not be repeated. Information that is not common between suppliers (e.g. different manufacturing processes) should have separate sections and be labeled accordingly (drug substance,manufacturer 1) and (drug substance, manufacturer 2).Can information in this section be provided by reference to a DMF?See individual questions for details. As a general overview:•Information to be referenced to the DMFo Drug substance structure elucidation;o Drug substance manufacturing process and controls;o Container/closure system used for packaging and storage of the drugsubstance;o Drug substance stability.•Information requested from ANDA Sponsoro Physicochemical properties;o Adequate drug substance specification and test methods including structure confirmation;o Impurity profile in drug substance (process impurity or degradant);o Limits for impurity/residual solvent limits;o Method validation/verification;o Reference standard.2.3.S.1 General InformationWhat are the nomenclature, molecular structure, molecular formula, and molecular weight?What format should be used for this information?Chemical Name:CAS #:USAN:Molecular Structure:Molecular Formula:Molecular Weight:What are the physicochemical properties including physical description, pKa, polymorphism, aqueous solubility (as function of pH), hygroscopicity, melting point, and partition coefficient?What format should be used for this information?Physical Description:pKa:Polymorphism:Solubility Characteristics:Hygroscopicity:Melting Point:Partition Coefficient:Should all of these properties be reported? Even if they are not critical?Report ALL physicochemical properties listed in the question even if they are not critical.If a property is not quantified, explain why, for example: “No pKa because there are no ionizable groups in the chemical structure” or “No melting point because compounddegrades on heating”.What solubility data should be provided?The BCS solubility classification3 of the drug substance should be determined for oral dosage forms.Report aqueous solubility as a function of pH at 37º C in tabular form. Provide actualvalues for the solubility and not descriptive phrases such as “slightly soluble”.3 See BCS guidance /cder/guidance/3618fnl.pdf for definitionSolvent Media and pH Solubility Form I(mg/ml) Solubility Form II(mg/ml)Should pH-solubility profiles be provided for all known polymorphic forms?No, it is essential that the pH-solubility profile be provided for the form present in the drug product. The relative solubility (at one pH) should be provided for any other more stable forms.Physicochemical information such as polymorphic form, pKa, solubility, is usually in the confidential section of DMF. Is reference to a DMF acceptable for this type of information?No, knowledge of API physicochemical properties is crucial to the successful development of a robust formulation and manufacturing process. In view of the critical nature of thisinformation, OGD does not consider simple reference to the DMF to be acceptable.The Guidance for Industry: M4Q: The CTD-Quality Questions and Answers/ Location Issues says only the polymorphic form used in the drug product should be described in S.1 and other known polymorphic forms should be described in S.3. OGD’s examples placed information about all known polymorphic forms in S.1. Where does OGD want this information?This information may be included in either S.1 or in S.3. Wherever presented, list allpolymorphic forms reported in literature and provide brief discussion (i.e., which one is the most stable form) and indicate which form is used for this product.Other polymorph information should be presented by the ANDA applicant as follows: • 2.3.S.3 Characterization: Studies performed (if any) and methods used to identify the potential polymorphic forms of the drug substance. (x-ray, DSC, and literature) • 2.3.S.4 Specification: Justification of whether a polymorph specification is needed and the proposed analytical method• 2.3.P.2.1.1 Pharmaceutical Development –Drug Substance: Studies conducted to evaluate if polymorphic form affects drug product propertiesWhy does OGD need to know the partition coefficient and other physicochemical properties?Physical and chemical properties may affect drug product development, manufacture, or performance.2.3.S.2 ManufactureWho manufactures the drug substance?How should this be answered?Provide the name, address, and responsibility of each manufacturer, including contractor, and each proposed production site or facility involved in manufacturing and testing.Include the DMF number, refer to the Letter of Authorization in the body of data, andidentify the US Agent (if applicable)How do the manufacturing processes and controls ensure consistent production of the drug substance?Can this question be answered by reference to a DMF?Yes. It is preferable to mention the source of the material (synthetic or natural) when both sources are available.The DMF holder’s COA for the batch used to manufacture the exhibit batches should be provided in the body of data at 3.2.S.4.4.If there is no DMF, what information should be provided?A complete description of the manufacturing process and controls used to produce the drugsubstance.2.3.S.3 CharacterizationHow was the drug substance structure elucidated and characterized?Can structure elucidation be answered by reference to a DMF?Yes.What information should be provided for chiral drug substances?When the drug substance contains one or more chiral centers, the applicant should indicate whether it is a racemate or a specific enantiomer.When the drug substance is a specific enantiomer, then tests to identify and/or quantify that enantiomer should be included. Discussion of chirality should include the potential forinterconversion between enantiomers (e.g. racemization/epimerization).How were potential impurities identified and characterized?List related compounds potentially present in the drug substance. Identify impurities bynames, structures, or RRT/HPLC. Under origin, classify impurities as process impurities and/or degradants.Structure Origin ID ChemicalName[SpecifiedImpurity]Is identification of potential impurities needed if there is a USP related substances method?Yes.Can this question be answered by reference to a DMF?The ANDA should include a list of potential impurities and their origins. The methodsused to identify and characterize these impurities can be incorporated by reference to the DMF.According to the CTD guidance, section S.3 should contain a list of potential impurities and the basis for the acceptance criteria for impurities, however in the OGD examples this information was in section S.4. Where should it go?This information may be included in either S.3 or in S.4.2.3.S.4 Control of Drug SubstanceWhat is the drug substance specification? Does it include all the critical drug substance attributes that affect the manufacturing and quality of the drug product?What format should be used for presenting the specification?Include a table of specifications. Include the results for the batch(es) of drug substance used to produce the exhibit batch(es). Identify impurities in a footnote. Test results and acceptance criteria should be provided as numerical values with proper units whenapplicable.Tests Acceptancecriteria AnalyticalprocedureTest results for Lot#AppearanceIdentificationA:B:AssayResidualSolventsSpecified