BP-2016-Ferrous Fumarate and Folic Acid Tablets
职工慢性病种药品目录(2018年)
硝酸甘油
Nitroglycerin
硝酸异山梨酯
Isosorbide Dinitrate
尼群地平
Nitrendipine
糖尿病出现合并症
舌下片剂 缓释控释剂型 口乙类
乙类 甲类 甲类 甲类 甲类 乙类 乙类 甲类 甲类 乙类 甲类 甲类 乙类 乙类 乙类 乙类 乙类 乙类 乙类 乙类
注射剂 注射剂 口服常释剂型 口服常释剂型 口服常释剂型 缓释控释剂型 口服常释剂型 口服常释剂型 口服常释剂型 滴丸剂 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型
口服常释剂型
口服常释剂型
注射剂 口服常释剂型
注射剂
注射剂 口服常释剂型
Adenosine Triphosphate 注射剂
右旋糖酐
Dextran
包醛氧淀粉
Coated Aldehyde Oxystarch
葡萄糖氯化钠
Glucose and Sodium Chloride
甘油磷酸钠
Sodium Glycerophosphate
糖尿病出现合并症
口服常释剂型 缓释控释剂型 颗粒剂 注射剂 注射剂 颗粒剂 口服常释剂型
注射剂 注射剂 注射剂 注射剂 注射剂
吲达帕胺
Indapamide
利血平
Reserpine
多巴胺
Dopamine
多巴酚丁胺
Dobutamine
间羟胺
Metaraminol
去甲肾上腺素
Noradrenaline Bitartrate
糖尿病出现合并症
口服常释剂型 口服常释剂型 口服常释剂型 缓释控释剂型 缓释控释剂型 口服常释剂型 口服常释剂型 注射剂 口服常释剂型 口服常释剂型 缓释控释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 口服常释剂型 缓释控释剂型 口服常释剂型 口服常释剂型
农业部公布的饲料添加剂品种目录-中华人民共和国农业部公告
农业部公布的饲料添加剂品种目录-中华人民共
和国农业部公告
第318号
为加大饲料添加剂的治理，按照《饲料和饲料添加剂治理条例》（以下简称《条例》）的规定，现公布《饲料添加剂品种名目》（以下简称“名目”），并就有关事宜公告如下：
一、生产、经营和使用名目中的饲料添加剂应遵守《条例》的有关规定。
二、在中国境内生产名目1中带“*”的饲料添加剂品种，应按照《新饲料和新饲料添加剂治理方法》办理新饲料添加剂证书。
三、名目2中的饲料添加剂品种在爱护期内只承诺获得新饲料添加剂证书的企业生产。
爱护期后,任何企业生产名目2中的饲料添加剂品种都应按照《饲料添加剂和添加剂预混合饲料生产许可证治理方法》的规定办理生产许可证。
四、1999年7月26日农业部公布的《承诺使用的饲料添加剂品种名目》（农业部公告第105号）即日起废止。
特此公告
二OO三年十二月九日
附件：
名目1：
饲料添加剂品种名目
2003年12月
共191种（类）
注：在中国境内生产带“*”的饲料添加剂需办理新饲料添加剂证书。
名目2：
爱护期内的饲料添加剂品种名目
1. The Approved Feed Additives
Total: 191 species (or categories)
Notes: Enterprises to produce the feed additives with the asterisk ‘*’ in China must apply for a new feed additive
certificate.
2、Feed Additives in the Protecting Period。
产品目录医药
类型 GENRE
药品名称 PRODUCT NAME 萘普生片 Naproxen Tablets 阿司匹林片 Acetylsalicylic Acid Tablets 复方双氯芬酸钠缓释胶囊 Compound Diclofenac Sodium Sustained-release Capsules 对乙酰氨基酚片 Paracetamol Tablets 吲哚美辛胶囊 Indometacin Capsules 双氯芬酸钾片 Diclofenac Potassium Tablets 吲哚美辛片 Indomethacin Tablets 尼美舒利片 Nimesulide Tablets 尼美舒利胶囊 Nimesulide Capsules 布洛芬片 Ibuprofen Tablets 扑热息痛+布洛芬复方片 Paracetamol+lbuprofen Tablets 扑热息痛+布洛芬胶囊 Paracetamol+Ibuprofen Capsules 布洛芬+扑热息痛片 Ibuprofen+Paracetamol Tablets 扑热息痛+阿司匹林+咖啡因 胶囊 Paracetamol+Acetylsalicyl ic Acid +Caffein Capsules 扑热息痛+布洛芬+咖啡因胶 囊 Paracetamol+Ibuprofen+Caf fein Capsules
片剂 Tablet 胶囊 Capsule 片剂 Tablet 胶囊 Capsule 片剂 Tablet 片剂 Tablet 胶囊 Capsule 片剂 Tablet 胶囊 Capsule 片剂 Tablet 胶囊 Capsule 片剂 Tablet 颗粒 Granule 胶囊 Capsule 片剂 Tablet 胶囊 Capsule
医疗保险用药清单(1)
医保统一编码中文名称英文名称剂型L010********a庆大霉素Gentamycin 口服常释剂型L010********a甲硝唑Metronidazole 口服常释剂型L010********b特比萘芬Terbinafine 口服常释剂型L010********a小檗碱Berberine 口服常释剂型L020********a阿苯达唑Albendazole 口服常释剂型L020********b哌嗪Piperazine 口服常释剂型L020********b双羟萘酸噻嘧啶Pyrantel Pamoate 口服常释剂型L020********a甲硝唑Metronidazole 口服常释剂型L03010100001a阿司匹林Aspirin 口服常释剂型L03010100002a布洛芬Ibuprofen 口服常释剂型L03010100003a对乙酰氨基酚Paracetamol 口服常释剂型 颗粒剂L03010100004a双氯芬酸Diclofenac 口服常释剂型 缓释控释剂型L03010100008b布洛芬Ibuprofen 口服液体剂 缓释控释剂型 颗粒剂L03010100010b布洛芬Ibuprofen 乳膏剂L03010100012b对乙酰氨基酚Paracetamol 缓释控释剂型 口服液体剂口服常释剂型L03010100014b复方阿司匹林Compound Aspirin PreparaL03010100015b复方对乙酰氨基酚Compound Paracetamol 口服常释剂型L03010100022b萘普生Naproxen 口服常释剂型 缓释控释剂型L03010300002b氨基葡萄糖Glucosamine 口服常释剂型颗粒剂L03010300005b复方氯唑沙宗Compound Chlorzoxazone口服常释剂型L03010300007b辣椒碱Capsaicin 软膏剂L04020000008b罗通定Rotundine 口服常释剂型L06010100001b维生素A Vitamin A 口服常释剂型L06010200002a维生素B2Vitamin B2 口服常释剂型L06010200005b维生素B1Vitamin B1 口服常释剂型L06010200007b维生素B6Vitamin B6 口服常释剂型L06010200008b烟酸Nicotinic Acid 口服常释剂型 缓释控释剂型L06010300002b维生素C Vitamin C 口服常释剂型L06010500001b复合维生素B Compound Vitamin B 口服常释剂型L06010500002b干酵母Dried Yeast 口服常释剂型L06010500005b五维他Five Vitamins 口服液体剂L06020100001a葡萄糖酸钙Calcium Gluconate 口服常释剂型L06020100004b碳酸钙Calcium Carbonate 口服常释剂型L06020100005b碳酸钙D3(维生素D3碳酸钙)Calcium Carbonate and Vi口服常释剂型L06020100007c牡蛎碳酸钙Oyster Shell Calcium 口服常释剂型颗粒剂L06020200002b硫酸锌Zinc Sulfate 口服常释剂型L06020200003b硒酵母Selenious Yeast 口服常释剂型L08040100004b雌二醇Estradiol 凝胶剂L08040100005b结合雌激素Conjugated Estrogens 口服常释剂型L08040100006b结合雌激素/甲羟孕酮Conjugated Estrogens and口服常释剂型L08040100007b尼尔雌醇Nilestriol 口服常释剂型L08040100009b戊酸雌二醇Estradiol Valerate 口服常释剂型L08040210008b炔诺酮Norethisterone 口服常释剂型 丸剂L11010100001a氯苯那敏Chlorphenamine 口服常释剂型L11010200001a苯海拉明Diphenhydramine 口服常释剂型L11010300001a异丙嗪Promethazine 口服常释剂型L11010400002b去氯羟嗪Decloxizine 口服常释剂型L11010400003b西替利嗪Cetirizine 口服常释剂型L11010500001a赛庚啶Cyproheptadine 口服常释剂型L11010500003b氯雷他定Loratadine 口服常释剂型L11010600001b茶苯海明Dimenhydrinate 口服常释剂型L11010600002b曲普利啶Triprolidine 口服常释剂型L11020000001b酮替芬Ketotifen 口服常释剂型L12090000003b谷维素Oryzanol 口服常释剂型L12090000007b腺苷钴胺Cobamamide 口服常释剂型L130********a氯丙嗪Chlorpromazine 口服常释剂型L130********b氯美扎酮Chlormezanone 口服常释剂型L14010000001a溴己新Bromhexine 口服常释剂型L14010000002a氨溴索Ambroxol 口服常释剂型 口服液体剂L14010000004b标准桃金娘油Myrtol Standardized 口服常释剂型L14020000002a喷托维林Pentoxyverine 口服常释剂型L14020000008b右美沙芬Dextromethorphan 口服常释剂型 颗粒剂L14030100006b二羟丙茶碱Diprophylline 口服常释剂型吸入剂L14030400001b倍氯米松Beclometasone DipropionaL14030400002b布地奈德Budesonide 吸入剂L14030400003b氟替卡松Fluticasone 吸入剂 软膏剂L14030500002b色甘酸钠Sodium Cromoglicate 吸入剂L150********a大黄碳酸氢钠Rnei and Sodium Bicabron口服常释剂型L150********a复方氢氧化铝Compound Aluminium Hyd口服常释剂型L150********a枸橼酸铋钾Bismuth Potassium Citrate口服常释剂型L150********a碳酸氢钠Sodium Bicarbonate 口服常释剂型L150********b复方铝酸铋Compound Bismuth Alumin颗粒剂L150********b胶体果胶铋Colloidal Bismuth Pectin 口服常释剂型L150********b枸橼酸铋钾Bismuth Potassium Citrate颗粒剂L150********b硫糖铝Sucralfate 口服常释剂型 口服液体剂L150********b铝碳酸镁Hydrotalcite 口服常释剂型L150********b瑞巴派特Rebamipide 口服常释剂型L150********b替普瑞酮Teprenone 口服常释剂型L150********a法莫替丁Famotidine 口服常释剂型L150********a雷尼替丁Ranitidine 口服常释剂型L150********a西咪替丁Cimetidine 口服常释剂型L150********a奥美拉唑Omeprazole 口服常释剂型L150********a乳酶生Lactasin 口服常释剂型口服常释剂型L150********b米曲菌胰酶Oryz-Aspergillus Enzyme aL150********b胰酶Pancreatin 口服常释剂型L150********a颠茄Belladonna 口服常释剂型 口服液体剂L150********a山莨菪碱Anisodamine 口服常释剂型L150********b溴丙胺太林Propantheline Bromide 口服常释剂型L150********a多潘立酮Domperidone 口服常释剂型L150********b莫沙必利Mosapride 口服常释剂型 颗粒剂L150********b伊托必利Itopride 口服常释剂型L150********b依托必利Itopride 口服常释剂型L150********b甘油Glycerin 栓剂 灌肠剂L150********a蒙脱石Smectite 口服散剂L151********b多烯磷脂酰胆碱Polyene Phosphatidyl Cho口服常释剂型L151********b复方甘草甜素（复方甘草酸苷）Compound Glycyrrhizin 口服常释剂型口服常释剂型L151********b甘草酸二铵Diammonium GlycyrrhizinaL151********b葡醛内酯Glucurolactone 口服常释剂型L151********b乳果糖Lactulose 糖浆剂 口服散剂 口服液体剂L151********b苯丙醇Phenylpropanol 口服常释剂型L151********b复方阿嗪米特Compound Azintamide 口服常释剂型L151********b去氢胆酸Dehydrocholic Acid 口服常释剂型L151********b复方角菜酸酯Compound Carraghenates栓剂L151********b二甲硅油Dimethicone 口服常释剂型L151********b复方丙谷胺西咪替丁片片剂L151********b复方颠茄铋镁片片剂L151********b复方颠茄氢氧化铝片片剂L151********b复方颠茄氢氧化铝散散剂L151********b复方淀粉酶口服溶液口服溶液剂L151********b复方雷尼替丁胶囊胶囊L151********b复方龙胆碳酸氢钠片片剂L151********b复方芦荟维U片片剂L151********b复方木香铝镁片片剂L151********b复方木香小檗碱片片剂L151********b复方尿囊素片片剂L151********b复方嗜酸乳杆菌片片剂L151********b复方碳酸钙咀嚼片片剂L151********b复方维生素U胶囊胶囊L151********b复方胃蛋白酶颗粒颗粒剂L151********b复方消化酶胶囊胶囊L151********b复方溴丙胺太林铝镁片片剂L151********b复合乳酸菌胶囊胶囊L151********b盖胃平片片剂L151********b海藻酸铝镁颗粒颗粒剂L151********b硫糖铝小檗碱片片剂L151********b龙胆碳酸氢钠片(健胃片)片剂L151********b龙胆碳酸氢钠散散剂L151********b铝镁颠茄片片剂L151********b铝镁混悬液口服混悬液L151********b铝镁加混悬液口服混悬液L151********b神黄钠铝胶囊胶囊L151********b鼠李铋镁片片剂L151********b碳酸钙甘氨酸胶囊胶囊L151********b维U颠茄铝胶囊胶囊L151********b维U颠茄铝胶囊Ⅱ胶囊L151********b维U颠茄铝镁胶囊胶囊L151********b维U颠茄铝镁片片剂L151********b维U颠茄铝镁片Ⅱ片剂L151********b复方谷氨酰胺肠溶胶囊胶囊L17040000002b醋酸钙Calcium Acetate 口服常释剂型L180********b蚓激酶Lumbrokinase 口服常释剂型L180********a硫酸亚铁Ferrous Sulfate 口服常释剂型 缓释控释剂型L180********b富马酸亚铁Ferrous Fumarate 口服常释剂型 咀嚼片L180********b琥珀酸亚铁Ferrous Succinate 口服常释剂型L180********b葡萄糖酸亚铁Ferrous Gluconate 口服常释剂型L180********a叶酸Folic Acid 口服常释剂型L180********b腺苷钴胺Cobamamide 口服常释剂型L180********b氨肽素Amino Polypeptide 口服常释剂型L180********b肌苷Inosine 口服常释剂型L180********b鲨肝醇Batiol 口服常释剂型L180********b维生素B4Vitamin B4 口服常释剂型L180********a阿司匹林Aspirin 口服常释剂型L19020000002a口服补液盐Oral Rehydration Salts 口服散剂L20010101001a红霉素Erythromycin 软膏剂L20010101003b过氧苯甲酰Benzoyl Peroxide 软膏剂 凝胶剂L20010101005b磺胺嘧啶银Sulfadiazine Silver 外用散剂 软膏剂L20010101006b甲硝唑Metronidazole 凝胶剂L20010101009b克林霉素Clindamycin 外用液体剂L20010101011b克罗米通Crotamiton 软膏剂L20010101014b硼酸Boric Acid 外用液体剂 软膏剂L20010101015b升华硫Sublimed Sulfur 软膏剂L20010102001a克霉唑Clotrimazole 软膏剂L20010102002a咪康唑Miconazole 软膏剂L20010102005b布替萘芬Butenafine 软膏剂L20010102007b环吡酮胺Ciclopirox Olamine 软膏剂L20010102008b联苯苄唑Bifonazole 外用液体剂 软膏剂L20010102009b莫匹罗星Mupirocin 软膏剂软膏剂L20010102011b曲安奈德益康唑（益康唑曲安奈德）Econazole and TriamcinoloL20010102014b酮康唑Ketoconazole 软膏剂L20010102015b益康唑Econazole 软膏剂L20010103001a阿昔洛韦Aciclovir 软膏剂L20010103003b硫磺Sulfur 软膏剂L20010103004b喷昔洛韦Penciclovir 软膏剂L20010201001b二硫化硒Selenium Sulfide 外用液体剂L20010201004b煤焦油Coal Tar 外用液体剂 软膏剂L20010202001a水杨酸Salicylic Acid 软膏剂L20010202002a鱼石脂Ichthammol 软膏剂L20010202004b复方水杨酸Compound Salicylic Acid L外用液体剂L20010300002a氢化可的松Hydrocortisone 软膏剂L20010300005b地奈德Desonide 软膏剂L20010300007b丁酸氢化可的松Hydrocortisone 软膏剂L20010300010b糠酸莫米松Mometasone Furoate 软膏剂L20010400001a炉甘石Calamine 外用液体剂 软膏剂L20010400002a尿素Urea 软膏剂L20010400003a维A酸Tretinoin 软膏剂 凝胶剂L20010400011b鬼臼毒素Podophyllotoxin 外用液体剂L20010400019b氧化锌Zinc Oxide 软膏剂L20010400020b依沙吖啶Ethacridine 外用液体剂L20010400022b樟脑Camphor 软膏剂 外用液体剂 醑剂L20020101001a红霉素Erythromycin 眼膏剂L20020101002a金霉素Chlortetracycline 眼膏剂L20020101010b磺胺醋酰钠Sodium Sulfacetamide 滴眼剂L20020400002a可的松Cortisone 滴眼剂 眼膏剂L20020500003b羟苯磺酸Dobesilate 口服常释剂型L20020500004b人工泪液Artificial Tear 滴眼剂L20020500005b色甘酸钠Sodium Cromoglicate 滴眼剂L20020500006b双氯芬酸钠Diclofenac Sodium 滴眼剂L20020500007b透明质酸钠（玻璃酸钠）Sodium Hyaluronate 滴眼剂L20030000001a地芬尼多Difenidol 口服常释剂型L20030000002a复方硼砂Compound Borax Solution含漱液L20030000004a麻黄碱Ephedrine 滴鼻剂L20030000010b呋麻Ephedrine and Nitrofurazo滴鼻剂L20030000013b复方醋酸曲安奈德Compound Triamcinolone 滴耳剂L20030000020b克霉唑Clotrimazole 贴剂L20030000028b羟甲唑啉Oxymetazoline 滴鼻剂 吸入剂L20030000031b色甘酸钠Sodium Cromoglicate 滴鼻剂L20030000032b酮替芬Ketolifen 吸入剂L20040000002b替硝唑Tinidazole 外用液体剂L20040000003b西吡氯铵Cetylpyridinium Chloride 外用液体剂L20050300001a甲硝唑Metronidazole 阴道泡腾片 栓剂L20050300002a克霉唑Clotrimazole 阴道片 栓剂L20050300003a咪康唑Miconazole 栓剂L20050300004a制霉素Nysfungin 阴道泡腾片 栓剂L20050300005b复方莪术油Compound Zedoary Turme栓剂L20050300006b复方甲硝唑Compound Metrnidazole 阴道泡腾片 栓剂L20050300009b替硝唑Tinidazole 阴道泡腾片 栓剂L20050300011b硝呋太尔制霉菌素Nifuratel and Nysfungin 栓剂 阴道软胶囊软膏剂L20050300012b益康唑Econazole 栓剂L21040000010a药用炭Medicinal Charcoal 口服常释剂型 口服散剂E00000000003d麦迪霉素口服常释剂型E00000000009d吗啉胍口服常释剂型E00000000035d米非司酮口服常释剂型E00000000036d米索前列醇口服常释剂型E00000000054d丙戊酸镁片剂E00000000064d硫必利（泰必利）片E00000000089d丙卡特罗口服液E00000000129d乳酸亚铁口服常释剂型E00000000170d硫酸锌尿囊素滴眼剂E00000000211d西替利嗪滴鼻剂F00000000233d清热解毒糖浆糖浆L010********e阿莫西林双氯西林口服常释剂型L010********e头孢拉定干混悬剂L010********e头孢克洛干混悬剂L010********e复方头孢克洛口服常释剂型L010********e头孢地尼颗粒剂L010********e头孢他美酯口服常释剂型L010********e头孢泊肟酯口服常释剂型干混悬剂L010********e氯霉素口服常释剂型L010********e阿奇霉素干混悬剂L010********e罗红霉素缓释控释剂型颗粒剂L010********e克拉霉素缓释控释剂型干混悬剂L010********e交沙霉素口服常释剂型L010********e克林霉素棕榈酸（酯）口服常释剂型干混悬剂L010********e阿昔洛韦颗粒剂L010********e利巴韦林含片L010********e乌洛托品口服常释剂型L020********e左旋咪唑口服常释剂型L020********a乙胺嗪Diethylcarbamazine 口服常释剂型L03000000001e对乙酰氨基酚咀嚼片剂L03000000002e复方氨基比林(安痛定)口服常释剂型L03000000003e双氯芬酸贴剂L03000000004e复方布洛芬口服常释剂型L03000000005e酚麻美敏口服液体剂L03000000006e酚氨咖敏口服常释剂型L03000000008s氨酚伪麻滴剂L03000000009s复方氨酚甲麻口服液L03000000010s氨酚麻美口服液体剂L03000000011s小儿氨酚黄那敏颗粒剂L03000000012s伪麻美沙芬滴剂L03000000013s氨酚烷胺颗粒剂L06000000001e阿司匹林维生素C泡腾片剂L06000000002e复合维生素口服常释剂型L06000000004e三维B口服常释剂型L06000000005e维生素E口服常释剂型L06000000006e葡萄糖酸锌口服常释剂型L06000000007e碳酸钙(D3)口服液体剂型咀嚼片剂L06000000008s葡萄糖酸钙锌溶液剂L06000000009s多维元素滴剂L06000000010s赖氨葡锌颗粒颗粒剂L08000000001e炔雌醇环丙孕酮口服常释剂型L09000000003e匹多莫德口服常释剂型L10000000001e氟尿嘧啶口服液体剂型L11000000001e氯雷他定糖浆剂L11000000002e氯雷伪麻缓释控释剂型L11000000003e特非那定口服常释剂型L11000000004e非索非那定口服常释剂型L11000000005e地氯雷他定口服常释剂型L12000000002e奥拉西坦口服常释剂型L12000000003e苯巴比妥东莨菪碱口服常释剂型L12000000004e氨酚拉明口服常释剂型L12000000005e天麻素口服常释剂型L12000000007e复方五味子糖浆剂L130********e复方地西泮口服常释剂型L14000000001e氯化铵口服常释剂型L14000000002e右美沙芬口服液体剂型L14000000003e茶碱麻黄碱口服常释剂型L14000000004s氨溴特罗口服液L150********e法莫替丁咀嚼片剂L150********e枸橼酸铋雷尼替丁口服常释剂型L150********e多潘立酮口服液体剂型L150********e苦参素(苦参总碱)口服常释剂型L150********e门冬氨酸鸟氨酸颗粒剂L150********e复方谷氨酰胺口服常释剂型L150********e托尼萘酸口服常释剂型L16000000001e复方卡托普利口服常释剂型L16000000002e氯沙坦钾氢氯噻嗪口服常释剂型L16000000003e缬沙坦氢氯噻嗪口服常释剂型L16000000004e硝酸异山梨酯吸入剂L16000000005e复方硫酸双肼屈嗪口服常释剂型L16000000006e尼可地尔口服常释剂型L180********e右旋糖酐铁口服常释剂型L20010000001e布替奈芬喷雾剂乳膏剂搽剂L20010000002e复方地塞米松乳膏剂L20010000003e氟芬那酸丁酯软膏剂L20010000004e复方柳唑吸入剂L20010000006e酮康唑洗剂L20020000001e吡嘧司特滴眼剂L20020101012b那他霉素Natamycin 滴眼剂滴眼剂 眼膏剂L20020101015b妥布霉素地塞米松Tobramycin and DexamethL20020101017b左氧氟沙星Levofloxacin 眼用凝胶L20020102004b更昔洛韦Ganciclovir 眼用凝胶L20020202003b溴莫尼定Brimonidine 滴眼剂L20020203003b左布诺洛尔Levobunolol 滴眼剂L20020204002b布林佐胺Brinzolamide 滴眼剂L20040000004e双氯芬酸喷雾剂L20060000001a碘[131I]化钠Sodium Iodide[131I] 口服常释剂型 L20060000011b锝[99mTc]气溶胶Technetium[99mTc] Aeros吸入剂 L20060000027b碳[14C]尿素Carbon[14C] Urea 口服常释剂型 L03010100009b布洛芬Ibuprofen 栓剂口服液体剂L14020000007b可愈糖浆Codeine and Guaifenesin SL150********b地衣芽胞杆菌活菌制剂Bacillus Licheniformis 口服常释剂型L150********b枯草杆菌、肠球菌二联活菌制剂Live Combined B.Subtilis a口服常释剂型L150********b枯草杆菌二联活菌制剂Live Combined Bacillus Su口服常释剂型L150********b双歧杆菌三联活菌制剂Bifid Tiple Viable 口服常释剂型 口服散剂L150********b双歧杆菌活菌制剂Live Bifidobacterium Prepa口服常释剂型L07020100001b氨基酸型肠内营养剂Enteral Nutritional Powder(口服散剂L07020200001b短肽型肠内营养剂Enteral Nutritional Powder(口服散剂 口服液体剂L07020300001b疾病特异型肠内营养剂Disease-specific Enteral N口服散剂 口服液体剂L07020300002b整蛋白型肠内营养剂High Energy Enteral Nutriti口服散剂 口服液体剂L08050240001b吡格列酮Pioglitazone 口服常释剂型L08070300004b氯膦酸二钠Clodronate Disodium 口服常释剂型L04010000007b芬太尼Fentanyl 贴剂L010********b恩曲他滨Emtricitabine 口服常释剂型L010********b齐多拉米双夫定Zidovudine and Lamivudin口服常释剂型L010********b沙奎那韦Saquinavir 口服常释剂型L130********b利培酮Risperidone 口腔崩解片L130********b阿立哌唑Aripiprazole 口腔崩解片L08000000002e二甲双胍罗格列酮口服常释剂型L08050240002b罗格列酮Rosiglitazone 口服常释剂型L16080000001b厄贝沙坦Irbesartan 口服常释剂型 缓释控释剂型L16080000002b坎地沙坦Candesartan 口服常释剂型L16080000003b氯沙坦钾Losartan Potassium 口服常释剂型L16080000004b替米沙坦Telmisartan 口服常释剂型L16080000005b缬沙坦Valsartan 口服常释剂型L16080000006c奥美沙坦酯Olmesartan 口服常释剂型L010********b金刚乙胺Rimantadine 口服常释剂型 口服液体剂 颗粒剂L12060000013c哌甲酯Methylphenidate 缓释控释剂型L150********c消旋卡多曲Racecadotril 颗粒剂L010********b阿莫西林Amoxicillin 口服液体剂颗粒剂L150********b多潘立酮Domperidone 栓剂L010********b伏立康唑Voriconazole 口服液体剂L010********b莫西沙星Maxifloxacin 口服常释剂型L010********b吉米沙星Gemifloxacin 口服常释剂型口服常释剂型L010********c安妥沙星Antofloxacin HydrochlorideL10010100031b替莫唑胺Temozolomide 口服常释剂型L11010500005b依巴斯汀Ebastine 口服常释剂型L130********b氨磺必利Amisulpride 口服常释剂型L14030100004b多索茶碱Doxofylline 口服常释剂型L14030300004b福莫特罗Formoterol 吸入剂L14030300010b沙美特罗Salmeterol 吸入剂L14030500003b扎鲁司特Zafirlukast 口服常释剂型L14030600001b布地奈德福莫特罗Budesonide and Formotero吸入剂L14030600002b沙美特罗替卡松（氟替卡松沙美特罗）Salmeterol Xinafoate and F（Fluticasone and Salmeterol）吸入剂L14030600003b 复方异丙托溴铵（异丙托溴铵沙丁胺醇）Ipratropine Bromide and S吸入剂L16110100002b阿托伐他汀Atorvastatin 口服常释剂型L16110100003b氟伐他汀Fluvastatin 口服常释剂型缓释控释剂型L16110100004b洛伐他汀Lovastatin 口服常释剂型L16110100005b普伐他汀Pravastatin 口服常释剂型L16110100006b瑞舒伐他汀Rosuvastatin 口服常释剂型L16110100007b辛伐他汀Simvastatin 滴丸剂L20020205001b贝美前列素Bimatoprost 滴眼剂L20020205002b拉坦前列素Latanoprost 滴眼剂L20020205003b曲伏前列素Travoprost 滴眼剂L03010100027g汉防己甲素Tetrandrine 口服常释剂型 