ImpuritiesRC1RC2RC3Any UnspecifiedImpurityTotal Impurities[AdditionalSpecification]*RC 1: [impurity identity]RC 2: [impurity identity]RC 3: [impurity identity]What tests should be included in the drug substance specification?USP drugs must meet the USP monograph requirements, but other tests should be included when appropriate. For USP and non USP drugs, other references (EP, BP, JP, the DMF holder’s specifications, and ICH guidances) can be used to help identify appropriate tests.Only relevant tests should be included in the specification. Justify whether specific tests such as optical rotation, water content, impurities, residual solvents; solid state properties(e.g. polymorphic form, particle size distribution, etc) should be included in thespecification of drug substance or not.Does OGD accept foreign pharmacopeia tests and criteria for drug substances?There are several examples where a drug substance is covered by a monograph in EP or JP, but not in the USP. ANDA and DMF holders can obtain information regardingphysicochemical properties, structure of related impurities, storage conditions, analytical test methods, and reference standards from EP or JP to support their submission to OGD.Although the USP remains our official compendium, we usually accept EP when the drug substance is not in USP (However, a complete validation report for EP methods should be provided in the ANDA).For each test in the specification, is the analytical method(s) suitable for its intended use and, if necessary, validated? What is the justification for the acceptance criterion?What level of detail does OGD expect for the analytical method justifications and validations?Provide a summary of each non-USP method. This can be in a tabular or descriptive form.It should include the critical parameters for the method and system suitability criteria ifapplicable. See an example in section 2.3.P.5 of this document.For each analytical procedure, provide a page number/link to the location of validationinformation in Module 3. For quantitative non-compendial analytical methods, provide a summary table for the method validation. See an example in section 2.3.P.5 of thisdocument.Is validation needed for a USP method?No, but USP methods should be verified and an ANDA sponsor should ensure that theUSP assay method is specific (e.g. main peak can be separated from all process impurities arising from their manufacturing process and from degradation products) and the USPrelated substance method is specific (e.g. all the process impurities and degradants can be separated from each other and also separated from main peak).Is validation needed if the USP method is modified or replaced by an in-house method?Yes. Data supporting the equivalence or superiority of the in-house method should beprovided. In case of a dispute, the USP method will be considered the official method.Is reference to the DMF for drug substance analytical method validations acceptable?No. ANDA sponsors need to either provide full validation reports from the ANDA holder or reference full validation reports from the DMF holder (provided there is a copy of the method validation report in the ANDA and method verification from the ANDA holder). AppearanceIdentityAssayImpurities (Organic impurities)What format should be used for related substances?List related compounds potentially present in the drug substance. (Either here or S.3)Name Structure Origin[SpecifiedImpurity]Provide batch results and justifications for the proposed acceptance criteria. See guidance on ANDA DS impurities4 for acceptable justifications. If the DS is compendial, include the USP limits in the table. If the RLD product is used for justification/qualification, then its results should also be included. If an ICH justification is used, then the calculation of the ICH limits should be explained.To use the ICH limits, determine the Maximum Daily Dose (MDD) indicated in the label and use it to calculate the ICH Thresholds: Reporting Threshold (RT), Identification1. The amount of drug substance administered per day2. Higher reporting thresholds should be scientifically justified3. Lower thresholds can be appropriate if the impurity is unusually toxicSponsors can use the ICH limits to ensure the LOQ for the analytical method is equal or below the RT, establish the limit for “Any Unspecified Impurity” to equal or below the IT, and establish limits for each “Specified Identified Impurity” and each “SpecifiedUnidentified Impurity”5 to equal or below the QT.An impurity must be qualified if a limit is established above the QT. Options forqualification include reference to the specific impurity listed in a USP monograph,comparison to the RLD product, identifying the impurity as a significant metabolite of the drug substance, literature references including other compendial monographs (EP, BP, JP), or conducting a toxicity study.4/cder/guidance/6422dft.pdf5 The ANDA DS guidance states “For unidentified impurities to be listed in the drug substance specification, we recommend that you clearly state the procedure used and assumptions made in establishing the level of the impurity. It is important that unidentified specified impurities be referred to by an appropriate qualitative analytical descriptive label (e.g., unidentified A, unidentified with relative retention of 0.9)”. Q3A(R) states “When identification of an impurity is not feasible, a summary of the laboratory studies demonstrating the unsuccessful effort should be included in the application.”Name DrugSubstance(Lot #)USPLimit forDrugSubstanceRLDDrugProduct(Lot #)ProposedAcceptancecriteriaJustification[Specified Impurity,Identified][BatchResults][BatchResults][SpecifiedImpurity,Unidentified]Any UnspecifiedImpurityTotalImpuritiesInclude the column for RLD drug product only if that data is used to justify the drugsubstance limit (example a process impurity that is also found in the RLD).What is OGD’s policy on genotoxic impurities?FDA is developing a guidance for genotoxic impurities. According to the ICH Q3A lower thresholds are appropriate for impurities that are unusally toxic.If impurities levels for an approved generic drug are higher than the RLD, can the approved generic drug data be used as justification for a higher impurity specification?According to ANDA DP and DS Impurity guidances, any approved drug product can be used to qualify an impurity level. However, the guidances qualify this by later stating “This approved human drug product is generally the reference listed drug (RLD). However, you may also compare the profile to a different drug product with the same route ofadministration and similar characteristics (e.g. tablet versus capsule) if samples of thereference listed drug are unavailable or in the case of an ANDA submitted pursuant to a suitability petition.”What if there are no impurities’ tests found in the USP monograph for a USP drug substance? What should the ANDA sponsor do?Please work with your supplier (DMF Holder) to ensure that potential synthetic process impurities (e.g. isomers (if any), side reaction products), degradation impurities, metalcatalysts, and residual solvents are adequately captured by your impurities test method.There may be information available in published literature as well, regarding potentialimpurities.Can levels of an impurity found in the RLD and identified by RRT be used