L12070000005g右佐匹克隆eszopiclone 口服常释剂型L20010300013g氢醌Hydroquinone 软膏剂L20010400004g阿达帕林Adapalene 凝胶剂L20010400023g重组人表皮生长因子Recombinant Human Epid凝胶剂 吸入剂 外用液体剂L20020500010g小牛血清去蛋白Deproteinised Calf Serum 眼用凝胶L20020500011g小牛血去蛋白提取物Deproteinised Calf Blood E眼用凝胶L20020500015g重组牛碱性成纤维细胞生长因子(融合蛋白)Recombinant Bovine Basic眼用凝胶L23000000020g重组牛碱性成纤维细胞生长因子(融合蛋白)Recombinant Bovine Basic外用冻干制剂L23000000022g重组人碱性成纤维细胞生长因子Recombinant Human Basi外用冻干制剂L06020100006b碳酸钙D3(维生素D3碳酸钙)Calcium Carbonate and Vi颗粒剂L010********b阿德福韦酯Adefovir Dipivoxil 口服常释剂型L010********b恩替卡韦Entecavir 口服常释剂型L010********b拉米夫定Lamivudine 口服常释剂型L010********b替比夫定Telbivudin 口服常释剂型L150********b双歧杆菌乳杆菌三联活菌制剂Live Combined Bifidobacte口服常释剂型L150********c酪酸梭菌肠球菌三联活菌制剂Clostridium butyricum TO-口服散剂口服常释剂型L010********b奥司他韦Oseltamivir 口服常释剂型L180********b贝前列素Beraprost 口服常释剂型L180********b沙格雷酯Sarpogrelate 口服常释剂型L180********b西洛他唑Cilostazol 口服常释剂型L12040000008b长春西汀Vinpocetine 口服常释剂型L20010400014b卡泊三醇Calcipotriol 外用液体剂L20010400015b卡泊三醇Calcipotriol 软膏剂L17040000005b非那吡啶Phenazopyridine 口服常释剂型L12080000001b利扎曲普坦Rizatriptan 口服常释剂型L12080000003b舒马普坦Sumatriptan 口服常释剂型L12080000004b佐米曲普坦Zolmitriptan 口服常释剂型L010********b法罗培南Faropenem 口服常释剂型L0901*******a环孢素Ciclosporin 口服常释剂型 口服液体剂L0901*******b吗替麦考酚酯Mycophenolate Mofetil 口服常释剂型L0901*******b麦考酚钠Mycophenolate Sodium 口服常释剂型L0901*******b咪唑立宾Mizoribine 口服常释剂型L0901*******b他克莫司Tacrolimus 口服常释剂型L0901*******b西罗莫司Sirolimus 口服常释剂型 口服液体剂L12050000001b多奈哌齐Donepezil 口服常释剂型L12050000002b卡巴拉汀Rivastigmine 口服常释剂型L12010102002b美金刚Memantine 口服常释剂型L12010105001b恩他卡朋Entacapone 口服常释剂型L08040220002b米非司酮Mifepristone 口服常释剂型L08040220003c复方米非司酮Compound Mifepristone 口服常释剂型L20050100004p地诺前列酮Dinoprostone 栓剂L20050100008p米索前列醇Misoprostol 口服常释剂型L08080000003b胰激肽原酶Pancreatic Kininogenase 口服常释剂型L11010400004b左西替利嗪Levocetirizine 口服常释剂型 口服液体剂口服常释剂型L19020000007b门冬氨酸钾镁Potassium Magnesium AspL180********b利伐沙班Rivaroxaban 口服常释剂型L010********b伊曲康唑Itraconazole 口服液体剂L03010100024b双氯芬酸二乙胺Didofenac Diethylamine 软膏剂 凝胶剂L10040000008c伊马替尼Imatinib 口服常释剂型L03010200003b塞来昔布Celecoxib 口服常释剂型L10030000003b榄香烯Elemene 口服液体剂L08070100002b降钙素Calcitonin 吸入剂L08070400001b阿法骨化醇Alfacalcidol 口服常释剂型L08070300001b阿仑膦酸钠Alendronate Sodium 口服常释剂型L08070300002b利塞膦酸钠Sodium Risedronate 口服常释剂型L08070300006b羟乙膦酸钠Etidronate Disodium 口服常释剂型L08070400003b雷奈酸锶Strontium Ranelate 干混悬剂M03020000023b百令胶囊（片）胶囊M03020000024b金水宝胶囊（片）胶囊M03020000025b至灵胶囊胶囊M03020000026b宁心宝胶囊胶囊L20010400016b他克莫司Tacrolimus 软膏剂L04020000002b氨酚曲马多Paracetamol and Tramado口服常释剂型L151********b还原型谷胱甘肽Glutathione 口服常释剂型L010********b伏立康唑Voriconazole 口服常释剂型E00000000043d环孢素口服常释剂型口服液体剂E00000000041d吗替麦考酚酯口服常释剂型E00000000013d塞来昔布口服常释剂型L010********b阿莫西林克拉维酸Amoxicillin and Clavulanat口服液体剂颗粒剂E00000000001d阿莫西林/双氯西林钠胶囊E00000000004d周效磺胺片剂E00000000005d柳氮磺胺吡啶片剂E00000000006d利福定片剂、胶囊剂E00000000010d吗啉呱片剂E00000000015d噁丙秦片剂E00000000017d炎痛静片剂E00000000018d酮基布洛芬(优洛芬)片剂、胶囊剂E00000000020d氢溴酸高乌甲素片剂E00000000021d烟酰胺片剂E00000000022d复方利多卡因贴剂贴剂E00000000023d维生素AD滴剂E00000000024d维生素B12片剂E00000000025d维生素E胶丸剂E00000000027d芦丁片剂E00000000028d复方芦丁片剂E00000000030d复合维生素B溶液剂E00000000032d氯烯雌醚滴丸E00000000038d盐酸苯乙双胍片剂E00000000039d甲苯磺丁脲（D860）片剂E00000000047d氨喋呤片剂E00000000048d复方喃氟啶片剂、胶囊剂E00000000052d曲尼司特胶囊剂E00000000053d右苄替米特片剂E00000000055d丙戊酰胺(癫健安)片剂E00000000056d尼莫地平控释片E00000000058d环扁桃酯（抗栓丸）胶囊剂E00000000060d吡硫醇（脑复新）片剂E00000000061d异戊巴比妥片剂E00000000062d导眠能片剂E00000000063d水合氯醛溶液剂E00000000068d三唑仑片剂E00000000069d哌醋甲酯片剂E00000000070d匹莫林片剂E00000000071d咪色林(米安色林)片剂E00000000074d异丙肾上腺素喷雾剂E00000000075d复方长效茶碱片剂E00000000076d复方长效氨茶碱片剂E00000000077d定喘止咳片剂E00000000078d强力安喘通胶囊剂E00000000079d舍雷肽酶片剂片剂E00000000080d氢氧化铝片剂、凝胶剂E00000000081d丙谷胺片剂E00000000082d麦滋林-S颗粒E00000000083d咳特灵片片剂E00000000085d胃蛋白酶片剂E00000000086d胃蛋白酶合剂E00000000087d多酶片片剂E00000000088d稀盐酸溶液剂E00000000090d胃复康片剂E00000000091d多潘立酮混悬剂E00000000092d比沙可啶片剂E00000000093d次碳酸铋片剂E00000000094d鞣酸蛋白片剂E00000000095d谷氨酸片剂E00000000099d利胆素片剂E00000000100d水飞蓟宾葡甲胺片剂E00000000104d甘草甜素片剂E00000000106d丽珠胃三联片剂片剂E00000000107d川芎嗪片剂E00000000108d西沙比利片剂片剂E00000000112d泛硫乙胺(潘特生)片剂E00000000114d多烯康胶丸E00000000115d复方氯贝丁酯（降酯平）片剂E00000000116d复方降压平片剂片剂E00000000121d茜草双酯片剂E00000000134d酞丁胺软膏E00000000135d新肤松软膏E00000000136d甲磺灭脓散剂E00000000138d林可霉素-利多卡因凝胶E00000000139d水杨酸酊剂E00000000140d复方雷锁辛溶液剂E00000000141d水杨酸苯酚软膏剂E00000000142d丙体-六六六霜剂E00000000143d氨溶液溶液E00000000144d二氧化钛霜剂E00000000145d高锰酸钾散剂E00000000146d复方鱼肝油软膏E00000000147d维胺酯胶囊剂E00000000148d氯化氨基汞软膏E00000000149d赛庚啶软膏E00000000151d樟脑薄荷柳酯乳膏E00000000152d聚维酮碘溶液剂、软膏剂E00000000153d新霉素滴眼剂E00000000154d小诺霉素滴眼剂E00000000155d卡那霉素滴眼剂E00000000156d吗林呱滴眼剂E00000000157d环胞苷滴眼剂E00000000158d酞丁安滴眼剂E00000000159d多粘菌素B滴眼剂E00000000160d四环素眼膏E00000000161d新地松滴眼剂E00000000162d新福林滴眼剂E00000000164d肾上腺素滴眼剂E00000000165d氢化可的松眼膏E00000000167d吡诺克辛滴眼剂E00000000171d硫酸锌滴眼剂E00000000172d黄氧化汞眼膏E00000000173d甲基纤维素滴眼剂E00000000174d消炎痛滴眼剂E00000000175d复方萘甲唑啉滴眼剂E00000000176d眼氨肽滴眼剂E00000000177d氯化氨基汞眼膏E00000000178d乙基吗啡滴眼剂E00000000179d干扰素滴眼剂E00000000180d氨基乙磺酸滴眼剂E00000000181d羟甲唑啉滴眼剂E00000000182d醋甲唑胺片剂E00000000183d酮替芬滴眼剂E00000000184d角膜宁滴眼剂E00000000185d碘喉片片剂E00000000186d西地碘片剂E00000000188d溶菌酶口含片E00000000189d洗必泰口含片含漱液E00000000190d度米芬口含片E00000000191d碳酸氢钠滴耳液滴耳剂E00000000192d氯霉素滴耳剂E00000000193d酚甘油滴耳剂E00000000194d硼酸甘油滴耳剂E00000000195d新可滴耳剂滴耳液E00000000196d鱼石脂甘油滴耳剂E00000000197d可麻滴鼻剂滴鼻剂E00000000198d茚咪唑林滴鼻剂E00000000199d复方苯海拉明滴鼻剂E00000000200d弱蛋白银滴鼻剂E00000000201d双唑泰栓剂E00000000202d洗必泰栓剂E00000000204d卵磷脂络合碘片剂片剂E00000000209d标准桃金娘油胶囊胶囊E00000000210d复方硫酸新霉素滴耳滴耳剂E00000000212dα-干扰素栓剂栓剂F00000000217d羚羊感冒胶囊胶囊F00000000218d羚羊感冒片片剂F00000000219d强力感冒片（强效片片剂F00000000220d感冒灵片片剂F00000000225d便秘通浸膏剂浸膏剂F00000000226d肠泰口服液口服液F00000000227d凉膈散散剂F00000000228d牛黄消炎灵胶囊胶囊F00000000231d北豆根片片剂F00000000232d清热消炎宁片片剂F00000000239d藿香正气酊剂酊剂F00000000243d熊胆丸丸剂F00000000244d小建中口服液口服液F00000000246d鲜竹沥口服液口服液F00000000255d当归冲剂冲剂F00000000256d当归膏膏剂F00000000257d当归丸丸剂F00000000269d甲亢灵片片剂F00000000270d中汇川黄液口服液F00000000281d谷参肠安胶囊胶囊F00000000285d杜仲胶囊胶囊F00000000286d龟鹿补肾（片剂、胶片剂、胶囊剂F00000000293d脂必妥胶囊胶囊F00000000294d月见草油丸丸剂F00000000295d去腐生肌散散剂F00000000299d马应龙麝香痔疮栓栓剂F00000000316d 益母草流浸膏浸膏 F00000000318d 妇科止带片片剂 F00000000319d 障翳片片剂 F00000000326d 鼻炎糖浆糖浆 F00000000329d 清音片片剂 F00000000331d 回生第一丹丹 F00000000332d 沈阳红药气雾剂气雾剂 F00000000338d 白斑膏膏剂 F00000000339d 青黛丸丸剂 F00000000340d 益心康泰胶囊胶囊 F00000000341d 八仙宁胶囊胶囊 F00000000342d 血脉痛胶囊胶囊 F00000000343d 肤福来喷雾剂喷雾剂L010********a 青霉素V Phenoxymethylpenicillin 口服常释剂型 颗粒剂 L010********b 苯唑西林Oxacillin 口服常释剂型 L010********a 阿莫西林Amoxicillin 口服常释剂型 L010********c 氨苄西林Ampicillin 口服常释剂型 L010********a 阿莫西林克拉维酸Amoxicillin and Clavulanat 口服常释剂型 L010********a 头孢氨苄Cefalexin 口服常释剂型 颗粒剂 L010********a 头孢拉定Cefradine 口服常释剂型 L010********b 头孢羟氨苄Cefadroxil 口服常释剂型 颗粒剂 L010********c 头孢氨苄Cefalexin 缓释控释剂型 L010********a 头孢呋辛Cefuroxime 口服常释剂型 L010********b 头孢丙烯Cefprozil 口服常释剂型 口服液体剂 颗粒剂 L010********b 头孢克洛Cefaclor 口服常释剂型 缓释控释剂型 颗粒剂 L010********b 头孢地尼Cefdinir 口服常释剂型L010********b 头孢克肟Cefixime 口服常释剂型口服液体剂颗粒剂L010********a 多西环素Doxycycline 口服常释剂型 L010********a 四环素Tetracycline 口服常释剂型 L010********a 土霉素Oxytetracycline 口服常释剂型 L010********b 米诺环素Minocycline 口服常释剂型 颗粒剂 L010********a 阿奇霉素Azithromycin 口服常释剂型 颗粒剂 L010********a 红霉素Erythromycin 口服常释剂型 L010********b 地红霉素Dirithromycin 口服常释剂型 L010********b 琥乙红霉素Erythromycin Ethylsuccina 口服常释剂型 颗粒剂 L010********b 克拉霉素Clarithromycin 口服常释剂型 颗粒剂 L010********b 罗红霉素Roxithromycin 口服常释剂型 L010********b 乙酰螺旋霉素Acetylspiramycin 口服常释剂型 L010********c 螺旋霉素Spiramycin 口服常释剂型 L010********a 克林霉素Clindamycin 口服常释剂型 L010********b 林可霉素Lincomycin 口服常释剂型 L010********b 磷霉素Fosfomycin 口服常释剂型 口服散剂 L010********b 粘菌素（黏菌素）Colistin 口服常释剂型 L010********a 复方磺胺甲 唑Compound Sulfamethoxaz 口服常释剂型 L010********a 磺胺嘧啶Sulfadiazine 口服常释剂型 