for qualification?Qualification of a specified unidentified impurity by means of comparative RRT, UVspectra, and mass spectrometry with the RLD may be acceptable. However, the ANDAsponsor should make every attempt to identify the impurity.If levels are higher than in an approved drug product then the sponsor should provide data for qualification of the safety of this impurity at this level.Can a limit from a USP monograph for “any unspecified impurity” be used to justify a limit for “any unspecified impurity” greater than the ICH Q3 identification threshold?No. Any unspecified impurity (any unknown) limit should not exceed ICH Q3A “IT”based on MDD. Non-specific compendial acceptance criteria (e.g. Any Individual Impurity is NMT 0.5%) should not be used for justification of proposed impurity acceptance criteria.However, if the USP limit is less than the ICH threshold, then the USP limit should be used. Can a limit for an identified impurity in the drug substance be qualified with data obtained from RLD drug product samples treated under the stressed conditions?No. Test various samples of marketed drug product over the span of its shelf life (ideally, near the end of shelf-life). Data generated from accelerated or stressed studies of the RLD is considered inappropriate.Impurities (Residual Solvents)Will OGD base residual solvent acceptance limits on ICH limits or process capability?The ICH guidance on residual solvents6 provides safety limits for residual solvents but also indicates that “residual solvents should be removed to the extent possible”. ANDA residual solvent limits should be within the ICH safety limits, but the review of the ANDA includes both of these considerations.OGD generally accepts the ICH limits when they are applied to the drug product.What about solvents that are not listed in Q3C?Levels should be qualified for safety.Impurities (Inorganic impurities)Polymorphic FormWhen is a specification on polymorphic form necessary?See ANDA polymorphism guidance7 for a detailed discussion.Particle SizeWhen is a drug substance particle size specification necessary?A specification should be included when the particle size is critical to either drug productperformance or manufacturing.For example, in a dry blending process, the particle size distribution of the drug substance and excipients may affect the mixing process. For a low solubility drug, the drug substance particle size may have a critical impact on the dissolution of the drug product. For a high solubility drug, particle size is often not critical to product performance.6 /cder/guidance/Q3Cfnl.pdf7/cder/guidance/6154dft.pdfWhat justification is necessary for drug substance particle size specifications?As for other API properties, the specificity and range of acceptance criteria for particle size, and the justification thereof, could vary from none to very tight limits, depending upon the criticality of this property for that drug product.Particle size specifications should be justified based on whether a change in particle sizewill affect the ability to manufacture the product or the final product performance.In general, a sponsor either should demonstrate through mechanistic understanding orempirical experiments how changes in material characteristics such as particle size affecttheir product.In the absence of pharmaceutical development studies, the particle size specificationshould represent the material used to produce the exhibit batch.When should the particle size be specified as distribution [d90,d50,d10] and when is a single point limit appropriate?When critical, a particle size should be specified by the distribution. There may be othersituations when a single point limit can be justified by pharmaceutical development studies.2.3.S.5 Reference StandardsHow were the primary reference standards certified?For non-compendial, in-house reference standards, what type of qualification data is recommended? Will a COA be sufficient?COA should be included in Module 3, along with details of its preparation, qualification,and characterization. This should be summarized in the QOS.In terms of the qualification data that may be requested, it is expected that these reference standards be of the highest possible purity (e.g. may necessitate an additionalrecrystallization beyond those used in the normal manufacturing process of the activeingredient) and be fully characterized (e.g. may necessitate in the qualification reportadditional characterization information such as proof of structure via NMR) beyond theidentification tests that are typically reported in a drug substance COA. StandardLaboratory Practice for preparation of reference standards entails recrystallization toconstant physical measurements or to literature values for the pure material.2.3.S.6 Container Closure SystemWhat container closure is used for packaging and storage of the drug substance?Can this question be answered by reference to a DMF?Yes.。
小学上册第二次英语第2单元期末试卷

小学上册英语第2单元期末试卷英语试题一、综合题(本题有100小题,每小题1分,共100分.每小题不选、错误,均不给分)1.The teacher _____ the students' questions. (answers)2.What do we call the time it takes for the Earth to orbit the Sun?A. DayB. MonthC. YearD. DecadeC3.The __________ is a famous area known for its traditional medicine.4.Which of these is not a primary color?A. RedB. BlueC. GreenD. YellowC5.The Kuiper Belt is located beyond the orbit of ______.6.The ancient Egyptians used ______ (草纸) for writing.7.Road was an important trade route between __________ (东西方). The Silk8.What is your name in English?A. NameB. TitleC. IdentityD. Label9.I can ______ (制定) plans for my future.10.I have a special ______ (相册) where I keep all my favorite ______ (照片).11.__________ are used in the cleaning industry for stain removal.12.The otter is known for using tools to access ________________ (食物).13. A __________ is a reaction that involves the combination of substances.14.The _______ (The Age of Exploration) expanded global trade networks.15.The blanket is _______ (keeping) me warm.16.__________ are important for the ecosystem because they pollinate flowers.17.The turtle can hide in its _______ (壳).18.They are riding their ______ (bikes).19.Which fruit is often used to make wine?A. GrapeB. AppleC. CherryD. PeachA20.Which month comes after June?A. MayB.JulyC.AugustD.September答案:B21.Some animals hibernate during the ______ to conserve energy.22. A _______ can be used to measure the speed of a falling object.23.I love to _______ (写) letters to my friends.24.I love _______ (玩游戏) with my friends.25. A rabbit's ears are used for ______.26.The puppy is _____ in the yard. (playing)27. A ______ (种植计划) can enhance community well-being.28.The sun sets in the _____ (west).29.Herbs can be used in both ______ (烹饪) and medicine.30.The stars are ________ tonight.31.Certain plants produce ______ that are used in perfumes. (某些植物产生用于香水的香料。
2020届上海市金山区高三英语二模试题及答案word