L010********b 甲氧苄啶Trimethoprim 口服常释剂型 L010********b 联磺甲氧苄啶Sulfamethoxazole, Sulfadia 口服常释剂型 L010********a 吡哌酸Pipemidic Acid 口服常释剂型 L010********a 环丙沙星Ciprofloxacin 口服常释剂型 L010********a 诺氟沙星Norfloxacin 口服常释剂型 L010********a 左氧氟沙星Levofloxacin 口服常释剂型 L010********b 洛美沙星Lomefloxacin 口服常释剂型 L010********b 氧氟沙星Ofloxacin 口服常释剂型 L010********c 司帕沙星Sparfloxacin 口服常释剂型 L010********b 替硝唑Tinidazole 口服常释剂型 L010********c 苯酰甲硝唑Benzoylmetronidazole 口服液体剂 L010********a 呋喃妥因Nitrofurantoin 口服常释剂型L010********a 利福平Rifampicin 口服常释剂型 L010********a 乙胺丁醇Ethambutol 口服常释剂型 L010********a 异烟肼Isoniazid 口服常释剂型 L010********b 丙硫异烟胺Protionamide 口服常释剂型 L010********b 利福布汀Rifabutin 口服常释剂型 L010********b 帕司烟肼Pasiniazid 口服常释剂型 L010********b 乙胺吡嗪利福异烟ⅡEthambutol,Pyrazinamide,Ⅱ 口服常释剂型 L010********b 乙胺利福异烟Ethambutol Rifampicin and 口服常释剂型 L010********b 异福（异烟肼/利福平）Isoniazid and Rifampicin 口服常释剂型 L010********b 异福酰胺（异烟肼/利福平/吡嗪酰胺）Isoniazid ，Rifampicin and Pyrazinamide 口服常释剂型 L010********a 氨苯砜Dapsone 口服常释剂型 L010********b 氯法齐明Clofazimine 口服常释剂型 L010********b 克霉唑Clotrimazole 口服常释剂型 L010********b 咪康唑Miconazole 口服常释剂型 L010********a 氟康唑Fluconazol 口服常释剂型 L010********b 伊曲康唑Itraconazole 口服常释剂型 L010********a 制霉素Nysfungin 口服常释剂型 L010********b 氟胞嘧啶Flucytosine 口服常释剂型 L010********a 阿昔洛韦Aciclovir 口服常释剂型 L010********a 利巴韦林Ribavirin 口服常释剂型 颗粒剂 L010********b 伐昔洛韦Valaciclovir 口服常释剂型 L010********b 泛昔洛韦Famciclovir 口服常释剂型 L010********b 更昔洛韦Ganciclovir 口服常释剂型 L010********a 鱼腥草素Houttuyfonate 口服常释剂型 L010********b 大蒜素Garlicin 口服常释剂型 L020********a 吡喹酮Praziquantel 口服常释剂型 L020********a 硫氯酚Bithionol 口服常释剂型 L020********a 蒿甲醚Artemether 口服常释剂型 L020********b 青蒿素Artemisinin 栓剂 L020********a 伯氨喹Primaquine 口服常释剂型 L020********a 奎宁Quinine 口服常释剂型 L020********a 氯喹Chloroquine 口服常释剂型 L020********a 乙胺嘧啶Pyrimethamine 口服常释剂型 L020********b 磺胺多辛Sulfadoxine 口服常释剂型 L020********b 咯萘啶Malaridine 口服常释剂型 L020********b 哌喹Piperaquine 口服常释剂型 L020********b 羟氯喹Hydroxychloroquine 口服常释剂型 L020********b 乙胺嘧啶Pyrimethamine 贴剂 L020********a 甲苯咪唑Mebendazol 口服常释剂型 L020********b 氯硝柳胺Niclosamide 口服常释剂型 L020********b 双羟萘酸噻嘧啶Pyrantel Pamoate 软膏剂 L020********a 葡萄糖酸锑钠Sodium Stibogluconate 口服常释剂型 L020********a 喷他脒Pentamidine 口服常释剂型 L020********b 双碘喹啉Diiodohydroxyquinoline 口服常释剂型 L03010100005a 吲哚美辛Indometacin 栓剂 L03010100006b 安乃近Metamizole 口服常释剂型 L03010100007b 吡罗昔康Piroxicam 口服常释剂型 缓释控释剂型 贴剂 L03010100011b 醋氯芬酸Aceclofenac 口服常释剂型 缓释控释剂型 L03010100016b 精氨酸布洛芬Ibuprofen Arginine 颗粒剂 口服散剂 L03010100019b 洛索洛芬Loxoprofen 口服常释剂型 L03010100021b 萘丁美酮Nabumetone 口服常释剂型 缓释控释剂型 L03010100023b舒林酸Sulindac 口服常释剂型 缓释控释剂型L03010100025b 吲哚美辛Indometacin 口服常释剂型缓释控释剂型缓控释颗粒剂L03010100026c 贝诺酯Benorilate 口服常释剂型 L03010100029c 金诺芬Auranofin 口服常释剂型 L03010100030c 依托芬那酯Etofenamate 软膏剂 L03010100031c 阿西美辛Acemetacin 缓释控释剂型L03010300003b 氨糖美辛Glucosamine Indomethacin 口服常释剂型 L03010300008b 来氟米特Leflunomide 口服常释剂型 L03010300009c 阿咖酚Paracetamol ,Caffene and 口服散剂 L03020000001a 秋水仙碱Colchicine 口服常释剂型 L03020000002a 别嘌醇Allopurinol 口服常释剂型 L03020000003b 苯溴马隆Benzbromarone 口服常释剂型 L03020000004b 别嘌醇Allopurinol 缓释控释剂型 L03020000005b 丙磺舒Probenecid 口服常释剂型 L04010000003a 吗啡Morphine 口服常释剂型 L04010000005b 氨酚羟考酮(对乙酰氨基酚羟考酮)Oxycodone Acetaminophe 口服常释剂型 L04010000008b 吗啡Morphine 缓释控释剂型 L04010000009b 美沙酮Methadone 口服常释剂型 口服液体剂 L04010000011b 羟考酮Oxycodone 口服常释剂型 缓释控释剂型 L04010000014b 双氢可待因Dihydrocodeine 口服常释剂型 缓释控释剂型 L04020000001b 氨酚待因[I 号,II 号]Paracetamol and Codeine 口服常释剂型 L04020000003b 氨酚双氢可待因(对乙酰氨基酚双氢可待因)Paracetamol and Dihydroc 口服常释剂型 L04020000004b 布桂嗪Bucinnazine 口服常释剂型 L04020000006b 草乌甲素Bulleyaconitine A 口服常释剂型 L04020000007b 复方丙氧氨酚Propoxyphene Napsylate a 口服常释剂型 L04020000010b洛芬待因(布洛芬可待因)Ibuprofen and Codeine 口服常释剂型 缓释控释剂型L04020000011b 曲马多Tramadol 口服常释剂型缓释控释剂型口服液体剂L04020000013b 四氢帕马丁Tetrahydropalmatine 口服常释剂型 L05010100001a 恩氟烷Enflurane 液体剂型 L05010100002a 异氟烷Isoflurane 液体剂型 L05010100003b 地氟烷Desflurane 液体剂型 L05010100004b 七氟烷Sevoflurane 液体剂型 L05010100005b 氧化亚氮Nitrous Oxide 气体剂型 L05020100003b 丁卡因Tetracaine 口服液体剂 溶液剂 L05020200004b 利多卡因Lidocaine 外用液体剂 吸入剂 凝胶剂 L05020200005b 利多卡因(Ⅰ)Lidocaine(Ⅰ) 胶浆剂 L05020200008c 达克罗宁Dyclonine 口服液体剂 L05030120002b 巴氯芬Baclofen 口服常释剂型 L06010200011c β-胡萝卜素β-Carotene 口服常释剂型 L06010400002a 维生素D2Vitamin D2 口服常释剂型 L06010400004b 维生素D3Vitamin D3 口服常释剂型 L0701*******c 复方氨基酸（8-11）Compound Amino Acids 口服常释剂型 L07020400001b 复方α-酮酸Compound α-Ketoacid 口服常释剂型 L07020400002c 水解蛋白Oral Protein Hydrolysate 口服散剂 L08010000002a 去氨加压素Desmopressin 口服常释剂型 L08010000004b 垂体后叶Posterior Pituitary Powder 吸入剂 L08010000007b 戈舍瑞林Goserelin 口服常释剂型 L08010000011b 去氨加压素Desmopressin 吸入剂 L08010000013b 鞣酸加压素Vasopressin Tannate 吸入剂 L08020000001a 地塞米松Dexamethasone 口服常释剂型 L08020000003a 泼尼松Prednisone 口服常释剂型 L08020000004a 氢化可的松Hydrocortisone 口服常释剂型 L08020000006b 倍他米松Betamethasone 口服常释剂型 L08020000008b 甲泼尼龙Methylprednisolone 口服常释剂型 L08020000010b 可的松Cortisone 口服常释剂型 L08020000011b 泼尼松龙Prednisolone 口服常释剂型 L08020000014b 曲安西龙Triamcinolone 口服常释剂型 L08030100002a 甲睾酮Methyltestosterone 口服常释剂型 L08030100003b 达那唑Danazol 口服常释剂型 L08030100005b 十一酸睾酮Testosterone Undecanoate 口服常释剂型 L08030200002b 司坦唑醇Stanozolol 口服常释剂型 L08030200003b 替勃龙Tibolone 口服常释剂型 L08040100001a 己烯雌酚Diethylstilbestrol 口服常释剂型。
第29章-作用于血液及造血系统的药物(梁秋云)
第二节 促凝血药（止血药）
一、维生素K类 二、抗纤维蛋白溶解药
一、维生素K类（vitamin K） 【种类、来源】
VitK1,VitK2：天然，脂溶性，需胆汁协 助吸收
VitK3、VitK4：人工合成，水溶性，不 需胆汁协助吸收
[作用及机制]
VitaminK 的 主 要 作 用 是 参 与 肝 脏 合 成凝血因子Ⅱ、Ⅶ、Ⅸ、Ⅹ、抗凝血蛋 白C和抗凝血蛋白S。
【作用】
叶酸缺乏导致DNA代谢障碍，造成巨 幼红细胞性贫血。
维生素B12参与叶酸的循环利用和维 持有鞘神经纤维功能，缺乏时出现贫血 ＋神经损害。
【应用】
1、巨幼红细胞性贫血：叶酸＋ VitB12 叶酸对抗药所致的巨幼红细胞性贫
血需用甲酰四氢叶酸钙（亚叶酸钙）（ 二氢叶酸还原酶受抑制，四氢叶酸的生 成障碍） 2、恶性贫血： VitB12＋叶酸
•血小板膜糖蛋白受体阻断药：
阿司匹林（aspirin）
抑制环氧酶→PG↓→TXA2↓ 临床上可用于心绞痛、心肌梗死等疾病的 预防和治疗。 注意：每天用量50mg-70mg。
利多格雷（ridogrel）
Ridogrel是强大的TXA2合成酶抑制剂 和中度的TXA2受体阻断剂。
临床用于血栓病的治疗尤其对新形成 的血栓疗效较好。
，须骨髓移植。 4.肾性贫血：重组红细胞生成素（慢性肾
衰，肾脏不能产生足量的红细胞生成素, 导致红细胞水平下降,发生肾性贫血 ）
常用的口服铁剂
硫酸亚铁（ferrous sulfate）
枸橼酸铁铵（ferric ammonium citrate） 富马酸亚铁（ferrous fumarate）
注射铁剂
VitaminK 缺 乏 时 ， 肝 脏 仅 能 合 成 无 凝血活性的凝血因子Ⅱ、Ⅶ、Ⅸ、Ⅹ、 抗凝血蛋白C和S，引起凝血障碍，凝血 酶原时间延长而导致出血。
克拉维酸钾-BP2016
Potassium ClavulanateGeneral Notices(Ph. Eur. monograph 1140)C8H8KNO5237.3 61177-45-5Action and useBeta-lactamase inhibitor, potentiation of the action of amoxicillin and ticarcillin.PreparationsCo-amoxiclav InjectionCo-amoxiclav Oral SuspensionCo-amoxiclav TabletsDispersible Co-amoxiclav TabletsTicarcillin and Clavulanic Acid InfusionDEFINITIONPotassium(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate, the potassium salt of a substance produced by the growth of certain strains of Streptomyces clavuligerus or obtained by any other means.Content96.5 per cent to 102.0 per cent (anhydrous substance).CHARACTERSAppearanceWhite or almost white, crystalline powder, hygroscopic.SolubilityFreely soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in acetone. PRODUCTIONThe methods of production, extraction and purification are such that clavam-2-carboxylate is eliminated or present at a level not exceeding 0.01 per cent.IDENTIFICATIONA.Infrared absorption spectrophotometry (2.2.24).Comparison Ph. Eur. reference spectrum of potassium clavulanate.It gives reaction (b) of potassium ( B.2.3.1).TESTSSolution SDissolve 0.400 g in carbon dioxide-free water R and dilute to 20.0 mL with the same solvent. pH (2.2.3)5.5 to 8.0.Dilute 5 mL of solution S to 10 mL with carbon dioxide-free water R.Specific optical rotation (2.2.7)+ 53 to + 63 (anhydrous substance), determined on solution S.Polymeric impurities and other impurities absorbing at 278 nmDissolve 50.0 mg in 0.1 M phosphate buffer solution pH 7.0 R and dilute to 50.0 mL with the same buffer solution. Measure the absorbance immediately.The absorbance (2.2.25) of the solution determined at 278 nm is not greater than 0.40. Related substancesLiquid chromatography (2.2.29). Prepare the solutions immediately before use.Test solution Dissolve 0.250 g of the substance to be examined in mobile phase A and dilute to 25.0 mL with mobile phase A.Reference solution (a) Dilute 1.0 mL of the test solution to 100.0 mL with mobile phase A. Reference solution (b) Dissolve 10 mg of lithium clavulanate CRS and 10 mg of amoxicillin trihydrate CRS in mobile phase A and dilute to 100 mL with mobile phase A.Reference solution (c) Dissolve 2 mg of potassium clavulanate impurity G CRS in 20 mL of mobile phase A.Column:—size: l = 0.10 m, Ø = 4.6 mm;—stationary phase: octadecylsilyl silica gel for chromatography R (5 µm); —temperature: 40 °C.Mobile phase:—mobile phase A: a 7.8 g/L solution of sodium dihydrogen phosphate R adjusted to pH 4.0with phosphoric acid R;—mobile phase B: a mixture of equal volumes of methanol R and mobile phase A;Flow rate 1 mL/min.Detection Spectrophotometer at 230 nm.Injection 20 µL.Relative retention With reference to clavulanate (retention time = about 3 min): impurityE = about 2.3; impurity G = about 3.6.System suitability: reference solution (b):—resolution: minimum 13 between the peaks due to clavulanate (1st peak) and amoxicillin(2nd peak).Limits:—impurities E, G: for each impurity, not more than the area of the principal peak in the chromatogram obtained with reference solution (a) (1.0 per cent);—any other impurity: for each impurity, not more than 0.2 times the area of the principal peak in the chromatogram obtained with reference solution (a) (0.2 per cent);—total: not more than twice the area of the principal peak in the chromatogram obtained with reference solution (a) (2.0 per cent);—disregard limit: 0.05 times the area of the principal peak in the chromatogram obtained with reference solution (a) (0.05 per cent).Aliphatic aminesGas chromatography (2.2.28).The method shown below can be used to determine the following aliphatic amines:1,1-dimethylethylamine; tetramethylethylenediamine;1,1,3,3-tetramethylbutylamine; N,N′-diisopropylethylenediamine;2,2′-oxybis(N,N)dimethylethylamine.Internal standard solution Dissolve 50 µL of 3-methylpentan-2-one R in water R and dilute to 100.0 mL with the same solvent.Test solution Weigh 1.00 g of the substance to be examined into a centrifuge tube. Add 5.0 mL of the internal standard solution, 5.0 mL of dilute sodium hydroxide solution R, 10.0 mL of water R, 5.0 mL of 2-methylpropanol R and 5 g of sodium chloride R. Shake vigorously for 1 min. Centrifuge to separate the layers.Reference solution Dissolve 80.0 mg of each of the followingamines: 1,1-dimethylethylamine R;tetramethylethylenediamine R; 1,1,3,3-tetramethylbutylamine R ; N,N′-diisopropylethylenediamine R and 2,2′-oxybis(N,N-dimethylethylamine) R in diluteReference solution (b) Dissolve 10 mg of amoxicillin trihydrate CRS in 10 mL of reference solution (a).Column:—size: l = 0.3 m, Ø = 4.6 mm;—stationary phase: octadecylsilyl silica gel for chromatography R (10 µm).Mobile phase Mix 5 volumes of methanol R1 and 95 volumes of a 15 g/L solution of sodium dihydrogen phosphate R previously adjusted to pH 4.0 with dilute phosphoric acid R.Flow rate 1 mL/min.Detection Spectrophotometer at 230 nm.Injection 10 µL.System suitability: reference solution (b):—resolution: minimum 3.5 between the peaks due to clavulanate (1st peak) and amoxicillin(2nd peak).1 mg of clavulanate (C8H9NO5) is equivalent to 1.191 mg of C8H8KNO5.STORAGEIn an airtight container, at a temperature of 2 °C to 8 °C. If the substance is sterile, store in a sterile, airtight, tamper-proof container.IMPURITIESSpecified impurities E, G, H, J, K, L, M.Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other/unspecified impurities and/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use): A, B, C, D, F.By liquid chromatography A, B, C, D, E, F, G.By gas chromatography H, J, K, L, M.R = H: 2,2′-(pyrazine-2,5-diyl)diethanol, A.R = CH B.2-CH2-CO2H: 3-[3,6-bis(2-hydroxyethyl)pyrazin-2-yl]propanoic acid,R = CH C.2-CH3: 2,2′-(3-ethylpyrazine-2,5-diyl)diethanol,4-(2-hydroxyethyl)-1 D.H-pyrrole-3-carboxylic acid,(2E.R,4R,5Z)-2-(carboxymethyl)-5-(2-hydroxyethylidene)-3-[[(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]oxazolidine-4-carboxylic acid,4-[[[[4-(2-hydroxyethyl)-1 F.H-pyrrol-3-yl]carbonyl]oxy]methyl]-1H-pyrrole-3-carboxylic acid,4-[[(1 G.S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-4-oxobutanoic acid(N-(hydrogensuccinyl)tyrosine),2-methylpropan-2-amine (2-amino-2-methylpropane, H. tert-butylamine, ethyldimethylamine),J.N,N,N′,N′-tetramethylethane-1,2-diamine(1,2-bis(dimethylamino)ethane, N,N,N′,N′-tetramethylethylenediamine),2,4,4-trimethylpentan-2-amine (2-amino-2,4,4-trimethylpentane, 1,1,3,3-tetramethylbutylamine), K.L.N,N′-diisopropylethane-1,2-diamine (N,N′-bis(1-methylethyl)ethane-1,2-diamine),2,2′-oxybis( M.N,N-dimethylethanamine) (bis[2-(dimethylamino)ethyl]ether, N,N,N′,N′-tetramethyl(oxydiethylene)diamine).。
进口保健食品之营养素补充剂备案申报指南
进口营养素补充剂（维生素和矿物质）备案申报指南根据《保健食品注册与备案管理办法》规定：首次进口的属于补充维生素、矿物质等营养物质的保健食品应当依法备案。
但很多企业对备案的相关问题和内容并不了解，经常询问半天还是不知所云。
本文北京天健华成国际投资顾问有限公司保健食品注册部将就进口营养素补充剂备案的各方面问题进行全面讲解。
一、什么是营养素补充剂？根据《营养素补充剂申报与审评规定（试行）》，营养素补充剂是指以补充维生素、矿物质而不以提供能量为目的的产品。
其作用是补充膳食供给的不足，预防营养缺乏和降低发生某些慢性退行性疾病的危险性。
营养素补充剂属于保健食品，但是有别于功能性保健食品的一个类别。
营养素补充剂必须符合下列要求：（一）仅限于补充维生素和矿物质。
维生素和矿物质的种类应当符合《维生素、矿物质种类和用量》的规定。
（二）《维生素、矿物质化合物名单》中的物品可作为营养素补充剂的原料来源；从食物的可食部分提取的维生素和矿物质，不得含有达到作用剂量的其他生物活性物质。
（三）辅料应当仅以满足产品工艺需要或改善产品色、香、味为目的，并且应当符合相应的国家标准。
（四）适宜人群为成人的，其维生素、矿物质的每日推荐摄入量应当符合《维生素、矿物质种类和用量》的规定；适宜人群为孕妇、乳母以及18岁以下人群的，其维生素、矿物质每日推荐摄入量应控制在我国该人群该种营养素推荐摄入量（RNIs或AIs）的1/3～2/3水平。
（五）产品每日推荐摄入的总量应当较小，其主要形式为片剂、胶囊、颗粒剂或口服液。
颗粒剂每日食用量不得超过20克，口服液每日食用量不得超过30毫升。
二、何为保健食品备案？保健食品备案，是指保健食品生产企业依照法定程序、条件和要求，将表明产品安全性、保健功能和质量可控性的材料提交食品药品监督管理部门进行存档、公开、备查的过程。
与保健食品注册制需要对申请注册的保健食品的安全性、保健功能和质量可控性等相关申请材料进行系统评价和审评、审批过程不同，备案制省去了反复困扰申报企业的审评环节，也节约了大量时间、精力和费用。
微通道反应器内纳米头孢呋辛酯制备工艺优化_张乾霞
第38卷第1期2011年北京化工大学学报(自然科学版)Journa l o f Be iji ng U n i ve rsity o f Che m i ca l T echno l ogy (N a t ura l Sc i ence)V o.l 38,N o .12011微通道反应器内纳米头孢呋辛酯制备工艺优化张乾霞 娄金婷 周 月 段永鸿 王洁欣*(北京化工大学化学工程学院,北京 100029)摘 要:在Y 型微通道反应器中,采用反溶剂沉淀法制备头孢呋辛酯纳米颗粒。
通过正交实验,系统研究药物溶液质量浓度、沉淀温度、溶剂流量和反溶剂流量等因素对产物粒径的影响。
得到的适宜制备工艺条件为:药物溶液质量浓度0108g /mL 、沉淀温度5e 、溶剂流量3mL /m i n ,以及反溶剂流量80mL /m in ,制备出了粒径为260~340n m,且粒径分布窄的纳米颗粒。
实验还进一步利用扫描电镜、X 射线衍射、红外光谱分析和体外溶出实验对原料药及产品性质进行表征,结果表明:微粉化产品为无定形,溶出度明显优于原料药。
关键词:纳米头孢呋辛酯;反溶剂沉淀法;Y 型微通道反应器;正交实验中图分类号:R 917收稿日期:2010-05-12基金项目:国家自然科学基金(20806004);国家/8630计划(2009AA 033301)第一作者:女,1986年生,硕士生*通讯联系人E -ma i:l w ang j x@m a i.l buct .edu .cn引 言头孢呋辛酯(CFA,1-乙酰氧基乙酯)是对革兰氏阳性和革兰氏阴性菌有高活性的头孢菌类抗生素。
通常它存在结晶型和无定形两种形态,后者表现出较高的生物利用度。
作为水溶性很差的药物,CFA 在胃肠道中的溶解度较低,这限制了它的有效吸收。
因此,提高药物溶出度以改善体内吸收,成为提高其生物利用度的关键。
根据Noyes -W h itney 方程,药物的溶出度与药物颗粒的粒径成反比关系,减小颗粒粒径可提高药物的溶出度,进而提高其生物利用度[1]。
2016年最新SCI中科院JCR分区(2015年年底出版)