2020上海金山高三英语二模I.Listening ComprehensionSection ADirections: In Section A, you will hear ten short conversations between two speakers. At the end of each conversation, a question will be asked about what was said. The conversations and the questions will be spoken only once. After you hear a conversation and the question about it, read the four possible answers on your paper, and decide which one is the best answer to the question you have heard.1. A. In a hospital. B. In a school.C. In a kindergarten.D. In a tourist office.2. A. Improving her cooking skills. B. Tasting the food made by Tom.C. Having a picnic.D. Showcasing her talents to Tom.3. A. Supportive.B. Hesitant.C. Indifferent.D. Disapproving.4. A. In January.B. Until winter vacation.C. During Christmas season.D. Right now.5. A. The foundation of the theatre. B. A change to the theatre.1/ 37C. The removal of the seats.D. The figure of the audience.6. A. It can help to find the patients easilyB. It can record patients' conditions.C. It gives patients medical advice.D. It makes records available to doctors and nurses.7. A. He doesn't want to draw.B. He prefers to make the labor division himself.C. He is good at drawing.D. He is happy because he doesn't have to draw.8. A. The key to the woman's success.B. The changes on the market.C. The management of the woman's company.D. The feeling of being a manager.9. A. To paint the doors. B. To paint the ceiling.C. To continue his job.D. To take the job home2/ 3710. A. Because she is accustomed to the food there.B. Because the food is better there than at the school dining hall.C. Because it is a quiet place.D. Because they can't go to the school dining hall.Section BDirections: In Section B, you will hear several passages and longer conversations, after each passage or conversation, you will be asked several questions. The passages and the conversations will be read twice, but the questions will be spoken only once. When you hear a question, read the four possible answers on your paper and decide which one is the best answer to the question you have heard.Questions 11 to 13 are based on the following passage.11. A. Factors determining intelligence.B. A story of identical twins.C. The importance of intelligence.D. How to get a higher IQ.12. A. Because only one could enter college.B. Because they were abandoned by their parents.C. Because their parents died when they were only babies.D. Because the psychologists did an experiment researching human intelligence.13. A. John got a better education than his identical brother. Peter.B. Children growing up in wealthy families are smarter.3/ 37C. Environment is important to the development of one's intelligence.D. An isolated community has more educational opportunities.Questions 14 through 16 are based on the following passage.14. A. Unwrapping a new album.B. Having a newly-bought car.C. Entering a newly-purchased house.D. Having access to an online account.15. A. It is nice to share the account on Amazon.B. The sharing economy makes full use of cars.C. Consumers consider ownership more important than access.D. The sharing economy makes clear relationship between consumers and products.16. A. The sharing economy develops car manufacturing.B. It is good for environment to increase the usage of goods.C. The sharing economy reshapes the market and benefits people.D. In the sharing economy, companies bridge the gap between people and resources.Questions 17 and 18 are based on the following conversation.17. A. Products.B. Locations.4/ 37C. Coffee making techniques.D. Staff quality.18. A. She made a questionnaire.B. She talked with customers.C. She wrote a handbook for the employeesD. She applied for a job at Starbucks.19. A. Customers are especially concerned about the service of a cafe.B. The more expensive the coffee beans and milk, the better the coffee is.C. Customers want more varieties of coffee.D. Customers rely on the brand image when they are making choices.20. A. Because the manual will be the latest version.B. Because it will tell customers detailed product information.C. Because it includes important policies and procedures.D. Because employees enjoy reading it.II. Grammar and VocabularySection ADirections: After reading the passage below, fill in the blanks to make the passage coherent and grammatically correct. For the blanks with a given word, fill in each blank with the proper form of the given word; for the other blanks, use one word that best fits each blank.A ban on distracted walking5/ 37You can’t walk down the street without passing so-called “smart-phone zombies(僵尸).” They are too absorbed in their screen (21) _________ (watch) where they are going. Almost four in ten people admit having suffered a technology-related small accident (22) _________ they pay more attention to their electronic device than to the pavement.Now the city of Honolulu, Hawaii, has decided it’s time to take immediate action and make it illegal to cross the road while using a mobile phone. Those (23) _________ (catch) using phones, tablets or other electronic devices at crossing points could face a fine of up to $ 100.Honolulu is the first major U. S. city to ban (24) _________ is called “distracted walking.” It comes after a study found there (25) _________ (be) more than 11,000 injuries in the United States resulting from phone-related distraction while walking in the past few years.To explain the decision, mayor Kirk Caldwell said, “We hold the unfortunate honor of being a major city (26) _________ more pedestrians are hit in crosswalks than almost any other city in the country.”Under the fine systems. (27) _________ breaks this law for the first time will get a fine of $15 to $35. People breaking the law for a second or third time will get a $99 fine.The law, which is called the Distracted Walking Law, does permit an exception. Pedestrians (28) _________ use such devices in the street to call emergency services and rescue workers, such as firefighters and police officers.If you still want to text while walking, you could avoid (29) _________ (fine) in Honolulu by using a voice-controlled digital assistant such as Siri or Google Assistant. Or you could just wait (30) _________ you are again, safely, off the street.Section BDirections: Fill in each blank with a proper word chosen from the box. Each word can be used only once. Note that there is one word more than you need.6/ 37Giving kids allowances in the smart-phoneAllowances are a constant. No matter how much technology interferes with the parent-childrelationship, kids still want money and parents still want to impart(赋予)a basic work ethic. But putting stickers on chore(日常事务)charts and dropping coins in piggy banks don’t cut it with the smart-phone generation.Parents in search of more _____31_____ ways to teach children the value of money are turning to allowance-tracking apps, where kids can see their ______32______ rise and fall in real time.Bonnie Koon, a mother of three in Crawfordville, Fla., used to post a calendar on her refrigerator _____33______ her kids chores, to the embarrassment of her 16-year-old twins. After seeing a Facebook ad for the app Green-light, she ____34_____ it.Green-light links to parents’ bank accounts so that the payout can be seamless. Parents can encourage saving by paying interest on the money that isn’t spent ____35____ -- interest out of the parents’ own pockets, of course.It’s the first taste of ____36____ freedom for many kids, and it’s set in a relatively safe environment. Parents can determine spending limits and choose the retailers(零售商)where a child can make _____37_____. If a child attempts to buy something at an unapproved store or to spend more than the limit, the transaction(交易)is _____38_____ and parents get a notification. And if a kid loses the card, parents can immediately cancel it from the app.One of Ms. Koon’s twins. Brenna, works part time at a restaurant. She’s putting half of her pay check into a car-insurance savings fund she set up in the app, whit the goal of saving $450 by July. With each _____39______, the app gives Brenna a progress update.Some parents might worry that relying on apps to get kids to do chores only encourages themto be on their phones more. But parents who have chosen this approach argue that they are meeting7/ 37their kids where they are and that it takes the _____40_____ nagging(唠叨)out of the equation. The real-time look at their accounts makes the concepts of saving and spending more tangible than reviewing a bank statement.III. Reading ComprehensionSection ADirections: For each blank in the following passage there are four words or phrases marked A, B, C and D. Fill in each blank with the word or phrase that best fits the context.If you like to take a walk in the woods in the United States or you prefer to decorate a tree at Christmas, you should know that climate change is making both of those activities a lot more ____41____.Looking at two ____42____ and economically important species -- the Douglas fir and the Ponderosa pine -- scientists found that fires and drought _____43_____ by climate change make new growth difficult, especially in low-elevation forests, according to a study published Monday in the Proceedings of the National Academy of Sciences.Some forests in four regions in California, Colorado, the Northern Rockies and the southwestern part of the United States have crossed “a(n) ____44____ climate tipping(转折)point for post-fire tree generation,” the study says.Climate conditions over the past 20 years have _____45_____ changes that would have taken decades or even centuries to ____46____ across broad regions of the country. This is leading to the sudden _____47_____ of trees and making these lands increasingly unsuitable for tree regeneration.“Climate changes is _____48_____ our forests now, not just in some distant future. Maybe in areas where there are really _____49_____ seed sources, there could be some trees, but it is becoming really hard to get these trees back due to climate change,” said study co-author Kim Davis.8/ 37The problem probably won’t get any better, as climate change is making intense wildfires much more _____50_____. Western foresters say there used to be a fire season. But devastating and ____51____ fires have become a reality all year long. In 2018, fire cost California more than $9.05 billion, according to the USA insurance commissioner, the deadliest and most destructive wildfires season in the ______52______ history.A higher number of fires and low seed availability means a high probability that these trees in these regions won’t come back, Davis said. This study _____53______ on the driest and hottest areas of the Western forests, but researchers will next try to focus on how much will be impacted._____54____, there are some things people can do to ease some of this problem. Forest management plans that reduce high-severity burns can help. Increasingly, forest managers are considering allowing some fires to burn under more moderate conditions, Davis said, Forest _____55_____.41. A. convenient B. difficult C. encouraging D. frustrating42. A. ecologically B. apparently C. physically D. financially43. A. destroyed B. worsened C. extended D. established44. A. necessary B. enormous C. critical D. invisible45. A. accelerated B. delayed C. eliminated D. strengthened46. A. transform B. spread C. preserve D. escape47. A. extinction B. decline C. tragedy D. increase48. A. sustaining B. abandoning C. facilitating D. endangering49. A. sufficient B. limited C. moderate D. approximate50. occasional B. common C. essential D. temporary51. A. astonishing B. hopeless C. costly D. irreversible9/ 3752. A. world B. state C. human D. forest53. A. concentrated B. depended C. insisted D. commented54. A. As a result B. For example C. In fact D. What’s more55. A. savers B. managers C. researchers D. advocatesSection BDirections: Read the following three passages. Each passage is followed by several questions or unfinished statements. For each of them there are four choices marked A, B, C and D. Choose the one that fits best according to the information given in the passage you have just read.(A)EU members’ states have agreed to ban a toxic substance widely found in clothing because it poses an “acceptable risk” to the environment. Countries voted in favor of extending existing restrictions on nonylphenol ethoxylates (NPE) to imports to clothing and other textile products.The measure is intended to protect species in water. Use of NPE in textile manufature in Europe was banned over 10 years ago but the substance is still released into the water environment through imported textiles being washed.NPE degrades in the environment into substances including nonylphenol (NP), which accumulates in the bodies of fish and disturbs their hormones, harming fertility, growth and sexual development.NPE is used in textile manufacture as a cleaning and dyeing agent. The EU decision notes that several studies have found NPE to be present in textile items.A 2011 study by Greenpeace found NPE in two-thirds of clothes tested, including items sold10/ 37by big-name brads such as Adidas, H&M, Lacoste, and Ralph Lauren. The NGO (Non-Governmental Organizations) argued that although concentrations of NPE found in the clothes were low, the chemical’s existence in the environment posed a risk.The new ban on textiles containing NPE in concentrations equal to or greater than 0.01% will enter into force five years after it is adopted by the European Commission, which is likely to happen in September.In comments submitted to ECHA (European Chemicals Agency), clothing and textile firms have warned that obeying the restriction will be difficult because NPE ubiquitous in the supply chain and has numerous uses.The new restriction will not apply to second-hand goods or recycled textiles because it is assumed that these will already have been washed several times so they contain negligible(微不足道的)amounts of NPE.EU countries must eliminate pollution of water bodies by NP as it is a priority substance under the Water Framework Directive. A 2013 study by the UK environment agency warned that emissions from textiles could prevent progress towards this objective. It found 29% of imported cotton underwear contained NPE, which was released during the first two washes by the consumer.56. The 2011 study by Greenpeace found _________.A. 29% of imported cotton underwear contained NPEB. NPE had limited effects on aquatic speciesC. NPE was widely present in textile productsD. clothes of good quality had no concentrations of NPE57. What’s the possible meaning of the underlined part “is ubiquitous” is Paragraph 7?A. is legally protectedB. is not easy to be found11/ 37C. seems to be every whereD. is uncommon58. What can we learn from the text?A. The original ban on use of NPE was very effective.B. Recycled textile contain less NPE.C. The new ban on imports of textile has come into force.D. The UK environment agency is optimistic about the new ban.59. Which section of the website does the text come from?A. lifestyleB. technology.C. Business.D. Environment.