ISSN Full Title Category中科院JCR大类分区1467-2960FISH AND FISHERIES农林科学11774-0746Agronomy for Sustainable Development农林科学20038-0717SOIL BIOLOGY & BIOCHEMISTRY农林科学0065-2113ADVANCES IN AGRONOMY农林科学10168-1923AGRICULTURAL AND FOREST METEOROLOGY农林科学10829-318X TREE PHYSIOLOGY农林科学10178-2762BIOLOGY AND FERTILITY OF SOILS农林科学21085-3278LAND DEGRADATION & DEVELOPMENT农林科学0191-2917PLANT DISEASE农林科学30378-4290FIELD CROPS RESEARCH农林科学20032-079X PLANT AND SOIL农林科学11865-1674Transboundary and Emerging Diseases农林科学40021-8561JOURNAL OF AGRICULTURAL AND FOOD CHEMIS农林科学20308-521X AGRICULTURAL SYSTEMS农林科学10269-283X MEDICAL AND VETERINARY ENTOMOLOGY农林科学20926-6690INDUSTRIAL CROPS AND PRODUCTS农林科学30928-4249VETERINARY RESEARCH农林科学10016-7061GEODERMA农林科学21476-5810Veterinary and Comparative Oncology农林科学30960-3166REVIEWS IN FISH BIOLOGY AND FISHERIES农林科学21161-0301EUROPEAN JOURNAL OF AGRONOMY农林科学21526-498X PEST MANAGEMENT SCIENCE农林科学21935-5130Food and Bioprocess Technology农林科学21050-4648FISH & SHELLFISH IMMUNOLOGY农林科学0378-1127FOREST ECOLOGY AND MANAGEMENT农林科学21351-0754EUROPEAN JOURNAL OF SOIL SCIENCE农林科学20929-1393APPLIED SOIL ECOLOGY农林科学20167-1987SOIL & TILLAGE RESEARCH农林科学0022-0302JOURNAL OF DAIRY SCIENCE农林科学11054-6006FISHERIES OCEANOGRAPHY农林科学30378-1135VETERINARY MICROBIOLOGY农林科学30304-4017VETERINARY PARASITOLOGY农林科学30931-2250JOURNAL OF AGRONOMY AND CROP SCIENCE-ZE农林科学31049-8001INTERNATIONAL JOURNAL OF WILDLAND FIRE农林科学2 1084-2020ILAR JOURNAL农林科学2 1054-3139ICES JOURNAL OF MARINE SCIENCE农林科学3 0425-1644EQUINE VETERINARY JOURNAL农林科学2 0706-652X CANADIAN JOURNAL OF FISHERIES AND AQUATI农林科学3 0378-3774AGRICULTURAL WATER MANAGEMENT农林科学2 1380-3743MOLECULAR BREEDING农林科学3 0925-5214POSTHARVEST BIOLOGY AND TECHNOLOGY农林科学2 0739-7240DOMESTIC ANIMAL ENDOCRINOLOGY农林科学2 0167-5877PREVENTIVE VETERINARY MEDICINE农林科学1 1344-7610BREEDING SCIENCE农林科学4 0021-8812JOURNAL OF ANIMAL SCIENCE农林科学2 1612-4669EUROPEAN JOURNAL OF FOREST RESEARCH农林科学2 0015-752X FORESTRY农林科学3 0738-1360Marine Resource Economics农林科学4 0342-7188IRRIGATION SCIENCE农林科学2 0140-7775JOURNAL OF FISH DISEASES农林科学3 0749-0720VETERINARY CLINICS OF NORTH AMERICA-FOOD农林科学2 0022-1201JOURNAL OF FORESTRY农林科学3 0377-8401ANIMAL FEED SCIENCE AND TECHNOLOGY农林科学2 1286-4560ANNALS OF FOREST SCIENCE农林科学3 1936-9751Food Analytical Methods农林科学3 1385-2256PRECISION AGRICULTURE农林科学2 0142-5242GRASS AND FORAGE SCIENCE农林科学3 0165-7836FISHERIES RESEARCH农林科学3 1385-1314NUTRIENT CYCLING IN AGROECOSYSTEMS农林科学3 0891-6640JOURNAL OF VETERINARY INTERNAL MEDICINE农林科学2 0044-8486AQUACULTURE农林科学3 0043-1745WEED SCIENCE农林科学3 0300-9858VETERINARY PATHOLOGY农林科学4 1064-1262REVIEWS IN FISHERIES SCIENCE农林科学2 1389-9341FOREST POLICY AND ECONOMICS农林科学3 1751-7311Animal农林科学2 0169-4286NEW FORESTS农林科学31461-9555AGRICULTURAL AND FOREST ENTOMOLOGY农林科学3 0093-691X THERIOGENOLOGY农林科学4 0969-997X FISHERIES MANAGEMENT AND ECOLOGY农林科学4 1090-0233VETERINARY JOURNAL农林科学1 0177-5103DISEASES OF AQUATIC ORGANISMS农林科学3 0959-4493VETERINARY DERMATOLOGY农林科学3 0361-5995SOIL SCIENCE SOCIETY OF AMERICA JOURNAL农林科学3 1467-2987VETERINARY ANAESTHESIA AND ANALGESIA农林科学3 0906-6691ECOLOGY OF FRESHWATER FISH农林科学3 0090-0656FISHERY BULLETIN农林科学3 0168-1591APPLIED ANIMAL BEHAVIOUR SCIENCE农林科学4 0043-1737WEED RESEARCH农林科学3 0045-5067CANADIAN JOURNAL OF FOREST RESEARCH-REV农林科学3 0032-5791POULTRY SCIENCE农林科学3 0931-1890TREES-STRUCTURE AND FUNCTION农林科学2 0307-9457AVIAN PATHOLOGY农林科学2 0920-1742FISH PHYSIOLOGY AND BIOCHEMISTRY农林科学3 1537-5110BIOSYSTEMS ENGINEERING农林科学3 0889-048X AGRICULTURE AND HUMAN VALUES农林科学1 0179-9541PLANT BREEDING农林科学4 0022-0299JOURNAL OF DAIRY RESEARCH农林科学3 0022-4561JOURNAL OF SOIL AND WATER CONSERVATION农林科学3 0261-1929ATLA-ALTERNATIVES TO LABORATORY ANIMAL农林科学4 0011-183X CROP SCIENCE农林科学3 0015-749X FOREST SCIENCE农林科学3 0931-2668JOURNAL OF ANIMAL BREEDING AND GENETICS-农林科学2 0003-1488JAVMA-JOURNAL OF THE AMERICAN VETERINAR农林科学2 0282-7581SCANDINAVIAN JOURNAL OF FOREST RESEARCH农林科学4 0165-2427VETERINARY IMMUNOLOGY AND IMMUNOPATH农林科学4 0936-6768REPRODUCTION IN DOMESTIC ANIMALS农林科学3 0378-4320ANIMAL REPRODUCTION SCIENCE农林科学2 0042-4900VETERINARY RECORD农林科学3 0261-2194CROP PROTECTION农林科学3 0929-1873EUROPEAN JOURNAL OF PLANT PATHOLOGY农林科学30002-8487TRANSACTIONS OF THE AMERICAN FISHERIES SO农林科学3 0266-0032SOIL USE AND MANAGEMENT农林科学3 0925-9864GENETIC RESOURCES AND CROP EVOLUTION农林科学4 1436-8730JOURNAL OF PLANT NUTRITION AND SOIL SCIEN农林科学4 1058-8183VETERINARY RADIOLOGY & ULTRASOUND农林科学0002-1962AGRONOMY JOURNAL农林科学3 1550-7424Rangeland Ecology & Management农林科学1938-9736Topics in Companion Animal Medicine农林科学4 0034-5288RESEARCH IN VETERINARY SCIENCE农林科学3 0931-2439JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL农林科学3 1353-5773AQUACULTURE NUTRITION农林科学3 0002-9254AMERICAN JOURNAL OF ENOLOGY AND VITICUL农林科学2 0014-2336EUPHYTICA农林科学3 0008-4271CANADIAN JOURNAL OF SOIL SCIENCE农林科学4 0044-605X ACTA VETERINARIA SCANDINAVICA农林科学3 1355-557X AQUACULTURE RESEARCH农林科学3 1437-4781FOREST PATHOLOGY农林科学3 1044-0046JOURNAL OF SUSTAINABLE AGRICULTURE农林科学0304-4238SCIENTIA HORTICULTURAE农林科学3 0090-3558JOURNAL OF 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1023-4063CCAMLR SCIENCE农林科学4 2075-8251Acta Naturae农林科学41745-039X ARCHIVES OF ANIMAL NUTRITION-ARCHIV FUR T农林科学3 0899-7659JOURNAL OF AQUATIC ANIMAL HEALTH农林科学4 0954-0105FOOD AND AGRICULTURAL IMMUNOLOGY农林科学4 0967-6120AQUACULTURE INTERNATIONAL农林科学4 1558-7878Journal of Veterinary Behavior-Clinical Applications and农林科学4 0275-5947NORTH AMERICAN JOURNAL OF FISHERIES MANA农林科学4 0008-0845CALIFORNIA AGRICULTURE农林科学3 0007-1668BRITISH POULTRY SCIENCE农林科学3 1187-7863JOURNAL OF AGRICULTURAL & ENVIRONMENTA农林科学1300-011X Turkish Journal of Agriculture and Forestry农林科学4 1758-1559Avian Biology Research农林科学4 0253-1933REVUE SCIENTIFIQUE ET TECHNIQUE DE L OFFIC农林科学4 2070-2620Southern Forests农林科学4 0018-5345HORTSCIENCE农林科学3 0932-0814VETERINARY AND COMPARATIVE ORTHOPAEDIC农林科学4 0047-1917JAPANESE JOURNAL OF VETERINARY RESEARCH农林科学4 1939-3210Food Additives & Contaminants Part B-Surveillance农林科学0919-9268FISHERIES SCIENCE农林科学4 0748-321X JOURNAL OF VETERINARY MEDICAL EDUCATION农林科学4 0737-0806JOURNAL OF EQUINE 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1082-6742JOURNAL OF AVIAN MEDICINE AND SURGERY农林科学4 0010-3624COMMUNICATIONS IN SOIL SCIENCE AND PLANT农林科学4 1527-3741JOURNAL OF THE AMERICAN POMOLOGICAL SOC农林科学4 1300-7580Tarim Bilimleri Dergisi-Journal of Agricultural Sciences农林科学4 0108-0288BULLETIN OF THE EUROPEAN ASSOCIATION OF F农林科学4 0254-0223Ciencia e Tecnica Vitivinicola农林科学4 0042-4870BULLETIN OF THE VETERINARY INSTITUTE IN PU农林科学4 1699-6887ITEA-Informacion Tecnica Economica Agraria农林科学4 0334-9152ISRAEL JOURNAL OF VETERINARY MEDICINE农林科学4 1311-9109Propagation of Ornamental Plants农林科学4 1226-8763Korean Journal of Horticultural Science & Technology农林科学0102-0536Horticultura Brasileira农林科学4 0187-7380Revista Fitotecnia Mexicana农林科学4 0035-1555REVUE DE MEDECINE VETERINAIRE农林科学4 0039-7660Sylwan农林科学4 1511-2780Journal of Oil Palm Research农林科学4 0301-732X ARCHIVOS DE MEDICINA VETERINARIA农林科学4 1611-4426EUROPEAN JOURNAL OF HORTICULTURAL SCIEN农林科学4 0567-8315ACTA VETERINARIA-BEOGRAD农林科学4 1222-4227Romanian Agricultural Research农林科学4 0037-5349SILVAE GENETICA农林科学4 0139-3006ACTA ALIMENTARIA农林科学4 1166-7699CAHIERS AGRICULTURES农林科学4 1405-3195AGROCIENCIA农林科学4 1300-6045Kafkas Universitesi Veteriner Fakultesi Dergisi农林科学4 0031-7454PHILIPPINE AGRICULTURAL SCIENTIST农林科学4 0023-6152JOURNAL OF THE FACULTY OF AGRICULTURE KY农林科学4 1728-1997Iranian Journal of Veterinary Research农林科学4 0014-0309Erwerbs-Obstbau农林科学4 1225-8563Korean Journal for Food Science of Animal Resources农林科学40263-841X IN PRACTICE农林科学4 0104-7760Cerne农林科学4 0008-1078CALIFORNIA FISH AND GAME农林科学4 1300-0128TURKISH JOURNAL OF VETERINARY & ANIMAL S农林科学0102-0935ARQUIVO BRASILEIRO DE MEDICINA VETERINAR农林科学4 0103-9954CIENCIA FLORESTAL农林科学4 1300-0861Ankara Universitesi Veteriner Fakultesi Dergisi农林科学4 0002-1857AGROCHIMICA农林科学4 0002-1482AGRICULTURAL HISTORY农林科学4 0177-7726PFERDEHEILKUNDE农林科学4 0798-2259REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VE农林科学4 