(B)LettersComments on the March Issue12/ 3760. How did Antia Lawrence react to her husband’s diagnosis?A. She felt very painful.B. She gained some life lessons.C. She paid more attention to her own health.D. She showed deep sympathy for her husband.61. According to Sam Kieffer’s letter, what can be learn about John All?A. He is an expert in mountaineeringB. He wrote the article entitled Trapped Inside a Glacier.C. Not all people could survive in the same situation as he did.D. His story is the best one that Sam Kieffer has ever read in Reader’s Digest.13/ 3762. Who is likely to disagree with what is said in the commented article?A. Edward Deckerd.B. Antia Lawrence.C. Sam Kieffer.D. Janet Toole(C)What makes us love some things and hate others? We know that sometimes even the tiniest change can result in a huge difference in how we perceive something, so is there any rhyme or reason to our tastes and preferences? Here are three factors which play a role.1. Conforming to expectationIn London a few years ago, two talented rappers called Silibil N’ Brains took to the stage to perform at a music industry show for unsigned bands. They were an instant hit. Their outrageous West Coast - American style, brilliant rap lyrics and couldn’t - care - less attitude had the music industry’s talent spotters falling over themselves to sign the pair. In a short space of time, Silibil N’ Brains had a deal with a top management company, a contract with a major record label and an advance of $70,000 -- and they hadn’t even made a record. Before long, they were on tour with Eminem and out partying with Madonna. They were living the dream.But two years ago the same two rappers were laughed off stage by the same talent spotters for singing the same sons. So what was the difference? Amazingly, it was their accent. You see, Silibil N’ Brains weren’t, in fact, from West Coast U. S. A. at all. They were from Dundee in Scotland. During the first audition they had used their Scottish accents when rapping and it had not gone down well. “They just laughed at us,” recalled Brains. “We were heartbroken. We went back to Scotland with our tail between our legs”. The lesson for them was that to succeed, you have to conform to expectations and at that time everyone expected rappers to be American.2. The benefit of hindsightSome people are simply ahead of their time. It’s common knowledge that Vincent van Gogh sold only one painting in his lifetime -- the other 900 or so were unknown and unloved until after14/ 37his death. Monet’s paintings. at least in his early career, was considered incomplete and ugly by critics at the time, while Vermeer, the painter of Girl With a Pearl Earring, even had to use his mother-in-law as a guarantor when he borrowed money -- so unable was he to sell any of his work! Now that public taste has caught up with these artists, more or less anything they touched has an astronomical price tag attached to it. Perhaps the reason is that it just takes a while to get used to something -- after all, not all beauty is obvious at first sight.3. A reassuring price tagIn a world where the range of products on offer can be completely bewildering, we often look to price as an indication of quality. We may think we prefer the expensive wine to the cheap one, but we may simply be influenced by the price tag. Even professionals can make the mistake. A researcher from the University of Bordeaux in France took an average bottle of red wine and poured it into two empty bottles, on with an expensive label and the other with a cheap one. Then he invited 57 wine “experts” to taste the wine. Forty of them recommended the wine from the expensive bottle, describing it as “agreeable”, “complex”, “balanced” and “rounded.” while the same wine from the expensive bottle, describing it as “agreeable”, “complex”, “balanced” and “rounded,” while the same wine from the cheap bottle was described as “weak” and “flat”, with only 12 of the experts recommending it. The study made the researcher unpopular with the French wine tasters, but he did prove that price has a significant impact on taste.63. Which of the following statements about Silibil N’ Brains is true?A. Talent spotters fell in love with them at first sight.B. They are from the West Coast of AmericaC. Their success was attributed to behaving and sounding like American rappers.D. They were friends with famous stars like Madonna even before they succeeded.64. The underlined phrases “with our tail between our legs” indicates that _________.A. their first audition proved a failureB. they felt proud of their performance15/ 37C. they learned a valuable lessonD. being humble might contribute to their future success65. We an infer from the second factor that ________.A. some artists are better known when they are alive than when they are deadB. public taste usually falls behind famous artistsC. beauty at first sight lasts much longerD. Monet’s paintings are priceless because of their incompleteness66. What can we learn from the last paragraph?A. A price tag always fails to indicate the quality of a product.B. A price tag is less likely to confuse customers than the packaging.C. Low price will make the wine unpopular with tastersD. A price tag will cloud a person’s judgement of something.Section CDirections: Read the following. Fill in each blank with a proper sentence given in the box. Each sentence can be used only once. Note that there are two more sentences than you need.16/ 37Are Bamboo-Eating Pandas Really Herbivores?On the outside, giant pandas look like herbivores(食草动物). They spend nearly all of their waking hours eating bamboo. But on the inside, they’re built like carnivores(食肉动物). About half of the calories they eat come from protein, according to a new study.The ancestor of giant pandas were omnivorous(杂食的). They are both animals and plants, and had the digestive system and gut bacteria to metabolize(使发生新陈代谢)them. They had “umami taste receptors,” to appreciate the flavors of meat.However, about 2.4 million years ago, things began to change. _____67_____ Their jaw and teeth evolved to help them crush bamboo, and their wrist bone became capable of grasping the stalks (杆)of their favorite plant. Scientists think pandas switched to eating bamboo partly because they didn’t have to fight with other animals to get it. Bamboo is high in fiber but has a low concentration of nutrients, so pandas have to eat 20 to 40 pounds of the plant every day just to get by.David Raubenheimer, a nutritional ecologist at the University of Sydney, and his colleagues17/ 37put GPS trackers on two giant pandas and followed their movement throughout the year. They discovered that the pandas followed the protein. _______68______ At the start of the cycle, they ate Bashania fargesii leaves until they got the chance to feast on young shoots, which contained more protein.The more the shoots grew, the more their protein was diluted(冲淡)by fiber. That caused the pandas to move to higher ground, where Fargesia qinlingensis grew. First, they ate the shoots, but these, too, went from being protein - rich to fiber-rich as they grew. The panda responded by switching to the leaves. ______69______ The researchers found that about half of the calories the pandas ate were in the form of protein._______70_______ “They can know exactly where to go, and when to go, so they can get the most of the nutrients that their ecosystem can provide,” said Silvia Pineda - Munoz, who was not involved in the study.The work also shows that classifying an animals as herbivore or carnivore is more complex than one might sassume. “It’s not whether you’re eating plants but what of the plants you’re eating,” said Pineda - Munoz.IV. Summary WritingDirections: Read the following passage. Summarize the main idea and the main point(s) of the passage in no more than 60 words. Use your own words as far as possible.71. Herbal MedicineHerbal medicine, which has been used for medicinal purposes, is the use of plants to treat diseases. Many herbalists use the entire plant, from the flowers, stems, leaves, and roots, in the form of everything from teas to pills. These plants contain natural, chemical things that can treat the body for a variety of diseases, such as allergies, asthma, rheumatoid arthritis, migraine, chronic fatigue, and cancer, among others.18/ 37Nowadays an increasing number of people prefer to adopt these plants to treat their diseases because, compared with chemical medicine, herbal medicine has its own advantages. Herbal medicine and remedies are more effective than chemical medicine for certain diseases. The chemical medicine given by a chemist could have certain negative side effects. However, many of the herbal medicine and remedies to not have negative side effects. If any, they are softer than chemical medicine. Obesity is the cause of many of the health problems. Herbal medicine can help weight loss more effectively and improve overall health.However, the cure using herbal medicine and supplements would take some time, and therefore people are supposed to possess enough patience. Worse still, herbal medicine contains a variety of ingredients and people have to be sure that their body agrees with the ingredients and that it is not allergic(过敏).A point worth mentioning here is that herbal remedies and medicine for certain illnesses may have negative side effects. These side effects may not be shown at once, but would take months or even years. In the early stages, if the herbal medicine is not agreeing with you, it is wise to stop using it.When used correctly and directed by doctors, herbs can help treat a variety of disease. But keep in mind that the herbal medicine industry is not regulated, so herbal products are often misleading and may contain additives that are not listed on the label. Some herbs may cause allergic reactions or interact with other drugs, and some are poisonous if used improperly or at high doses. Taking herbs on your own increases your risk.V. TranslationDirections: Translate the following sentences into English, using the words given in the brackets.72. 一闻到这种蛋糕的味道我就总会想起童年。
小学三年级下册第八次英语第1单元期末试卷(答案和解释)

小学三年级下册英语第1单元期末试卷(答案和解释)英语试题一、综合题(本题有50小题,每小题2分,共100分.每小题不选、错误,均不给分)1.______ you like ice cream?A. DoB. AreC. DoesD. Have2.What do you use to write?A. ShoesB. PenC. TableD. Hat3.My school is very big. It has a large playground where we play football and basketball. The classrooms are bright and clean. I like my school because the teachers are friendly and kind.4.Which of these is a month?A. MondayB. JanuaryC. SummerD. Winter5.What do we use to clean the floor?A. MopB. KnifeC. SpoonD. Plate6.What do you use to write on paper?A. KnifeB. PenC. SpoonD. Plate7.Which of these animals can fly?A. FishB. CatC. BirdD. Elephant8.Which of these is a body part?A. HandB. TableC. ShoeD. Spoon9.What do we use to write on a blackboard?A. PenB. ChalkC. RulerD. Paper10.It _______ (be) a rainy day yesterday, so I _______ (stay) indoors all afternoon. I _______ (read) a book and _______ (watch) TV. Later, I _______ (call) my friend to make plans for the weekend.11.Which one is a holiday?A. ChristmasB. MondayC. WinterD. February12.Which one is a number?A. SevenB. SpoonC. PlateD. Dog13.Which of these is a month of the year?A. SundayB. MarchC. FridayD. September14.Which of these is a type of weather?A. WindB. BicycleC. TableD. House15.I ______ (not/understand) the math problem yesterday, but my teacher ______ (explain) it to me. After she ______ (help) me, I ______ (get) the answer. I ______ (be) so happy that I ______ (finish) my homework quickly.16.Today is my birthday. I am having a big __ at my house. My friends are coming over, and we will play many __ like musical chairs and pin the tail on the __. My mother made a delicious __, and there will be lots of __ for everyone. I am very __ because I love spending time with my friends.17.Which animal is known for jumping?A. ElephantB. KangarooC. DogD. Fish18.Which sentence is correct?A. She walked to the park yesterday.B. She walk to the park yesterday.C. She walking to the park yesterday.D. She walked to park yesterday.19.What is the opposite of "hard"?A. SoftB. WarmC. ColdD. Heavy20.I always _______ (bring) my lunch to school, but today I _______ (forget). I_______ (buy) a sandwich from the cafeteria instead. My friends _______ (laugh) at me because I _______ (never) forget my lunch.21.Which season comes after spring?A. WinterB. SummerC. FallD. AutumnA. PotatoB. AppleC. CarrotD. Onion23.Which one is a musical instrument?A. PianoB. HatC. ChairD. Table24.What animal says "meow"?A. DogB. CatC. BirdD. Cow25.What do we use to eat food?A. KnifeB. SpoonC. PlateD. Fork26.What is the opposite of "young"?A. BigB. OldC. TallD. Short27.Which of these is used for reading?A. BookB. PlateC. SpoonD. Cup28.What is the opposite of "happy"?A. SadB. AngryC. SleepyD. Excited29.Which of these is a time of day?A. MondayB. MorningC. SummerD. December30.I live in a __. It is not very __, but it is comfortable. My room has a __, a __, and a __. I love to sit on my bed and read my favorite __. Sometimes, I listen to music and feel very __ in my room.31.Which one is a furniture item?A. ChairB. SpoonC. KnifeD. Plate32.Which one is a body part?A. KneeB. PlateC. KnifeD. Spoon33.Choose the correct sentence.A. I am go to school.B. I goes to school.C. I am going to school.D. I going to school.A. CarB. DogC. ElephantD. Cat35.Which of these is used to eat spaghetti?A. KnifeB. SpoonC. ForkD. Plate36.Which one is used to cut paper?A. KnifeB. ScissorsC. ForkD. Spoon37.Which of the following is a common mode of transportation used to travel by air?A. CarB. AirplaneC. BicycleD. Boat38.I love reading books. My favorite book is about a __. The story is very __, and I can learn a lot from it. I read this book every __ before bed. My mom also likes to read, but her favorite books are about __. We always talk about our books together.39.I ______ (go) to the park every weekend. Last Saturday, I ______ (go) with my friends. We ______ (play) soccer and ______ (have) a picnic. The weather ______ (be) very nice, and we ______ (enjoy) the day. After that, we ______ (take) some photos and ______ (leave) the park at 5:00 p.m.40.Which of these is a sport?A. SoccerB. SpoonC. ChairD. Table41.What is the opposite of "hot"?A. ColdB. WarmC. SweetD. Happy42.Which of these is used to clean the floor?A. MopB. SpoonC. ForkD. Knife43.Which of the following is used to write?A. PenB. SpoonC. CupD. Plate44.Which of these is a number?A. BananaB. SevenC. DogD. Car45.In the morning, I ______ (brush) my teeth and ______ (eat) breakfast. After breakfast, I ______ (leave) for school at 7:30. My dad ______ (drive) me to school every day.A. TigerB. ElephantC. DogD. Lion47.I always ______ (wake) up early on weekdays. After I ______ (wake), I ______ (brush) my teeth and ______ (have) breakfast. Then, I ______ (leave) for school. My school ______ (be) not far from my house, so I usually ______ (walk) there. Sometimes,I ______ (take) the bus when I am late.48.Which of these is a vegetable?A. TomatoB. AppleC. OrangeD. Carrot49.Which of these is a type of tree?A. PineB. ChairC. SpoonD. Plate50.What is the opposite of "happy"?A. SadB. TallC. BigD. Small(答案及解释)。