0969-1251CATTLE PRACTICE农林科学4 0025-004X MAGYAR ALLATORVOSOK LAPJA农林科学4 0115-463X Philippine Journal of Crop Science农林科学4 0367-8318INDIAN JOURNAL OF ANIMAL SCIENCES农林科学0125-6491Thai Journal of Veterinary Medicine农林科学4 0021-5392NIPPON SUISAN GAKKAISHI农林科学4 1676-546X Semina-Ciencias Agrarias农林科学4 0972-1665Journal of Agrometeorology农林科学4 0019-5022INDIAN JOURNAL OF AGRICULTURAL SCIENCES农林科学0972-8538Indian Journal of Horticulture农林科学4 0972-2963Animal Nutrition and Feed Technology农林科学4 0049-3864TIERAERZTLICHE UMSCHAU农林科学4 0122-0268Revista MVZ Cordoba农林科学4 0971-6777JOURNAL OF CAMEL PRACTICE AND RESEARCH农林科学4 0023-2076KLEINTIERPRAXIS农林科学4 0084-5841AMA-Agricultural Mechanization in Asia Africa and Lati农林科学4 1120-5776IPPOLOGIA农林科学IF升降IF 2015IF 2014IF 2013IF 2012IF 2011IF 2010区下降8.2588.755 5.855 5.800 6.434 4.489区上升 3.992 2.841 3.573 3.330 2.972 1.650区下降 3.932 4.410 3.654 3.504 3.242 2.978区下降 3.893 5.021 5.060 5.204 3.640 3.800区下降 3.762 3.894 3.421 3.389 3.228 3.197区上升 3.655 3.405 2.853 2.876 2.403 2.292区上升 3.398 3.396 2.505 2.319 2.156 1.757区上升 3.089 2.058 1.991 1.402 1.250 1.326区上升 3.020 2.742 2.455 2.449 2.387 2.121区上升 2.976 2.608 2.474 2.474 2.232 2.336区下降 2.952 3.235 2.638 2.733 2.773 2.517区下降 2.944 3.116 2.096 1.809 2.448 1.854区下降 2.912 3.107 2.906 2.823 2.816 2.469区上升 2.906 2.453 2.504 2.899 2.907 2.110区上升 2.860 2.333 2.208 1.910 1.895 2.092区下降 2.837 3.208 2.468 2.469 2.507 2.103区下降 2.815 3.383 3.426 4.060 3.765 3.579区上升 2.772 2.509 2.345 2.318 2.176 2.461区上升 2.733 1.448 1.422 1.561 1.1270.804区上升 2.726 2.564 2.270 2.500 3.609 2.161区下降 2.704 2.918 2.800 2.477 2.455 2.419区下降 2.694 2.743 2.594 2.251 2.313 2.190区下降 2.691 3.126 4.115 3.703 3.576 2.238区下降 2.674 3.034 2.964 3.322 3.044 2.892区下降 2.660 2.667 2.766 2.487 1.992 1.950区上升 2.649 2.387 2.651 2.340 1.932 2.131区上升 2.644 2.206 2.106 2.368 2.399 2.122区上升 2.622 2.575 2.367 2.425 2.100 2.883区上升 2.573 2.550 2.566 2.564 2.497 2.463区上升 2.543 2.542 2.195 2.044 2.015 2.427区下降 2.511 2.726 3.127 3.327 3.256 2.874区下降 2.460 2.545 2.381 2.579 2.331 2.278区下降 2.444 2.618 2.151 2.433 1.952 2.283区下降 2.429 2.506 2.322 2.231 2.215 1.901区上升 2.393 1.051 1.582 2.333 2.692 2.806区下降 2.377 2.525 2.277 2.007 1.808 1.920区上升 2.374 2.369 2.286 1.456 1.799 1.837区上升 2.287 2.276 2.323 2.213 2.166 1.951区下降 2.286 2.333 2.203 1.998 1.782 2.016区下降 2.246 2.281 3.251 2.852 2.193 2.272区下降 2.223 2.628 2.454 2.411 2.256 2.311区上升 2.171 1.783 2.377 2.056 1.896 1.651区下降 2.167 2.506 2.389 2.046 2.070 2.121区上升 2.125 1.342 1.040 1.2480.992 1.382区上升 2.108 1.920 2.093 2.096 2.580 2.466区上升 2.095 1.682 1.959 1.982 1.942 1.867区上升 2.093 1.865 1.677 1.337 1.460 1.418区上升 2.071 1.159 1.261 1.0830.5850.492区下降 2.056 2.843 2.289 1.635 2.113 1.753区上升 2.056 1.507 1.591 2.000 1.603 1.697区上升 2.000 1.750 2.400 1.474 1.0380.671区上升 2.000 1.629 1.244 1.3540.926 1.405区下降 1.997 2.086 1.608 1.691 1.720 1.866区上升 1.981 1.536 1.630 1.788 1.326 1.441区上升 1.956 1.802 1.969 1.943 1.932 1.400区下降 1.929 2.010 1.728 1.549 1.683 1.000区下降 1.922 1.932 1.567 1.099 1.108 1.316区上升 1.903 1.843 1.695 1.586 1.656 1.531区上升 1.897 1.733 1.416 1.792 1.957 1.350区下降 1.879 2.224 2.064 1.992 2.277 2.168区上升 1.878 1.828 2.009 2.041 2.044 1.925区上升 1.870 1.684 1.759 1.733 1.528 1.451区下降 1.869 2.038 1.929 1.945 1.333 1.367区下降 1.867 2.368 2.417 1.946 2.163 1.939区上升 1.856 1.810 1.638 1.4820.895 1.155区上升 1.841 1.784 1.648 1.744 1.458 1.461区上升 1.829 1.783 1.636 1.1840.9150.728区上升 1.818 1.556 1.467 1.596 1.484 1.554区下降 1.798 1.845 2.082 1.963 2.045 2.073区上升 1.760 1.136 1.028 1.2940.798 1.264区下降 1.755 2.165 2.424 2.239 2.796 2.323区上升 1.752 1.586 1.734 2.201 1.572 1.687区下降 1.732 1.993 2.020 1.943 1.647 1.543区下降 1.721 2.000 1.821 1.979 1.866 2.179区下降 1.720 1.776 1.3400.944 1.290 1.426区上升 1.701 1.590 1.935 1.573 1.432 1.512区下降 1.694 1.783 1.135 1.0980.756 1.245区上升 1.691 1.626 1.497 1.918 1.555 1.831区下降 1.687 2.015 2.045 1.924 1.622 2.033区上升 1.683 1.657 1.559 1.685 1.574 1.246区上升 1.672 1.544 1.516 1.728 1.582 1.673区下降 1.651 1.869 1.925 1.685 1.444 1.603区下降 1.639 2.041 1.729 1.711 1.967 1.654区下降 1.622 1.676 1.545 1.528 1.607 1.232区上升 1.619 1.367 1.357 1.3540.983 1.102区上升 1.617 1.359 1.355 1.540 1.054 1.123区上升 1.598 1.338 1.175 1.596 1.391 1.026区上升 1.598 1.394 1.373 1.566 1.807 1.343区下降 1.595 1.811 1.722 1.265 1.407 1.033区上升 1.592 1.317 1.373 1.455 1.346 1.580区上升 1.575 1.478 1.513 1.641 2.020 1.735区上升 1.573 1.523 1.093 1.047 1.196 1.444区下降 1.566 2.059 1.654 1.455 1.574 1.706区下降 1.557 1.672 1.715 1.791 1.860 1.714区上升 1.537 1.115 1.065 1.1970.949 1.075区下降 1.535 1.748 1.877 2.076 2.176 1.963区上升 1.515 1.177 1.392 1.356 1.606 1.606区下降 1.511 1.581 1.897 1.750 1.721 1.563区下降 1.493 1.633 1.803 1.248 1.482 1.504区下降 1.493 1.539 1.303 1.402 1.517 1.331区下降 1.490 1.707 1.610 1.413 1.575 1.931区上升 1.468 1.314 1.546 1.592 1.603 1.256区下降 1.466 1.968 1.832 1.608 1.510 2.027区下降 1.461 1.482 1.593 1.554 1.538 1.238区下降 1.459 1.663 1.380 1.596 1.969 1.595区上升 1.453 1.262 1.414 1.082 1.107 1.055区下降 1.441 1.542 1.518 1.794 1.797 1.416区下降 1.439 1.464 1.733 1.461 1.4380.921区上升 1.411 1.1600.926 1.0360.4900.074区下降 1.409 1.511 1.774 1.649 1.330 1.345区上升 1.406 1.317 1.2540.855 1.106 1.229区下降 1.395 1.665 1.688 2.179 1.393 1.482区下降 1.388 1.632 1.856 1.826 1.667 1.171区下降 1.385 1.692 1.643 1.554 1.597 1.405区上升 1.382 1.0000.9120.821 1.121 1.000区下降 1.377 1.382 1.345 1.367 1.196 1.000区上升 1.376 1.320 1.422 1.203 1.186 1.099区下降 1.373 1.485 1.670 1.7400.9480.872区上升 1.3720.8490.7440.6730.4390.385区下降 1.365 1.504 1.396 1.527 1.045 1.197区上升 1.355 1.305 1.271 1.079 1.415 1.373区下降 1.355 1.530 1.094 1.2740.6210.844区上升 1.353 1.232 1.181 1.214 1.381 1.546区上升 1.335 1.214 1.348 1.269 1.413 1.528区上升 1.314 1.228 1.433 1.1350.907 1.209区下降 1.302 1.365 1.317 1.643 1.091 1.000区上升 1.276 1.047 1.1220.9380.905 1.009区上升 1.273 1.208 1.290 1.556 1.2390.793区上升 1.2600.6180.5450.3560.3020.432区上升 1.256 1.219 1.0570.887 1.136 1.205区下降 1.253 2.317 2.878 2.367 3.077 2.833区下降 1.250 1.2920.920 1.2310.7310.917区上升 1.241 1.107 1.734 1.462 1.623 2.003区下降 1.236 1.364 1.0760.8220.978 1.050区上升 1.226 1.113 1.113 1.078 1.0760.697区下降 1.215 1.240 1.373 1.378 1.183 1.016区上升 1.2050.7710.6250.6900.7330.528区上升 1.2040.951 1.086 1.234 1.2220.667区上升 1.200 1.0000.7930.9230.5970.925区下降 1.189 1.323 1.349 1.181 1.675 1.408区上升 1.1830.8710.922 1.079 1.190 1.008区下降 1.181 1.232 1.406 1.4210.9470.901区下降 1.178 1.7060.4430.3310.3330.132区下降 1.177 1.470 1.140 1.248 1.182 1.190区上升 1.171 1.100 1.249 1.506 1.295 1.410区上升 1.164 1.1420.926 1.161 1.1530.887区下降 1.156 1.219 1.080 1.380 1.681 1.291区持平 1.143 1.143 1.2500.9600.5400.491区下降 1.143 1.786 1.2040.8110.867 1.100区上升 1.125 1.099 1.124 1.295 1.395 1.428区下降 1.120 1.208 1.1110.000 1.1610.935区下降 1.117 1.142 1.025 1.5740.7140.580区上升 1.0890.907 1.177 1.000 1.1730.965区下降 1.089 1.158 1.247 1.104 1.476 1.613区下降 1.087 1.126 1.380 1.183 1.1540.574区上升 1.0810.9830.9560.7700.9270.660区上升 1.079 1.069 1.062 1.0600.8570.627区上升 1.0740.9570.795 1.042 1.2390.825区上升 1.0640.8810.7550.7210.7140.643区下降 1.062 1.0870.9590.748 1.125 1.516区下降 1.058 1.141 1.113 1.2120.9250.749区下降 1.052 1.220 1.528 2.0380.8520.693区下降 1.051 1.160 1.015 1.2880.8400.536区上升 1.046 1.0180.9180.945 1.006 1.158区上升 1.0410.989 1.242 1.265 1.437 1.572区上升 1.0220.853 1.1880.939 1.294 1.312区上升 1.0140.919 1.071 1.152 1.062 1.227区上升 1.0000.5500.0000.0000.800 1.286区上升 1.0000.8720.4770.0000.0000.000区上升 1.0000.892 1.0950.987 1.1650.900区上升0.9860.968 1.5500.8330.924 1.153区上升0.9860.9840.7300.7140.6330.612区上升0.9840.960 1.0370.9120.8800.753区下降0.957 1.221 1.6530.0000.7960.698区下降0.954 1.110 1.1790.943 1.203 1.073区下降0.951 1.0210.8140.8140.9180.500区上升0.9360.782 1.147 1.005 1.033 1.064区下降0.935 1.250 1.296 1.1090.9610.750区上升0.9290.9140.7310.7030.6750.648区上升0.9280.8950.6740.3000.4420.083区上升0.9100.0000.690 1.099 1.609 1.238区上升0.9040.5210.3880.5670.6060.500区上升0.9020.8550.9380.7780.8860.696区下降0.894 1.031 1.0130.812 1.0640.931区下降0.889 1.0320.6540.4640.5670.696区下降0.8800.9140.8310.8910.7830.905区上升0.8780.8550.8970.9370.8190.684区上升0.8750.8260.6500.5730.3820.638区下降0.8710.8920.6210.6710.7290.472区上升0.8620.7830.7580.9640.7110.755区下降0.8210.8600.6200.6980.6600.453区下降0.8190.9310.8870.8200.6170.972区下降0.8170.970 1.090 1.115 1.0030.950区下降0.816 1.039 1.432 1.638 1.0190.838区下降0.8090.9240.7960.8640.8160.782区上升0.8040.4440.6000.6790.7690.655区下降0.792 1.042 1.051 1.1440.9230.974区下降0.7820.8750.8760.8510.7220.713区上升0.7820.6790.8390.8530.6700.515区下降0.775 1.0090.8380.7670.8740.780区下降0.767 1.028 1.145 1.1000.5690.635区上升0.7600.7200.7330.5680.5320.491区下降0.7440.8240.9640.8780.677 1.018区下降0.7420.8140.4650.3760.5230.387区上升0.7390.6940.8910.7290.5930.712区下降0.7380.7940.8590.7500.6620.800区下降0.7320.9330.7530.7080.8390.780区下降0.7290.7530.889 1.017 1.1110.989区上升0.7220.5080.6910.6350.5000.869区上升0.7190.7120.6670.6280.3480.309区上升0.7180.6040.7890.3420.2580.139区上升0.7030.5140.6590.6150.6460.407区上升0.7000.672 1.0000.8600.694 1.380区上升0.6880.5810.7370.7220.4810.444区上升0.6810.6190.6000.4180.5960.392区下降0.6810.7050.2390.2500.2500.411区上升0.6810.5140.3810.3120.3170.392区上升0.6790.6110.6050.4890.3530.346区下降0.6750.7060.7550.6640.5790.645区上升0.6720.5160.7630.6720.4060.354区下降0.6460.802 1.1730.673 1.2640.642区下降0.6460.6700.8660.8680.6760.609区下降0.6460.6500.7050.6990.6200.460区上升0.6400.4800.4960.7260.5730.564区下降0.6400.7260.3950.5310.5670.448区下降0.6390.7560.6790.7480.5940.644区上升0.6310.2730.6070.7290.4840.393区上升0.6280.6030.2160.2470.1940.222区下降0.6250.8040.830 1.0220.9130.771区上升0.6250.4120.3260.2210.2660.276区上升0.6050.2710.4810.5440.2470.481区下降0.6040.7120.5700.5650.5070.435区上升0.6000.3670.3920.4470.4790.225区上升0.5900.5190.1960.0000.0000.000区下降0.5860.9200.7860.4770.5330.600区持平0.5860.5860.8460.9120.7450.753区下降0.5860.6670.5370.4670.5190.323区下降0.5830.6620.5970.6390.4840.712区下降0.5750.6760.6610.7560.6870.681区上升0.5560.5250.4470.6490.5000.344区上升0.5520.5220.6910.3930.5470.375区下降0.5450.9200.802 1.0000.9250.868区下降0.5430.5910.7570.6360.6590.692区上升0.5410.5090.5100.6370.5460.839区下降0.5370.6040.7170.7070.4390.743区上升0.5340.0000.3680.3950.4940.565区上升0.5310.3330.4000.3730.4220.448区下降0.5230.5780.6850.8460.6350.793区下降0.5200.6380.5000.4350.6320.464区上升0.5160.4740.767 1.0630.9840.882区上升0.5120.4340.4000.4350.3590.214区下降0.5100.7170.6850.9220.552 1.108区下降0.5050.7730.6970.5450.6880.480区上升0.5040.3450.5380.2420.4160.412区上升0.5030.3260.4630.4160.5190.595区下降0.4940.5360.5260.6410.7260.512区下降0.4910.6000.7060.3790.5970.449区下降0.4910.5260.5940.3940.4120.235区下降0.4800.7060.7040.6200.6050.503区上升0.4780.3680.5380.5560.5520.375区上升0.4690.4480.3930.4310.5340.403区上升0.4550.3330.2290.3480.5310.359区上升0.4510.3840.3960.5950.7680.614区下降0.4410.5900.4680.4950.4100.393区下降0.436 1.054 1.6340.884 1.2210.789区下降0.4350.4790.1230.4000.2180.193区上升0.4290.3180.3370.3620.3120.275区上升0.4240.3150.4270.3810.4730.456区上升0.4170.2300.3610.3260.2910.179区下降0.4140.4870.2960.6450.4400.265区上升0.4120.3040.3790.5320.2000.364区下降0.4050.4910.5710.5260.5070.355区下降0.4030.4240.4320.9440.4260.313区上升0.4000.3750.324 1.0000.4000.806区下降0.3970.8950.7600.3200.5090.627区下降0.3930.6720.5160.6250.5650.551区下降0.3900.4230.4200.5060.4320.397区上升0.3820.2000.3140.4290.5220.444区上升0.3750.2500.0470.2800.2040.033区下降0.3730.5650.5540.2880.4140.513区上升0.3680.1000.2780.2630.6360.300区下降0.3570.3650.3770.4140.3210.218区上升0.3570.2920.3490.2500.1190.066区上升0.3500.2000.1800.2960.2090.086区下降0.3460.3510.4920.5000.3660.222区下降0.3390.3430.3310.2370.4160.281区下降0.3350.3730.5130.3280.3200.312区上升0.3270.2950.2640.2660.2170.192区上升0.3230.0000.2510.2200.1750.198区上升0.3220.2950.2630.1590.1550.149区上升0.3210.1770.2300.2370.1480.113区下降0.3060.4120.3540.5320.5000.240区上升0.3020.2810.3810.3540.4890.367区上升0.2920.1330.2580.1670.1690.179区上升0.2810.1860.2260.5160.4850.310区上升0.2780.2400.4400.7780.6890.543区下降0.2740.4270.4750.4440.3790.505区下降0.2640.3900.5970.3050.2880.173区上升0.2620.0490.3120.3740.2940.264区下降0.2580.2870.4580.4950.2430.141区下降0.2560.3680.3150.3210.3570.145区上升0.2550.2180.2120.2720.2400.352区上升0.2530.2170.1590.2810.0790.016区下降0.2500.3080.1940.8700.2590.276区下降0.2500.2530.2480.2690.4970.339区上升0.2480.1810.3380.2540.2070.151区下降0.2440.3600.2150.2830.2380.266区上升0.2430.1470.2940.1470.2500.129区下降0.2420.3160.2210.2360.2760.342区上升0.2400.1980.2690.2910.2540.349区下降0.2220.2440.2860.2400.1910.128区上升0.2190.2100.1520.1920.1760.171区下降0.2080.3140.3100.2500.2790.288区下降0.1940.3240.1140.3120.2580.375区下降0.1900.2370.2080.2350.3580.320区下降0.1900.2020.1390.1840.1090.122区上升0.1900.0710.0000.1710.3290.194区持平0.1850.1850.1460.2010.3000.200区上升0.1700.0390.1520.0750.0890.102区上升0.1600.0000.1320.1220.1470.137区上升0.1590.1230.1480.1940.0750.118区上升0.1530.1480.1440.1100.1210.165区下降0.1470.1820.3010.2290.1850.163区下降0.1450.1620.1460.1140.1420.065区上升0.1410.0000.1770.1700.1560.102区上升0.1340.1050.1250.1810.2290.062区上升0.1330.0000.3550.3230.1880.353区下降0.1200.1480.0820.2730.1430.167区下降0.1040.3180.1820.0740.1470.055区上升0.0900.0830.1280.0610.1630.223区下降0.0790.1000.1250.1190.2520.202区下降0.0090.0570.0620.0540.0340.040区持平0.0000.0000.1350.0500.1760.054JCR-2014收录中科院JCR大类分区SCI收录本土期刊包含港澳收录1保持收录收录2保持收录收录保持收录收录1保持收录收录1保持收录收录1保持收录收录2保持收录收录保持收录收录3保持收录收录2保持收录收录1保持收录收录4保持收录收录2保持收录收录1保持收录收录2保持收录收录3保持收录收录1保持收录收录2保持收录收录3保持收录收录2保持收录收录2保持收录收录2保持收录收录2保持收录收录保持收录收录2保持收录收录2保持收录收录2保持收录收录保持收录收录1保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录2保持收录收录3保持收录收录2保持收录收录3保持收录收录2保持收录收录3保持收录收录2保持收录收录2保持收录收录1保持收录收录4保持收录收录2保持收录收录2保持收录收录3保持收录收录4保持收录收录2保持收录收录3保持收录收录2保持收录收录3保持收录收录2保持收录收录3保持收录收录3保持收录收录2保持收录收录3保持收录收录3保持收录收录3保持收录收录2保持收录收录3保持收录收录3保持收录收录4保持收录收录2保持收录收录3保持收录收录2保持收录收录3保持收录收录4保持收录收录4保持收录收录1保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录4保持收录收录3保持收录收录3保持收录收录3保持收录收录2保持收录收录2保持收录收录3保持收录收录3保持收录收录1保持收录收录4保持收录收录3保持收录收录3保持收录收录4保持收录收录3保持收录收录3保持收录收录2保持收录收录2保持收录收录4保持收录收录4保持收录收录3保持收录收录2保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录4保持收录收录4保持收录收录保持收录收录3保持收录收录保持收录收录4保持收录收录3保持收录收录3保持收录收录3保持收录收录2保持收录收录3保持收录收录4保持收录收录3保持收录收录3保持收录收录3保持收录收录保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录4保持收录收录3保持收录收录3保持收录收录4保持收录收录3保持收录收录2保持收录收录3保持收录收录3保持收录收录3保持收录收录4保持收录收录4保持收录收录4保持收录收录3保持收录收录4保持收录收录4保持收录收录3保持收录收录4保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录3保持收录收录4保持收录收录3保持收录收录4保持收录收录3保持收录收录保持收录收录4保持收录收录4保持收录收录4保持收录收录4保持收录收录4保持收录收录4保持收录收录3保持收录收录3保持收录收录4保持收录收录3保持收录收录4保持收录收录4保持收录收录4保持收录收录4保持收录。
细胞铁死亡在脓毒症相关脏器损伤中的研究进展
细胞铁死亡在脓毒症相关脏器损伤中的研究进展摘要:脓毒症相关脏器损伤是一种常见的、由脓毒症引起的器官功能降低的危重临床疾病，最终导致患者死亡率增加；目前对脓毒症相关脏器损伤尚未形成规范的临床治疗手段。
脓毒症相关脏器损伤的发病机制十分复杂，与氧化应激、炎症反应、缺血再灌注损伤、细胞程序性死亡等机制密切相关。
细胞铁死亡作为细胞程序性死亡的关键部分，参与脓毒症相关脏器损伤的进展过程。
越来越多的研究表明，铁死亡在脓毒症相关脏器损伤的发生中发挥重要作用。
因此，本文拟深入探讨细胞铁死亡参与脓毒症相关脏器损伤发生的具体机制，对阐述脓毒症相关脏器损伤发生的病理机制，提出新的预防和治疗靶点具有重要意义。
关键词：铁死亡；脓毒症，脓毒症相关脏器损伤1. 细胞铁死亡的概述铁死亡于2012年由Dixon首次提出为一种新的细胞程序性死亡方式[1]。
细胞铁死亡的发生机制主要包括四种途径：GPX4途径失调、脂质过氧化增加、铁离子超载和抗氧化通路紊乱[2]。
在此我们回顾了脓毒症相关脏器损伤中铁死亡的发生和调节机制，详细介绍了基于铁死亡的脓毒症相关脏器损伤治疗的机遇和挑战，充分阐述针对脓毒症相关脏器损伤中细胞铁死亡发生的临床治疗新策略。
2. 细胞铁死亡参与脓毒症相关脏器损伤发生的分子机制2.1 GPX4调节途径作为一种强大的抗氧化剂，谷胱甘肽（GSH）在铁死亡中起着关键作用。
System Xc−是质膜上的胱氨酸/谷氨酸反转运蛋白，运输细胞外胱氨酸以换取细胞内谷氨酸，由十二道跨膜转运蛋白SLC7A11偶联单程跨膜调节蛋白SLC3A2组成[3]。
此外，胱氨酸-tRNA合成酶（CARS）调节的转硫途径也是胱氨酸输入的一种方式[4]。
内化后，胱氨酸通过GSH或硫氧还蛋白还原酶1（TXNRD1）迅速还原为半胱氨酸[5]。
随后谷氨酸、半胱氨酸和甘氨酸依次合成GSH。
谷胱甘肽过氧化物酶4（GPX4）使用谷胱甘肽通过消除磷脂过氧化物来保护细胞免受铁死亡[6]。