A-LEVEL Economics past paper

This publication may be reproduced only in accordance withEdexcel Limited copyright policy.©2006 Edexcel Limited.Printer’s Log. No.M22041AW850/S6354/57570 5/6/7/5/5/Paper Reference(s)6354/01Edexcel GCEEconomicsAdvancedUnit 4 – Industrial EconomicsThursday 26 January 2006 – AfternoonTime: 1 hour 15 minutes Materials required for examinationItems included with question papers Nil NilInstructions to CandidatesIn the boxes above, write your centre number, candidate number, your surname, initials and signature.Check that you have the correct question paper.Answer ALL the questions in Section A in the spaces provided in this question paper.•For each question there are five suggested answers: A, B, C, D or E.•When you have selected your answer to the question, write the chosen letter in the box provided.•You can only offer one answer to each question.•After making your selection you should offer an explanation of why you have made that choice.Your explanation may include a diagram.Answer ONE question from Section B in the spaces provided in this question paper.Information for CandidatesThe marks for individual questions and the parts of questions are shown in round brackets: e.g. (2).The paper is divided into two sections, A and B; both sections are equally weighted. The total mark for this paper is 80. There are 24 pages in this question paper. Any blank pages are indicated.Advice to CandidatesYou will be assessed on your ability to organise and present information, ideas, descriptions and arguments clearly and logically, including your use of grammar, punctuation and spelling.You are advised to divide your time equally between Section A and Section B.Examiner’s use only Team Leader’s use only*M22041A0124*2*M22041A0224*3Turn over *M22041A0324*4*M22041A0424*5Turn over *M22041A0524*6*M22041A0624*7Turn over *M22041A0724*8*M22041A0824*9Turn over *M22041A0924*10*M22041A01024*11Turn over *M22041A01124*12*M22041A01224*13Turn over *M22041A01324*14*M22041A01424*15Turn over *M22041A01524*16*M22041A01624*17Turn over *M22041A01724*18*M22041A01824*19Turn over *M22041A01924*20*M22041A02024*21Turn over *M22041A02124*22*M22041A02224*23 *M22041A02324*24*M22041A02424*。
七年级-人教版-英语-上册-Unit-8-Section-A-(Grammar-Focus-3c)

变所有格;如果为各自所有,则每个名词都要变所有格。
e.g. Mary is Mr. and Mrs. Green’s daughter. 玛丽是格林夫妇的女儿。
Jim’s and Bob’s rooms are very big. 吉姆和鲍勃的房间都很大。
Jerry and Tom’s bedroom
第二十四
第二十五 第二十六
第二十七
第二十八
twenty-ninth thirtieth thirty-first 第二十九 第三十 第三十一
询问他人生日日期:“When is +sb’s(形容词性物主代词/名词所有格)+birthday?”
When is your birthday? When is his birthday?
—When is your birthday, Jim? —My birthday is on December 2nd.
Warm up
Jim Alice Jane Lily
12月2日 3月8日 5月7日 9月21日
—When is your birthday, Alice? —My birthday is on March 8th.
形容词性 物主代词
My birthday is on May 2nd. His birthday is on January 17th.
When is her birthday? When is Alice’s birthday?
It’s in August. 名词 所有格 Her birthday is on September 5th.
My birthday is on May 2nd. 我的生日是5月2日。
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load power for three-wire system using only two Wattmeters. Provide the required equations to support your answer. Solution: Figure should be provided.
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c)
Design the network of Figure 7 such that the system will turn on 10 s after the switch is closed.
e)
Draw the equivalent circuit of a power transformer. Sketch a phasor diagram for the power transformer on an inductive load and explain the physical meaning of each variable listed in the phasor diagram a) n 120 f rpm , we have, f
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3.
a)
The circuit shown in Figure 5 employs a multimeter with an internal resistance of 10 MΩ in the voltmeter mode. The switch is closed at t=0 s.
i) ii) iii)
Find the voltage across the coil the instant after the switch is closed. What is the final value of the current iL? How much time must pass before iL reaches 10 mA? What is the voltmeter reading at t=12 ms?
4.
a)
A 4-pole synchronous generator is driven by a prime mover at a speed of 1800 rpm. Calculate the frequency of the terminal voltage. What is spinning reserve? Explain briefly why it is needed The line voltage at the terminals of a 3-phase load is 33(1+j0) kV and the line current is 10-30o kA. Determine the complex power delivered to the load.
1 1.25 103 0.625 kW/m2 2
ii)
iii)
Find the total power delivered. Answer: PT =9000 W
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2.
a)
Given a three-phase unbalanced-Y load, show how to measure the total real
3
Figure 2 c i)
Explain in details, with the aid of circuit diagrams and equations, a method of how to measure the mutual inductance M practically in a laboratory environment. Solution: Using series adding circuit: . V VR +V1 V2
=IR (j L1I j MI ) ( j L2 I j MI )
RR
.
L L1 L2 2M
and series opposing circuits:
V 2 jMI j( L1 L2 ) I I ( R1 R2 ) R R1 R2 L L1 L2 2 M Hence:
January 2013 EXAMINATIONS Answers
1. a)
Find the total inductance of the series coils shown in Figure 1.
Figure 1 Answer: 6.4 H b)
For the residential supply shown in Figure 2 (assuming a totally resistive load) :
b) c)
d)
The wind turbines at North Hoyle, off the Welsh coast, are each rated at 2 MW maximum output. For a wind speed of 10 m s-1 the electrical output is 1.34 MW. Given that the area swept by the blades of the turbine is 5027 m 2 and the density of air is 1.25 kg m-3, determine the overall efficiency of the energy conversion process.
p
pn 4 1800 60 Hz. 120 120
b) Large generators cannot be started very quickly – they need a time measured in hours, not seconds, to start from cold, thus the generator companies MUST keep some machines operating at no load or part load – this is called “spinning reserve”. Once a machine is rotating and synchronised and the boilers up to temperature the load can be increased quickly to meet the demand of the consumers. This is because that the power supply and power demand in a power system need to be balanced. Otherwise, the frequency and/or voltage of the system will change. c) S 3VI * 3 33 1030 571.630 495 j 285.8 MVA. d) The wind power per m2 is: P
LA L1 L2 2M LB L1 L2 2M
M
ii)
LA LB 4
For the circuit shown in Figure 3, find the maximum power delivered to the speaker. Answer: I1= 0.83 A Power=2.78 W.
4 4 4 3 2
ii) iii)
iv) v)
Answers:
Figure 4 Total 20
i. Zero. Balanced load, Z1=Z2=Z3. ii. PL=1200 W. Total power=3600 W.
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i)
Design the system to ensure a balanced load (i.e. find the value of R). Answer: 1920 Ω Find the magnitude of the currents I1 and I2 and the line voltage VL. Answers: I1=5A I2 =8.33 A VL =4152 V
p u Ai A u B iB uC iC i Au AC iB u BC i A u A uC iB u B uC
iC i A iB
b)
For the Y-connected load of Figure 4:
i)
What is the net current and voltage at the neutral point n and why? Use a phasor diagram to support your answer. Find the average real power to each phase and the total real power each phase and the total reactive power. Find the apparent power to each phase and the total apparent power. Find the power factor of the load.